Publications | Max Planck Institute for Intelligent Systems

Elastic modulus affects adhesive strength of gecko-inspired synthetics in variable temperature and humidity

Mitchell, CT, Drotlef, D, Dayan, CB, Sitti, M, Stark, AY

In INTEGRATIVE AND COMPARATIVE BIOLOGY, pages: E372-E372, OXFORD UNIV PRESS INC JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA, March 2019 (inproceedings)

pi Mitchell, CT, Drotlef, D, Dayan, CB, Sitti, M, Stark, AY Elastic modulus affects adhesive strength of gecko-inspired synthetics in variable temperature and humidity In INTEGRATIVE AND COMPARATIVE BIOLOGY, pages: E372-E372, OXFORD UNIV PRESS INC JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA, March 2019 (inproceedings)

X-ray Optics Fabrication Using Unorthodox Approaches

Sanli, U., Baluktsian, M., Ceylan, H., Sitti, M., Weigand, M., Schütz, G., Keskinbora, K.

Bulletin of the American Physical Society, APS, 2019 (article)

mms pi

mms pi Sanli, U., Baluktsian, M., Ceylan, H., Sitti, M., Weigand, M., Schütz, G., Keskinbora, K. X-ray Optics Fabrication Using Unorthodox Approaches Bulletin of the American Physical Society, APS, 2019 (article)

Temperature Gradients Drive Bulk Flow Within Microchannel Lined by Fluid–Fluid Interfaces

Amador, G. J., Ren, Z., Tabak, A. F., Alapan, Y., Yasa, O., Sitti, M.

Small, 15, Wiley Online Library, 2019 (article)

pi Amador, G. J., Ren, Z., Tabak, A. F., Alapan, Y., Yasa, O., Sitti, M. Temperature Gradients Drive Bulk Flow Within Microchannel Lined by Fluid–Fluid Interfaces Small, 15, Wiley Online Library, 2019 (article)

Microrobotics and Microorganisms: Biohybrid Autonomous Cellular Robots

Alapan, Y., Yasa, O., Yigit, B., Yasa, I. C., Erkoc, P., Sitti, M.

Annual Review of Control, Robotics, and Autonomous Systems, 2019 (article)

pi Alapan, Y., Yasa, O., Yigit, B., Yasa, I. C., Erkoc, P., Sitti, M. Microrobotics and Microorganisms: Biohybrid Autonomous Cellular Robots Annual Review of Control, Robotics, and Autonomous Systems, 2019 (article)

Woodward, M. A., Sitti, M.

Tailored Magnetic Springs for Shape-Memory Alloy Actuated Mechanisms in Miniature Robots

IEEE Transactions on Robotics, 35, 2019 (article)

Abstract

Animals can incorporate large numbers of actuators because of the characteristics of muscles; whereas, robots cannot, as typical motors tend to be large, heavy, and inefficient. However, shape-memory alloys (SMA), materials that contract during heating because of change in their crystal structure, provide another option. SMA, though, is unidirectional and therefore requires an additional force to reset (extend) the actuator, which is typically provided by springs or antagonistic actuation. These strategies, however, tend to limit the actuator's work output and functionality as their force-displacement relationships typically produce increasing resistive force with limited variability. In contrast, magnetic springs-composed of permanent magnets, where the interaction force between magnets mimics a spring force-have much more variable force-displacement relationships and scale well with SMA. However, as of yet, no method for designing magnetic springs for SMA-actuators has been demonstrated. Therefore, in this paper, we present a new methodology to tailor magnetic springs to the characteristics of these actuators, with experimental results both for the device and robot-integrated SMA-actuators. We found magnetic building blocks, based on sets of permanent magnets, which are well-suited to SMAs and have the potential to incorporate features such as holding force, state transitioning, friction minimization, auto-alignment, and self-mounting. We show magnetic springs that vary by more than 3 N in 750 $\mu$m and two SMA-actuated devices that allow the MultiMo-Bat to reach heights of up to 4.5 m without, and 3.6 m with, integrated gliding airfoils. Our results demonstrate the potential of this methodology to add previously impossible functionality to smart material actuators. We anticipate this methodology will inspire broader consideration of the use of magnetic springs in miniature robots and further study of the potential of tailored magnetic springs throughout mechanical systems.

pi Woodward, M. A., Sitti, M. Tailored Magnetic Springs for Shape-Memory Alloy Actuated Mechanisms in Miniature Robots IEEE Transactions on Robotics, 35, 2019 (article)

Magnetically Actuated Soft Capsule Endoscope for Fine-Needle Biopsy

Son, D., Gilbert, H., Sitti, M.

