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77 results (View BibTeX file of all listed publications)

2011

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Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Abstract
PURPOSE Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. We assess additional attenuation of the PET emission signals in the presence of oral and intraveneous (iv) MRCA made up of iron oxide and Gd-chelates, respectively. METHOD AND MATERIALS Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and integrated whole-body PET/MR (Biograph mMR, Siemens) using oral (Lumirem) and intraveneous (Gadovist) MRCA. Reference PET attenuation values were determined on a small-animal PET (Inveon, Siemens) using standard PET transmission imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% conc.), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs. The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1. PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction. RESULTS Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347. Lumirem had little effect on PET attenuation with (C3) being 13% and 10% higher than (C2) on PET/CT and PET/MR, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower than (Sy2) on PET/CT and 1.2% higher than (Sy2) on PET/MR. CONCLUSION MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

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2011

ei Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T. Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction (SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Web [BibTex]

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Optimization for Machine Learning

Sra, S., Nowozin, S., Wright, S.

pages: 494, Neural information processing series, MIT Press, Cambridge, MA, USA, December 2011 (book)

Abstract
The interplay between optimization and machine learning is one of the most important developments in modern computational science. Optimization formulations and methods are proving to be vital in designing algorithms to extract essential knowledge from huge volumes of data. Machine learning, however, is not simply a consumer of optimization technology but a rapidly evolving field that is itself generating new optimization ideas. This book captures the state of the art of the interaction between optimization and machine learning in a way that is accessible to researchers in both fields. Optimization approaches have enjoyed prominence in machine learning because of their wide applicability and attractive theoretical properties. The increasing complexity, size, and variety of today's machine learning models call for the reassessment of existing assumptions. This book starts the process of reassessment. It describes the resurgence in novel contexts of established frameworks such as first-order methods, stochastic approximations, convex relaxations, interior-point methods, and proximal methods. It also devotes attention to newer themes such as regularized optimization, robust optimization, gradient and subgradient methods, splitting techniques, and second-order methods. Many of these techniques draw inspiration from other fields, including operations research, theoretical computer science, and subfields of optimization. The book will enrich the ongoing cross-fertilization between the machine learning community and these other fields, and within the broader optimization community.

ei

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ei Sra, S., Nowozin, S., Wright, S. Optimization for Machine Learning pages: 494, Neural information processing series, MIT Press, Cambridge, MA, USA, December 2011 (book)

Web [BibTex]

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Cooperative Cuts: a new use of submodularity in image segmentation

Jegelka, S.

Second I.S.T. Austria Symposium on Computer Vision and Machine Learning, October 2011 (talk)

ei

Web [BibTex]

ei Jegelka, S. Cooperative Cuts: a new use of submodularity in image segmentation Second I.S.T. Austria Symposium on Computer Vision and Machine Learning, October 2011 (talk)

Web [BibTex]

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Effect of MR Contrast Agents on Quantitative Accuracy of PET in Combined Whole-Body PET/MR Imaging

Lois, C., Bezrukov, I., Schmidt, H., Schwenzer, N., Werner, M., Pichler, B., Kupferschläger, J., Beyer, T.

2011(MIC3-3), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
Combined whole-body PET/MR systems are being tested in clinical practice today. Integrated imaging protocols entail the use of MR contrast agents (MRCA) that could bias PET attenuation correction. In this work, we assess the effect of MRCA in PET/MR imaging. We analyze the effect of oral and intravenous MRCA on PET activity after attenuation correction. We conclude that in clinical scenarios, MRCA are not expected to lead to significant attenuation of PET signals, and that attenuation maps are not biased after the ingestion of adequate oral contrasts.

ei

Web [BibTex]

ei Lois, C., Bezrukov, I., Schmidt, H., Schwenzer, N., Werner, M., Pichler, B., Kupferschläger, J., Beyer, T. Effect of MR Contrast Agents on Quantitative Accuracy of PET in Combined Whole-Body PET/MR Imaging 2011(MIC3-3), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Web [BibTex]

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First Results on Patients and Phantoms of a Fully Integrated Clinical Whole-Body PET/MRI

Schmidt, H., Schwenzer, N., Bezrukov, I., Kolb, A., Mantlik, F., Kupferschläger, J., Lois, C., Sauter, A., Brendle, C., Pfannenberg, C., Pichler, B.

