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2019


Towards Geometric Understanding of Motion
Towards Geometric Understanding of Motion

Ranjan, A.

University of Tübingen, December 2019 (phdthesis)

Abstract

The motion of the world is inherently dependent on the spatial structure of the world and its geometry. Therefore, classical optical flow methods try to model this geometry to solve for the motion. However, recent deep learning methods take a completely different approach. They try to predict optical flow by learning from labelled data. Although deep networks have shown state-of-the-art performance on classification problems in computer vision, they have not been as effective in solving optical flow. The key reason is that deep learning methods do not explicitly model the structure of the world in a neural network, and instead expect the network to learn about the structure from data. We hypothesize that it is difficult for a network to learn about motion without any constraint on the structure of the world. Therefore, we explore several approaches to explicitly model the geometry of the world and its spatial structure in deep neural networks.

The spatial structure in images can be captured by representing it at multiple scales. To represent multiple scales of images in deep neural nets, we introduce a Spatial Pyramid Network (SpyNet). Such a network can leverage global information for estimating large motions and local information for estimating small motions. We show that SpyNet significantly improves over previous optical flow networks while also being the smallest and fastest neural network for motion estimation. SPyNet achieves a 97% reduction in model parameters over previous methods and is more accurate.

The spatial structure of the world extends to people and their motion. Humans have a very well-defined structure, and this information is useful in estimating optical flow for humans. To leverage this information, we create a synthetic dataset for human optical flow using a statistical human body model and motion capture sequences. We use this dataset to train deep networks and see significant improvement in the ability of the networks to estimate human optical flow.

The structure and geometry of the world affects the motion. Therefore, learning about the structure of the scene together with the motion can benefit both problems. To facilitate this, we introduce Competitive Collaboration, where several neural networks are constrained by geometry and can jointly learn about structure and motion in the scene without any labels. To this end, we show that jointly learning single view depth prediction, camera motion, optical flow and motion segmentation using Competitive Collaboration achieves state-of-the-art results among unsupervised approaches.

Our findings provide support for our hypothesis that explicit constraints on structure and geometry of the world lead to better methods for motion estimation.

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PhD Thesis [BibTex]

2019


PhD Thesis [BibTex]


Semi-supervised learning, causality, and the conditional cluster assumption
Semi-supervised learning, causality, and the conditional cluster assumption

von Kügelgen, J., Mey, A., Loog, M., Schölkopf, B.

NeurIPS 2019 Workshop “Do the right thing”: machine learning and causal inference for improved decision making, December 2019 (poster)

ei

Poster PDF link (url) [BibTex]

Poster PDF link (url) [BibTex]


Optimal experimental design via Bayesian optimization: active causal structure learning for Gaussian process networks
Optimal experimental design via Bayesian optimization: active causal structure learning for Gaussian process networks

von Kügelgen, J., Rubenstein, P. K., Schölkopf, B., Weller, A.

NeurIPS 2019 Workshop “Do the right thing”: machine learning and causal inference for improved decision making, December 2019 (poster)

ei

arXiv Poster link (url) [BibTex]

arXiv Poster link (url) [BibTex]


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Robot Learning for Muscular Robots

Büchler, D.

Technical University Darmstadt, Germany, December 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Real Time Probabilistic Models for Robot Trajectories

Gomez-Gonzalez, S.

Technical University Darmstadt, Germany, December 2019 (phdthesis)

ei

[BibTex]

[BibTex]


AirCap -- Aerial Outdoor Motion Capture
AirCap – Aerial Outdoor Motion Capture

Ahmad, A., Price, E., Tallamraju, R., Saini, N., Lawless, G., Ludwig, R., Martinovic, I., Bülthoff, H. H., Black, M. J.

IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2019), Workshop on Aerial Swarms, November 2019 (misc)

Abstract
This paper presents an overview of the Grassroots project Aerial Outdoor Motion Capture (AirCap) running at the Max Planck Institute for Intelligent Systems. AirCap's goal is to achieve markerless, unconstrained, human motion capture (mocap) in unknown and unstructured outdoor environments. To that end, we have developed an autonomous flying motion capture system using a team of aerial vehicles (MAVs) with only on-board, monocular RGB cameras. We have conducted several real robot experiments involving up to 3 aerial vehicles autonomously tracking and following a person in several challenging scenarios using our approach of active cooperative perception developed in AirCap. Using the images captured by these robots during the experiments, we have demonstrated a successful offline body pose and shape estimation with sufficiently high accuracy. Overall, we have demonstrated the first fully autonomous flying motion capture system involving multiple robots for outdoor scenarios.

