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2019


Soft-magnetic coatings as possible sensors for magnetic imaging of superconductors
Soft-magnetic coatings as possible sensors for magnetic imaging of superconductors

Ionescu, A., Simmendinger, J., Bihler, M., Miksch, C., Fischer, P., Soltan, S., Schütz, G., Albrecht, J.

Supercond. Sci. and Tech., 33, pages: 015002, IOP, December 2019 (article)

Abstract
Magnetic imaging of superconductors typically requires a soft-magnetic material placed on top of the superconductor to probe local magnetic fields. For reasonable results the influence of the magnet onto the superconductor has to be small. Thin YBCO films with soft-magnetic coatings are investigated using SQUID magnetometry. Detailed measurements of the magnetic moment as a function of temperature, magnetic field and time have been performed for different heterostructures. It is found that the modification of the superconducting transport in these heterostructures strongly depends on the magnetic and structural properties of the soft-magnetic material. This effect is especially pronounced for an inhomogeneous coating consisting of ferromagnetic nanoparticles.

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link (url) DOI [BibTex]

2019


link (url) DOI [BibTex]


HPLC of monolayer-protected Gold clusters with baseline separation
HPLC of monolayer-protected Gold clusters with baseline separation

Knoppe, S., Vogt, P.

Analytical Chemistry, 91, pages: 1603, December 2019 (article)

Abstract
The properties of ultrasmall metal nanoparticles (ca. 10–200 metal atoms), or monolayer-protected metal clusters (MPCs), drastically depend on their atomic structure. For systematic characterization and application, assessment of their purity is of high importance. Currently, the gold standard for purity control of MPCs is mass spectrometry (MS). Mass spectrometry, however, cannot always detect small impurities; MS of certain clusters, for example, ESI-TOF of Au40(SR)24, is not successful at all. We here present a simple reversed-phase HPLC method for purity control of a series of small alkanethiolate-protected gold clusters. The method allows the detection of small impurities with high sensitivity. Linear correlation between alkyl chain length of Au25(SC_n H_(2n+1))18 clusters (n = 6, 8, 10, 12) and their retention time was noticed.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A semi-analytical model for dynamic analysis of non-uniform plates

Gozum, M. M., Serhat, G., Basdogan, I.

Applied Mathematical Modelling, 76, pages: 883–899, December 2019 (article)

Abstract
Dynamic properties of the plate structures can be enhanced by introducing discontinuities of different kinds such as using surface-bonded discrete patches or spatially varying the stiffness and mass properties of the plate. Fast and reliable design of such complex structures requires efficient and accurate modeling tools. In this study, a novel semi-analytical model is developed for the dynamic analysis of plates having discrete and/or continuous non-uniformities. Two-dimensional Heaviside unit step functions are utilized to represent the discontinuities. Different from existing numerical methods based on Heaviside functions, a numerical technique is proposed for modeling the discontinuities that are not necessarily aligned with the plate axes. The governing equations are derived using Hamilton's principle and Rayleigh–Ritz method is used for determining the modal variables. The surface-bonded patches are used to demonstrate discrete non-uniformities where variable-stiffness laminates are selected to represent continuous non-uniform structures. Natural frequencies and mode shapes obtained using the proposed method are validated with finite element analyses and the existing results from the literature. The results show that the developed model performs accurately and efficiently.

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DOI [BibTex]

DOI [BibTex]


A Robotic Framework to Facilitate Sensory Experiences for Children with Autism Spectrum Disorder: A Preliminary Study
A Robotic Framework to Facilitate Sensory Experiences for Children with Autism Spectrum Disorder: A Preliminary Study

Javed, H., Burns, R., Jeong, M., Howard, A. M., Park, C. H.

ACM Transactions on Human-Robot Interaction (THRI), 9(1), December 2019 (article)

Abstract
The diagnosis of Autism Spectrum Disorder (ASD) in children is commonly accompanied by a diagnosis of sensory processing disorders. Abnormalities are usually reported in multiple sensory processing domains, showing a higher prevalence of unusual responses, particularly to tactile, auditory, and visual stimuli. This article discusses a novel robot-based framework designed to target sensory difficulties faced by children with ASD in a controlled setting. The setup consists of a number of sensory stations, together with two different robotic agents that navigate the stations and interact with the stimuli. These stimuli are designed to resemble real-world scenarios that form a common part of one’s everyday experiences. Given the strong interest of children with ASD in technology in general and robots in particular, we attempt to utilize our robotic platform to demonstrate socially acceptable responses to the stimuli in an interactive, pedagogical setting that encourages the child’s social, motor, and vocal skills, while providing a diverse sensory experience. A preliminary user study was conducted to evaluate the efficacy of the proposed framework, with a total of 18 participants (5 with ASD and 13 typically developing) between the ages of 4 and 12 years. We derive a measure of social engagement, based on which we evaluate the effectiveness of the robots and sensory stations to identify key design features that can improve social engagement in children.

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DOI [BibTex]

DOI [BibTex]


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Hierarchical Task-Parameterized Learning from Demonstration for Collaborative Object Movement

Hu, S., Kuchenbecker, K. J.

