@article{item_3265782,
  title = {{Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions}},
  journal = {{Angewandte Chemie International Edition}},
  abstract = {{Zinc ions play an important role in numerous crucial biological processes in the human body. The ability to image the function of Zn 2+ would be a significant asset to biomedical research for monitoring various physiopathologies dependent on its fate. To this end, we developed a novel Gd 3+ chelate that can selectively recognize Zn 2+ over other abundant endogenous metal ions and alter its paramagnetic properties. More specifically, this lanthanide chelate displayed an extraordinary increase in longitudinal relaxivity ( r 1 ) of over 400\textpercent upon interaction with Zn 2+ at 7 T and 25 \mbox{$^\circ$}C, which is the greatest r 1 enhancement observed for any of the metal ion-responsive Gd-based complexes at high magnetic field. A "turn-on" mechanism responsible for these massive changes was confirmed through NMR and luminescence lifetime studies on a 13 C-labeled Eu 3+ analogue. This molecular platform represents a new momentum in developing highly suitable magnetic resonance imaging contrast agents for functional molecular imaging studies of Zn 2+ .}},
  volume = {60},
  number = {11},
  pages = {5734--5738},
  publisher = {Wiley-VCH},
  address = {Weinheim},
  year = {2021},
  slug = {item_3265782},
  author = {Wang, G and Angelovski, G}
}