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2008


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A non-parametric Bayesian alternative to spike sorting

Wood, F., Black, M. J.

J. Neuroscience Methods, 173(1):1–12, August 2008 (article)

Abstract
The analysis of extra-cellular neural recordings typically begins with careful spike sorting and all analysis of the data then rests on the correctness of the resulting spike trains. In many situations this is unproblematic as experimental and spike sorting procedures often focus on well isolated units. There is evidence in the literature, however, that errors in spike sorting can occur even with carefully collected and selected data. Additionally, chronically implanted electrodes and arrays with fixed electrodes cannot be easily adjusted to provide well isolated units. In these situations, multiple units may be recorded and the assignment of waveforms to units may be ambiguous. At the same time, analysis of such data may be both scientifically important and clinically relevant. In this paper we address this issue using a novel probabilistic model that accounts for several important sources of uncertainty and error in spike sorting. In lieu of sorting neural data to produce a single best spike train, we estimate a probabilistic model of spike trains given the observed data. We show how such a distribution over spike sortings can support standard neuroscientific questions while providing a representation of uncertainty in the analysis. As a representative illustration of the approach, we analyzed primary motor cortical tuning with respect to hand movement in data recorded with a chronic multi-electrode array in non-human primates.We found that the probabilistic analysis generally agrees with human sorters but suggests the presence of tuned units not detected by humans.

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pdf preprint pdf from publisher PubMed [BibTex]

2008


pdf preprint pdf from publisher PubMed [BibTex]


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Learning to control in operational space

Peters, J., Schaal, S.

International Journal of Robotics Research, 27, pages: 197-212, 2008, clmc (article)

Abstract
One of the most general frameworks for phrasing control problems for complex, redundant robots is operational space control. However, while this framework is of essential importance for robotics and well-understood from an analytical point of view, it can be prohibitively hard to achieve accurate control in face of modeling errors, which are inevitable in com- plex robots, e.g., humanoid robots. In this paper, we suggest a learning approach for opertional space control as a direct inverse model learning problem. A first important insight for this paper is that a physically cor- rect solution to the inverse problem with redundant degrees-of-freedom does exist when learning of the inverse map is performed in a suitable piecewise linear way. The second crucial component for our work is based on the insight that many operational space controllers can be understood in terms of a constrained optimal control problem. The cost function as- sociated with this optimal control problem allows us to formulate a learn- ing algorithm that automatically synthesizes a globally consistent desired resolution of redundancy while learning the operational space controller. From the machine learning point of view, this learning problem corre- sponds to a reinforcement learning problem that maximizes an immediate reward. We employ an expectation-maximization policy search algorithm in order to solve this problem. Evaluations on a three degrees of freedom robot arm are used to illustrate the suggested approach. The applica- tion to a physically realistic simulator of the anthropomorphic SARCOS Master arm demonstrates feasibility for complex high degree-of-freedom robots. We also show that the proposed method works in the setting of learning resolved motion rate control on real, physical Mitsubishi PA-10 medical robotics arm.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia

(J. Neural Engineering Highlights of 2008 Collection)

Kim, S., Simeral, J., Hochberg, L., Donoghue, J. P., Black, M. J.

J. Neural Engineering, 5, pages: 455–476, 2008 (article)

Abstract
Computer-mediated connections between human motor cortical neurons and assistive devices promise to improve or restore lost function in people with paralysis. Recently, a pilot clinical study of an intracortical neural interface system demonstrated that a tetraplegic human was able to obtain continuous two-dimensional control of a computer cursor using neural activity recorded from his motor cortex. This control, however, was not sufficiently accurate for reliable use in many common computer control tasks. Here, we studied several central design choices for such a system including the kinematic representation for cursor movement, the decoding method that translates neuronal ensemble spiking activity into a control signal and the cursor control task used during training for optimizing the parameters of the decoding method. In two tetraplegic participants, we found that controlling a cursor’s velocity resulted in more accurate closed-loop control than controlling its position directly and that cursor velocity control was achieved more rapidly than position control. Control quality was further improved over conventional linear filters by using a probabilistic method, the Kalman filter, to decode human motor cortical activity. Performance assessment based on standard metrics used for the evaluation of a wide range of pointing devices demonstrated significantly improved cursor control with velocity rather than position decoding.

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pdf preprint pdf from publisher [BibTex]

pdf preprint pdf from publisher [BibTex]


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Adaptation to a sub-optimal desired trajectory

M. Mistry, E. A. G. L. T. Y. S. S. M. K.

Advances in Computational Motor Control VII, Symposium at the Society for Neuroscience Meeting, Washington DC, 2008, 2008, clmc (article)

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PDF [BibTex]

PDF [BibTex]


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Brownian Warps for Non-Rigid Registration

Mads Nielsen, Peter Johansen, Andrew Jackson, Benny Lautrup, Soren Hauberg

Journal of Mathematical Imaging and Vision, 31, pages: 221-231, Springer Netherlands, 2008 (article)

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Publishers site PDF [BibTex]

Publishers site PDF [BibTex]


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Operational space control: A theoretical and emprical comparison

Nakanishi, J., Cory, R., Mistry, M., Peters, J., Schaal, S.