Applied Bionics and Biomechanics, (9765383), December 2019 (article)

Abstract
Learning from demonstration (LfD) enables a robot to emulate natural human movement instead of merely executing preprogrammed behaviors. This article presents a hierarchical LfD structure of task-parameterized models for object movement tasks, which are ubiquitous in everyday life and could benefit from robotic support. Our approach uses the task-parameterized Gaussian mixture model (TP-GMM) algorithm to encode sets of demonstrations in separate models that each correspond to a different task situation. The robot then maximizes its expected performance in a new situation by either selecting a good existing model or requesting new demonstrations. Compared to a standard implementation that encodes all demonstrations together for all test situations, the proposed approach offers four advantages. First, a simply defined distance function can be used to estimate test performance by calculating the similarity between a test situation and the existing models. Second, the proposed approach can improve generalization, e.g., better satisfying the demonstrated task constraints and speeding up task execution. Third, because the hierarchical structure encodes each demonstrated situation individually, a wider range of task situations can be modeled in the same framework without deteriorating performance. Last, adding or removing demonstrations incurs low computational load, and thus, the robot’s skill library can be built incrementally. We first instantiate the proposed approach in a simulated task to validate these advantages. We then show that the advantages transfer to real hardware for a task where naive participants collaborated with a Willow Garage PR2 robot to move a handheld object. For most tested scenarios, our hierarchical method achieved significantly better task performance and subjective ratings than both a passive model with only gravity compensation and a single TP-GMM encoding all demonstrations.

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DOI [BibTex]


Acoustic hologram enhanced phased arrays for ultrasonic particle manipulation
Acoustic hologram enhanced phased arrays for ultrasonic particle manipulation

Cox, L., Melde, K., Croxford, A., Fischer, P., Drinkwater, B.

Phys. Rev. Applied, 12, pages: 064055, November 2019 (article)

Abstract
The ability to shape ultrasound fields is important for particle manipulation, medical therapeutics and imaging applications. If the amplitude and/or phase is spatially varied across the wavefront then it is possible to project ‘acoustic images’. When attempting to form an arbitrary desired static sound field, acoustic holograms are superior to phased arrays due to their significantly higher phase fidelity. However, they lack the dynamic flexibility of phased arrays. Here, we demonstrate how to combine the high-fidelity advantages of acoustic holograms with the dynamic control of phased arrays in the ultrasonic frequency range. Holograms are used with a 64-element phased array, driven with continuous excitation. Moving the position of the projected hologram via phase delays which steer the output beam is demonstrated experimentally. This allows the creation of a much more tightly focused point than with the phased array alone, whilst still being reconfigurable. It also allows the complex movement at a water-air interface of a “phase surfer” along a phase track or the manipulation of a more arbitrarily shaped particle via amplitude traps. Furthermore, a particle manipulation device with two emitters and a single split hologram is demonstrated that allows the positioning of a “phase surfer” along a 1D axis. This paper opens the door for new applications with complex manipulation of ultrasound whilst minimising the complexity and cost of the apparatus.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media
A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media

Li., D., Jeong, M., Oren, E., Yu, T., Qiu, T.

Robotics, 8, pages: 87, MDPI, October 2019 (article)

Abstract
One major challenge for microrobots is to penetrate and effectively move through viscoelastic biological tissues. Most existing microrobots can only propel in viscous liquids. Recent advances demonstrate that sub-micron robots can actively penetrate nanoporous biological tissue, such as the vitreous of the eye. However, it is still difficult to propel a micron-sized device through dense biological tissue. Here, we report that a special twisted helical shape together with a high aspect ratio in cross-section permit a microrobot with a diameter of hundreds-of-micrometers to move through mouse liver tissue. The helical microrobot is driven by a rotating magnetic field and localized by ultrasound imaging inside the tissue. The twisted ribbon is made of molybdenum and a sharp tip is chemically etched to generate a higher pressure at the edge of the propeller to break the biopolymeric network of the dense tissue.

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link (url) DOI [BibTex]


Acoustic Holographic Cell Patterning in a Biocompatible Hydrogel
Acoustic Holographic Cell Patterning in a Biocompatible Hydrogel

Ma, Z., Holle, A., Melde, K., Qiu, T., Poeppel, K., Kadiri, V., Fischer, P.

Adv. Mat., 32(1904181), October 2019 (article)

Abstract
Acoustophoresis is promising as a rapid, biocompatible, non-contact cell manipulation method, where cells are arranged along the nodes or antinodes of the acoustic field. Typically, the acoustic field is formed in a resonator, which results in highly symmetric regular patterns. However, arbitrary, non-symmetrically shaped cell assemblies are necessary to obtain the irregular cellular arrangements found in biological tissues. We show that arbitrarily shaped cell patterns can be obtained from the complex acoustic field distribution defined by an acoustic hologram. Attenuation of the sound field induces localized acoustic streaming and the resultant convection flow gently delivers the suspended cells to the image plane where they form the designed pattern. We show that the process can be implemented in a biocompatible collagen solution, which can then undergo gelation to immobilize the cell pattern inside the viscoelastic matrix. The patterned cells exhibit F-actin-based protrusions, which indicates that the cells grow and thrive within the matrix. Cell viability assays and brightfield imaging after one week confirm cell survival and that the patterns persist. Acoustophoretic cell manipulation by holographic fields thus holds promise for non-contact, long-range, long-term cellular pattern formation, with a wide variety of potential applications in tissue engineering and mechanobiology.

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link (url) DOI [BibTex]


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Multi-objective optimization of composite plates using lamination parameters

Serhat, G., Basdogan, I.

Materials & Design, 180(107904), October 2019 (article)

Abstract
Laminated composite plates are extensively used in various industries due to their high stiffness-to-weight ratio and directional properties that allow optimization of the stiffness characteristics for specific applications. In multi-objective optimization problems, optimal designs for individual performance metrics may be conflicting, necessitating knowledge on the design requirements for different metrics and potential trade-offs. In this paper, a multi-objective design methodology for laminated composite plates with dynamic and load-carrying requirements is presented. Lamination parameters are used to characterize laminate stiffness matrices in a compact form resulting in a convex design space. Single and multi-objective optimization studies are carried out to determine the optimal stiffness properties. For improving the dynamic performance, maximization of the fundamental frequency metric is aimed. For enhancing the load-carrying capability, buckling load and equivalent stiffness metrics are maximized. Conforming and conflicting behavior of multiple objective functions for different plate geometries, boundary conditions and load cases are presented by determining Pareto-optimal solutions. The results provide a valuable insight for multi-objective optimization of laminated composite plates and show that presented methodology can be used in the design of such structures for improving the dynamic and load-carrying performance.