Soft robotics, Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New …, 2019 (article)

pi Son, D., Gilbert, H., Sitti, M. Magnetically Actuated Soft Capsule Endoscope for Fine-Needle Biopsy Soft robotics, Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New …, 2019 (article)

Thrust and Hydrodynamic Efficiency of the Bundled Flagella

Danis, U., Rasooli, R., Chen, C., Dur, O., Sitti, M., Pekkan, K.

Micromachines, 10, 2019 (article)

pi Danis, U., Rasooli, R., Chen, C., Dur, O., Sitti, M., Pekkan, K. Thrust and Hydrodynamic Efficiency of the Bundled Flagella Micromachines, 10, 2019 (article)

3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release

Ceylan, H., Yasa, I. C., Yasa, O., Tabak, A. F., Giltinan, J., Sitti, M.

ACS Nano, ACS Publications, 2019 (article)

pi Ceylan, H., Yasa, I. C., Yasa, O., Tabak, A. F., Giltinan, J., Sitti, M. 3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release ACS Nano, ACS Publications, 2019 (article)

The near and far of a pair of magnetic capillary disks

Koens, L., Wang, W., Sitti, M., Lauga, E.

Soft Matter, 2019 (article)

pi Koens, L., Wang, W., Sitti, M., Lauga, E. The near and far of a pair of magnetic capillary disks Soft Matter, 2019 (article)

Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters

Hu, X., Torati, S. R., Kim, H., Yoon, J., Lim, B., Kim, K., Sitti, M., Kim, C.

Small, Wiley Online Library, 2019 (article)

pi Hu, X., Torati, S. R., Kim, H., Yoon, J., Lim, B., Kim, K., Sitti, M., Kim, C. Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters Small, Wiley Online Library, 2019 (article)

Precise Control of Lyotropic Chromonic Liquid Crystals Alignment through Surface Topography

Guo, Y., Shahsavan, H., Davidson, Z., Sitti, M.

ACS applied materials \& interfaces, ACS Publications, 2019 (article)

pi Guo, Y., Shahsavan, H., Davidson, Z., Sitti, M. Precise Control of Lyotropic Chromonic Liquid Crystals Alignment through Surface Topography ACS applied materials \& interfaces, ACS Publications, 2019 (article)

Multi-functional soft-bodied jellyfish-like swimming

Ren, Z., Hu, W., Dong, X., Sitti, M.

Nature communications, 10, 2019 (article)

pi Ren, Z., Hu, W., Dong, X., Sitti, M. Multi-functional soft-bodied jellyfish-like swimming Nature communications, 10, 2019 (article)

Welcome to Progress in Biomedical Engineering

Sitti, M.

Progress in Biomedical Engineering, 1, IOP Publishing, 2019 (article)

pi Sitti, M. Welcome to Progress in Biomedical Engineering Progress in Biomedical Engineering, 1, IOP Publishing, 2019 (article)

Mechanics of a pressure-controlled adhesive membrane for soft robotic gripping on curved surfaces

Song, S., Drotlef, D., Paik, J., Majidi, C., Sitti, M.

Extreme Mechanics Letters, Elsevier, 2019 (article)

pi Song, S., Drotlef, D., Paik, J., Majidi, C., Sitti, M. Mechanics of a pressure-controlled adhesive membrane for soft robotic gripping on curved surfaces Extreme Mechanics Letters, Elsevier, 2019 (article)

Graphene oxide synergistically enhances antibiotic efficacy in Vancomycin resistance Staphylococcus aureus

Singh, V., Kumar, V., Kashyap, S., Singh, A. V., Kishore, V., Sitti, M., Saxena, P. S., Srivastava, A.