2011(J2-8), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
First clinical fully integrated whole-body PET/MR scanners are just entering the field. Here, we present studies toward quantification accuracy and variation within the PET field of view of small lesions from our BrainPET/MRI, a dedicated clinical brain scanner which was installed three years ago in Tbingen. Also, we present first results for patient and phantom scans of a fully integral whole-body PET/MRI, which was installed two months ago at our department. The quantification accuracy and homogeneity of the BrainPET-Insert (Siemens Medical Solutions, Germany) installed inside the magnet bore of a clinical 3T MRI scanner (Magnetom TIM Trio, Siemens Medical Solutions, Germany) was evaluated by using eight hollow spheres with inner diameters from 3.95 to 7.86 mm placed at different positions inside a homogeneous cylinder phantom with an 9:1 and 6:1 sphere to background ratio. The quantification accuracy for small lesions at different positions in the PET FoV shows a standard deviation of up to 11% and is acceptable for quantitative brain studies where the homogeneity of quantification on the entire FoV is essental. Image quality and resolution of the new Siemens whole-body PET/MR system (Biograph mMR, Siemens Medical Solutions, Germany) was evaluated according to the NEMA NU2 2007 protocol using a body phantom containing six spheres with inner diameter from 10 to 37 mm at sphere to background ratios of 8:1 and 4:1 and the F-18 point sources located at different positions inside the PET FoV, respectively. The evaluation of the whole-body PET/MR system reveals a good PET image quality and resolution comparable to state-of-the-art clinical PET/CT scanners. First images of patient studies carried out at the whole-body PET/MR are presented highlighting the potency of combined PET/MR imaging.

ei

Web [BibTex]

ei Schmidt, H., Schwenzer, N., Bezrukov, I., Kolb, A., Mantlik, F., Kupferschläger, J., Lois, C., Sauter, A., Brendle, C., Pfannenberg, C., Pichler, B. First Results on Patients and Phantoms of a Fully Integrated Clinical Whole-Body PET/MRI 2011(J2-8), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Web [BibTex]

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Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(OP314), Annual Congress of the European Association of Nuclear Medicine (EANM), October 2011 (talk)

Abstract
PURPOSE:Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. MRCA are made up of iron oxide and Gd-chelates for oral and intravenous (iv) application, respectively. We assess additional attenuation of the PET emission signals in the presence of oral and iv MRCA.MATERIALS AND METHODS:Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and an integrated whole-body PET/MR (Biograph mMR, Siemens). Two common MRCA were evaluated: Lumirem (oral) and Gadovist (iv).Reference PET attenuation values were determined on a dedicated small-animal PET (Inveon, Siemens) using equivalent standard PET transmission source imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% concentration), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs.The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1.PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction (AC). Since Teflon is not correctly identified on MR, PET(/MR) data were reconstructed using MR-AC and CT-AC.RESULTS:Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347.Lumirem had little effect on PET attenuation with (C3) being 13%, 10% and 11% higher than (C2) on PET/CT, PET/MR with MR-AC, and PET/MR with CT-AC, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower, 1.2% higher, and 3.5% lower than (Sy2) on PET/CT, PET/MR with MR-AC and PET/MR with CT-AC, respectively.CONCLUSION:MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

ei Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T. Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging (OP314), Annual Congress of the European Association of Nuclear Medicine (EANM), October 2011 (talk)

Web [BibTex]

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Multi-parametric Tumor Characterization and Therapy Monitoring using Simultaneous PET/MRI: initial results for Lung Cancer and GvHD

Sauter, A., Schmidt, H., Gueckel, B., Brendle, C., Bezrukov, I., Mantlik, F., Kolb, A., Mueller, M., Reimold, M., Federmann, B., Hetzel, J., Claussen, C., Pfannenberg, C., Horger, M., Pichler, B., Schwenzer, N.

