Header logo is


1999


no image
Engineering Support Vector Machine Kernels That Recognize Translation Initiation Sites in DNA

Zien, A., Rätsch, G., Mika, S., Schölkopf, B., Lemmen, C., Smola, A., Lengauer, T., Müller, K.

In German Conference on Bioinformatics (GCB 1999), October 1999 (inproceedings)

Abstract
In order to extract protein sequences from nucleotide sequences, it is an important step to recognize points from which regions encoding pro­ teins start, the so­called translation initiation sites (TIS). This can be modeled as a classification prob­ lem. We demonstrate the power of support vector machines (SVMs) for this task, and show how to suc­ cessfully incorporate biological prior knowledge by engineering an appropriate kernel function.

ei

Web [BibTex]

1999


Web [BibTex]


no image
Tele-touch feedback of surfaces at the micro/nano scale: Modeling and experiments

Sitti, M., Horighuchi, S., Hashimoto, H.

In Intelligent Robots and Systems, 1999. IROS’99. Proceedings. 1999 IEEE/RSJ International Conference on, 2, pages: 882-888, 1999 (inproceedings)

pi

[BibTex]

[BibTex]


no image
Challenge to micro/nanomanipulation using atomic force microscope

Hashimoto, H., Sitti, M.

In Micromechatronics and Human Science, 1999. MHS’99. Proceedings of 1999 International Symposium on, pages: 35-42, 1999 (inproceedings)

pi

[BibTex]

[BibTex]


no image
< 研究速報>(< 小特集> マイクロマシン)

Sitti, M., 橋本秀紀,

生産研究, 51(8):651-653, 東京大学, 1999 (article)

pi

[BibTex]

[BibTex]


no image
Visualization interface for AFM-based nano-manipulation

Horiguchi, S., Sitti, M., Hashimoto, H.

In Industrial Electronics, 1999. ISIE’99. Proceedings of the IEEE International Symposium on, 1, pages: 310-315, 1999 (inproceedings)

pi

[BibTex]

[BibTex]


no image
Micro/Nano Manipulation Using Atomic Force Microscope.

Sitti, M., Hashimoto, H.

生産研究, 51(8):651-653, 東京大学生産技術研究所, 1999 (article)

pi

[BibTex]

[BibTex]


no image
Is imitation learning the route to humanoid robots?

Schaal, S.

Trends in Cognitive Sciences, 3(6):233-242, 1999, clmc (article)

Abstract
This review will focus on two recent developments in artificial intelligence and neural computation: learning from imitation and the development of humanoid robots. It will be postulated that the study of imitation learning offers a promising route to gain new insights into mechanisms of perceptual motor control that could ultimately lead to the creation of autonomous humanoid robots. This hope is justified because imitation learning channels research efforts towards three important issues: efficient motor learning, the connection between action and perception, and modular motor control in form of movement primitives. In order to make these points, first, a brief review of imitation learning will be given from the view of psychology and neuroscience. In these fields, representations and functional connections between action and perception have been explored that contribute to the understanding of motor acts of other beings. The recent discovery that some areas in the primate brain are active during both movement perception and execution provided a first idea of the possible neural basis of imitation. Secondly, computational approaches to imitation learning will be described, initially from the perspective of traditional AI and robotics, and then with a focus on neural network models and statistical learning research. Parallels and differences between biological and computational approaches to imitation will be highlighted. The review will end with an overview of current projects that actually employ imitation learning for humanoid robots.

am

link (url) [BibTex]

link (url) [BibTex]


no image
Tele-nanorobotics 2-d manipulation of micro/nanoparticles using afm

Sitti, M., Horiguchi, S., Hashimoto, H.

In Advanced Intelligent Mechatronics, 1999. Proceedings. 1999 IEEE/ASME International Conference on, pages: 786-786, 1999 (inproceedings)

pi

[BibTex]

[BibTex]


no image
Virtual Reality-Based Teleoperation in the Micro/Nano World.

Sitti, M., Hashimoto, H.

生産研究, 51(8):654-656, 東京大学生産技術研究所, 1999 (article)

pi

[BibTex]

[BibTex]


no image
Nonparametric regression for learning nonlinear transformations

Schaal, S.

