@article{item_2643783,
  title = {{AGuIX\textregistered from bench to bedside: Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine}},
  journal = {{British Journal of Radiology}},
  abstract = {{AGuIX\textregistered are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck\ldots). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.}},
  volume = {92},
  number = {1093},
  pages = {1--19},
  publisher = {British Institute of Radiology},
  address = {London},
  year = {2019},
  slug = {item_2643783},
  author = {Lux, F and Tran, VL and Thomas, E and Dufort, S and Rossetti, F and Martini, M and Truillet, C and Doussineau, T and Bort, G and Denat, F and Boschetti, F and Angelovski, G and Detappe, A and Cr\'emillieux, Y and Mignet, M and Doan, BT and Larrat, B and Meriaux, S and Barbier, E and Roux, S and Fries, P and M\"uller, A and Abadjian, MC and Anderson, C and Canet-Soulas, E and Bouziotis, P and Barberi-Heyob, M and Verry, C and Balosso, J and Evans, M and Sidi-Boumedine, J and Janier, M and Butterworth, K and McMahon, S and Prise, K and Aloy, MT and Ardail, D and Rodriguez-Lafrasse, C and Porcel, E and Lacombe, S and Berbeco, R and Allouch, A and Perfettini, JL and Chargari, C and Deutsch, E and Le Duc, G and Tillement, O}
}