(T110), 2011 World Molecular Imaging Congress (WMIC), September 2011 (talk)

Abstract
Hybrid imaging modalities such as [18F]FDG-PET/CT are superior in staging of e.g. lung cancer disease compared with stand-alone modalities. Clinical PET/MRI systems are about to enter the field of hybrid imaging and offer potential advantages. One added value could be a deeper insight into the tumor metabolism and tumorigenesis due to the combination of PET and dedicated MR methods such as MRS and DWI. Additionally, therapy monitoring of diffucult to diagnose disease such as chronic sclerodermic GvHD (csGvHD) can potentially be improved by this combination. We have applied PET/MRI in 3 patients with lung cancer and 4 patients with csGvHD before and during therapy. All 3 patients had lung cancer confirmed by histology (2 adenocarcinoma, 1 carcinoid). First, a [18F]FDG-PET/CT was performed with the following parameters: injected dose 351.7±25.1 MBq, uptake time 59.0±2.6 min, 3 min/bed. Subsequently, patients were brought to the PET/MRI imaging facility. The whole-body PET/MRI Biograph mMR system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The MRI is a modified Verio system with a magnet bore of 60 cm. The following parameters for PET acquisition were applied: uptake time 121.3±2.3 min, 3 bed positions, 6 min/bed. T1w, T2w, and DWI MR images were recorded simultaneously for each bed. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. The 4 patients with GvHD were brought to the brainPET/MRI imaging facility 2:10h-2:28h after tracer injection. A 9 min brainPET-acquisition with simultaneous MRI of the lower extremities was accomplished. MRI examination included T1-weighted (pre and post gadolinium) and T2-weighted sequences. Attenuation correction was calculated based on manual bone segmentation and thresholds for soft tissue, fat and air. Soleus muscle (m), crural fascia (f1) and posterior crural intermuscular septum fascia (f2) were surrounded with ROIs based on the pre-treatment T1-weighted images and coregistered using IRW (Siemens). Fascia-to-muscle ratios for PET (f/m), T1 contrast uptake (T1_post-contrast_f-pre-contrast_f/post-contrast_m-pre-contrast_m) and T2 (T2_f/m) were calculated. Both patients with adenocarcinoma show a lower ADC value compared with the carcinoid patient suggesting a higher cellularity. This is also reflected in FDG-PET with higher SUV values. Our initial results reveal that PET/MRI can provide complementary information for a profound tumor characterization and therapy monitoring. The high soft tissue contrast provided by MRI is valuable for the assessment of the fascial inflammation. While in the first patient FDG and contrast uptake as well as edema, represented by T2 signals, decreased with ongoing therapy, all parameters remained comparatively stable in the second patient. Contrary to expectations, an increase in FDG uptake of patient 3 and 4 was accompanied by an increase of the T2 signals, but a decrease in contrast uptake. These initial results suggest that PET/MRI provides complementary information of the complex disease mechanisms in fibrosing disorders.

ei

Web [BibTex]

ei Sauter, A., Schmidt, H., Gueckel, B., Brendle, C., Bezrukov, I., Mantlik, F., Kolb, A., Mueller, M., Reimold, M., Federmann, B., Hetzel, J., Claussen, C., Pfannenberg, C., Horger, M., Pichler, B., Schwenzer, N. Multi-parametric Tumor Characterization and Therapy Monitoring using Simultaneous PET/MRI: initial results for Lung Cancer and GvHD (T110), 2011 World Molecular Imaging Congress (WMIC), September 2011 (talk)

Web [BibTex]

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Statistical Image Analysis and Percolation Theory

Langovoy, M., Habeck, M., Schölkopf, B.

2011 Joint Statistical Meetings (JSM), August 2011 (talk)

Abstract
We develop a novel method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation theory. We specifically address the problem of detection of multiple objects of unknown shapes in the case of nonparametric noise. The noise density is unknown and can be heavy-tailed. The objects of interest have unknown varying intensities. No boundary shape constraints are imposed on the objects, only a set of weak bulk conditions is required. We view the object detection problem as hypothesis testing for discrete statistical inverse problems. We present an algorithm that allows to detect greyscale objects of various shapes in noisy images. We prove results on consistency and algorithmic complexity of our procedures. Applications to cryo-electron microscopy are presented.

ei

Web [BibTex]

ei Langovoy, M., Habeck, M., Schölkopf, B. Statistical Image Analysis and Percolation Theory 2011 Joint Statistical Meetings (JSM), August 2011 (talk)

Web [BibTex]

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Bayesian Time Series Models

Barber, D., Cemgil, A., Chiappa, S.

pages: 432, Cambridge University Press, Cambridge, UK, August 2011 (book)

ei

[BibTex]

ei Barber, D., Cemgil, A., Chiappa, S. Bayesian Time Series Models pages: 432, Cambridge University Press, Cambridge, UK, August 2011 (book)

[BibTex]

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Crowdsourcing for optimisation of deconvolution methods via an iPhone application

Lang, A.