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DOI [BibTex]

DOI [BibTex]


Arrays of plasmonic nanoparticle dimers with defined nanogap spacers
Arrays of plasmonic nanoparticle dimers with defined nanogap spacers

Jeong, H., Adams, M. C., Guenther, J., Alarcon-Correa, M., Kim, I., Choi, E., Miksch, C., Mark, A. F. M., Mark, A. G., Fischer, P.

ACS Nano, 13, pages: 11453-11459, September 2019 (article)

Abstract
Plasmonic molecules are building blocks of metallic nanostructures that give rise to intriguing optical phenomena with similarities to those seen in molecular systems. The ability to design plasmonic hybrid structures and molecules with nanometric resolution would enable applications in optical metamaterials and sensing that presently cannot be demonstrated, because of a lack of suitable fabrication methods allowing the structural control of the plasmonic atoms on a large scale. Here we demonstrate a wafer-scale “lithography-free” parallel fabrication scheme to realize nanogap plasmonic meta-molecules with precise control over their size, shape, material, and orientation. We demonstrate how we can tune the corresponding coupled resonances through the entire visible spectrum. Our fabrication method, based on glancing angle physical vapor deposition with gradient shadowing, permits critical parameters to be varied across the wafer and thus is ideally suited to screen potential structures. We obtain billions of aligned dimer structures with controlled variation of the spectral properties across the wafer. We spectroscopically map the plasmonic resonances of gold dimer structures and show that they not only are in good agreement with numerically modeled spectra, but also remain functional, at least for a year, in ambient conditions.

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link (url) DOI [BibTex]


Genetically modified M13 bacteriophage nanonets for enzyme catalysis and recovery
Genetically modified M13 bacteriophage nanonets for enzyme catalysis and recovery

Kadiri, V. M., Alarcon-Correa, M., Guenther, J. P., Ruppert, J., Bill, J., Rothenstein, D., Fischer, P.

Catalysts, 9, pages: 723, August 2019 (article)

Abstract
Enzyme-based biocatalysis exhibits multiple advantages over inorganic catalysts, including the biocompatibility and the unchallenged specificity of enzymes towards their substrate. The recovery and repeated use of enzymes is essential for any realistic application in biotechnology, but is not easily achieved with current strategies. For this purpose, enzymes are often immobilized on inorganic scaffolds, which could entail a reduction of the enzymes’ activity. Here, we show that immobilization to a nano-scaled biological scaffold, a nanonetwork of end-to-end cross-linked M13 bacteriophages, ensures high enzymatic activity and at the same time allows for the simple recovery of the enzymes. The bacteriophages have been genetically engineered to express AviTags at their ends, which permit biotinylation and their specific end-to-end self-assembly while allowing space on the major coat protein for enzyme coupling. We demonstrate that the phages form nanonetwork structures and that these so-called nanonets remain highly active even after re-using the nanonets multiple times in a flow-through reactor.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Light-controlled micromotors and soft microrobots
Light-controlled micromotors and soft microrobots

Palagi, S., Singh, D. P., Fischer, P.

Adv. Opt. Mat., 7, pages: 1900370, August 2019 (article)

Abstract
Mobile microscale devices and microrobots can be powered by catalytic reactions (chemical micromotors) or by external fields. This report is focused on the role of light as a versatile means for wirelessly powering and controlling such microdevices. Recent advances in the development of autonomous micromotors are discussed, where light permits their actuation with unprecedented control and thereby enables advances in the field of active matter. In addition, structuring the light field is a new means to drive soft microrobots that are based on (photo‐) responsive polymers. The behavior of the two main classes of thermo‐ and photoresponsive polymers adopted in microrobotics (poly(N‐isopropylacrylamide) and liquid‐crystal elastomers) is analyzed, and recent applications are reported. The advantages and limitations of controlling micromotors and microrobots by light are reviewed, and some of the remaining challenges in the development of novel photo‐active materials for micromotors and microrobots are discussed.

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link (url) DOI [BibTex]


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Low-Hysteresis and Low-Interference Soft Tactile Sensor Using a Conductive Coated Porous Elastomer and a Structure for Interference Reduction

Park, K., Kim, S., Lee, H., Park, I., Kim, J.

Sensors and Actuators A: Physical, 295, pages: 541-550, August 2019 (article)

Abstract
The need for soft whole-body tactile sensors is emerging. Piezoresistive materials are advantageous in terms of making large tactile sensors, but the hysteresis of piezoresistive materials is a major drawback. The hysteresis of a piezoresistive material should be attenuated to make a practical piezoresistive soft tactile sensor. In this paper, we introduce a low-hysteresis and low-interference soft tactile sensor using a conductive coated porous elastomer and a structure to reduce interference (grooves). The developed sensor exhibits low hysteresis because the transduction mechanism of the sensor is dominated by the contact between the conductive coated surface. In a cyclic loading experiment with different loading frequencies, the mechanical and piezoresistive hysteresis values of the sensor are less than 21.7% and 6.8%, respectively. The initial resistance change is found to be within 4% after the first loading cycle. To reduce the interference among the sensing points, we also propose a structure where the grooves are inserted between the adjacent electrodes. This structure is implemented during the molding process, which is adopted to extend the porous tactile sensor to large-scale and facile fabrication. The effects of the structure are investigated with respect to the normalized design parameters ΘD, ΘW, and ΘT in a simulation, and the result is validated for samples with the same design parameters. An indentation experiment also shows that the structure designed for interference reduction effectively attenuates the interference of the sensor array, indicating that the spatial resolution of the sensor array is improved. As a result, the sensor can exhibit low hysteresis and low interference simultaneously. This research can be used for many applications, such as robotic skin, grippers, and wearable devices.