In Prerational Intelligence in Strategies, High-Level Processes and Collective Behavior, 2, pages: 595-621, (Editors: Ritter, H.;Cruse, H.;Dean, J.), Kluwer Academic Publishers, 1999, clmc (inbook)

Abstract
Information processing in animals and artificial movement systems consists of a series of transformations that map sensory signals to intermediate representations, and finally to motor commands. Given the physical and neuroanatomical differences between individuals and the need for plasticity during development, it is highly likely that such transformations are learned rather than pre-programmed by evolution. Such self-organizing processes, capable of discovering nonlinear dependencies between different groups of signals, are one essential part of prerational intelligence. While neural network algorithms seem to be the natural choice when searching for solutions for learning transformations, this paper will take a more careful look at which types of neural networks are actually suited for the requirements of an autonomous learning system. The approach that we will pursue is guided by recent developments in learning theory that have linked neural network learning to well established statistical theories. In particular, this new statistical understanding has given rise to the development of neural network systems that are directly based on statistical methods. One family of such methods stems from nonparametric regression. This paper will compare nonparametric learning with the more widely used parametric counterparts in a non technical fashion, and investigate how these two families differ in their properties and their applicabilities. We will argue that nonparametric neural networks offer a set of characteristics that make them a very promising candidate for on-line learning in autonomous system.

am

link (url) [BibTex]

link (url) [BibTex]


no image
Segmentation of endpoint trajectories does not imply segmented control

Sternad, D., Schaal, D.

Experimental Brain Research, 124(1):118-136, 1999, clmc (article)

Abstract
While it is generally assumed that complex movements consist of a sequence of simpler units, the quest to define these units of action, or movement primitives, still remains an open question. In this context, two hypotheses of movement segmentation of endpoint trajectories in 3D human drawing movements are re-examined: (1) the stroke-based segmentation hypothesis based on the results that the proportionality coefficient of the 2/3 power law changes discontinuously with each new â??strokeâ?, and (2) the segmentation hypothesis inferred from the observation of piecewise planar endpoint trajectories of 3D drawing movements. In two experiments human subjects performed a set of elliptical and figure-8 patterns of different sizes and orientations using their whole arm in 3D. The kinematic characteristics of the endpoint trajectories and the seven joint angles of the arm were analyzed. While the endpoint trajectories produced similar segmentation features as reported in the literature, analyses of the joint angles show no obvious segmentation but rather continuous oscillatory patterns. By approximating the joint angle data of human subjects with sinusoidal trajectories, and by implementing this model on a 7-degree-of-freedom anthropomorphic robot arm, it is shown that such a continuous movement strategy can produce exactly the same features as observed by the above segmentation hypotheses. The origin of this apparent segmentation of endpoint trajectories is traced back to the nonlinear transformations of the forward kinematics of human arms. The presented results demonstrate that principles of discrete movement generation may not be reconciled with those of rhythmic movement as easily as has been previously suggested, while the generalization of nonlinear pattern generators to arm movements can offer an interesting alternative to approach the question of units of action.

am

link (url) [BibTex]

link (url) [BibTex]


no image
Two-dimensional fine particle positioning using a piezoresistive cantilever as a micro/nano-manipulator

Sitti, M., Hashimoto, H.

In Robotics and Automation, 1999. Proceedings. 1999 IEEE International Conference on, 4, pages: 2729-2735, 1999 (inproceedings)

pi

[BibTex]

[BibTex]


no image
Teleoperated nano scale object manipulation

Sitti, M., Hashimoto, H.

Recent Advances on Mechatronics, pages: 322-335, Singapore: Springer-Verlag, 1999 (article)

pi

[BibTex]

[BibTex]

1994


no image
Robot juggling: An implementation of memory-based learning

Schaal, S., Atkeson, C. G.

