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2018


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Reducing 3D Vibrations to 1D in Real Time

Park, G., Kuchenbecker, K. J.

pages: 21-24, Hands-on demonstration (4 pages) presented at AsiaHaptics, Incheon, South Korea, November 2018 (misc)

Abstract
For simple and realistic vibrotactile feedback, 3D accelerations from real contact interactions are usually rendered using a single-axis vibration actuator; this dimensional reduction can be performed in many ways. This demonstration implements a real-time conversion system that simultaneously measures 3D accelerations and renders corresponding 1D vibrations using a two-pen interface. In the demonstration, a user freely interacts with various objects using an In-Pen that contains a 3-axis accelerometer. The captured accelerations are converted to a single-axis signal, and an Out-Pen renders the reduced signal for the user to feel. We prepared seven conversion methods from the simple use of a single-axis signal to applying principal component analysis (PCA) so that users can compare the performance of each conversion method in this demonstration.

hi

DOI Project Page [BibTex]

2018


DOI Project Page [BibTex]


A Large-Scale Fabric-Based Tactile Sensor Using Electrical Resistance Tomography
A Large-Scale Fabric-Based Tactile Sensor Using Electrical Resistance Tomography

Lee, H., Park, K., Kim, J., Kuchenbecker, K. J.

pages: 107-109, Hands-on demonstration (3 pages) presented at AsiaHaptics, Incheon, South Korea, November 2018 (misc)

Abstract
Large-scale tactile sensing is important for household robots and human-robot interaction because contacts can occur all over a robot’s body surface. This paper presents a new fabric-based tactile sensor that is straightforward to manufacture and can cover a large area. The tactile sensor is made of conductive and non-conductive fabric layers, and the electrodes are stitched with conductive thread, so the resulting device is flexible and stretchable. The sensor utilizes internal array electrodes and a reconstruction method called electrical resistance tomography (ERT) to achieve a high spatial resolution with a small number of electrodes. The developed sensor shows that only 16 electrodes can accurately estimate single and multiple contacts over a square that measures 20 cm by 20 cm.

hi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


Statistical Modelling of Fingertip Deformations and Contact Forces during Tactile Interaction
Statistical Modelling of Fingertip Deformations and Contact Forces during Tactile Interaction

Gueorguiev, D., Tzionas, D., Pacchierotti, C., Black, M. J., Kuchenbecker, K. J.

Extended abstract presented at the Hand, Brain and Technology conference (HBT), Ascona, Switzerland, August 2018 (misc)

Abstract
Little is known about the shape and properties of the human finger during haptic interaction, even though these are essential parameters for controlling wearable finger devices and deliver realistic tactile feedback. This study explores a framework for four-dimensional scanning (3D over time) and modelling of finger-surface interactions, aiming to capture the motion and deformations of the entire finger with high resolution while simultaneously recording the interfacial forces at the contact. Preliminary results show that when the fingertip is actively pressing a rigid surface, it undergoes lateral expansion and proximal/distal bending, deformations that cannot be captured by imaging of the contact area alone. Therefore, we are currently capturing a dataset that will enable us to create a statistical model of the finger’s deformations and predict the contact forces induced by tactile interaction with objects. This technique could improve current methods for tactile rendering in wearable haptic devices, which rely on general physical modelling of the skin’s compliance, by developing an accurate model of the variations in finger properties across the human population. The availability of such a model will also enable a more realistic simulation of virtual finger behaviour in virtual reality (VR) environments, as well as the ability to accurately model a specific user’s finger from lower resolution data. It may also be relevant for inferring the physical properties of the underlying tissue from observing the surface mesh deformations, as previously shown for body tissues.

hi

Project Page [BibTex]

Project Page [BibTex]


A machine from machines
A machine from machines

Fischer, P.

Nature Physics, 14, pages: 1072–1073, July 2018 (misc)

Abstract
Building spinning microrotors that self-assemble and synchronize to form a gear sounds like an impossible feat. However, it has now been achieved using only a single type of building block -- a colloid that self-propels.

pf

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Reducing 3D Vibrations to 1D in Real Time

Park, G., Kuchenbecker, K. J.

Hands-on demonstration presented at EuroHaptics, Pisa, Italy, June 2018 (misc)

Abstract
In this demonstration, you will hold two pen-shaped modules: an in-pen and an out-pen. The in-pen is instrumented with a high-bandwidth three-axis accelerometer, and the out-pen contains a one-axis voice coil actuator. Use the in-pen to interact with different surfaces; the measured 3D accelerations are continually converted into 1D vibrations and rendered with the out-pen for you to feel. You can test conversion methods that range from simply selecting a single axis to applying a discrete Fourier transform or principal component analysis for realistic and brisk real-time conversion.

hi

Project Page [BibTex]

Project Page [BibTex]


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Haptipedia: Exploring Haptic Device Design Through Interactive Visualizations

Seifi, H., Fazlollahi, F., Park, G., Kuchenbecker, K. J., MacLean, K. E.