International Journal of Robotics Research, 27(6):737-757, 2008, clmc (article)

Abstract
Dexterous manipulation with a highly redundant movement system is one of the hallmarks of hu- man motor skills. From numerous behavioral studies, there is strong evidence that humans employ compliant task space control, i.e., they focus control only on task variables while keeping redundant degrees-of-freedom as compliant as possible. This strategy is robust towards unknown disturbances and simultaneously safe for the operator and the environment. The theory of operational space con- trol in robotics aims to achieve similar performance properties. However, despite various compelling theoretical lines of research, advanced operational space control is hardly found in actual robotics imple- mentations, in particular new kinds of robots like humanoids and service robots, which would strongly profit from compliant dexterous manipulation. To analyze the pros and cons of different approaches to operational space control, this paper focuses on a theoretical and empirical evaluation of different methods that have been suggested in the literature, but also some new variants of operational space controllers. We address formulations at the velocity, acceleration and force levels. First, we formulate all controllers in a common notational framework, including quaternion-based orientation control, and discuss some of their theoretical properties. Second, we present experimental comparisons of these approaches on a seven-degree-of-freedom anthropomorphic robot arm with several benchmark tasks. As an aside, we also introduce a novel parameter estimation algorithm for rigid body dynamics, which ensures physical consistency, as this issue was crucial for our successful robot implementations. Our extensive empirical results demonstrate that one of the simplified acceleration-based approaches can be advantageous in terms of task performance, ease of parameter tuning, and general robustness and compliance in face of inevitable modeling errors.

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link (url) [BibTex]

link (url) [BibTex]


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An Efficient Algorithm for Modelling Duration in Hidden Markov Models, with a Dramatic Application

Soren Hauberg, Jakob Sloth

Journal of Mathematical Imaging and Vision, 31, pages: 165-170, Springer Netherlands, 2008 (article)

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Publishers site Paper site PDF [BibTex]

Publishers site Paper site PDF [BibTex]


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A library for locally weighted projection regression

Klanke, S., Vijayakumar, S., Schaal, S.

Journal of Machine Learning Research, 9, pages: 623-626, 2008, clmc (article)

Abstract
In this paper we introduce an improved implementation of locally weighted projection regression (LWPR), a supervised learning algorithm that is capable of handling high-dimensional input data. As the key features, our code supports multi-threading, is available for multiple platforms, and provides wrappers for several programming languages.

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link (url) [BibTex]

link (url) [BibTex]


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Optimization strategies in human reinforcement learning

Hoffmann, H., Theodorou, E., Schaal, S.

Advances in Computational Motor Control VII, Symposium at the Society for Neuroscience Meeting, Washington DC, 2008, 2008, clmc (article)

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PDF [BibTex]

PDF [BibTex]

2007


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Learning static Gestalt laws through dynamic experience

Ostrovsky, Y., Wulff, J., Sinha, P.

Journal of Vision, 7(9):315-315, ARVO, June 2007 (article)

Abstract
The Gestalt laws (Wertheimer 1923) are widely regarded as the rules that help us parse the world into objects. However, it is unclear as to how these laws are acquired by an infant's visual system. Classically, these “laws” have been presumed to be innate (Kellman and Spelke 1983). But, more recent work in infant development, showing the protracted time-course over which these grouping principles emerge (e.g., Johnson and Aslin 1995; Craton 1996), suggests that visual experience might play a role in their genesis. Specifically, our studies of patients with late-onset vision (Project Prakash; VSS 2006) and evidence from infant development both point to an early role of common motion cues for object grouping. Here we explore the possibility that the privileged status of motion in the developmental timeline is not happenstance, but rather serves to bootstrap the learning of static Gestalt cues. Our approach involves computational analyses of real-world motion sequences to investigate whether primitive optic flow information is correlated with static figural cues that could eventually come to serve as proxies for grouping in the form of Gestalt principles. We calculated local optic flow maps and then examined how similarity of motion across image patches co-varied with similarity of certain figural properties in static frames. Results indicate that patches with similar motion are much more likely to have similar luminance, color, and orientation as compared to patches with dissimilar motion vectors. This regularity suggests that, in principle, common motion extracted from dynamic visual experience can provide enough information to bootstrap region grouping based on luminance and color and contour continuation mechanisms in static scenes. These observations, coupled with the cited experimental studies, lend credence to the hypothesis that static Gestalt laws might be learned through a bootstrapping process based on early dynamic experience.