ACS Applied Bio Materials, ACS Publications, 2019 (article)

pi Singh, V., Kumar, V., Kashyap, S., Singh, A. V., Kishore, V., Sitti, M., Saxena, P. S., Srivastava, A. Graphene oxide synergistically enhances antibiotic efficacy in Vancomycin resistance Staphylococcus aureus ACS Applied Bio Materials, ACS Publications, 2019 (article)

Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

Singh, A. V., Laux, P., Luch, A., Sudrik, C., Wiehr, S., Wild, A., Santamauro, G., Bill, J., Sitti, M.

Toxicology Mechanisms and Methods, 2019 (article)

pi Singh, A. V., Laux, P., Luch, A., Sudrik, C., Wiehr, S., Wild, A., Santamauro, G., Bill, J., Sitti, M. Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design Toxicology Mechanisms and Methods, 2019 (article)

Hakan Ceylan, I. C. Y. U. K. W. H. M. S.

Translational prospects of untethered medical microrobots

Progress in Biomedical Engineering, 1, 2019 (article)

pi Hakan Ceylan, I. C. Y. U. K. W. H. M. S. Translational prospects of untethered medical microrobots Progress in Biomedical Engineering, 1, 2019 (article)

Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery

Singh, A. V., Ansari, M. H. D., Dayan, C. B., Giltinan, J., Wang, S., Yu, Y., Kishore, V., Laux, P., Luch, A., Sitti, M.

Biomaterials, 219, Elsevier, 2019 (article)

pi Singh, A. V., Ansari, M. H. D., Dayan, C. B., Giltinan, J., Wang, S., Yu, Y., Kishore, V., Laux, P., Luch, A., Sitti, M. Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery Biomaterials, 219, Elsevier, 2019 (article)

Pena-Francesch, A., Giltinan, J., Sitti, M.

Multifunctional and biodegradable self-propelled protein motors

Nature communications, 10, Nature Publishing Group, 2019 (article)

pi Pena-Francesch, A., Giltinan, J., Sitti, M. Multifunctional and biodegradable self-propelled protein motors Nature communications, 10, Nature Publishing Group, 2019 (article)

Cohesive self-organization of mobile microrobotic swarms

Yigit, B., Alapan, Y., Sitti, M.

arXiv preprint arXiv:1907.05856, 2019 (article)

pi Yigit, B., Alapan, Y., Sitti, M. Cohesive self-organization of mobile microrobotic swarms arXiv preprint arXiv:1907.05856, 2019 (article)

Mobile microrobots for active therapeutic delivery

Erkoc, P., Yasa, I. C., Ceylan, H., Yasa, O., Alapan, Y., Sitti, M.

Advanced Therapeutics, Wiley Online Library, 2019 (article)

pi Erkoc, P., Yasa, I. C., Ceylan, H., Yasa, O., Alapan, Y., Sitti, M. Mobile microrobots for active therapeutic delivery Advanced Therapeutics, Wiley Online Library, 2019 (article)

Shape-encoded dynamic assembly of mobile micromachines

Alapan, Y., Yigit, B., Beker, O., Demirörs, A. F., Sitti, M.

Nature, 18, 2019 (article)

pi Alapan, Y., Yigit, B., Beker, O., Demirörs, A. F., Sitti, M. Shape-encoded dynamic assembly of mobile micromachines Nature, 18, 2019 (article)

Microfluidics Integrated Lithography‐Free Nanophotonic Biosensor for the Detection of Small Molecules

Sreekanth, K. V., Sreejith, S., Alapan, Y., Sitti, M., Lim, C. T., Singh, R.

Advanced Optical Materials, 2019 (article)

pi Sreekanth, K. V., Sreejith, S., Alapan, Y., Sitti, M., Lim, C. T., Singh, R. Microfluidics Integrated Lithography‐Free Nanophotonic Biosensor for the Detection of Small Molecules Advanced Optical Materials, 2019 (article)

Gecko-inspired composite microfibers for reversible adhesion on smooth and rough surfaces

Drotlef, D., Dayan, C., Sitti, M.