Hands-on demonstration presented at EuroHaptics, Pisa, Italy, June 2018 (misc)

Abstract
How many haptic devices have been proposed in the last 30 years? How can we leverage this rich source of design knowledge to inspire future innovations? Our goal is to make historical haptic invention accessible through interactive visualization of a comprehensive library – a Haptipedia – of devices that have been annotated with designer-relevant metadata. In this demonstration, participants can explore Haptipedia’s growing library of grounded force feedback devices through several prototype visualizations, interact with 3D simulations of the device mechanisms and movements, and tell us about the attributes and devices that could make Haptipedia a useful resource for the haptic design community.

hi

Project Page [BibTex]

Project Page [BibTex]


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Delivering 6-DOF Fingertip Tactile Cues

Young, E., Kuchenbecker, K. J.

Work-in-progress paper (5 pages) presented at EuroHaptics, Pisa, Italy, June 2018 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


Designing a Haptic Empathetic Robot Animal for Children with Autism
Designing a Haptic Empathetic Robot Animal for Children with Autism

Burns, R., Kuchenbecker, K. J.

Workshop paper (4 pages) presented at the Robotics: Science and Systems Workshop on Robot-Mediated Autism Intervention: Hardware, Software and Curriculum, Pittsburgh, USA, June 2018 (misc)

Abstract
Children with autism often endure sensory overload, may be nonverbal, and have difficulty understanding and relaying emotions. These experiences result in heightened stress during social interaction. Animal-assisted intervention has been found to improve the behavior of children with autism during social interaction, but live animal companions are not always feasible. We are thus in the process of designing a robotic animal to mimic some successful characteristics of animal-assisted intervention while trying to improve on others. The over-arching hypothesis of this research is that an appropriately designed robot animal can reduce stress in children with autism and empower them to engage in social interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Soft Multi-Axis Boundary-Electrode Tactile Sensors for Whole-Body Robotic Skin

Lee, H., Kim, J., Kuchenbecker, K. J.

Workshop paper (2 pages) presented at the RSS Pioneers Workshop, Pittsburgh, USA, June 2018 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


Impact of Trunk Orientation  for Dynamic Bipedal Locomotion
Impact of Trunk Orientation for Dynamic Bipedal Locomotion

Drama, Ö.

Dynamic Walking Conference, May 2018 (talk)

Abstract
Impact of trunk orientation for dynamic bipedal locomotion My research revolves around investigating the functional demands of bipedal running, with focus on stabilizing trunk orientation. When we think about postural stability, there are two critical questions we need to answer: What are the necessary and sufficient conditions to achieve and maintain trunk stability? I am concentrating on how morphology affects control strategies in achieving trunk stability. In particular, I denote the trunk pitch as the predominant morphology parameter and explore the requirements it imposes on a chosen control strategy. To analyze this, I use a spring loaded inverted pendulum model extended with a rigid trunk, which is actuated by a hip motor. The challenge for the controller design here is to have a single hip actuator to achieve two coupled tasks of moving the legs to generate motion and stabilizing the trunk. I enforce orthograde and pronograde postures and aim to identify the effect of these trunk orientations on the hip torque and ground reaction profiles for different control strategies.

dlg

Impact of trunk orientation for dynamic bipedal locomotion [DW 2018] link (url) Project Page [BibTex]


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Poster Abstract: Toward Fast Closed-loop Control over Multi-hop Low-power Wireless Networks

Mager, F., Baumann, D., Trimpe, S., Zimmerling, M.

Proceedings of the 17th ACM/IEEE Conference on Information Processing in Sensor Networks (IPSN), pages: 158-159, Porto, Portugal, April 2018 (poster)

ics

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Arm-Worn Tactile Displays

Kuchenbecker, K. J.

Cross-Cutting Challenge Interactive Discussion presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Fingertips and hands captivate the attention of most haptic interface designers, but humans can feel touch stimuli across the entire body surface. Trying to create devices that both can be worn and can deliver good haptic sensations raises challenges that rarely arise in other contexts. Most notably, tactile cues such as vibration, tapping, and squeezing are far simpler to implement in wearable systems than kinesthetic haptic feedback. This interactive discussion will present a variety of relevant projects to which I have contributed, attempting to pull out common themes and ideas for the future.

hi

[BibTex]

[BibTex]


Haptipedia: An Expert-Sourced Interactive Device Visualization for Haptic Designers
Haptipedia: An Expert-Sourced Interactive Device Visualization for Haptic Designers