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DOI [BibTex]

DOI [BibTex]


Superior Magnetic Performance in FePt L1_0 Nanomaterials
Superior Magnetic Performance in FePt L1_0 Nanomaterials

Son, K., Ryu, G. H., Jeong, H., Fink, L., Merz, M., Nagel, P., Schuppler, S., Richter, G., Goering, E., Schütz, G.

Small, 15(1902353), July 2019 (article)

Abstract
The discovery of the high maximum energy product of 59 MGOe for NdFeB magnets is a breakthrough in the development of permanent magnets with a tremendous impact in many fields of technology. This value is still the world record, for 40 years. This work reports on a reliable and robust route to realize nearly perfectly ordered L1_0-phase FePt nanoparticles, leading to an unprecedented energy product of 80 MGOe at room temperature. Furthermore, with a 3 nm Au coverage, the magnetic polarization of these nanomagnets can be enhanced by 25% exceeding 1.8 T. This exceptional magnetization and anisotropy is confirmed by using multiple imaging and spectroscopic methods, which reveal highly consistent results. Due to the unprecedented huge energy product, this material can be envisaged as a new advanced basic magnetic component in modern micro and nanosized devices.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Lamination parameter interpolation method for design of manufacturable variable-stiffness composite panels

Serhat, G., Basdogan, I.

AIAA Journal, 57(7):3052–3065, July 2019 (article)

Abstract
Variable-stiffness laminates have lately drawn attention because they offer potential for additional structural performance improvements. In the optimization studies, laminate stiffness properties can be described efficiently by using lamination parameters, which is a well-established formulation for constant-stiffness laminates. However, ensuring manufacturability in the design of variable-stiffness laminates with lamination parameters is difficult. In this paper, a novel method for the design of variable-stiffness composite panels using lamination parameters is proposed. The method constrains the design space by controlling the magnitude and direction of change for the lamination parameters, and subsequently leads to a smooth change in the fiber angles. The method is used to maximize the fundamental frequencies of several panels as example cases. The solutions are calculated for various panel geometries and boundary conditions using the developed finite element analysis software. After finding optimal lamination parameter distributions, corresponding discrete fiber angles and fiber paths are retrieved, and the minimum radii of curvature are calculated. The results demonstrate that the proposed design method provides manufacturable smooth fiber paths while using the compact stiffness formulation feature of lamination parameters.

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DOI [BibTex]


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Physical activity in non-ambulatory toddlers with cerebral palsy

M.Orlando, J., Pierce, S., Mohan, M., Skorup, J., Paremski, A., Bochnak, M., Prosser, L. A.

Research in Developmental Disabilities, 90, pages: 51-58, July 2019 (article)

Abstract
Background: Children with cerebral palsy are less likely to be physically active than their peers, however there is limited evidence regarding self-initiated physical activity in toddlers who are not able, or who may never be able, to walk. Aims: The aim of this study was to measure self-initiated physical activity and its relationship to gross motor function and participation in non-ambulatory toddlers with cerebral palsy. Methods and procedures: Participants were between the ages of 1–3 years. Physical activity during independent floor-play at home was recorded using a wearable tri-axial accelerometer worn on the child’s thigh. The Gross Motor Function Measure-66 and the Child Engagement in Daily Life, a parent-reported questionnaire of participation, were administered. Outcomes and results: Data were analyzed from the twenty participants who recorded at least 90 min of floor-play (mean: 229 min), resulting in 4598 total floor-play minutes. The relationship between physical activity and gross motor function was not statistically significant (r = 0.20; p = 0.39), nor were the relationships between physical activity and participation (r = 0.05−0.09; p = 0.71−0.84). Conclusions and implications: The results suggest physical activity during floor-play is not related to gross motor function or participation in non-ambulatory toddlers with cerebral palsy. Clinicians and researchers should independently measure physical activity, gross motor function, and participation.

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DOI [BibTex]

DOI [BibTex]


Implementation of a 6-{DOF} Parallel Continuum Manipulator for Delivering Fingertip Tactile Cues
Implementation of a 6-DOF Parallel Continuum Manipulator for Delivering Fingertip Tactile Cues

Young, E. M., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 12(3):295-306, June 2019 (article)

Abstract
Existing fingertip haptic devices can deliver different subsets of tactile cues in a compact package, but we have not yet seen a wearable six-degree-of-freedom (6-DOF) display. This paper presents the Fuppeteer (short for Fingertip Puppeteer), a device that is capable of controlling the position and orientation of a flat platform, such that any combination of normal and shear force can be delivered at any location on any human fingertip. We build on our previous work of designing a parallel continuum manipulator for fingertip haptics by presenting a motorized version in which six flexible Nitinol wires are actuated via independent roller mechanisms and proportional-derivative controllers. We evaluate the settling time and end-effector vibrations observed during system responses to step inputs. After creating a six-dimensional lookup table and adjusting simulated inputs using measured Jacobians, we show that the device can make contact with all parts of the fingertip with a mean error of 1.42 mm. Finally, we present results from a human-subject study. A total of 24 users discerned 9 evenly distributed contact locations with an average accuracy of 80.5%. Translational and rotational shear cues were identified reasonably well near the center of the fingertip and more poorly around the edges.