Hochschule Reutlingen, Germany, April 2011 (mastersthesis)

ei

[BibTex]

ei Lang, A. Crowdsourcing for optimisation of deconvolution methods via an iPhone application Hochschule Reutlingen, Germany, April 2011 (mastersthesis)

[BibTex]

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Cooperative Cuts

Jegelka, S.

COSA Workshop: Combinatorial Optimization, Statistics, and Applications, March 2011 (talk)

Abstract
Combinatorial problems with submodular cost functions have recently drawn interest. In a standard combinatorial problem, the sum-of-weights cost is replaced by a submodular set function. The result is a powerful model that is though very hard. In this talk, I will introduce cooperative cuts, minimum cuts with submodular edge weights. I will outline methods to approximately solve this problem, and show an application in computer vision. If time permits, the talk will also sketch regret-minimizing online algorithms for submodular-cost combinatorial problems. This is joint work with Jeff Bilmes (University of Washington).

ei

Web [BibTex]

ei Jegelka, S. Cooperative Cuts COSA Workshop: Combinatorial Optimization, Statistics, and Applications, March 2011 (talk)

Web [BibTex]

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Handbook of Statistical Bioinformatics

Lu, H., Schölkopf, B., Zhao, H.

pages: 627, Springer Handbooks of Computational Statistics, Springer, Berlin, Germany, 2011 (book)

ei

Web DOI [BibTex]

ei Lu, H., Schölkopf, B., Zhao, H. Handbook of Statistical Bioinformatics pages: 627, Springer Handbooks of Computational Statistics, Springer, Berlin, Germany, 2011 (book)

Web DOI [BibTex]

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Model Learning in Robot Control

Nguyen-Tuong, D.

Albert-Ludwigs-Universität Freiburg, Germany, 2011 (phdthesis)

ei

[BibTex]

ei Nguyen-Tuong, D. Model Learning in Robot Control Albert-Ludwigs-Universität Freiburg, Germany, 2011 (phdthesis)

[BibTex]

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Iterative path integral stochastic optimal control: Theory and applications to motor control

Theodorou, E. A.

University of Southern California, University of Southern California, Los Angeles, CA, 2011 (phdthesis)

am

PDF [BibTex]

am Theodorou, E. A. Iterative path integral stochastic optimal control: Theory and applications to motor control University of Southern California, University of Southern California, Los Angeles, CA, 2011 (phdthesis)

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Learning of grasp selection based on shape-templates

Herzog, A.

Karlsruhe Institute of Technology, 2011 (mastersthesis)

am

[BibTex]

am Herzog, A. Learning of grasp selection based on shape-templates Karlsruhe Institute of Technology, 2011 (mastersthesis)

[BibTex]

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Ferromagnetism of ZnO influenced by physical and chemical treatment

Chen, Y.

Universität Stuttgart, Stuttgart, 2011 (mastersthesis)

mms

[BibTex]

mms Chen, Y. Ferromagnetism of ZnO influenced by physical and chemical treatment Universität Stuttgart, Stuttgart, 2011 (mastersthesis)

[BibTex]

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Herstellung und Charakterisierung von ultradünnen, funktionellen CoFeB Filmen

Streckenbach, F.

Hochschule Esslingen / Hochschule Aalen, Esslingen / Aalen, 2011 (mastersthesis)

mms

[BibTex]

mms Streckenbach, F. Herstellung und Charakterisierung von ultradünnen, funktionellen CoFeB Filmen Hochschule Esslingen / Hochschule Aalen, Esslingen / Aalen, 2011 (mastersthesis)

[BibTex]

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Hydrogen adsorption on metal-organic frameworks

Streppel, B.

Universität Stuttgart, Stuttgart, 2011 (phdthesis)

mms

link (url) [BibTex]

mms Streppel, B. Hydrogen adsorption on metal-organic frameworks Universität Stuttgart, Stuttgart, 2011 (phdthesis)

link (url) [BibTex]

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Piezo driven strain effects on magneto-crystalline anisotropy

Badr, E.