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Talk slides Project Page Project Page [BibTex]

Talk slides Project Page Project Page [BibTex]


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Interactive Augmented Reality for Robot-Assisted Surgery

Forte, M. P., Kuchenbecker, K. J.

Workshop extended abstract presented as a podium presentation at the IROS Workshop on Legacy Disruptors in Applied Telerobotics, Macau, November 2019 (misc) Accepted

hi

Project Page [BibTex]

Project Page [BibTex]


Method for providing a three dimensional body model
Method for providing a three dimensional body model

Loper, M., Mahmood, N., Black, M.

September 2019, U.S.~Patent 10,417,818 (misc)

Abstract
A method for providing a three-dimensional body model which may be applied for an animation, based on a moving body, wherein the method comprises providing a parametric three-dimensional body model, which allows shape and pose variations; applying a standard set of body markers; optimizing the set of body markers by generating an additional set of body markers and applying the same for providing 3D coordinate marker signals for capturing shape and pose of the body and dynamics of soft tissue; and automatically providing an animation by processing the 3D coordinate marker signals in order to provide a personalized three-dimensional body model, based on estimated shape and an estimated pose of the body by means of predicted marker locations.

ps

MoSh Project pdf [BibTex]


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High-Fidelity Multiphysics Finite Element Modeling of Finger-Surface Interactions with Tactile Feedback

Serhat, G., Kuchenbecker, K. J.

Work-in-progress paper (2 pages) presented at the IEEE World Haptics Conference (WHC), Tokyo, Japan, July 2019 (misc)

Abstract
In this study, we develop a high-fidelity finite element (FE) analysis framework that enables multiphysics simulation of the human finger in contact with a surface that is providing tactile feedback. We aim to elucidate a variety of physical interactions that can occur at finger-surface interfaces, including contact, friction, vibration, and electrovibration. We also develop novel FE-based methods that will allow prediction of nonconventional features such as real finger-surface contact area and finger stickiness. We envision using the developed computational tools for efficient design and optimization of haptic devices by replacing expensive and lengthy experimental procedures with high-fidelity simulation.

hi

[BibTex]

[BibTex]


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Fingertip Friction Enhances Perception of Normal Force Changes

Gueorguiev, D., Lambert, J., Thonnard, J., Kuchenbecker, K. J.

Work-in-progress paper (2 pages) presented at the IEEE World Haptics Conference (WHC), Tokyo, Japan, July 2019 (misc)

Abstract
Using a force-controlled robotic platform, we tested the human perception of positive and negative modulations in normal force during passive dynamic touch, which also induced a strong related change in the finger-surface lateral force. In a two-alternative forced-choice task, eleven participants had to detect brief variations in the normal force compared to a constant controlled pre-stimulation force of 1 N and report whether it had increased or decreased. The average 75% just noticeable difference (JND) was found to be around 0.25 N for detecting the peak change and 0.30 N for correctly reporting the increase or the decrease. Interestingly, the friction coefficient of a subject’s fingertip positively correlated with his or her performance at detecting the change and reporting its direction, which suggests that humans may use the lateral force as a sensory cue to perceive variations in the normal force.

hi

[BibTex]

[BibTex]


Inflatable Haptic Sensor for the Torso of a Hugging Robot
Inflatable Haptic Sensor for the Torso of a Hugging Robot

Block, A. E., Kuchenbecker, K. J.

Work-in-progress paper (2 pages) presented at the IEEE World Haptics Conference (WHC), Tokyo, Japan, July 2019 (misc)

Abstract
During hugs, humans naturally provide and intuit subtle non-verbal cues that signify the strength and duration of an exchanged hug. Personal preferences for this close interaction may vary greatly between people; robots do not currently have the abilities to perceive or understand these preferences. This work-in-progress paper discusses designing, building, and testing a novel inflatable torso that can simultaneously soften a robot and act as a tactile sensor to enable more natural and responsive hugging. Using PVC vinyl, a microphone, and a barometric pressure sensor, we created a small test chamber to demonstrate a proof of concept for the full torso. While contacting the chamber in several ways common in hugs (pat, squeeze, scratch, and rub), we recorded data from the two sensors. The preliminary results suggest that the complementary haptic sensing channels allow us to detect coarse and fine contacts typically experienced during hugs, regardless of user hand placement.

hi

Project Page [BibTex]

Project Page [BibTex]


Understanding the Pull-off Force of the Human Fingerpad
Understanding the Pull-off Force of the Human Fingerpad

Nam, S., Kuchenbecker, K. J.