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DOI Project Page [BibTex]


The acoustic hologram and particle manipulation with structured acoustic fields
The acoustic hologram and particle manipulation with structured acoustic fields

Melde, K.

Karlsruher Institut für Technologie (KIT), May 2019 (phdthesis)

Abstract
This thesis presents holograms as a novel approach to create arbitrary ultrasound fields. It is shown how any wavefront can simply be encoded in the thickness profile of a phase plate. Contemporary 3D-printers enable fabrication of structured surfaces with feature sizes corresponding to wavelengths of ultrasound up to 7.5 MHz in water—covering the majority of medical and industrial applications. The whole workflow for designing and creating acoustic holograms has been developed and is presented in this thesis. To reconstruct the encoded fields a single transducer element is sufficient. Arbitrary fields are demonstrated in transmission and reflection configurations in water and air and validated by extensive hydrophone scans. To complement these time-consuming measurements a new approach, based on thermography, is presented, which enables volumetric sound field scans in just a few seconds. Several original experiments demonstrate the advantages of using acoustic holograms for particle manipulation. Most notably, directed parallel assembly of microparticles in the shape of a projected acoustic image has been shown and extended to a fabrication method by fusing the particles in a polymerization reaction. Further, seemingly dynamic propulsion from a static hologram is demonstrated by controlling the phase gradient along a projected track. The necessary complexity to create ultrasound fields with set amplitude and phase distributions is easily managed using acoustic holograms. The acoustic hologram is a simple and cost-effective tool for shaping ultrasound fields with high-fidelity. It is expected to have an impact in many applications where ultrasound is employed.

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link (url) DOI [BibTex]


Recent advances in gold nanoparticles forbiomedical applications: from hybrid structuresto multi-functionality
Recent advances in gold nanoparticles forbiomedical applications: from hybrid structuresto multi-functionality

Jeong, H., Choi, E., Ellis, E., Lee, T.

J. of Mat. Chem. B, 7, pages: 3480, May 2019 (article)

Abstract
Gold nanoparticles (Au NPs) are arguably the most versatile nanomaterials reported to date. Recentadvances in nanofabrication and chemical synthesis have expanded the scope of Au NPs from classicalhomogeneous nanospheres to a wide range of hybrid nanostructures with programmable size, shapeand composition. Novel physiochemical properties can be achievedviadesign and engineering of thehybrid nanostructures. In this review we discuss the recent progress in the development of complexhybrid Au NPs and propose a classification framework based on three fundamental structuraldimensions (length scale, complexity and symmetry) to aid categorising, comparing and designingvarious types of Au NPs. Their novel functions and potential for biomedical applications will also bediscussed, featuring point-of-care diagnostics by advanced optical spectroscopy and assays, as well asminimally invasive surgeries and targeted drug delivery using multifunctional nano-robot

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link (url) DOI [BibTex]


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How Does It Feel to Clap Hands with a Robot?

Fitter, N. T., Kuchenbecker, K. J.

International Journal of Social Robotics, 12(1):113-127, April 2019 (article)

Abstract
Future robots may need lighthearted physical interaction capabilities to connect with people in meaningful ways. To begin exploring how users perceive playful human–robot hand-to-hand interaction, we conducted a study with 20 participants. Each user played simple hand-clapping games with the Rethink Robotics Baxter Research Robot during a 1-h-long session involving 24 randomly ordered conditions that varied in facial reactivity, physical reactivity, arm stiffness, and clapping tempo. Survey data and experiment recordings demonstrate that this interaction is viable: all users successfully completed the experiment and mentioned enjoying at least one game without prompting. Hand-clapping tempo was highly salient to users, and human-like robot errors were more widely accepted than mechanical errors. Furthermore, perceptions of Baxter varied in the following statistically significant ways: facial reactivity increased the robot’s perceived pleasantness and energeticness; physical reactivity decreased pleasantness, energeticness, and dominance; higher arm stiffness increased safety and decreased dominance; and faster tempo increased energeticness and increased dominance. These findings can motivate and guide roboticists who want to design social–physical human–robot interactions.

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DOI [BibTex]

DOI [BibTex]


Self-Assembled Phage-Based Colloids for High Localized Enzymatic Activity
Self-Assembled Phage-Based Colloids for High Localized Enzymatic Activity

Alarcon-Correa, M., Guenther, J., Troll, J., Kadiri, V. M., Bill, J., Fischer, P., Rothenstein, D.

ACS Nano, 13, pages: 5810–5815, March 2019 (article)

Abstract
Catalytically active colloids are model systems for chemical motors and active matter. It is desirable to replace the inorganic catalysts and the toxic fuels that are often used, with biocompatible enzymatic reactions. However, compared to inorganic catalysts, enzyme-coated colloids tend to exhibit less activity. Here, we show that the self-assembly of genetically engineered M13 bacteriophages that bind enzymes to magnetic beads ensures high and localized enzymatic activity. These phage-decorated colloids provide a proteinaceous environment for directed enzyme immobilization. The magnetic properties of the colloidal carrier particle permit repeated enzyme recovery from a reaction solution, while the enzymatic activity is retained. Moreover, localizing the phage-based construct with a magnetic field in a microcontainer allows the enzyme-phage-colloids to function as an enzymatic micropump, where the enzymatic reaction generates a fluid flow. This system shows the fastest fluid flow reported to date by a biocompatible enzymatic micropump. In addition, it is functional in complex media including blood where the enzyme driven micropump can be powered at the physiological blood-urea concentration.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Absolute diffusion measurements of active enzyme solutions by NMR
Absolute diffusion measurements of active enzyme solutions by NMR

Guenther, J., Majer, G., Fischer, P.