Universität Stuttgart, Stuttgart, 2011 (mastersthesis)

mms

[BibTex]

mms Badr, E. Piezo driven strain effects on magneto-crystalline anisotropy Universität Stuttgart, Stuttgart, 2011 (mastersthesis)

[BibTex]

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Magnetooptische Untersuchungen an granularen und beschichteten MgB2 Filmen

Stahl, C.

Universität Stuttgart, Stuttgart, 2011 (mastersthesis)

mms

[BibTex]

mms Stahl, C. Magnetooptische Untersuchungen an granularen und beschichteten MgB2 Filmen Universität Stuttgart, Stuttgart, 2011 (mastersthesis)

[BibTex]

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Mikromagnetismus der Wechselwirkung von Spinwellen mit Domänenwänden in Ferromagneten

Macke, S.

Universität Stuttgart, Stuttgart, 2011 (phdthesis)

mms

[BibTex]

mms Macke, S. Mikromagnetismus der Wechselwirkung von Spinwellen mit Domänenwänden in Ferromagneten Universität Stuttgart, Stuttgart, 2011 (phdthesis)

[BibTex]

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Herstellung und Qualifizierung gesputterter Magnesiumdiboridschichten

Breyer, F.

Hochschule Aalen, Aalen, 2011 (mastersthesis)

mms

[BibTex]

mms Breyer, F. Herstellung und Qualifizierung gesputterter Magnesiumdiboridschichten Hochschule Aalen, Aalen, 2011 (mastersthesis)

[BibTex]

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Study of krypton/xenon storage and separation in microporous frameworks

Soleimani Dorcheh, A.

Universität Darmstadt, Darmstadt, 2011 (mastersthesis)

mms

[BibTex]

mms Soleimani Dorcheh, A. Study of krypton/xenon storage and separation in microporous frameworks Universität Darmstadt, Darmstadt, 2011 (mastersthesis)

[BibTex]

2008

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BCPy2000

Hill, N., Schreiner, T., Puzicha, C., Farquhar, J.

Workshop "Machine Learning Open-Source Software" at NIPS, December 2008 (talk)

ei

Web [BibTex]

2008

ei Hill, N., Schreiner, T., Puzicha, C., Farquhar, J. BCPy2000 Workshop "Machine Learning Open-Source Software" at NIPS, December 2008 (talk)

Web [BibTex]

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Logistic Regression for Graph Classification

Shervashidze, N., Tsuda, K.

NIPS Workshop on "Structured Input - Structured Output" (NIPS SISO), December 2008 (talk)

Abstract
In this paper we deal with graph classification. We propose a new algorithm for performing sparse logistic regression for graphs, which is comparable in accuracy with other methods of graph classification and produces probabilistic output in addition. Sparsity is required for the reason of interpretability, which is often necessary in domains such as bioinformatics or chemoinformatics.

ei

Web [BibTex]

ei Shervashidze, N., Tsuda, K. Logistic Regression for Graph Classification NIPS Workshop on "Structured Input - Structured Output" (NIPS SISO), December 2008 (talk)

Web [BibTex]

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New Projected Quasi-Newton Methods with Applications

Sra, S.

Microsoft Research Tech-talk, December 2008 (talk)

Abstract
Box-constrained convex optimization problems are central to several applications in a variety of fields such as statistics, psychometrics, signal processing, medical imaging, and machine learning. Two fundamental examples are the non-negative least squares (NNLS) problem and the non-negative Kullback-Leibler (NNKL) divergence minimization problem. The non-negativity constraints are usually based on an underlying physical restriction, for e.g., when dealing with applications in astronomy, tomography, statistical estimation, or image restoration, the underlying parameters represent physical quantities such as concentration, weight, intensity, or frequency counts and are therefore only interpretable with non-negative values. Several modern optimization methods can be inefficient for simple problems such as NNLS and NNKL as they are really designed to handle far more general and complex problems. In this work we develop two simple quasi-Newton methods for solving box-constrained (differentiable) convex optimization problems that utilize the well-known BFGS and limited memory BFGS updates. We position our method between projected gradient (Rosen, 1960) and projected Newton (Bertsekas, 1982) methods, and prove its convergence under a simple Armijo step-size rule. We illustrate our method by showing applications to: Image deblurring, Positron Emission Tomography (PET) image reconstruction, and Non-negative Matrix Approximation (NMA). On medium sized data we observe performance competitive to established procedures, while for larger data the results are even better.

ei

PDF [BibTex]

ei Sra, S. New Projected Quasi-Newton Methods with Applications Microsoft Research Tech-talk, December 2008 (talk)

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MR-Based PET Attenuation Correction: Initial Results for Whole Body

Hofmann, M., Steinke, F., Aschoff, P., Lichy, M., Brady, M., Schölkopf, B., Pichler, B.