Work-in-progress paper (2 pages) presented at the IEEE World Haptics Conference (WHC), Tokyo, Japan, July 2019 (misc)

Abstract
To understand the adhesive force that occurs when a finger pulls off of a smooth surface, we built an apparatus to measure the fingerpad’s moisture, normal force, and real contact area over time during interactions with a glass plate. We recorded a total of 450 trials (45 interactions by each of ten human subjects), capturing a wide range of values across the aforementioned variables. The experimental results showed that the pull-off force increases with larger finger contact area and faster detachment rate. Additionally, moisture generally increases the contact area of the finger, but too much moisture can restrict the increase in the pull-off force.

hi

[BibTex]

[BibTex]


The Haptician and the Alphamonsters
The Haptician and the Alphamonsters

Forte, M. P., L’Orsa, R., Mohan, M., Nam, S., Kuchenbecker, K. J.

Student Innovation Challenge on Implementing Haptics in Virtual Reality Environment presented at the IEEE World Haptics Conference, Tokyo, Japan, July 2019, Maria Paola Forte, Rachael L'Orsa, Mayumi Mohan, and Saekwang Nam contributed equally to this publication (misc)

Abstract
Dysgraphia is a neurological disorder characterized by writing disabilities that affects between 7% and 15% of children. It presents itself in the form of unfinished letters, letter distortion, inconsistent letter size, letter collision, etc. Traditional therapeutic exercises require continuous assistance from teachers or occupational therapists. Autonomous partial or full haptic guidance can produce positive results, but children often become bored with the repetitive nature of such activities. Conversely, virtual rehabilitation with video games represents a new frontier for occupational therapy due to its highly motivational nature. Virtual reality (VR) adds an element of novelty and entertainment to therapy, thus motivating players to perform exercises more regularly. We propose leveraging the HTC VIVE Pro and the EXOS Wrist DK2 to create an immersive spellcasting “exergame” (exercise game) that helps motivate children with dysgraphia to improve writing fluency.

hi

Student Innovation Challenge – Virtual Reality [BibTex]

Student Innovation Challenge – Virtual Reality [BibTex]


Explorations of Shape-Changing Haptic Interfaces for Blind and Sighted Pedestrian Navigation
Explorations of Shape-Changing Haptic Interfaces for Blind and Sighted Pedestrian Navigation

Spiers, A., Kuchenbecker, K. J.

pages: 6, Workshop paper (6 pages) presented at the CHI 2019 Workshop on Hacking Blind Navigation, May 2019 (misc) Accepted

Abstract
Since the 1960s, technologists have worked to develop systems that facilitate independent navigation by vision-impaired (VI) pedestrians. These devices vary in terms of conveyed information and feedback modality. Unfortunately, many such prototypes never progress beyond laboratory testing. Conversely, smartphone-based navigation systems for sighted pedestrians have grown in robustness and capabilities, to the point of now being ubiquitous. How can we leverage the success of sighted navigation technology, which is driven by a larger global market, as a way to progress VI navigation systems? We believe one possibility is to make common devices that benefit both VI and sighted individuals, by providing information in a way that does not distract either user from their tasks or environment. To this end we have developed physical interfaces that eschew visual, audio or vibratory feedback, instead relying on the natural human ability to perceive the shape of a handheld object.

hi

[BibTex]

[BibTex]


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Bimanual Wrist-Squeezing Haptic Feedback Changes Speed-Force Tradeoff in Robotic Surgery Training

Cao, E., Machaca, S., Bernard, T., Wolfinger, B., Patterson, Z., Chi, A., Adrales, G. L., Kuchenbecker, K. J., Brown, J. D.