Control Systems Magazine, 14(1):57-71, 1994, clmc (article)

Abstract
This paper explores issues involved in implementing robot learning for a challenging dynamic task, using a case study from robot juggling. We use a memory-based local modeling approach (locally weighted regression) to represent a learned model of the task to be performed. Statistical tests are given to examine the uncertainty of a model, to optimize its prediction quality, and to deal with noisy and corrupted data. We develop an exploration algorithm that explicitly deals with prediction accuracy requirements during exploration. Using all these ingredients in combination with methods from optimal control, our robot achieves fast real-time learning of the task within 40 to 100 trials.

am

link (url) [BibTex]

1994


link (url) [BibTex]


no image
Robot learning by nonparametric regression

Schaal, S., Atkeson, C. G.

In Proceedings of the International Conference on Intelligent Robots and Systems (IROS’94), pages: 478-485, Munich Germany, 1994, clmc (inproceedings)

Abstract
We present an approach to robot learning grounded on a nonparametric regression technique, locally weighted regression. The model of the task to be performed is represented by infinitely many local linear models, i.e., the (hyper-) tangent planes at every query point. Such a model, however, is only generated when a query is performed and is not retained. This is in contrast to other methods using a finite set of linear models to accomplish a piecewise linear model. Architectural parameters of our approach, such as distance metrics, are also a function of the current query point instead of being global. Statistical tests are presented for when a local model is good enough such that it can be reliably used to build a local controller. These statistical measures also direct the exploration of the robot. We explicitly deal with the case where prediction accuracy requirements exist during exploration: By gradually shifting a center of exploration and controlling the speed of the shift with local prediction accuracy, a goal-directed exploration of state space takes place along the fringes of the current data support until the task goal is achieved. We illustrate this approach by describing how it has been used to enable a robot to learn a challenging juggling task: Within 40 to 100 trials the robot accomplished the task goal starting out with no initial experiences.

am

[BibTex]

[BibTex]


no image
Assessing the quality of learned local models

Schaal, S., Atkeson, C. G.

In Advances in Neural Information Processing Systems 6, pages: 160-167, (Editors: Cowan, J.;Tesauro, G.;Alspector, J.), Morgan Kaufmann, San Mateo, CA, 1994, clmc (inproceedings)

Abstract
An approach is presented to learning high dimensional functions in the case where the learning algorithm can affect the generation of new data. A local modeling algorithm, locally weighted regression, is used to represent the learned function. Architectural parameters of the approach, such as distance metrics, are also localized and become a function of the query point instead of being global. Statistical tests are given for when a local model is good enough and sampling should be moved to a new area. Our methods explicitly deal with the case where prediction accuracy requirements exist during exploration: By gradually shifting a "center of exploration" and controlling the speed of the shift with local prediction accuracy, a goal-directed exploration of state space takes place along the fringes of the current data support until the task goal is achieved. We illustrate this approach with simulation results and results from a real robot learning a complex juggling task.

am

link (url) [BibTex]

link (url) [BibTex]


no image
Memory-based robot learning

Schaal, S., Atkeson, C. G.

In IEEE International Conference on Robotics and Automation, 3, pages: 2928-2933, San Diego, CA, 1994, clmc (inproceedings)

Abstract
We present a memory-based local modeling approach to robot learning using a nonparametric regression technique, locally weighted regression. The model of the task to be performed is represented by infinitely many local linear models, the (hyper-) tangent planes at every query point. This is in contrast to other methods using a finite set of linear models to accomplish a piece-wise linear model. Architectural parameters of our approach, such as distance metrics, are a function of the current query point instead of being global. Statistical tests are presented for when a local model is good enough such that it can be reliably used to build a local controller. These statistical measures also direct the exploration of the robot. We explicitly deal with the case where prediction accuracy requirements exist during exploration: By gradually shifting a center of exploration and controlling the speed of the shift with local prediction accuracy, a goal-directed exploration of state space takes place along the fringes of the current data support until the task goal is achieved. We illustrate this approach by describing how it has been used to enable a robot to learn a challenging juggling task: within 40 to 100 trials the robot accomplished the task goal starting out with no initial experiences.

am

[BibTex]

[BibTex]


no image
Nonparametric regression for learning

Schaal, S.