Medical Imaging Conference, October 2008 (talk)

ei

[BibTex]

ei Hofmann, M., Steinke, F., Aschoff, P., Lichy, M., Brady, M., Schölkopf, B., Pichler, B. MR-Based PET Attenuation Correction: Initial Results for Whole Body Medical Imaging Conference, October 2008 (talk)

[BibTex]

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Nonparametric Indepedence Tests: Space Partitioning and Kernel Approaches

Gretton, A., Györfi, L.

19th International Conference on Algorithmic Learning Theory (ALT08), October 2008 (talk)

ei

PDF Web [BibTex]

ei Gretton, A., Györfi, L. Nonparametric Indepedence Tests: Space Partitioning and Kernel Approaches 19th International Conference on Algorithmic Learning Theory (ALT08), October 2008 (talk)

PDF Web [BibTex]

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Reinforcement Learning for Motor Primitives

Kober, J.

Biologische Kybernetik, University of Stuttgart, Stuttgart, Germany, August 2008 (diplomathesis)

ei

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ei Kober, J. Reinforcement Learning for Motor Primitives Biologische Kybernetik, University of Stuttgart, Stuttgart, Germany, August 2008 (diplomathesis)

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Asymmetries of Time Series under Inverting their Direction

Peters, J.

Biologische Kybernetik, University of Heidelberg, August 2008 (diplomathesis)

ei

PDF [BibTex]

ei Peters, J. Asymmetries of Time Series under Inverting their Direction Biologische Kybernetik, University of Heidelberg, August 2008 (diplomathesis)

PDF [BibTex]

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mGene: A Novel Discriminative Gene Finder

Schweikert, G., Zeller, G., Zien, A., Behr, J., Sonnenburg, S., Philips, P., Ong, C., Rätsch, G.

Worm Genomics and Systems Biology meeting, July 2008 (talk)

ei

[BibTex]

ei Schweikert, G., Zeller, G., Zien, A., Behr, J., Sonnenburg, S., Philips, P., Ong, C., Rätsch, G. mGene: A Novel Discriminative Gene Finder Worm Genomics and Systems Biology meeting, July 2008 (talk)

[BibTex]

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Learning an Interest Operator from Human Eye Movements

Kienzle, W.

Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, July 2008 (phdthesis)

ei

[BibTex]

ei Kienzle, W. Learning an Interest Operator from Human Eye Movements Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, July 2008 (phdthesis)

[BibTex]

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Discovering Common Sequence Variation in Arabidopsis thaliana

Rätsch, G., Clark, R., Schweikert, G., Toomajian, C., Ossowski, S., Zeller, G., Shinn, P., Warthman, N., Hu, T., Fu, G., Hinds, D., Cheng, H., Frazer, K., Huson, D., Schölkopf, B., Nordborg, M., Ecker, J., Weigel, D., Schneeberger, K., Bohlen, A.

16th Annual International Conference Intelligent Systems for Molecular Biology (ISMB), July 2008 (talk)

ei

Web [BibTex]

ei Rätsch, G., Clark, R., Schweikert, G., Toomajian, C., Ossowski, S., Zeller, G., Shinn, P., Warthman, N., Hu, T., Fu, G., Hinds, D., Cheng, H., Frazer, K., Huson, D., Schölkopf, B., Nordborg, M., Ecker, J., Weigel, D., Schneeberger, K., Bohlen, A. Discovering Common Sequence Variation in Arabidopsis thaliana 16th Annual International Conference Intelligent Systems for Molecular Biology (ISMB), July 2008 (talk)

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Coding Theory in Brain-Computer Interfaces

Martens, SMM.

