Under acute threat, biological agents need to choose adaptive actions to survive. In my talk, I will provide a decision-theoretic view on this problem and ask, what are potential computational algorithms for this choice, and how are they implemented in neural circuits. Rational design principles and non-human animal data tentatively suggest a specific architecture that heavily relies on tailored algorithms for specific threat scenarios. Virtual reality computer games provide an opportunity to translate non-human animal tasks to humans and investigate these algorithms across species. I will discuss the specific challenges for empirical inference on underlying neural circuits given such architecture.