Nanoparticles offer an effective approach to drug delivery, enabling targeted and controlled release of various therapeutic agents. These advancements could enhance the quality of life of patients by reducing injection frequency and minimizing drug toxicity. However, traditional nanoparticle formulations often face challenges in achieving high drug-loading capacity, controllability, real-time imaging, and effectively crossing physiological barriers like the blood-brain barrier, which limits their potential in treating certain diseases. In this study, we have developed magnetic metal–organic framework nanoparticles with high drug-loading capacity and real-time medical imaging capability, designed to efficiently transport drugs across the blood-brain barrier to brain tumor sites via reconfigurable particle swarms. These nanoparticles, featuring a hard magnetic FePt core for effective magnetic actuation and a porous ZIF-8 shell for high-capacity drug loading, demonstrate advanced navigation in complex cerebral circulation and enhance medical imaging modalities, including optoacoustic imaging and magnetic resonance tomography. Our in-vitro studies reveal the potential of these nanoparticles to overcome physiological endothelial barriers, offering new strategies for treating cerebrovascular diseases and other conditions, such as glioblastoma, where drug delivery is challenging.  Ex vivo and in vivo animal test results of these engineered nanoparticles demonstrate their promise for future minimally invasive cerebrovascular treatments, highlighting the critical need for further research to optimize the stability, safety, and biocompatibility of such nanoparticles.