Mixed-length multivariate covalent organic framework for combined near-infrared photodynamic therapy and drug delivery

@article{rodriguez2025mixed,
  title = {Mixed-length multivariate covalent organic framework for combined near-infrared photodynamic therapy and drug delivery},
  journal = {Journal of the American Chemical Society},
  abstract = {Covalent organic frameworks (COFs) have been emerging as versatile reticular materials due to their tunable structures and functionalities, enabled by precise molecular engineering at the atomic level. While the integration of multiple components into COFs has substantially expanded their structural complexity, the strategic engineering of diverse functionalities within a single framework via the random distribution of linkers with varying lengths remains largely unexplored. Here, we report a series of highly crystalline mixed-length multivariate COFs synthesized using azobenzene and bipyridine as linkers, where tuning the ratio of linkers and incorporating palladium effectively modulates the balance between near-infrared (NIR) light absorption and catalytic sites for NIR-generation of hydrogen peroxide (H2O2). Capitalizing on the deep tissue penetration of NIR light and the generated H2O2 as reactive oxygen species, as a proof of concept, the optimal mixed-length multivariate COF reduces breast cancer cell viability by almost 90% after 1 h of irradiation in a combined in vitro photodynamic therapy and drug delivery.},
  volume = {147},
  pages = {33472--33481},
  month = sep,
  year = {2025},
  author = {Rodr{\'\i}guez-Camargo, Andr{\'e}s and Yildiz, Erdost and Juela, Diego and Fischer, Felix Richard and Graf, Daniel and Rath, Bibhuti Bhusan and Ochsenfeld, Christian and Bauer, Matthias and Sitti, Metin and Yao, Liang and Lotsch, Bettina},
  doi = {https://doi.org/10.1021/jacs.5c07787},
  url = {https://pubs.acs.org/doi/full/10.1021/jacs.5c07787},
  month_numeric = {9}
}