In INTEGRATIVE AND COMPARATIVE BIOLOGY, pages: E58-E58, OXFORD UNIV PRESS INC JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA, 2019 (inproceedings)

pi Drotlef, D., Dayan, C., Sitti, M. Gecko-inspired composite microfibers for reversible adhesion on smooth and rough surfaces In INTEGRATIVE AND COMPARATIVE BIOLOGY, pages: E58-E58, OXFORD UNIV PRESS INC JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA, 2019 (inproceedings)

ENGINEERING Bio-inspired robotic collectives

Sitti, M.

Nature, 567, pages: 314-315, Macmillan Publishers Ltd., London, England, 2019 (article)

pi Sitti, M. ENGINEERING Bio-inspired robotic collectives Nature, 567, pages: 314-315, Macmillan Publishers Ltd., London, England, 2019 (article)

Immihan Ceren Yasa, A. F. T. O. Y. H. C. M. S.

3D‐Printed Microrobotic Transporters with Recapitulated Stem Cell Niche for Programmable and Active Cell Delivery

Advanced Functional Materials , 29, 2019 (article)

pi Immihan Ceren Yasa, A. F. T. O. Y. H. C. M. S. 3D‐Printed Microrobotic Transporters with Recapitulated Stem Cell Niche for Programmable and Active Cell Delivery Advanced Functional Materials , 29, 2019 (article)

Peptide-Induced Biomineralization of Tin Oxide (SnO2) Nanoparticles for Antibacterial Applications

Singh, A. V., Jahnke, T., Xiao, Y., Wang, S., Yu, Y., David, H., Richter, G., Laux, P., Luch, A., Srivastava, A., Saxena, P. S., Bill, J., Sitti, M.

Journal of nanoscience and nanotechnology, 19, American Scientific Publishers, 2019 (article)

pi Singh, A. V., Jahnke, T., Xiao, Y., Wang, S., Yu, Y., David, H., Richter, G., Laux, P., Luch, A., Srivastava, A., Saxena, P. S., Bill, J., Sitti, M. Peptide-Induced Biomineralization of Tin Oxide (SnO2) Nanoparticles for Antibacterial Applications Journal of nanoscience and nanotechnology, 19, American Scientific Publishers, 2019 (article)

Electromechanical actuation of dielectric liquid crystal elastomers for soft robotics

Davidson, Z., Shahsavan, H., Guo, Y., Hines, L., Xia, Y., Yang, S., Sitti, M.

Bulletin of the American Physical Society, APS, 2019 (article)

pi Davidson, Z., Shahsavan, H., Guo, Y., Hines, L., Xia, Y., Yang, S., Sitti, M. Electromechanical actuation of dielectric liquid crystal elastomers for soft robotics Bulletin of the American Physical Society, APS, 2019 (article)

Simultaneous Six-Degree-of-Freedom Control of a Single-Body Magnetic Microrobot

Giltinan, J., Sitti, M.

IEEE Robotics and Automation Letters, 4, 2019 (article)

pi Giltinan, J., Sitti, M. Simultaneous Six-Degree-of-Freedom Control of a Single-Body Magnetic Microrobot IEEE Robotics and Automation Letters, 4, 2019 (article)

Monolithic shape-programmable dielectric liquid crystal elastomer actuators

Davidson, Z. S., Shahsavan, H., Aghakhani, A., Guo, Y., Hines, L., Xia, Y., Yang, S., Sitti, M.

arXiv preprint arXiv:1904.09606, 2019 (article)

pi Davidson, Z. S., Shahsavan, H., Aghakhani, A., Guo, Y., Hines, L., Xia, Y., Yang, S., Sitti, M. Monolithic shape-programmable dielectric liquid crystal elastomer actuators arXiv preprint arXiv:1904.09606, 2019 (article)

Bio-inspired composite microfibers for strong and reversible adhesion on smooth surfaces

Drotlef, D., Dayan, C., Sitti, M.

Integrative and comparative biology, 2019 (article)

pi Drotlef, D., Dayan, C., Sitti, M. Bio-inspired composite microfibers for strong and reversible adhesion on smooth surfaces Integrative and comparative biology, 2019 (article)

Elevation and Azimuth Rotational Actuation of an Untethered Millirobot by MRI Gradient Coils

Erin, O., Gilbert, H. B., Tabak, A. F., Sitti, M.