Seifi, H., MacLean, K. E., Kuchenbecker, K. J., Park, G.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Much of three decades of haptic device invention is effectively lost to today’s designers: dispersion across time, region, and discipline imposes an incalculable drag on innovation in this field. Our goal is to make historical haptic invention accessible through interactive navigation of a comprehensive library – a Haptipedia – of devices that have been annotated with designer-relevant metadata. To build this open resource, we will systematically mine the literature and engage the haptics community for expert annotation. In a multi-year broad-based initiative, we will empirically derive salient attributes of haptic devices, design an interactive visualization tool where device creators and repurposers can efficiently explore and search Haptipedia, and establish methods and tools to manually and algorithmically collect data from the haptics literature and our community of experts. This paper outlines progress in compiling an initial corpus of grounded force-feedback devices and their attributes, and it presents a concept sketch of the interface we envision.

hi

Project Page [BibTex]

Project Page [BibTex]


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Exercising with Baxter: Design and Evaluation of Assistive Social-Physical Human-Robot Interaction

Fitter, N. T., Mohan, M., Kuchenbecker, K. J., Johnson, M. J.

Workshop paper (6 pages) presented at the HRI Workshop on Personal Robots for Exercising and Coaching, Chicago, USA, March 2018 (misc)

Abstract
The worldwide population of older adults is steadily increasing and will soon exceed the capacity of assisted living facilities. Accordingly, we aim to understand whether appropriately designed robots could help older adults stay active and engaged while living at home. We developed eight human-robot exercise games for the Baxter Research Robot with the guidance of experts in game design, therapy, and rehabilitation. After extensive iteration, these games were employed in a user study that tested their viability with 20 younger and 20 older adult users. All participants were willing to enter Baxter’s workspace and physically interact with the robot. User trust and confidence in Baxter increased significantly between pre- and post-experiment assessments, and one individual from the target user population supplied us with abundant positive feedback about her experience. The preliminary results presented in this paper indicate potential for the use of two-armed human-scale robots for social-physical exercise interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Representation of sensory uncertainty in macaque visual cortex

Goris, R., Henaff, O., Meding, K.

Computational and Systems Neuroscience (COSYNE) 2018, March 2018 (poster)

ei

[BibTex]

[BibTex]


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Defining Social Robot Roles in Rehabilitation Based on Observed Patient-Therapist Interactions in Stroke Therapy

Johnson, M., Mohan, M., Mendonca, R.

Workshop paper (2 pages) presented at the HRI Workshop on Social Robots in Therapy: Focusing on Autonomy and Ethical Challenges, Chicago, USA, March 2018 (misc)

Abstract
In this paper, we discuss how to improve robot-patient interactions in task-oriented stroke therapy, which currently do not accurately model therapist-patient interactions in the real world. From observations of patient-therapist interactions in task-oriented stroke therapy captured in 8 videos, we describe three dyads of interactions where the therapist and the patient take on a set of acting states or roles and are motivated to move from one role to another when certain physical or verbal stimuli or cues are sensed and received. We propose possible model for robot-patient interaction and discuss challenges to its implementation, including the ethics

hi

link (url) [BibTex]

link (url) [BibTex]


Emotionally Supporting Humans Through Robot Hugs
Emotionally Supporting Humans Through Robot Hugs

Block, A. E., Kuchenbecker, K. J.

Workshop paper (2 pages) presented at the HRI Pioneers Workshop, Chicago, USA, March 2018 (misc)

Abstract
Hugs are one of the first forms of contact and affection humans experience. Due to their prevalence and health benefits, we want to enable robots to safely hug humans. This research strives to create and study a high fidelity robotic system that provides emotional support to people through hugs. This paper outlines our previous work evaluating human responses to a prototype’s physical and behavioral characteristics, and then it lays out our ongoing and future work.

hi

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


Towards a Statistical Model of Fingertip Contact Deformations from 4{D} Data
Towards a Statistical Model of Fingertip Contact Deformations from 4D Data

Gueorguiev, D., Tzionas, D., Pacchierotti, C., Black, M. J., Kuchenbecker, K. J.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Little is known about the shape and properties of the human finger during haptic interaction even though this knowledge is essential to control wearable finger devices and deliver realistic tactile feedback. This study explores a framework for four-dimensional scanning and modeling of finger-surface interactions, aiming to capture the motion and deformations of the entire finger with high resolution. The results show that when the fingertip is actively pressing a rigid surface, it undergoes lateral expansion of about 0.2 cm and proximal/distal bending of about 30◦, deformations that cannot be captured by imaging of the contact area alone. This project constitutes a first step towards an accurate statistical model of the finger’s behavior during haptic interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Can Humans Infer Haptic Surface Properties from Images?