J. Chem. Phys., 150(124201), March 2019 (article)

Abstract
The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their substrate or inhibitor. In this context, major importance is given to the enzyme fructose-bisphosphate aldolase, for which enhanced diffusion has been reported even though the catalysed reaction is endothermic. Additionally, enhanced diffusion of tracer particles surrounding the active aldolase enzymes has been reported. These studies suggest that active enzymes can act as chemical motors that self-propel and give rise to enhanced diffusion. However, fluorescence studies of enzymes can, despite several advantages, suffer from artefacts. Here we show that the absolute diffusion coefficients of active enzyme solutions can be determined with Pulsed Field Gradient Nuclear Magnetic Resonance (PFG-NMR). The advantage of PFG-NMR is that the motion of the molecule of interest is directly observed in its native state without the need for any labelling. Further, PFG-NMR is model-free and thus yields absolute diffusion constants. Our PFG-NMR experiments of solutions containing active fructose-bisphosphate aldolase from rabbit muscle do not show any diffusion enhancement for the active enzymes nor the surrounding molecules. Additionally, we do not observe any diffusion enhancement of aldolase in the presence of its inhibitor pyrophosphate.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Chemical Nanomotors at the Gram Scale Form a Dense Active Optorheological Medium
Chemical Nanomotors at the Gram Scale Form a Dense Active Optorheological Medium

Choudhury, U., Singh, D. P., Qiu, T., Fischer, P.

Adv. Mat., 31(1807382), Febuary 2019 (article)

Abstract
The rheological properties of a colloidal suspension are a function of the concentration of the colloids and their interactions. While suspensions of passive colloids are well studied and have been shown to form crystals, gels, and glasses, examples of energy‐consuming “active” colloidal suspensions are still largely unexplored. Active suspensions of biological matter, such as motile bacteria or dense mixtures of active actin–motor–protein mixtures have, respectively, reveals superfluid‐like and gel‐like states. Attractive inanimate systems for active matter are chemically self‐propelled particles. It has so far been challenging to use these swimming particles at high enough densities to affect the bulk material properties of the suspension. Here, it is shown that light‐triggered asymmetric titanium dioxide that self‐propel, can be obtained in large quantities, and self‐organize to make a gram‐scale active medium. The suspension shows an activity‐dependent tenfold reversible change in its bulk viscosity.

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link (url) DOI [BibTex]


First Observation of Optical Activity in Hyper-Rayleigh Scattering
First Observation of Optical Activity in Hyper-Rayleigh Scattering

Collins, J., Rusimova, K., Hooper, D., Jeong, H. H., Ohnoutek, L., Pradaux-Caggiano, F., Verbiest, T., Carbery, D., Fischer, P., Valev, V.

Phys. Rev. X, 9(011024), January 2019 (article)

Abstract
Chiral nano- or metamaterials and surfaces enable striking photonic properties, such as negative refractive index and superchiral light, driving promising applications in novel optical components, nanorobotics, and enhanced chiral molecular interactions with light. In characterizing chirality, although nonlinear chiroptical techniques are typically much more sensitive than their linear optical counterparts, separating true chirality from anisotropy is a major challenge. Here, we report the first observation of optical activity in second-harmonic hyper-Rayleigh scattering (HRS). We demonstrate the effect in a 3D isotropic suspension of Ag nanohelices in water. The effect is 5 orders of magnitude stronger than linear optical activity and is well pronounced above the multiphoton luminescence background. Because of its sensitivity, isotropic environment, and straightforward experimental geometry, HRS optical activity constitutes a fundamental experimental breakthrough in chiral photonics for media including nanomaterials, metamaterials, and chemical molecules.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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The Perception of Ultrasonic Square Reductions of Friction With Variable Sharpness and Duration

Gueorguiev, D., Vezzoli, E., Sednaoui, T., Grisoni, L., Lemaire-Semail, B.

IEEE Transactions on Haptics, 12(2):179-188, January 2019 (article)

Abstract
The human perception of square ultrasonic modulation of the finger-surface friction was investigated during active tactile exploration by using short frictional cues of varying duration and sharpness. In a first experiment, we asked participants to discriminate the transition time and duration of short square ultrasonic reductions of friction. They proved very sensitive to discriminate millisecond differences in these two parameters with the average psychophysical thresholds being 2.3–2.4 ms for both parameters. A second experiment focused on the perception of square friction reductions with variable transition times and durations. We found that for durations of the stimulation larger than 90 ms, participants often perceived three or four edges when only two stimulations were presented while they consistently felt two edges for signals shorter than 50 ms. A subsequent analysis of the contact forces induced by these ultrasonic stimulations during slow and fast active exploration showed that two identical consecutive ultrasonic pulses can induce significantly different frictional dynamics especially during fast motion of the finger. These results confirm the human sensitivity to transient frictional cues and suggest that the human perception of square reductions of friction can depend on their sharpness and duration as well as on the speed of exploration.

hi

DOI [BibTex]

DOI [BibTex]


Tactile Roughness Perception of Virtual Gratings by Electrovibration
Tactile Roughness Perception of Virtual Gratings by Electrovibration

Isleyen, A., Vardar, Y., Basdogan, C.

IEEE Transactions on Haptics, 2019 (article) Accepted

hi

[BibTex]

[BibTex]


Dynamics of self-propelled colloids and their application as active matter
Dynamics of self-propelled colloids and their application as active matter

Choudhury, U.