IEEE Transactions on Robotics, IEEE, 2019 (article)

pi Erin, O., Gilbert, H. B., Tabak, A. F., Sitti, M. Elevation and Azimuth Rotational Actuation of an Untethered Millirobot by MRI Gradient Coils IEEE Transactions on Robotics, IEEE, 2019 (article)

Learning to Navigate Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Gilbert, H. B., Mahmood, F., Durr, N. J., Araujo, H., Sarı, A. E., Ajay, A., Sitti, M.

IEEE Robotics and Automation Letters, 4, 2019 (article)

pi Turan, M., Almalioglu, Y., Gilbert, H. B., Mahmood, F., Durr, N. J., Araujo, H., Sarı, A. E., Ajay, A., Sitti, M. Learning to Navigate Endoscopic Capsule Robots IEEE Robotics and Automation Letters, 4, 2019 (article)

2015

Untethered Magnetic Micromanipulation

Diller, E., Sitti, M.

In Micro-and Nanomanipulation Tools, 13, 10, Wiley-VCH Verlag GmbH & Co. KGaA, November 2015 (inbook)

Abstract

This chapter discusses the methods and state of the art in microscale manipulation in remote environments using untethered microrobotic devices. It focuses on manipulation at the size scale of tens to hundreds of microns, where small size leads to a dominance of microscale physical effects and challenges in fabrication and actuation. To motivate the challenges of operating at this size scale, the chapter includes coverage of the physical forces relevant to microrobot motion and manipulation below the millimeter-size scale. It then introduces the actuation methods commonly used in untethered manipulation schemes, with particular focus on magnetic actuation due to its wide use in the field. The chapter divides these manipulation techniques into two types: contact manipulation, which relies on direct pushing or grasping of objects for motion, and noncontact manipulation, which relies indirectly on induced fluid flow from the microrobot motion to move objects without any direct contact.

2015

pi Diller, E., Sitti, M. Untethered Magnetic Micromanipulation In Micro-and Nanomanipulation Tools, 13, 10, Wiley-VCH Verlag GmbH & Co. KGaA, November 2015 (inbook)

Compliant wing design for a flapping wing micro air vehicle

Colmenares, D., Kania, R., Zhang, W., Sitti, M.

In Intelligent Robots and Systems (IROS), 2015 IEEE/RSJ International Conference on, pages: 32-39, September 2015 (inproceedings)

Abstract

In this work, we examine several wing designs for a motor-driven, flapping-wing micro air vehicle capable of liftoff. The full system consists of two wings independently driven by geared pager motors that include a spring in parallel with the output shaft. The linear transmission allows for resonant operation, while control is achieved by direct drive of the wing angle. Wings used in previous work were chosen to be fully rigid for simplicity of modeling and fabrication. However, biological wings are highly flexible and other micro air vehicles have successfully utilized flexible wing structures for specialized tasks. The goal of our study is to determine if wing flexibility can be generally used to increase wing performance. Two approaches to lift improvement using flexible wings are explored, resonance of the wing cantilever structure and dynamic wing twisting. We design and test several wings that are compared using different figures of merit. A twisted design improved lift per power by 73.6% and maximum lift production by 53.2% compared to the original rigid design. Wing twist is then modeled in order to propose optimal wing twist profiles that can maximize either wing efficiency or lift production.

pi Colmenares, D., Kania, R., Zhang, W., Sitti, M. Compliant wing design for a flapping wing micro air vehicle In Intelligent Robots and Systems (IROS), 2015 IEEE/RSJ International Conference on, pages: 32-39, September 2015 (inproceedings)

Methods of forming dry adhesive structures

Sitti, M., Murphy, M., Aksak, B.

September 2015, US Patent 9,120,953 (patent)

Abstract

Methods of forming dry adhesives including a method of making a dry adhesive including applying a liquid polymer to the second end of the stem, molding the liquid polymer on the stem in a mold, wherein the mold includes a recess having a cross-sectional area that is less than a cross-sectional area of the second end of the stem, curing the liquid polymer in the mold to form a tip at the second end of the stem, wherein the tip includes a second layer stem; corresponding to the recess in the mold, and removing the tip from the mold after the liquid polymer cures.

pi Sitti, M., Murphy, M., Aksak, B. Methods of forming dry adhesive structures September 2015, US Patent 9,120,953 (patent)

Millimeter-scale magnetic swimmers using elastomeric undulations

Zhang, J., Diller, E.