Burka, A., Kuchenbecker, K. J.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Human children typically experience their surroundings both visually and haptically, providing ample opportunities to learn rich cross-sensory associations. To thrive in human environments and interact with the real world, robots also need to build models of these cross-sensory associations; current advances in machine learning should make it possible to infer models from large amounts of data. We previously built a visuo-haptic sensing device, the Proton Pack, and are using it to collect a large database of matched multimodal data from tool-surface interactions. As a benchmark to compare with machine learning performance, we conducted a human subject study (n = 84) on estimating haptic surface properties (here: hardness, roughness, friction, and warmness) from images. Using a 100-surface subset of our database, we showed images to study participants and collected 5635 ratings of the four haptic properties, which we compared with ratings made by the Proton Pack operator and with physical data recorded using motion, force, and vibration sensors. Preliminary results indicate weak correlation between participant and operator ratings, but potential for matching up certain human ratings (particularly hardness and roughness) with features from the literature.

hi

Project Page [BibTex]

Project Page [BibTex]


Co-Registration -- Simultaneous Alignment and Modeling of Articulated {3D} Shapes
Co-Registration – Simultaneous Alignment and Modeling of Articulated 3D Shapes

Black, M., Hirshberg, D., Loper, M., Rachlin, E., Weiss, A.

Febuary 2018, U.S.~Patent 9,898,848 (misc)

Abstract
Present application refers to a method, a model generation unit and a computer program (product) for generating trained models (M) of moving persons, based on physically measured person scan data (S). The approach is based on a common template (T) for the respective person and on the measured person scan data (S) in different shapes and different poses. Scan data are measured with a 3D laser scanner. A generic personal model is used for co-registering a set of person scan data (S) aligning the template (T) to the set of person scans (S) while simultaneously training the generic personal model to become a trained person model (M) by constraining the generic person model to be scan-specific, person-specific and pose-specific and providing the trained model (M), based on the co registering of the measured object scan data (S).

ps

text [BibTex]


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Die kybernetische Revolution

Schölkopf, B.

15-Mar-2018, Süddeutsche Zeitung, 2018 (misc)

ei

link (url) [BibTex]

link (url) [BibTex]


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Generalized phase locking analysis of electrophysiology data

Safavi, S., Panagiotaropoulos, T., Kapoor, V., Logothetis, N. K., Besserve, M.

7th AREADNE Conference on Research in Encoding and Decoding of Neural Ensembles, 2018 (poster)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Photorealistic Video Super Resolution

Pérez-Pellitero, E., Sajjadi, M. S. M., Hirsch, M., Schölkopf, B.

Workshop and Challenge on Perceptual Image Restoration and Manipulation (PIRM) at the 15th European Conference on Computer Vision (ECCV), 2018 (poster)

ei

[BibTex]

[BibTex]


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Retinal image quality of the human eye across the visual field

Meding, K., Hirsch, M., Wichmann, F. A.

14th Biannual Conference of the German Society for Cognitive Science (KOGWIS 2018), 2018 (poster)

ei

[BibTex]

[BibTex]


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Emission and propagation of multi-dimensional spin waves in anisotropic spin textures

Sluka, V., Schneider, T., Gallardo, R. A., Kakay, A., Weigand, M., Warnatz, T., Mattheis, R., Roldan-Molina, A., Landeros, P., Tiberkevich, V., Slavin, A., Schütz, G., Erbe, A., Deac, A., Lindner, J., Raabe, J., Fassbender, J., Wintz, S.

2018 (misc)

mms

link (url) [BibTex]

link (url) [BibTex]


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Thermal skyrmion diffusion applied in probabilistic computing

Zázvorka, J., Jakobs, F., Heinze, D., Keil, N., Kromin, S., Jaiswal, S., Litzius, K., Jakob, G., Virnau, P., Pinna, D., Everschor-Sitte, K., Donges, A., Nowak, U., Kläui, M.

2018 (misc)

mms

link (url) [BibTex]

link (url) [BibTex]

2014


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Local Gaussian Regression

Meier, F., Hennig, P., Schaal, S.

arXiv preprint, March 2014, clmc (misc)

Abstract
Abstract: Locally weighted regression was created as a nonparametric learning method that is computationally efficient, can learn from very large amounts of data and add data incrementally. An interesting feature of locally weighted regression is that it can work with ...

am pn

Web link (url) [BibTex]

2014


Web link (url) [BibTex]


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Fibrillar structures to reduce viscous drag on aerodynamic and hydrodynamic wall surfaces

Castillo, L., Aksak, B., Sitti, M.

March 2014, US Patent App. 14/774,767 (misc)

pi

[BibTex]

[BibTex]


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The design of microfibers with mushroom-shaped tips for optimal adhesion

Sitti, M., Aksak, B.

