GLINT: Establishing reproducible APT-, NOE- and gluco-CEST measurement at 3 T: evaluated at 3 clinical sites
{Aims and objectives: Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) allows for indirect detection of diluted molecules via their saturation transfer to the abundant water pool [1-3]. Many different diluted solutes were reported to be detectable with CEST, including endogenous solutes such [...] Methods and materials: MRI was performed at 3 T (Prisma, Siemens Healthcare) in three healthy subjects, each at a different clinical site: University College London (UCL), Max Planck Institute (MPI) for Biological Cybernetics in Germany, and Tel Aviv University (TAU) in Israel. In addition, one patient with one brain tum[...] Results: All three sites produced similar CEST contrasts with stable signal distribution over all slices. APT-weighted images exhibited the expected low contrast in healthy tissues (Figure 2). Spectrally selective amide- and NOE-CEST maps (Figure 3) showed gray- and white-matter contrast comparable to that r[...] Conclusion: At clinical field strengths, CEST effects are spectrally broadened and lower in magnitude, and therefore harder to isolate compared to experiments at ultra-high magnetic field strengths. Translation of CEST imaging to clinical field strengths is therefore challenging. In this study, a fast 3D snap[...]}
| Author(s): | Deshmane, A and Zaiss, M and Herz, K and Rivlin, M and Kujawa, A and Kim, M and Navon, G and Golay, X and Scheffler, K |
| Book Title: | 25th European Congress of Radiology (ECR 2019) |
| Year: | 2019 |
| Bibtex Type: | Miscellaneous (misc) |
| DOI: | 10.26044/ecr2019/C-1311 |
| Electronic Archiving: | grant_archive |
BibTex
@misc{item_3032321,
title = {{GLINT: Establishing reproducible APT-, NOE- and gluco-CEST measurement at 3 T: evaluated at 3 clinical sites}},
booktitle = {{25th European Congress of Radiology (ECR 2019)}},
abstract = {{Aims and objectives: Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) allows for indirect detection of diluted molecules via their saturation transfer to the abundant water pool [1-3]. Many different diluted solutes were reported to be detectable with CEST, including endogenous solutes such [...] Methods and materials: MRI was performed at 3 T (Prisma, Siemens Healthcare) in three healthy subjects, each at a different clinical site: University College London (UCL), Max Planck Institute (MPI) for Biological Cybernetics in Germany, and Tel Aviv University (TAU) in Israel. In addition, one patient with one brain tum[...] Results: All three sites produced similar CEST contrasts with stable signal distribution over all slices. APT-weighted images exhibited the expected low contrast in healthy tissues (Figure 2). Spectrally selective amide- and NOE-CEST maps (Figure 3) showed gray- and white-matter contrast comparable to that r[...] Conclusion: At clinical field strengths, CEST effects are spectrally broadened and lower in magnitude, and therefore harder to isolate compared to experiments at ultra-high magnetic field strengths. Translation of CEST imaging to clinical field strengths is therefore challenging. In this study, a fast 3D snap[...]}},
year = {2019},
slug = {item_3032321},
author = {Deshmane, A and Zaiss, M and Herz, K and Rivlin, M and Kujawa, A and Kim, M and Navon, G and Golay, X and Scheffler, K}
}