In 2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), pages: 1706-1711, September 2015 (inproceedings)

Abstract

This paper presents a new soft-bodied millimeterscale swimmer actuated by rotating uniform magnetic fields. The proposed swimmer moves through internal undulatory deformations, resulting from a magnetization profile programmed into its body. To understand the motion of the swimmer, a mathematical model is developed to describe the general relationship between the deflection of a flexible strip and its magnetization profile. As a special case, the situation of the swimmer on the water surface is analyzed and predictions made by the model are experimentally verified. Experimental results show the controllability of the proposed swimmer under a computer vision-based closed-loop controller. The swimmers have nominal dimensions of 1.5×4.9×0.06 mm and a top speed of 50 mm/s (10 body lengths per second). Waypoint following and multiagent control are demonstrated for swimmers constrained at the air-water interface and underwater swimming is also shown, suggesting the promising potential of this type of swimmer in biomedical and microfluidic applications.

link (url) DOI [BibTex]

pi Zhang, J., Diller, E. Millimeter-scale magnetic swimmers using elastomeric undulations In 2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), pages: 1706-1711, September 2015 (inproceedings)

link (url) DOI [BibTex]

Experimental investigation of optimal adhesion of mushroomlike elastomer microfibrillar adhesives

Marvi, H., Song, S., Sitti, M.

Langmuir, 31(37):10119-10124, American Chemical Society, August 2015 (article)

Abstract

Optimal fiber designs for the maximal pull-off force have been indispensable for increasing the attachment performance of recently introduced gecko-inspired reversible micro/nanofibrillar adhesives. There are several theoretical studies on such optimal designs; however, due to the lack of three-dimensional (3D) fabrication techniques that can fabricate such optimal designs in 3D, there have not been many experimental investigations on this challenge. In this study, we benefitted from recent advances in two-photon lithography techniques to fabricate mushroomlike polyurethane elastomer fibers with different aspect ratios of tip to stalk diameter (β) and tip wedge angles (θ) to investigate the effect of these two parameters on the pull-off force. We found similar trends to those predicted theoretically. We found that β has an impact on the slope of the force-displacement curve while both β and θ play a role in the stress distribution and crack propagation. We found that these effects are coupled and the optimal set of parameters also depends on the fiber material. This is the first experimental verification of such optimal designs proposed for mushroomlike microfibers. This experimental approach could be used to evaluate a wide range of complex microstructured adhesive designs suggested in the literature and optimize them.

pi Marvi, H., Song, S., Sitti, M. Experimental investigation of optimal adhesion of mushroomlike elastomer microfibrillar adhesives Langmuir, 31(37):10119-10124, American Chemical Society, August 2015 (article)

Micro-fiber arrays with tip coating and transfer method for preparing same

Sitti, M., Washburn, N. R., Glass, P. S., Chung, H.

July 2015, US Patent 9,079,215 (patent)

Abstract

Present invention describes a patterned and coated micro- and nano-scale fibers elastomeric material for enhanced adhesion in wet or dry environments. A multi-step fabrication process including optical lithography, micromolding, polymer synthesis, dipping, stamping, and photopolymerization is described to produce uniform arrays of micron-scale fibers with mushroom-shaped tips coated with a thin layer of an intrinsically adhesive synthetic polymer, such as lightly crosslinked p(DMA-co-MEA).

pi Sitti, M., Washburn, N. R., Glass, P. S., Chung, H. Micro-fiber arrays with tip coating and transfer method for preparing same July 2015, US Patent 9,079,215 (patent)

pH-taxis of biohybrid microsystems

Zhuang, J., Carlsen, R. W., Sitti, M.