February 2014, US Patent App. 14/766,561 (misc)

pi

[BibTex]

[BibTex]


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Dynamical source analysis of hippocampal sharp-wave ripple episodes

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

Bernstein Conference, 2014 (poster)

ei

DOI [BibTex]

DOI [BibTex]


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Unsupervised identification of neural events in local field potentials

Besserve, M., Schölkopf, B., Logothetis, N. K.

44th Annual Meeting of the Society for Neuroscience (Neuroscience), 2014 (talk)

ei

[BibTex]

[BibTex]


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FID-guided retrospective motion correction based on autofocusing

Babayeva, M., Loktyushin, A., Kober, T., Granziera, C., Nickisch, H., Gruetter, R., Krueger, G.

Joint Annual Meeting ISMRM-ESMRMB, Milano, Italy, 2014 (poster)

ei

[BibTex]

[BibTex]


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Quantifying statistical dependency

Besserve, M.

Research Network on Learning Systems Summer School, 2014 (talk)

ei

[BibTex]

[BibTex]


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Cluster analysis of sharp-wave ripple field potential signatures in the macaque hippocampus

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

Computational and Systems Neuroscience Meeting (COSYNE), 2014 (poster)

ei

[BibTex]

[BibTex]

2011


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Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Abstract
PURPOSE Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. We assess additional attenuation of the PET emission signals in the presence of oral and intraveneous (iv) MRCA made up of iron oxide and Gd-chelates, respectively. METHOD AND MATERIALS Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and integrated whole-body PET/MR (Biograph mMR, Siemens) using oral (Lumirem) and intraveneous (Gadovist) MRCA. Reference PET attenuation values were determined on a small-animal PET (Inveon, Siemens) using standard PET transmission imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% conc.), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs. The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1. PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction. RESULTS Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347. Lumirem had little effect on PET attenuation with (C3) being 13% and 10% higher than (C2) on PET/CT and PET/MR, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower than (Sy2) on PET/CT and 1.2% higher than (Sy2) on PET/MR. CONCLUSION MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

2011


Web [BibTex]


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Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N.

41(239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience), November 2011 (poster)

Abstract
The inferior convexity of the macaque prefrontal cortex (icPFC) is known to be involved in higher order processing of sensory information mediating stimulus selection, attention and working memory. Until now, the vast majority of electrophysiological investigations of the icPFC employed single electrode recordings. As a result, relatively little is known about the spatiotemporal structure of neuronal activity in this cortical area. Here we study in detail the spatiotemporal properties of local field potentials (LFP's) in the icPFC using multi electrode recordings during anesthesia. We computed the LFP-LFP coherence as a function of frequency for thousands of pairs of simultaneously recorded sites anterior to the arcuate and inferior to the principal sulcus. We observed two distinct peaks of coherent oscillatory activity between approximately 4-10 and 15-25 Hz. We then quantified the instantaneous phase of these frequency bands using the Hilbert transform and found robust phase gradients across recording sites. The dependency of the phase on the spatial location reflects the existence of traveling waves of electrical activity in the icPFC. The dominant axis of these traveling waves roughly followed the ventral-dorsal plane. Preliminary results show that repeated visual stimulation with a 10s movie had no dramatic effect on the spatial structure of the traveling waves. Traveling waves of electrical activity in the icPFC could reflect highly organized cortical processing in this area of prefrontal cortex.

ei

Web [BibTex]

Web [BibTex]


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Cooperative Cuts: a new use of submodularity in image segmentation

Jegelka, S.

Second I.S.T. Austria Symposium on Computer Vision and Machine Learning, October 2011 (talk)

ei

Web [BibTex]

Web [BibTex]


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Effect of MR Contrast Agents on Quantitative Accuracy of PET in Combined Whole-Body PET/MR Imaging

Lois, C., Bezrukov, I., Schmidt, H., Schwenzer, N., Werner, M., Pichler, B., Kupferschläger, J., Beyer, T.

2011(MIC3-3), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
Combined whole-body PET/MR systems are being tested in clinical practice today. Integrated imaging protocols entail the use of MR contrast agents (MRCA) that could bias PET attenuation correction. In this work, we assess the effect of MRCA in PET/MR imaging. We analyze the effect of oral and intravenous MRCA on PET activity after attenuation correction. We conclude that in clinical scenarios, MRCA are not expected to lead to significant attenuation of PET signals, and that attenuation maps are not biased after the ingestion of adequate oral contrasts.

ei

Web [BibTex]

Web [BibTex]


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First Results on Patients and Phantoms of a Fully Integrated Clinical Whole-Body PET/MRI

Schmidt, H., Schwenzer, N., Bezrukov, I., Kolb, A., Mantlik, F., Kupferschläger, J., Lois, C., Sauter, A., Brendle, C., Pfannenberg, C., Pichler, B.