In Conference on Adaptive Behavior and Learning, Center of Interdisciplinary Research (ZIF) Bielefeld Germany, also technical report TR-H-098 of the ATR Human Information Processing Research Laboratories, 1994, clmc (inproceedings)

Abstract
In recent years, learning theory has been increasingly influenced by the fact that many learning algorithms have at least in part a comprehensive interpretation in terms of well established statistical theories. Furthermore, with little modification, several statistical methods can be directly cast into learning algorithms. One family of such methods stems from nonparametric regression. This paper compares nonparametric learning with the more widely used parametric counterparts and investigates how these two families differ in their properties and their applicability. 

am

link (url) [BibTex]

link (url) [BibTex]

1993


no image
Learning passive motor control strategies with genetic algorithms

Schaal, S., Sternad, D.

In 1992 Lectures in complex systems, pages: 913-918, (Editors: Nadel, L.;Stein, D.), Addison-Wesley, Redwood City, CA, 1993, clmc (inbook)

Abstract
This study investigates learning passive motor control strategies. Passive control is understood as control without active error correction; the movement is stabilized by particular properties of the controlling dynamics. We analyze the task of juggling a ball on a racket. An approximation to the optimal solution of the task is derived by means of optimization theory. In order to model the learning process, the problem is coded for a genetic algorithm in representations without sensory or with sensory information. For all representations the genetic algorithm is able to find passive control strategies, but learning speed and the quality of the outcome are significantly different. A comparison with data from human subjects shows that humans seem to apply yet different movement strategies to the ones proposed. For the feedback representation some implications arise for learning from demonstration.

am

link (url) [BibTex]

1993


link (url) [BibTex]


no image
A genetic algorithm for evolution from an ecological perspective

Sternad, D., Schaal, S.

In 1992 Lectures in Complex Systems, pages: 223-231, (Editors: Nadel, L.;Stein, D.), Addison-Wesley, Redwood City, CA, 1993, clmc (inbook)

Abstract
In the population model presented, an evolutionary dynamic is explored which is based on the operator characteristics of genetic algorithms. An essential modification in the genetic algorithms is the inclusion of a constraint in the mixing of the gene pool. The pairing for the crossover is governed by a selection principle based on a complementarity criterion derived from the theoretical tenet of perception-action (P-A) mutuality of ecological psychology. According to Swenson and Turvey [37] P-A mutuality underlies evolution and is an integral part of its thermodynamics. The present simulation tested the contribution of P-A-cycles in evolutionary dynamics. A numerical experiment compares the population's evolution with and without this intentional component. The effect is measured in the difference of the rate of energy dissipation, as well as in three operationalized aspects of complexity. The results support the predicted increase in the rate of energy dissipation, paralleled by an increase in the average heterogeneity of the population. Furthermore, the spatio-temporal evolution of the system is tested for the characteristic power-law relations of a nonlinear system poised in a critical state. The frequency distribution of consecutive increases in population size shows a significantly different exponent in functional relationship.

am

[BibTex]

[BibTex]


no image
Roles for memory-based learning in robotics

Atkeson, C. G., Schaal, S.

In Proceedings of the Sixth International Symposium on Robotics Research, pages: 503-521, Hidden Valley, PA, 1993, clmc (inproceedings)

am

[BibTex]

[BibTex]


no image
Design concurrent calculation: A CAD- and data-integrated approach

Schaal, S., Ehrlenspiel, K.

Journal of Engineering Design, 4, pages: 71-85, 1993, clmc (article)

Abstract
Besides functional regards, product design demands increasingly more for further reaching considerations. Quality alone cannot suffice anymore to compete in the market; design for manufacturability, for assembly, for recycling, etc., are well-known keywords. Those can largely be reduced to the necessity of design for costs. This paper focuses on a CAD-based approach to design concurrent calculation. It will discuss how, in the meantime well-established, tools like feature technology, knowledge-based systems, and relational databases can be blended into one coherent concept to achieve an entirely CAD- and data-integrated cost information tool. This system is able to extract data from the CAD-system, combine it with data about the company specific manufacturing environment, and subsequently autonomously evaluate manufacturability aspects and costs of the given CAD-model. Within minutes the designer gets quantitative in-formation about the major cost sources of his/her design. Additionally, some alternative methods for approximating manu-facturing times from empirical data, namely neural networks and local weighted regression, are introduced.

am

[BibTex]

[BibTex]


no image
Open loop stable control strategies for robot juggling

Schaal, S., Atkeson, C. G.