Scientific reports, 5, Nature Publishing Group, June 2015 (article)

Abstract

The last decade has seen an increasing number of studies developing bacteria and other cell-integrated biohybrid microsystems. However, the highly stochastic motion of these microsystems severely limits their potential use. Here, we present a method that exploits the pH sensing of flagellated bacteria to realize robust drift control of multi-bacteria propelled microrobots. Under three specifically configured pH gradients, we demonstrate that the microrobots exhibit both unidirectional and bidirectional pH-tactic behaviors, which are also observed in free-swimming bacteria. From trajectory analysis, we find that the swimming direction and speed biases are two major factors that contribute to their tactic drift motion. The motion analysis of microrobots also sheds light on the propulsion dynamics of the flagellated bacteria as bioactuators. It is expected that similar driving mechanisms are shared among pH-taxis, chemotaxis, and thermotaxis. By identifying the mechanism that drives the tactic behavior of bacteria-propelled microsystems, this study opens up an avenue towards improving the control of biohybrid microsystems. Furthermore, assuming that it is possible to tune the preferred pH of bioactuators by genetic engineering, these biohybrid microsystems could potentially be applied to sense the pH gradient induced by cancerous cells in stagnant fluids inside human body and realize targeted drug delivery.

pi Zhuang, J., Carlsen, R. W., Sitti, M. pH-taxis of biohybrid microsystems Scientific reports, 5, Nature Publishing Group, June 2015 (article)

Fiberbot: A miniature crawling robot using a directional fibrillar pad

Han, Y., Marvi, H., Sitti, M.

In Robotics and Automation (ICRA), 2015 IEEE International Conference on, pages: 3122-3127, May 2015 (inproceedings)

Abstract

Vibration-driven locomotion has been widely used for crawling robot studies. Such robots usually have a vibration motor as the actuator and a fibrillar structure for providing directional friction on the substrate. However, there has not been any studies about the effect of fiber structure on robot crawling performance. In this paper, we develop Fiberbot, a custom made mini vibration robot, for studying the effect of fiber angle on robot velocity, steering, and climbing performance. It is known that the friction force with and against fibers depends on the fiber angle. Thus, we first present a new fabrication method for making millimeter scale fibers at a wide range of angles. We then show that using 30° angle fibers that have the highest friction anisotropy (ratio of backward to forward friction force) among the other fibers we fabricated in this study, Fiberbot speed on glass increases to 13.8±0.4 cm/s (compared to ν = 0.6±0.1 cm/s using vertical fibers). We also demonstrate that the locomotion direction of Fiberbot depends on the tilting direction of fibers and we can steer the robot by rotating the fiber pad. Fiberbot could also climb on glass at inclinations of up to 10° when equipped with fibers of high friction anisotropy. We show that adding a rigid tail to the robot it can climb on glass at 25° inclines. Moreover, the robot is able to crawl on rough surfaces such as wood (ν = 10.0±0.2 cm/s using 30° fiber pad). Fiberbot, a low-cost vibration robot equipped with a custom-designed fiber pad with steering and climbing capabilities could be used for studies on collective behavior on a wide range of topographies as well as search and exploratory missions.

pi Han, Y., Marvi, H., Sitti, M. Fiberbot: A miniature crawling robot using a directional fibrillar pad In Robotics and Automation (ICRA), 2015 IEEE International Conference on, pages: 3122-3127, May 2015 (inproceedings)

Platform design and tethered flight of a motor-driven flapping-wing system

Hines, L., Colmenares, D., Sitti, M.

In Robotics and Automation (ICRA), 2015 IEEE International Conference on, pages: 5838-5845, May 2015 (inproceedings)

Abstract

In this work, we examine two design modifications to a tethered motor-driven flapping-wing system. Previously, we had demonstrated a simple mechanism utilizing a linear transmission for resonant operation and direct drive of the wing flapping angle for control. The initial two-wing system had a weight of 2.7 grams and a maximum lift-to-weight ratio of 1.4. While capable of vertical takeoff, in open-loop flight it demonstrated instability and pitch oscillations at the wing flapping frequency, leading to flight times of only a few wing strokes. Here the effect of vertical wing offset as well as an alternative multi-wing layout is investigated and experimentally tested with newly constructed prototypes. With only a change in vertical wing offset, stable open-loop flight of the two-wing flapping system is shown to be theoretically possible, but difficult to achieve with our current design and operating parameters. Both of the new two and four-wing systems, however, prove capable of flying to the end of the tether, with the four-wing system prototype eliminating disruptive wing beat oscillations.