Extended abstract presented as an ePoster at the Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Baltimore, USA, April 2019 (misc) Accepted

hi

[BibTex]

[BibTex]


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Interactive Augmented Reality for Robot-Assisted Surgery

Forte, M. P., Kuchenbecker, K. J.

Extended abstract presented as an Emerging Technology ePoster at the Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Baltimore, Maryland, USA, April 2019 (misc) Accepted

hi

Project Page [BibTex]

Project Page [BibTex]


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Demo Abstract: Fast Feedback Control and Coordination with Mode Changes for Wireless Cyber-Physical Systems

(Best Demo Award)

Mager, F., Baumann, D., Jacob, R., Thiele, L., Trimpe, S., Zimmerling, M.

Proceedings of the 18th ACM/IEEE Conference on Information Processing in Sensor Networks (IPSN), pages: 340-341, 18th ACM/IEEE Conference on Information Processing in Sensor Networks (IPSN), April 2019 (poster)

ics

arXiv PDF DOI [BibTex]

arXiv PDF DOI [BibTex]


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A Design Tool for Therapeutic Social-Physical Human-Robot Interactions

Mohan, M., Kuchenbecker, K. J.

Workshop paper (3 pages) presented at the HRI Pioneers Workshop, Daegu, South Korea, March 2019 (misc)

Abstract
We live in an aging society; social-physical human-robot interaction has the potential to keep our elderly adults healthy by motivating them to exercise. After summarizing prior work, this paper proposes a tool that can be used to design exercise and therapy interactions to be performed by an upper-body humanoid robot. The interaction design tool comprises a teleoperation system that transmits the operator’s arm motions, head motions and facial expression along with an interface to monitor and assess the motion of the user interacting with the robot. We plan to use this platform to create dynamic and intuitive exercise interactions.

hi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


Fast and Resource-Efficient Control of Wireless Cyber-Physical Systems
Fast and Resource-Efficient Control of Wireless Cyber-Physical Systems

Baumann, D.

KTH Royal Institute of Technology, Stockholm, Febuary 2019 (phdthesis)

ics

PDF [BibTex]

PDF [BibTex]


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Learning Transferable Representations

Rojas-Carulla, M.

University of Cambridge, UK, 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Sample-efficient deep reinforcement learning for continuous control

Gu, S.

University of Cambridge, UK, 2019 (phdthesis)

ei

[BibTex]


Perceiving Systems (2016-2018)
Perceiving Systems (2016-2018)
Scientific Advisory Board Report, 2019 (misc)

ps

pdf [BibTex]

pdf [BibTex]


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X-ray microscopic characterization of high-Tc-supercoductors using image processing

Bihler, M.

Universität Stuttgart, Stuttgart, 2019 (mastersthesis)

mms

[BibTex]


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Spatial Filtering based on Riemannian Manifold for Brain-Computer Interfacing

Xu, J.

Technical University of Munich, Germany, 2019 (mastersthesis)

ei

[BibTex]

[BibTex]


Toward Expert-Sourcing of a Haptic Device Repository
Toward Expert-Sourcing of a Haptic Device Repository

Seifi, H., Ip, J., Agrawal, A., Kuchenbecker, K. J., MacLean, K. E.

Glasgow, UK, 2019 (misc)

Abstract
Haptipedia is an online taxonomy, database, and visualization that aims to accelerate ideation of new haptic devices and interactions in human-computer interaction, virtual reality, haptics, and robotics. The current version of Haptipedia (105 devices) was created through iterative design, data entry, and evaluation by our team of experts. Next, we aim to greatly increase the number of devices and keep Haptipedia updated by soliciting data entry and verification from haptics experts worldwide.

hi

link (url) [BibTex]

link (url) [BibTex]


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Perception of temporal dependencies in autoregressive motion

Meding, K., Schölkopf, B., Wichmann, F. A.

European Conference on Visual Perception (ECVP), 2019 (poster)

ei

[BibTex]

[BibTex]


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A special issue on hydrogen-based Energy storage

Hirscher, M.

{International Journal of Hydrogen Energy}, 44, pages: 7737, Elsevier, Amsterdam, 2019 (misc)

mms

DOI [BibTex]

DOI [BibTex]


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Novel X-ray lenses for direct and coherent imaging

Sanli, U. T.