2011(J2-8), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
First clinical fully integrated whole-body PET/MR scanners are just entering the field. Here, we present studies toward quantification accuracy and variation within the PET field of view of small lesions from our BrainPET/MRI, a dedicated clinical brain scanner which was installed three years ago in Tbingen. Also, we present first results for patient and phantom scans of a fully integral whole-body PET/MRI, which was installed two months ago at our department. The quantification accuracy and homogeneity of the BrainPET-Insert (Siemens Medical Solutions, Germany) installed inside the magnet bore of a clinical 3T MRI scanner (Magnetom TIM Trio, Siemens Medical Solutions, Germany) was evaluated by using eight hollow spheres with inner diameters from 3.95 to 7.86 mm placed at different positions inside a homogeneous cylinder phantom with an 9:1 and 6:1 sphere to background ratio. The quantification accuracy for small lesions at different positions in the PET FoV shows a standard deviation of up to 11% and is acceptable for quantitative brain studies where the homogeneity of quantification on the entire FoV is essental. Image quality and resolution of the new Siemens whole-body PET/MR system (Biograph mMR, Siemens Medical Solutions, Germany) was evaluated according to the NEMA NU2 2007 protocol using a body phantom containing six spheres with inner diameter from 10 to 37 mm at sphere to background ratios of 8:1 and 4:1 and the F-18 point sources located at different positions inside the PET FoV, respectively. The evaluation of the whole-body PET/MR system reveals a good PET image quality and resolution comparable to state-of-the-art clinical PET/CT scanners. First images of patient studies carried out at the whole-body PET/MR are presented highlighting the potency of combined PET/MR imaging.

ei

Web [BibTex]

Web [BibTex]


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Evaluation and Optimization of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Schmidt, H., Kolb, A., Beyer, T., Reimold, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-96), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
Combined PET/MR provides simultaneous molecular and functional information in an anatomical context with unique soft tissue contrast. However, PET/MR does not support direct derivation of attenuation maps of objects and tissues within the measured PET field-of-view. Valid attenuation maps are required for quantitative PET imaging, specifically for scientific brain studies. Therefore, several methods have been proposed for MR-based attenuation correction (MR-AC). Last year, we performed an evaluation of different MR-AC methods, including simple MR thresholding, atlas- and machine learning-based MR-AC. CT-based AC served as gold standard reference. RoIs from 2 anatomic brain atlases with different levels of detail were used for evaluation of correction accuracy. We now extend our evaluation of different MR-AC methods by using an enlarged dataset of 23 patients from the integrated BrainPET/MR (Siemens Healthcare). Further, we analyze options for improving the MR-AC performance in terms of speed and accuracy. Finally, we assess the impact of ignoring BrainPET positioning aids during the course of MR-AC. This extended study confirms the overall prediction accuracy evaluation results of the first evaluation in a larger patient population. Removing datasets affected by metal artifacts from the Atlas-Patch database helped to improve prediction accuracy, although the size of the database was reduced by one half. Significant improvement in prediction speed can be gained at a cost of only slightly reduced accuracy, while further optimizations are still possible.

ei

Web [BibTex]

Web [BibTex]


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Atlas- and Pattern Recognition Based Attenuation Correction on Simultaneous Whole-Body PET/MR

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Hofmann, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-116), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
With the recent availability of clinical whole-body PET/MRI it is possible to evaluate and further develop MR-based attenuation correction methods using simultaneously acquired PET/MR data. We present first results for MRAC on patient data acquired on a fully integrated whole-body PET/MRI (Biograph mMR, Siemens) using our method that applies atlas registration and pattern recognition (ATPR) and compare them to the segmentation-based (SEG) method provided by the manufacturer. The ATPR method makes use of a database of previously aligned pairs of MR-CT volumes to predict attenuation values on a continuous scale. The robustness of the method in presence of MR artifacts was improved by location and size based detection. Lesion to liver and lesion to blood ratios (LLR and LBR) were compared for both methods on 29 iso-contour ROIs in 4 patients. ATPR showed >20% higher LBR and LLR for ROIs in and >7% near osseous tissue. For ROIs in soft tissue, both methods yielded similar ratios with max. differences <6% . For ROIs located within metal artifacts in the MR image, ATPR showed >190% higher LLR and LBR than SEG, where ratios <0.1 occured. For lesions in the neighborhood of artifacts, both ratios were >15% higher for ATPR. If artifacts in MR volumes caused by metal implants are not accounted for in the computation of attenuation maps, they can lead to a strong decrease of lesion to background ratios, even to disappearance of hot spots. Metal implants are likely to occur in the patient collective receiving combined PET/MR scans, of our first 10 patients, 3 had metal implants. Our method is currently able to account for artifacts in the pelvis caused by prostheses. The ability of the ATPR method to account for bone leads to a significant increase of LLR and LBR in osseous tissue, which supports our previous evaluations with combined PET/CT and PET/MR data. For lesions within soft tissue, lesion to background ratios of ATPR and SEG were comparable.