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link (url) DOI [BibTex]

2007


link (url) DOI [BibTex]


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Neuromotor prosthesis development

Donoghue, J., Hochberg, L., Nurmikko, A., Black, M., Simeral, J., Friehs, G.

Medicine & Health Rhode Island, 90(1):12-15, January 2007 (article)

Abstract
Article describes a neuromotor prosthesis (NMP), in development at Brown University, that records human brain signals, decodes them, and transforms them into movement commands. An NMP is described as a system consisting of a neural interface, a decoding system, and a user interface, also called an effector; a closed-loop system would be completed by a feedback signal from the effector to the brain. The interface is based on neural spiking, a source of information-rich, rapid, complex control signals from the nervous system. The NMP described, named BrainGate, consists of a match-head sized platform with 100 thread-thin electrodes implanted just into the surface of the motor cortex where commands to move the hand emanate. Neural signals are decoded by a rack of computers that displays the resultant output as the motion of a cursor on a computer monitor. While computer cursor motion represents a form of virtual device control, this same command signal could be routed to a device to command motion of paralyzed muscles or the actions of prosthetic limbs. The researchers’ overall goal is the development of a fully implantable, wireless multi-neuron sensor for broad research, neural prosthetic, and human neurodiagnostic applications.

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pdf [BibTex]

pdf [BibTex]


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The new robotics - towards human-centered machines

Schaal, S.

HFSP Journal Frontiers of Interdisciplinary Research in the Life Sciences, 1(2):115-126, 2007, clmc (article)

Abstract
Research in robotics has moved away from its primary focus on industrial applications. The New Robotics is a vision that has been developed in past years by our own university and many other national and international research instiutions and addresses how increasingly more human-like robots can live among us and take over tasks where our current society has shortcomings. Elder care, physical therapy, child education, search and rescue, and general assistance in daily life situations are some of the examples that will benefit from the New Robotics in the near future. With these goals in mind, research for the New Robotics has to embrace a broad interdisciplinary approach, ranging from traditional mathematical issues of robotics to novel issues in psychology, neuroscience, and ethics. This paper outlines some of the important research problems that will need to be resolved to make the New Robotics a reality.

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link (url) [BibTex]

link (url) [BibTex]


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On the spatial statistics of optical flow

Roth, S., Black, M. J.

International Journal of Computer Vision, 74(1):33-50, 2007 (article)

Abstract
We present an analysis of the spatial and temporal statistics of "natural" optical flow fields and a novel flow algorithm that exploits their spatial statistics. Training flow fields are constructed using range images of natural scenes and 3D camera motions recovered from hand-held and car-mounted video sequences. A detailed analysis of optical flow statistics in natural scenes is presented and machine learning methods are developed to learn a Markov random field model of optical flow. The prior probability of a flow field is formulated as a Field-of-Experts model that captures the spatial statistics in overlapping patches and is trained using contrastive divergence. This new optical flow prior is compared with previous robust priors and is incorporated into a recent, accurate algorithm for dense optical flow computation. Experiments with natural and synthetic sequences illustrate how the learned optical flow prior quantitatively improves flow accuracy and how it captures the rich spatial structure found in natural scene motion.

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pdf preprint pdf from publisher [BibTex]

pdf preprint pdf from publisher [BibTex]


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Assistive technology and robotic control using MI ensemble-based neural interface systems in humans with tetraplegia

Donoghue, J. P., Nurmikko, A., Black, M. J., Hochberg, L.

Journal of Physiology, Special Issue on Brain Computer Interfaces, 579, pages: 603-611, 2007 (article)

Abstract
This review describes the rationale, early stage development, and initial human application of neural interface systems (NISs) for humans with paralysis. NISs are emerging medical devices designed to allowpersonswith paralysis to operate assistive technologies or to reanimatemuscles based upon a command signal that is obtained directly fromthe brain. Such systems require the development of sensors to detect brain signals, decoders to transformneural activity signals into a useful command, and an interface for the user.We review initial pilot trial results of an NIS that is based on an intracortical microelectrode sensor that derives control signals from the motor cortex.We review recent findings showing, first, that neurons engaged by movement intentions persist in motor cortex years after injury or disease to the motor system, and second, that signals derived from motor cortex can be used by persons with paralysis to operate a range of devices. We suggest that, with further development, this form of NIS holds promise as a useful new neurotechnology for those with limited motor function or communication.We also discuss the additional potential for neural sensors to be used in the diagnosis and management of various neurological conditions and as a new way to learn about human brain function.

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pdf preprint pdf from publisher DOI [BibTex]

pdf preprint pdf from publisher DOI [BibTex]