Universität Stuttgart, Stuttgart, 2019 (phdthesis)

mms

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Nanoscale X-ray imaging of spin dynamics in Yttrium iron garnet

Förster, J., Wintz, S., Bailey, J., Finizio, S., Josten, E., Meertens, D., Dubs, C., Bozhko, D. A., Stoll, H., Dieterle, G., Traeger, N., Raabe, J., Slavin, A. N., Weigand, M., Gräfe, J., Schütz, G.

2019 (misc)

mms

link (url) [BibTex]

link (url) [BibTex]


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Reconfigurable nanoscale spin wave majority gate with frequency-division multiplexing

Talmelli, G., Devolder, T., Träger, N., Förster, J., Wintz, S., Weigand, M., Stoll, H., Heyns, M., Schütz, G., Radu, I., Gräfe, J., Ciubotaru, F., Adelmann, C.

2019 (misc)

Abstract
Spin waves are excitations in ferromagnetic media that have been proposed as information carriers in spintronic devices with potentially much lower operation power than conventional charge-based electronics. The wave nature of spin waves can be exploited to design majority gates by coding information in their phase and using interference for computation. However, a scalable spin wave majority gate design that can be co-integrated alongside conventional Si-based electronics is still lacking. Here, we demonstrate a reconfigurable nanoscale inline spin wave majority gate with ultrasmall footprint, frequency-division multiplexing, and fan-out. Time-resolved imaging of the magnetisation dynamics by scanning transmission x-ray microscopy reveals the operation mode of the device and validates the full logic majority truth table. All-electrical spin wave spectroscopy further demonstrates spin wave majority gates with sub-micron dimensions, sub-micron spin wave wavelengths, and reconfigurable input and output ports. We also show that interference-based computation allows for frequency-division multiplexing as well as the computation of different logic functions in the same device. Such devices can thus form the foundation of a future spin-wave-based superscalar vector computing platform.

mms

link (url) [BibTex]

link (url) [BibTex]


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Quantification of tumor heterogeneity using PET/MRI and machine learning

Katiyar, P.

Eberhard Karls Universität Tübingen, Germany, 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Phenomenal Causality and Sensory Realism

Bruijns, S. A., Meding, K., Schölkopf, B., Wichmann, F. A.

European Conference on Visual Perception (ECVP), 2019 (poster)

ei

[BibTex]

[BibTex]


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Hydrogen Energy

Hirscher, M., Autrey, T., Orimo, S.

{ChemPhysChem}, 20, pages: 1153-1411, Wiley-VCH, Weinheim, Germany, 2019 (misc)

mms

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Real-space imaging of confined magnetic skyrmion tubes

Birch, M. T., Cortés-Ortuño, D., Turnbull, L. A., Wilson, M. N., Groß, F., Träger, N., Laurenson, A., Bukin, N., Moody, S. H., Weigand, M., Schütz, G., Popescu, H., Fan, R., Steadman, P., Verezhak, J. A. T., Balakrishnan, G., Loudon, J. C., Twitchett-Harrison, A. C., Hovorka, O., Fangohr, H., Ogrin, F., Gräfe, J., Hatton, P. D.

2019 (misc)

mms

link (url) [BibTex]

link (url) [BibTex]


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Actively Learning Dynamical Systems with Gaussian Processes

Buisson-Fenet, M.

Mines ParisTech, PSL Research University, 2019 (mastersthesis)