ei

Web [BibTex]

Web [BibTex]


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Retrospective blind motion correction of MR images

Loktyushin, A., Nickisch, H., Pohmann, R.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):498, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
We present a retrospective method, which significantly reduces ghosting and blurring artifacts due to subject motion. No modifications to the sequence (as in [2, 3]), or the use of additional equipment (as in [1]) are required. Our method iteratively searches for the transformation, that applied to the lines in k-space -- yields the sparsest Laplacian filter output in the spatial domain.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Model based reconstruction for GRE EPI

Blecher, W., Pohmann, R., Schölkopf, B., Seeger, M.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):493-494, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
Model based nonlinear image reconstruction methods for MRI [3] are at the heart of modern reconstruction techniques (e.g.compressed sensing [6]). In general, models are expressed as a matrix equation where y and u are column vectors of k-space and image data, X model matrix and e independent noise. However, solving the corresponding linear system is not tractable. Therefore fast nonlinear algorithms that minimize a function wrt.the unknown image are the method of choice: In this work a model for gradient echo EPI, is proposed that incorporates N/2 Ghost correction and correction for field inhomogeneities. In addition to reconstruction from full data, the model allows for sparse reconstruction, joint estimation of image, field-, and relaxation-map (like [5,8] for spiral imaging), and improved N/2 ghost correction.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(OP314), Annual Congress of the European Association of Nuclear Medicine (EANM), October 2011 (talk)

Abstract
PURPOSE:Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. MRCA are made up of iron oxide and Gd-chelates for oral and intravenous (iv) application, respectively. We assess additional attenuation of the PET emission signals in the presence of oral and iv MRCA.MATERIALS AND METHODS:Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and an integrated whole-body PET/MR (Biograph mMR, Siemens). Two common MRCA were evaluated: Lumirem (oral) and Gadovist (iv).Reference PET attenuation values were determined on a dedicated small-animal PET (Inveon, Siemens) using equivalent standard PET transmission source imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% concentration), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs.The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1.PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction (AC). Since Teflon is not correctly identified on MR, PET(/MR) data were reconstructed using MR-AC and CT-AC.RESULTS:Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347.Lumirem had little effect on PET attenuation with (C3) being 13%, 10% and 11% higher than (C2) on PET/CT, PET/MR with MR-AC, and PET/MR with CT-AC, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower, 1.2% higher, and 3.5% lower than (Sy2) on PET/CT, PET/MR with MR-AC and PET/MR with CT-AC, respectively.CONCLUSION:MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

Web [BibTex]


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Simultaneous multimodal imaging of patients with bronchial carcinoma in a whole body MR/PET system

Brendle, C., Sauter, A., Schmidt, H., Schraml, C., Bezrukov, I., Martirosian, P., Hetzel, J., Müller, M., Claussen, C., Schwenzer, N., Pfannenberg, C.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):141, 28th annual scientific meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRB), October 2011 (poster)

Abstract
Purpose/Introduction: Lung cancer is among the most frequent cancers (1). Exact determination of tumour extent and viability is crucial for adequate therapy guidance. [18F]-FDG-PET allows accurate staging and the evaluation of therapy response based on glucose metabolism. Diffusion weighted MRI (DWI) is another promising tool for the evaluation of tumour viability (2,3). The aim of the study was the simultaneous PET-MR acquisition in lung cancer patients and correlation of PET and MR data. Subjects and Methods: Seven patients (age 38-73 years, mean 61 years) with highly suspected or known bronchial carcinoma were examined. First, a [18F]-FDG-PET/CT was performed (injected dose: 332-380 MBq). Subsequently, patients were examined at the whole-body MR/PET (Siemens Biograph mMR). The MRI is a modified 3T Verio whole body system with a magnet bore of 60 cm (max. amplitude gradients 45 mT/m, max. slew rate 200 T/m/s). Concerning the PET, the whole-body MR/PET system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The following parameters for PET acquisition were applied: 2 bed positions, 6 min/bed with an average uptake time of 124 min after injection (range: 110-143 min). The attenuation correction of PET data was conducted with a segmentation-based method provided by the manufacturer. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. DWI MR images were recorded simultaneously for each bed using two b-values (0/800 s/mm2). SUVmax and ADCmin were assessed in a ROI analysis. The following ratios were calculated: SUVmax(tumor)/SUVmean(liver) and ADCmin(tumor)/ADCmean(muscle). Correlation between SUV and ADC was analyzed (Pearson’s correlation). Results: Diagnostic scans could be obtained in all patients with good tumour delineation. The spatial matching of PET and DWI data was very exact. Most tumours showed a pronounced FDG-uptake in combination with decreased ADC values. Significant correlation was found between SUV and ADC ratios (r = -0.87, p = 0.0118). Discussion/Conclusion: Simultaneous MR/PET imaging of lung cancer is feasible. The whole-body MR/PET system can provide complementary information regarding tumour viability and cellularity which could facilitate a more profound tumour characterization. Further studies have to be done to evaluate the importance of these parameters for therapy decisions and monitoring

ei

Web DOI [BibTex]