In IEEE International Conference on Robotics and Automation, 3, pages: 913-918, Piscataway, NJ: IEEE, Georgia, Atlanta, May 2-6, 1993, clmc (inproceedings)

Abstract
In a series of case studies out of the field of dynamic manipulation (Mason, 1992), different principles for open loop stable control are introduced and analyzed. This investigation may provide some insight into how open loop control can serve as a useful foundation for closed loop control and, particularly, what to focus on in learning control. 

am

link (url) [BibTex]

link (url) [BibTex]


no image
In vivo diabetic wound healing with nanofibrous scaffolds modified with gentamicin and recombinant human epidermal growth factor

Dwivedi, C., Pandey, I., Pandey, H., Patil, S., Mishra, S. B., Pandey, A. C., Zamboni, P., Ramteke, P. W., Singh, A. V.

Journal of Biomedical Materials Research Part A, 106(3):641-651, March (article)

Abstract
Abstract Diabetic wounds are susceptible to microbial infection. The treatment of these wounds requires a higher payload of growth factors. With this in mind, the strategy for this study was to utilize a novel payload comprising of Eudragit RL/RS 100 nanofibers carrying the bacterial inhibitor gentamicin sulfate (GS) in concert with recombinant human epidermal growth factor (rhEGF); an accelerator of wound healing. GS containing Eudragit was electrospun to yield nanofiber scaffolds, which were further modified by covalent immobilization of rhEGF to their surface. This novel fabricated nanoscaffold was characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction. The thermal behavior of the nanoscaffold was determined using thermogravimetric analysis and differential scanning calorimetry. In the in vitro antibacterial assays, the nanoscaffolds exhibited comparable antibacterial activity to pure gentemicin powder. In vivo work using female C57/BL6 mice, the nanoscaffolds induced faster wound healing activity in dorsal wounds compared to the control. The paradigm in this study presents a robust in vivo model to enhance the applicability of drug delivery systems in wound healing applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 641–651, 2018.

pi

link (url) DOI [BibTex]


link (url) DOI [BibTex]


Thumb xl gpcr cons
Classified Regression for Bayesian Optimization: Robot Learning with Unknown Penalties

Marco, A., Baumann, D., Hennig, P., Trimpe, S.

Submitted to Journal (under review) (article)

Abstract
Learning robot controllers by minimizing a black-box objective cost using Bayesian optimization (BO) can be time-consuming and challenging. It is very often the case that some roll-outs result in failure behaviors, causing premature experiment detention. In such cases, the designer is forced to decide on heuristic cost penalties because the acquired data is often scarce, or not comparable with that of the stable policies. To overcome this, we propose a Bayesian model that captures exactly what we know about the cost of unstable controllers prior to data collection: Nothing, except that it should be a somewhat large number. The resulting Bayesian model, approximated with a Gaussian process, predicts high cost values in regions where failures are likely to occur. In this way, the model guides the BO exploration toward regions of stability. We demonstrate the benefits of the proposed model in several illustrative and statistical synthetic benchmarks, and also in experiments on a real robotic platform. In addition, we propose and experimentally validate a new BO method to account for unknown constraints. Such method is an extension of Max-Value Entropy Search, a recent information-theoretic method, to solve unconstrained global optimization problems.

PDF link (url) [BibTex]


no image
test jon
(book)

[BibTex]


no image
test
(article)

[BibTex]

[BibTex]


no image
Geometric Image Synthesis

Alhaija, H. A., Mustikovela, S. K., Geiger, A., Rother, C.

(conference)

avg

Project Page [BibTex]

Project Page [BibTex]


no image
Robotics Research

Tong, Chi Hay, Furgale, Paul, Barfoot, Timothy D, Guizilini, Vitor, Ramos, Fabio, Chen, Yushan, T\uumová, Jana, Ulusoy, Alphan, Belta, Calin, Tenorth, Moritz, others

(article)

pi

[BibTex]

[BibTex]