Abstract
Predicting the behavior of complex systems is of great importance in many fields such as engineering, economics or meteorology. The evolution of such systems often follows a certain structure, which can be induced, for example from the laws of physics or of market forces. Mathematically, this structure is often captured by differential equations. The internal functional dependencies, however, are usually unknown. Hence, using machine learning approaches that recreate this structure directly from data is a promising alternative to designing physics-based models. In particular, for high dimensional systems with nonlinear effects, this can be a challenging task. Learning dynamical systems is different from the classical machine learning tasks, such as image processing, and necessitates different tools. Indeed, dynamical systems can be actuated, often by applying torques or voltages. Hence, the user has a power of decision over the system, and can drive it to certain states by going through the dynamics. Actuating this system generates data, from which a machine learning model of the dynamics can be trained. However, gathering informative data that is representative of the whole state space remains a challenging task. The question of active learning then becomes important: which control inputs should be chosen by the user so that the data generated during an experiment is informative, and enables efficient training of the dynamics model? In this context, Gaussian processes can be a useful framework for approximating system dynamics. Indeed, they perform well on small and medium sized data sets, as opposed to most other machine learning frameworks. This is particularly important considering data is often costly to generate and process, most of all when producing it involves actuating a complex physical system. Gaussian processes also yield a notion of uncertainty, which indicates how sure the model is about its predictions. In this work, we investigate in a principled way how to actively learn dynamical systems, by selecting control inputs that generate informative data. We model the system dynamics by a Gaussian process, and use information-theoretic criteria to identify control trajectories that maximize the information gain. Thus, the input space can be explored efficiently, leading to a data-efficient training of the model. We propose several methods, investigate their theoretical properties and compare them extensively in a numerical benchmark. The final method proves to be efficient at generating informative data. Thus, it yields the lowest prediction error with the same amount of samples on most benchmark systems. We propose several variants of this method, allowing the user to trade off computations with prediction accuracy, and show it is versatile enough to take additional objectives into account.

ics

[BibTex]

[BibTex]

2011


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Projected Newton-type methods in machine learning

Schmidt, M., Kim, D., Sra, S.

In Optimization for Machine Learning, pages: 305-330, (Editors: Sra, S., Nowozin, S. and Wright, S. J.), MIT Press, Cambridge, MA, USA, December 2011 (inbook)

Abstract
We consider projected Newton-type methods for solving large-scale optimization problems arising in machine learning and related fields. We first introduce an algorithmic framework for projected Newton-type methods by reviewing a canonical projected (quasi-)Newton method. This method, while conceptually pleasing, has a high computation cost per iteration. Thus, we discuss two variants that are more scalable, namely, two-metric projection and inexact projection methods. Finally, we show how to apply the Newton-type framework to handle non-smooth objectives. Examples are provided throughout the chapter to illustrate machine learning applications of our framework.

ei

PDF Web [BibTex]

2011


PDF Web [BibTex]


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Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N.

41(239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience), November 2011 (poster)

Abstract
The inferior convexity of the macaque prefrontal cortex (icPFC) is known to be involved in higher order processing of sensory information mediating stimulus selection, attention and working memory. Until now, the vast majority of electrophysiological investigations of the icPFC employed single electrode recordings. As a result, relatively little is known about the spatiotemporal structure of neuronal activity in this cortical area. Here we study in detail the spatiotemporal properties of local field potentials (LFP's) in the icPFC using multi electrode recordings during anesthesia. We computed the LFP-LFP coherence as a function of frequency for thousands of pairs of simultaneously recorded sites anterior to the arcuate and inferior to the principal sulcus. We observed two distinct peaks of coherent oscillatory activity between approximately 4-10 and 15-25 Hz. We then quantified the instantaneous phase of these frequency bands using the Hilbert transform and found robust phase gradients across recording sites. The dependency of the phase on the spatial location reflects the existence of traveling waves of electrical activity in the icPFC. The dominant axis of these traveling waves roughly followed the ventral-dorsal plane. Preliminary results show that repeated visual stimulation with a 10s movie had no dramatic effect on the spatial structure of the traveling waves. Traveling waves of electrical activity in the icPFC could reflect highly organized cortical processing in this area of prefrontal cortex.

ei

Web [BibTex]

Web [BibTex]


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Evaluation and Optimization of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Schmidt, H., Kolb, A., Beyer, T., Reimold, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-96), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
Combined PET/MR provides simultaneous molecular and functional information in an anatomical context with unique soft tissue contrast. However, PET/MR does not support direct derivation of attenuation maps of objects and tissues within the measured PET field-of-view. Valid attenuation maps are required for quantitative PET imaging, specifically for scientific brain studies. Therefore, several methods have been proposed for MR-based attenuation correction (MR-AC). Last year, we performed an evaluation of different MR-AC methods, including simple MR thresholding, atlas- and machine learning-based MR-AC. CT-based AC served as gold standard reference. RoIs from 2 anatomic brain atlases with different levels of detail were used for evaluation of correction accuracy. We now extend our evaluation of different MR-AC methods by using an enlarged dataset of 23 patients from the integrated BrainPET/MR (Siemens Healthcare). Further, we analyze options for improving the MR-AC performance in terms of speed and accuracy. Finally, we assess the impact of ignoring BrainPET positioning aids during the course of MR-AC. This extended study confirms the overall prediction accuracy evaluation results of the first evaluation in a larger patient population. Removing datasets affected by metal artifacts from the Atlas-Patch database helped to improve prediction accuracy, although the size of the database was reduced by one half. Significant improvement in prediction speed can be gained at a cost of only slightly reduced accuracy, while further optimizations are still possible.