Web DOI [BibTex]


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Multi-parametric Tumor Characterization and Therapy Monitoring using Simultaneous PET/MRI: initial results for Lung Cancer and GvHD

Sauter, A., Schmidt, H., Gueckel, B., Brendle, C., Bezrukov, I., Mantlik, F., Kolb, A., Mueller, M., Reimold, M., Federmann, B., Hetzel, J., Claussen, C., Pfannenberg, C., Horger, M., Pichler, B., Schwenzer, N.

(T110), 2011 World Molecular Imaging Congress (WMIC), September 2011 (talk)

Abstract
Hybrid imaging modalities such as [18F]FDG-PET/CT are superior in staging of e.g. lung cancer disease compared with stand-alone modalities. Clinical PET/MRI systems are about to enter the field of hybrid imaging and offer potential advantages. One added value could be a deeper insight into the tumor metabolism and tumorigenesis due to the combination of PET and dedicated MR methods such as MRS and DWI. Additionally, therapy monitoring of diffucult to diagnose disease such as chronic sclerodermic GvHD (csGvHD) can potentially be improved by this combination. We have applied PET/MRI in 3 patients with lung cancer and 4 patients with csGvHD before and during therapy. All 3 patients had lung cancer confirmed by histology (2 adenocarcinoma, 1 carcinoid). First, a [18F]FDG-PET/CT was performed with the following parameters: injected dose 351.7±25.1 MBq, uptake time 59.0±2.6 min, 3 min/bed. Subsequently, patients were brought to the PET/MRI imaging facility. The whole-body PET/MRI Biograph mMR system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The MRI is a modified Verio system with a magnet bore of 60 cm. The following parameters for PET acquisition were applied: uptake time 121.3±2.3 min, 3 bed positions, 6 min/bed. T1w, T2w, and DWI MR images were recorded simultaneously for each bed. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. The 4 patients with GvHD were brought to the brainPET/MRI imaging facility 2:10h-2:28h after tracer injection. A 9 min brainPET-acquisition with simultaneous MRI of the lower extremities was accomplished. MRI examination included T1-weighted (pre and post gadolinium) and T2-weighted sequences. Attenuation correction was calculated based on manual bone segmentation and thresholds for soft tissue, fat and air. Soleus muscle (m), crural fascia (f1) and posterior crural intermuscular septum fascia (f2) were surrounded with ROIs based on the pre-treatment T1-weighted images and coregistered using IRW (Siemens). Fascia-to-muscle ratios for PET (f/m), T1 contrast uptake (T1_post-contrast_f-pre-contrast_f/post-contrast_m-pre-contrast_m) and T2 (T2_f/m) were calculated. Both patients with adenocarcinoma show a lower ADC value compared with the carcinoid patient suggesting a higher cellularity. This is also reflected in FDG-PET with higher SUV values. Our initial results reveal that PET/MRI can provide complementary information for a profound tumor characterization and therapy monitoring. The high soft tissue contrast provided by MRI is valuable for the assessment of the fascial inflammation. While in the first patient FDG and contrast uptake as well as edema, represented by T2 signals, decreased with ongoing therapy, all parameters remained comparatively stable in the second patient. Contrary to expectations, an increase in FDG uptake of patient 3 and 4 was accompanied by an increase of the T2 signals, but a decrease in contrast uptake. These initial results suggest that PET/MRI provides complementary information of the complex disease mechanisms in fibrosing disorders.

ei

Web [BibTex]

Web [BibTex]


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Statistical Image Analysis and Percolation Theory

Langovoy, M., Habeck, M., Schölkopf, B.

2011 Joint Statistical Meetings (JSM), August 2011 (talk)

Abstract
We develop a novel method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation theory. We specifically address the problem of detection of multiple objects of unknown shapes in the case of nonparametric noise. The noise density is unknown and can be heavy-tailed. The objects of interest have unknown varying intensities. No boundary shape constraints are imposed on the objects, only a set of weak bulk conditions is required. We view the object detection problem as hypothesis testing for discrete statistical inverse problems. We present an algorithm that allows to detect greyscale objects of various shapes in noisy images. We prove results on consistency and algorithmic complexity of our procedures. Applications to cryo-electron microscopy are presented.

ei

Web [BibTex]

Web [BibTex]