Soria Summerschool on Computational Mathematics "Algebraic Coding Theory" (S3CM), July 2008 (talk)

ei

Web [BibTex]

ei Martens, SMM. Coding Theory in Brain-Computer Interfaces Soria Summerschool on Computational Mathematics "Algebraic Coding Theory" (S3CM), July 2008 (talk)

Web [BibTex]

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Motor Skill Learning for Cognitive Robotics

Peters, J.

6th International Cognitive Robotics Workshop (CogRob), July 2008 (talk)

Abstract
Autonomous robots that can assist humans in situations of daily life have been a long standing vision of robotics, artificial intelligence, and cognitive sciences. A first step towards this goal is to create robots that can learn tasks triggered by environmental context or higher level instruction. However, learning techniques have yet to live up to this promise as only few methods manage to scale to high-dimensional manipulator or humanoid robots. In this tutorial, we give a general overview on motor skill learning for cognitive robotics using research at ATR, USC, CMU and Max-Planck in order to illustrate the problems in motor skill learning. For doing so, we discuss task-appropriate representations and algorithms for learning robot motor skills. Among the topics are the learning basic movements or motor primitives by imitation and reinforcement learning, learning rhytmic and discrete movements, fast regression methods for learning inverse dynamics and setups for learning task-space policies. Examples on various robots, e.g., SARCOS DB, the SARCOS Master Arm, BDI Little Dog and a Barrett WAM, are shown and include Ball-in-a-Cup, T-Ball, Juggling, Devil-Sticking, Operational Space Control and many others.

ei

Web [BibTex]

ei Peters, J. Motor Skill Learning for Cognitive Robotics 6th International Cognitive Robotics Workshop (CogRob), July 2008 (talk)

Web [BibTex]

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Painless Embeddings of Distributions: the Function Space View (Part 1)

Fukumizu, K., Gretton, A., Smola, A.

25th International Conference on Machine Learning (ICML), July 2008 (talk)

Abstract
This tutorial will give an introduction to the recent understanding and methodology of the kernel method: dealing with higher order statistics by embedding painlessly random variables/probability distributions. In the early days of kernel machines research, the "kernel trick" was considered a useful way of constructing nonlinear algorithms from linear ones. More recently, however, it has become clear that a potentially more far reaching use of kernels is as a linear way of dealing with higher order statistics by embedding distributions in a suitable reproducing kernel Hilbert space (RKHS). Notably, unlike the straightforward expansion of higher order moments or conventional characteristic function approach, the use of kernels or RKHS provides a painless, tractable way of embedding distributions. This line of reasoning leads naturally to the questions: what does it mean to embed a distribution in an RKHS? when is this embedding injective (and thus, when do different distributions have unique mappings)? what implications are there for learning algorithms that make use of these embeddings? This tutorial aims at answering these questions. There are a great variety of applications in machine learning and computer science, which require distribution estimation and/or comparison.

ei

PDF Web [BibTex]

ei Fukumizu, K., Gretton, A., Smola, A. Painless Embeddings of Distributions: the Function Space View (Part 1) 25th International Conference on Machine Learning (ICML), July 2008 (talk)

PDF Web [BibTex]

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Reinforcement Learning for Robotics

Peters, J.

8th European Workshop on Reinforcement Learning for Robotics (EWRL), July 2008 (talk)

ei

Web [BibTex]

ei Peters, J. Reinforcement Learning for Robotics 8th European Workshop on Reinforcement Learning for Robotics (EWRL), July 2008 (talk)

Web [BibTex]

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Thin-Plate Splines Between Riemannian Manifolds

Steinke, F., Hein, M., Schölkopf, B.

Workshop on Geometry and Statistics of Shapes, June 2008 (talk)

Abstract
With the help of differential geometry we describe a framework to define a thin-plate spline like energy for maps between arbitrary Riemannian manifolds. The so-called Eells energy only depends on the intrinsic geometry of the input and output manifold, but not on their respective representation. The energy can then be used for regression between manifolds, we present results for cases where the outputs are rotations, sets of angles, or points on 3D surfaces. In the future we plan to also target regression where the output is an element of "shape space", understood as a Riemannian manifold. One could also further explore the meaning of the Eells energy when applied to diffeomorphisms between shapes, especially with regard to its potential use as a distance measure between shapes that does not depend on the embedding or the parametrisation of the shapes.

ei

Web [BibTex]

ei Steinke, F., Hein, M., Schölkopf, B. Thin-Plate Splines Between Riemannian Manifolds Workshop on Geometry and Statistics of Shapes, June 2008 (talk)

Web [BibTex]

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Learning resolved velocity control

Peters, J.