ei

Web [BibTex]

Web [BibTex]


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Atlas- and Pattern Recognition Based Attenuation Correction on Simultaneous Whole-Body PET/MR

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Hofmann, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-116), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
With the recent availability of clinical whole-body PET/MRI it is possible to evaluate and further develop MR-based attenuation correction methods using simultaneously acquired PET/MR data. We present first results for MRAC on patient data acquired on a fully integrated whole-body PET/MRI (Biograph mMR, Siemens) using our method that applies atlas registration and pattern recognition (ATPR) and compare them to the segmentation-based (SEG) method provided by the manufacturer. The ATPR method makes use of a database of previously aligned pairs of MR-CT volumes to predict attenuation values on a continuous scale. The robustness of the method in presence of MR artifacts was improved by location and size based detection. Lesion to liver and lesion to blood ratios (LLR and LBR) were compared for both methods on 29 iso-contour ROIs in 4 patients. ATPR showed >20% higher LBR and LLR for ROIs in and >7% near osseous tissue. For ROIs in soft tissue, both methods yielded similar ratios with max. differences <6% . For ROIs located within metal artifacts in the MR image, ATPR showed >190% higher LLR and LBR than SEG, where ratios <0.1 occured. For lesions in the neighborhood of artifacts, both ratios were >15% higher for ATPR. If artifacts in MR volumes caused by metal implants are not accounted for in the computation of attenuation maps, they can lead to a strong decrease of lesion to background ratios, even to disappearance of hot spots. Metal implants are likely to occur in the patient collective receiving combined PET/MR scans, of our first 10 patients, 3 had metal implants. Our method is currently able to account for artifacts in the pelvis caused by prostheses. The ability of the ATPR method to account for bone leads to a significant increase of LLR and LBR in osseous tissue, which supports our previous evaluations with combined PET/CT and PET/MR data. For lesions within soft tissue, lesion to background ratios of ATPR and SEG were comparable.

ei

Web [BibTex]

Web [BibTex]


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Retrospective blind motion correction of MR images

Loktyushin, A., Nickisch, H., Pohmann, R.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):498, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
We present a retrospective method, which significantly reduces ghosting and blurring artifacts due to subject motion. No modifications to the sequence (as in [2, 3]), or the use of additional equipment (as in [1]) are required. Our method iteratively searches for the transformation, that applied to the lines in k-space -- yields the sparsest Laplacian filter output in the spatial domain.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Model based reconstruction for GRE EPI

Blecher, W., Pohmann, R., Schölkopf, B., Seeger, M.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):493-494, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
Model based nonlinear image reconstruction methods for MRI [3] are at the heart of modern reconstruction techniques (e.g.compressed sensing [6]). In general, models are expressed as a matrix equation where y and u are column vectors of k-space and image data, X model matrix and e independent noise. However, solving the corresponding linear system is not tractable. Therefore fast nonlinear algorithms that minimize a function wrt.the unknown image are the method of choice: In this work a model for gradient echo EPI, is proposed that incorporates N/2 Ghost correction and correction for field inhomogeneities. In addition to reconstruction from full data, the model allows for sparse reconstruction, joint estimation of image, field-, and relaxation-map (like [5,8] for spiral imaging), and improved N/2 ghost correction.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Simultaneous multimodal imaging of patients with bronchial carcinoma in a whole body MR/PET system

Brendle, C., Sauter, A., Schmidt, H., Schraml, C., Bezrukov, I., Martirosian, P., Hetzel, J., Müller, M., Claussen, C., Schwenzer, N., Pfannenberg, C.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):141, 28th annual scientific meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRB), October 2011 (poster)