University of Groningen, Zernike Institute for Advanced Materials, 2019 (phdthesis)

Abstract
In this thesis, the behavior of active particles spanning from single particle dynamics to collective behavior of many particles is explored. Active colloids are out-of equilibrium systems that have been studied extensively over the past 15 years. This thesis addresses several phenomena that arise in the field of active colloids.

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link (url) [BibTex]

link (url) [BibTex]

2012


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Evaluation of Tactile Feedback Methods for Wrist Rotation Guidance

Stanley, A. A., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 5(3):240-251, July 2012 (article)

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[BibTex]

2012


[BibTex]


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Creating realistic virtual textures from contact acceleration data

Romano, J. M., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 5(2):109-119, April 2012, Cover article (article)

hi

[BibTex]

[BibTex]


Estimation of MIMO Closed-Loop Poles using Transfer Function Data
Estimation of MIMO Closed-Loop Poles using Transfer Function Data

Vardar, Y.

Eindhoven University of Technology, the Netherlands, 2012 (mastersthesis)

Abstract
For the development of high-tech systems such as lithographic positioning systems, throughput and accuracy are the main requirements. Nowadays, the trend to reach demanded accuracy and throughput levels is designing lightweight and consequently more flexible systems. To control these systems with a more effective and less conservative way, control design should go beyond the traditional rigid control and cope with the flexibilities that limit achievable bandwidth and performance. Therefore, conventional loop shaping methods are not sufficient to reach the performance criterions. Since obtaining an accurate parametric model is very complex and time-consuming for these high-tech systems, using well-developed model-based controller synthesis methods is also not a superior option. To achieve desired performance criterions, one solution can be implemented is reducing the gap between model-based and data-based control synthesis methods. In previous research, a method was developed to define the dynamic behavior of the system without a need for a parametric model. By this method transfer function data (TFD), which provides the information on the whole s-plane can be obtained from frequency response data (FRD) of the system. This innovation was a very important step to use data-based techniques for model-based controller synthesis methods. In this thesis firstly the standard technique to obtain TFD defined in [2] is extended. This standard technique to obtain TFD is not compatible with systems with pure integrators. To extend the methodology also for those systems, two techniques, which are altering the contour and filtering the system, are proposed. Then, the accuracy of TFD is investigated in detail. It is shown that the accuracy of TFD depends on the quality of FRD obtained and the computation techniques used to calculate TFD. Then, a technique which enables to determine the closed-loop poles of a MIMO system using TFD is discussed. The validity of the technique is proven with the help of complex function theory and calculus. Also, the factors that prevent determination of the closed-loop poles are discussed. In addition, it is observed that the accuracy of the closed-loop determination method depends on the quality of obtained TFD and the computation techniques. The proposed theory to obtain TFD and determination of closed-loop poles is validated with experiments conducted to a prototype lightweight system. Also, using experimental frequency response data of NXT-A7 test rig, the success of the proposed methodology is validated also for complex systems. Through these experimental results, it can be concluded that this new technique could be very advantageous in terms of ease of use and accuracy to determine the closed-loop poles of a MIMO lightly damped system.

hi

[BibTex]

[BibTex]


Fourier-transform photocurrent spectroscopy using a supercontinuum light source
Fourier-transform photocurrent spectroscopy using a supercontinuum light source

Petermann, C., Beigang, R., Fischer, P.

APPLIED PHYSICS LETTERS, 100(6), 2012 (article)

Abstract
We demonstrate an implementation of frequency-encoded photocurrent spectroscopy using a super-continuum light source. The spectrally broad light is spatially dispersed and modulated with a special mechanical chopper design that permits a continuous wavelength-dependent modulation. After recombination, the light beam contains a frequency encoded spectrum which enables us to map the spectral response of a given sample in 60 ms and with a lateral resolution of 10 mu m. (C) 2012 American Institute of Physics.

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DOI [BibTex]

DOI [BibTex]


Eine neue Form von Cavity Enhanced Absorption Spectroscopy
Eine neue Form von Cavity Enhanced Absorption Spectroscopy

Petermann, C., Fischer, P.

DE Gruyter, 79(1), 2012, Best paper award OPTO 2011 (article)

Abstract
Wir stellen eine Kopplungsmethode für resonatorgestützte Absorptionsmessungen vor, bei der Licht durch einen im Resonator platzierten akustooptischen Modulator aktiv ein- und ausgekoppelt wird. Dies ermöglicht es Cavity-Ring-Down-Spektroskopie (CRDS) mit breitbandigen und zeitlich inkohärenten Lichtquellen niedriger spektraler Leistungsdichte durchzuführen. Das Verfahren wird zum ersten Mal mit einer breitbandigen Superkontinuum-Quelle demonstriert.

___________________________________________________________________________________________

A new coupling scheme for cavity enhanced absorption spectroscopy makes use of an intracavity acousto-optical modulator to actively switch light into (and out of) a resonator. This allows cavity ringdown spectroscopy (CRDS) to be implemented with broadband temporally incoherent light sources with low spectral power densities. The method is demonstrated for the first time using a broadband supercontinuum source. Best paper award OPTO 2011.

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link (url) [BibTex]

link (url) [BibTex]


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Construct Validity of Instrument Vibrations as a Measure of Robotic Surgical Skill

Gomez, E. D., Bark, K., Rivera, C., McMahan, W., Remington, A., Lee, D. I., Williams, N., Murayama, K., Dumon, K., Kuchenbecker, K. J.

Journal of the American College of Surgeons, 215(3):S119-120, Chicago, Illinois, USA, 2012, Oral presentation given by Gomez at the {\em American College of Surgeons (ACS) Clinical Congress} (article)

hi

[BibTex]

[BibTex]

2009


Full phase and amplitude control in computer-generated holography
Full phase and amplitude control in computer-generated holography

Fratz, M., Fischer, P., Giel, D. M.