2008 IEEE International Conference on Robotics and Automation (ICRA), May 2008 (talk)

ei

Web [BibTex]

ei Peters, J. Learning resolved velocity control 2008 IEEE International Conference on Robotics and Automation (ICRA), May 2008 (talk)

Web [BibTex]

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Causal inference from statistical data

Sun, X.

Biologische Kybernetik, Technische Hochschule Karlsruhe, Karlsruhe, Germany, April 2008 (phdthesis)

ei

Web [BibTex]

ei Sun, X. Causal inference from statistical data Biologische Kybernetik, Technische Hochschule Karlsruhe, Karlsruhe, Germany, April 2008 (phdthesis)

Web [BibTex]

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Pairwise Correlations and Multineuronal Firing Patterns in Primary Visual Cortex

Berens, P.

Biologische Kybernetik, Eberhard Karls Universität Tübingen, Tübingen, Germany, April 2008 (diplomathesis)

ei

[BibTex]

ei Berens, P. Pairwise Correlations and Multineuronal Firing Patterns in Primary Visual Cortex Biologische Kybernetik, Eberhard Karls Universität Tübingen, Tübingen, Germany, April 2008 (diplomathesis)

[BibTex]

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Bayesian methods for protein structure determination

Habeck, M.

Machine Learning in Structural Bioinformatics, April 2008 (talk)

ei

Web [BibTex]

ei Habeck, M. Bayesian methods for protein structure determination Machine Learning in Structural Bioinformatics, April 2008 (talk)

Web [BibTex]

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Development and Application of a Python Scripting Framework for BCI2000

Schreiner, T.

Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, January 2008 (diplomathesis)

ei

[BibTex]

ei Schreiner, T. Development and Application of a Python Scripting Framework for BCI2000 Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, January 2008 (diplomathesis)

[BibTex]

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Efficient and Invariant Regularisation with Application to Computer Graphics

Walder, CJ.

Biologische Kybernetik, University of Queensland, Brisbane, Australia, January 2008 (phdthesis)

Abstract
This thesis develops the theory and practise of reproducing kernel methods. Many functional inverse problems which arise in, for example, machine learning and computer graphics, have been treated with practical success using methods based on a reproducing kernel Hilbert space perspective. This perspective is often theoretically convenient, in that many functional analysis problems reduce to linear algebra problems in these spaces. Somewhat more complex is the case of conditionally positive definite kernels, and we provide an introduction to both cases, deriving in a particularly elementary manner some key results for the conditionally positive definite case. A common complaint of the practitioner is the long running time of these kernel based algorithms. We provide novel ways of alleviating these problems by essentially using a non-standard function basis which yields computational advantages. That said, by doing so we must also forego the aforementioned theoretical conveniences, and hence need some additional analysis which we provide in order to make the approach practicable. We demonstrate that the method leads to state of the art performance on the problem of surface reconstruction from points. We also provide some analysis of kernels invariant to transformations such as translation and dilation, and show that this indicates the value of learning algorithms which use conditionally positive definite kernels. Correspondingly, we provide a few approaches for making such algorithms practicable. We do this either by modifying the kernel, or directly solving problems with conditionally positive definite kernels, which had previously only been solved with positive definite kernels. We demonstrate the advantage of this approach, in particular by attaining state of the art classification performance with only one free parameter.

ei

PDF [BibTex]

ei Walder, CJ. Efficient and Invariant Regularisation with Application to Computer Graphics Biologische Kybernetik, University of Queensland, Brisbane, Australia, January 2008 (phdthesis)

PDF [BibTex]

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Ab-initio Elektronentheorie der magnetischen Anisotropie im System FePt mit der Clusterentwicklungsmethode

Subkow, S.

Universität Stuttgart, Stuttgart, 2008 (mastersthesis)

mms

[BibTex]

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Magnetism of amorphous and highly anisotropic multilayer systems on flat substrates and nanospheres

Amaladass, E. P.

Universität Stuttgart, Stuttgart, 2008 (phdthesis)

mms

link (url) [BibTex]