Abstract
Purpose/Introduction: Lung cancer is among the most frequent cancers (1). Exact determination of tumour extent and viability is crucial for adequate therapy guidance. [18F]-FDG-PET allows accurate staging and the evaluation of therapy response based on glucose metabolism. Diffusion weighted MRI (DWI) is another promising tool for the evaluation of tumour viability (2,3). The aim of the study was the simultaneous PET-MR acquisition in lung cancer patients and correlation of PET and MR data. Subjects and Methods: Seven patients (age 38-73 years, mean 61 years) with highly suspected or known bronchial carcinoma were examined. First, a [18F]-FDG-PET/CT was performed (injected dose: 332-380 MBq). Subsequently, patients were examined at the whole-body MR/PET (Siemens Biograph mMR). The MRI is a modified 3T Verio whole body system with a magnet bore of 60 cm (max. amplitude gradients 45 mT/m, max. slew rate 200 T/m/s). Concerning the PET, the whole-body MR/PET system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The following parameters for PET acquisition were applied: 2 bed positions, 6 min/bed with an average uptake time of 124 min after injection (range: 110-143 min). The attenuation correction of PET data was conducted with a segmentation-based method provided by the manufacturer. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. DWI MR images were recorded simultaneously for each bed using two b-values (0/800 s/mm2). SUVmax and ADCmin were assessed in a ROI analysis. The following ratios were calculated: SUVmax(tumor)/SUVmean(liver) and ADCmin(tumor)/ADCmean(muscle). Correlation between SUV and ADC was analyzed (Pearson’s correlation). Results: Diagnostic scans could be obtained in all patients with good tumour delineation. The spatial matching of PET and DWI data was very exact. Most tumours showed a pronounced FDG-uptake in combination with decreased ADC values. Significant correlation was found between SUV and ADC ratios (r = -0.87, p = 0.0118). Discussion/Conclusion: Simultaneous MR/PET imaging of lung cancer is feasible. The whole-body MR/PET system can provide complementary information regarding tumour viability and cellularity which could facilitate a more profound tumour characterization. Further studies have to be done to evaluate the importance of these parameters for therapy decisions and monitoring

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Web DOI [BibTex]

Web DOI [BibTex]


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Statistical Learning Theory: Models, Concepts, and Results

von Luxburg, U., Schölkopf, B.

In Handbook of the History of Logic, Vol. 10: Inductive Logic, 10, pages: 651-706, (Editors: Gabbay, D. M., Hartmann, S. and Woods, J. H.), Elsevier North Holland, Amsterdam, Netherlands, May 2011 (inbook)

Abstract
Statistical learning theory provides the theoretical basis for many of today's machine learning algorithms and is arguably one of the most beautifully developed branches of artificial intelligence in general. It originated in Russia in the 1960s and gained wide popularity in the 1990s following the development of the so-called Support Vector Machine (SVM), which has become a standard tool for pattern recognition in a variety of domains ranging from computer vision to computational biology. Providing the basis of new learning algorithms, however, was not the only motivation for developing statistical learning theory. It was just as much a philosophical one, attempting to answer the question of what it is that allows us to draw valid conclusions from empirical data. In this article we attempt to give a gentle, non-technical overview over the key ideas and insights of statistical learning theory. We do not assume that the reader has a deep background in mathematics, statistics, or computer science. Given the nature of the subject matter, however, some familiarity with mathematical concepts and notations and some intuitive understanding of basic probability is required. There exist many excellent references to more technical surveys of the mathematics of statistical learning theory: the monographs by one of the founders of statistical learning theory ([Vapnik, 1995], [Vapnik, 1998]), a brief overview over statistical learning theory in Section 5 of [Sch{\"o}lkopf and Smola, 2002], more technical overview papers such as [Bousquet et al., 2003], [Mendelson, 2003], [Boucheron et al., 2005], [Herbrich and Williamson, 2002], and the monograph [Devroye et al., 1996].

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PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Crowdsourcing for optimisation of deconvolution methods via an iPhone application

Lang, A.

Hochschule Reutlingen, Germany, April 2011 (mastersthesis)

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[BibTex]

[BibTex]


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Robot Learning

Peters, J., Tedrake, R., Roy, N., Morimoto, J.

In Encyclopedia of Machine Learning, pages: 865-869, Encyclopedia of machine learning, (Editors: Sammut, C. and Webb, G. I.), Springer, New York, NY, USA, January 2011 (inbook)

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PDF Web DOI [BibTex]

PDF Web DOI [BibTex]