OPTICS LETTERS, 34(23):3659-3661, 2009 (article)

Abstract
We report what we believe to be the first realization of a computer-generated complex-valued hologram recorded in a single film of photoactive polymer. Complex-valued holograms give rise to a diffracted optical field with control over its amplitude and phase. The holograms are generated by a one-step direct laser writing process in which a spatial light modulator (SLM) is imaged onto a polymer film. Temporal modulation of the SLM during exposure controls both the strength of the induced birefringence and the orientation of the fast axis. We demonstrate that complex holograms can be used to impart arbitrary amplitude and phase profiles onto a beam and thereby open new possibilities in the control of optical beams. (C) 2009 Optical Society of America

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[BibTex]

2009


[BibTex]


Digital polarization holograms with defined magnitude and orientation of each pixel's birefringence
Digital polarization holograms with defined magnitude and orientation of each pixel’s birefringence

Fratz, M., Giel, D. M., Fischer, P.

OPTICS LETTERS, 34(8):1270-1272, 2009 (article)

Abstract
A new form of digital polarization holography is demonstrated that permits both the amplitude and the phase of a diffracted beam to be independently controlled. This permits two independent intensity images to be stored in the same hologram. To fabricate the holograms, a birefringence with defined retardance and orientation of the fast axis is recorded into a photopolymer film. The holograms are selectively read out by choosing the polarization state of the read beam. Polarization holograms of this kind increase the data density in holographic data storage and allow higher quality diffractive optical elements to be written. (C) 2009 Optical Society of America

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[BibTex]


Controlled Propulsion of Artificial Magnetic Nanostructured Propellers
Controlled Propulsion of Artificial Magnetic Nanostructured Propellers

Ghosh, A., Fischer, P.

NANO LETTERS, 9(6):2243-2245, 2009, Featured highlight ‘Nanotechnology: The helix that delivers’ Nature 459, 13 (2009). (article)

Abstract
For biomedical applications, such as targeted drug delivery and microsurgery, it is essential to develop a system of swimmers that can be propelled wirelessly in fluidic environments with good control. Here, we report the construction and operation of chiral colloidal propellers that can be navigated in water with micrometer-level precision using homogeneous magnetic fields. The propellers are made via nanostructured surfaces and can be produced in large numbers. The nanopropellers can carry chemicals, push loads, and act as local probes in rheological measurements.

Featured highlight ‘Nanotechnology: The helix that delivers’ Nature 459, 13 (2009).

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Video - Nanospropellers DOI [BibTex]

Video - Nanospropellers DOI [BibTex]


Absolute Asymmetric Reduction Based on the Relative Orientation of Achiral Reactants
Absolute Asymmetric Reduction Based on the Relative Orientation of Achiral Reactants

Kuhn, A., Fischer, P.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(37):6857-6860, 2009 (article)

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DOI [BibTex]

DOI [BibTex]

2000


Phenomenological damping in optical response tensors
Phenomenological damping in optical response tensors

Buckingham, A., Fischer, P.

PHYSICAL REVIEW A, 61(3), 2000 (article)

Abstract
Although perturbation theory applied to the optical response of a molecule or material system is only strictly valid far from resonances, it is often applied to ``near-resonance{''} conditions by means of complex energies incorporating damping. Inconsistent signs of the damping in optical response tensors have appeared in the recent literature, as have errors in the treatment of the perturbation by a static held. The ``equal-sign{''} convention used in a recent publication yields an unphysical material response, and Koroteev's intimation that linear electro-optical circular dichroism may exist in an optically active liquid under resonance conditions is also flawed. We show that the isotropic part of the Pockels tensor vanishes.

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DOI [BibTex]

2000


DOI [BibTex]


Ab initio investigation of the sum-frequency hyperpolarizability of small chiral molecules
Ab initio investigation of the sum-frequency hyperpolarizability of small chiral molecules

Champagne, B., Fischer, P., Buckingham, A.

CHEMICAL PHYSICS LETTERS, 331(1):83-88, 2000 (article)

Abstract
Using a sum-over-states procedure based on configuration interaction singles /6-311++G{*}{*}, we have computed the sum-frequency hyperpolarizability beta (ijk)(-3 omega; 2 omega, omega) Of two small chiral molecules, R-monofluoro-oxirane and R-(+)-propylene oxide. Excitation energies were scaled to fit experimental UV-absorption data and checked with ab initio values from time-dependent density functional theory. The isotropic part of the computed hyperpolarizabilities, beta(-3 omega; 2 omega, omega), is much smaller than that reported previously from sum-frequency generation experiments on aqueous solutions of arabinose. Comparison is made with a single-centre chiral model. (C) 2000 Elsevier Science B.V. All rights reserved.

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DOI [BibTex]

DOI [BibTex]


Three-wave mixing in chiral liquids
Three-wave mixing in chiral liquids

Fischer, P., Wiersma, D., Righini, R., Champagne, B., Buckingham, A.

PHYSICAL REVIEW LETTERS, 85(20):4253-4256, 2000 (article)

Abstract
Second-order nonlinear optical frequency conversion in isotropic systems is only dipole allowed for sum- and difference-frequency generation in chiral media. We develop a single-center chiral model of the three-wave mixing (sum:frequency generation) nonlinearity and estimate its magnitude. We also report results from ab initio calculations and from three- and four-wave mixing experiments in support of the theoretical estimates. We show that the second-order susceptibility in chiral liquids is much smaller than previously thought.

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DOI [BibTex]

DOI [BibTex]