pi Hines, L., Colmenares, D., Sitti, M. Platform design and tethered flight of a motor-driven flapping-wing system In Robotics and Automation (ICRA), 2015 IEEE International Conference on, pages: 5838-5845, May 2015 (inproceedings)

Structural optimization for flexure-based parallel mechanisms–Towards achieving optimal dynamic and stiffness properties

Lum, G. Z., Teo, T. J., Yeo, S. H., Yang, G., Sitti, M.

Precision Engineering, 42, pages: 195-207, Elsevier, May 2015 (article)

Abstract

Flexure-based parallel mechanisms (FPMs) are a type of compliant mechanisms that consist of a rigid end-effector that is articulated by several parallel, flexible limbs (a.k.a. sub-chains). Existing design methods can enhance the FPMs’ dynamic and stiffness properties by conducting a size optimization on their sub-chains. A similar optimization process, however, was not performed for their sub-chains’ topology, and this may severely limit the benefits of a size optimization. Thus, this paper proposes to use a structural optimization approach to synthesize and optimize the topology, shape and size of the FPMs’ sub-chains. The benefits of this approach are demonstrated via the design and development of a planar X − Y − θz FPM. A prototype of this FPM was evaluated experimentally to have a large workspace of 1.2 mm × 1.2 mm × 6°, a fundamental natural frequency of 102 Hz, and stiffness ratios that are greater than 120. The achieved properties show significant improvement over existing 3-degrees-of-freedom compliant mechanisms that can deflect more than 0.5 mm and 0.5°. These compliant mechanisms typically have stiffness ratios that are less than 60 and a fundamental natural frequency that is less than 45 Hz.

pi Lum, G. Z., Teo, T. J., Yeo, S. H., Yang, G., Sitti, M. Structural optimization for flexure-based parallel mechanisms–Towards achieving optimal dynamic and stiffness properties Precision Engineering, 42, pages: 195-207, Elsevier, May 2015 (article)

Controlled surface topography regulates collective 3D migration by epithelial–mesenchymal composite embryonic tissues

Song, J., Shawky, J. H., Kim, Y., Hazar, M., LeDuc, P. R., Sitti, M., Davidson, L. A.

Biomaterials, 58, pages: 1-9, Elsevier, April 2015 (article)

Abstract

Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topography. Most studies on surface topography and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multi-cellular tissues to topographical cues. Here, we examine the response to complex topographical cues of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis. We control topography using fabricated micropost arrays (MPAs) and investigate the collective 3D migration of these multi-cellular systems in these MPAs. We find that the topography regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing of the MPAs we uncover how 3D topographical cues disrupt collective cell migration. We find surface topography can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

pi Song, J., Shawky, J. H., Kim, Y., Hazar, M., LeDuc, P. R., Sitti, M., Davidson, L. A. Controlled surface topography regulates collective 3D migration by epithelial–mesenchymal composite embryonic tissues Biomaterials, 58, pages: 1-9, Elsevier, April 2015 (article)

Transfer Printing of Metallic Microstructures on Adhesion-Promoting Hydrogel Substrates

Wu, H., Sariola, V., Zhu, C., Zhao, J., Sitti, M., Bettinger, C. J.

Advanced Materials, 27(22):3398-3404, April 2015 (article)

Abstract

Fabrication schemes that integrate inorganic microstructures with hydrogel substrates are essential for advancing flexible electronics. A transfer printing process that is made possible through the design and synthesis of adhesion-promoting hydrogels as target substrates is reported. This fabrication technique may advance ultracompliant electronics by melding microfabricated structures with swollen hydrogel substrates.

pi Wu, H., Sariola, V., Zhu, C., Zhao, J., Sitti, M., Bettinger, C. J. Transfer Printing of Metallic Microstructures on Adhesion-Promoting Hydrogel Substrates Advanced Materials, 27(22):3398-3404, April 2015 (article)

Dry adhesives and methods for making dry adhesives

Sitti, M., Murphy, M., Aksak, B.

March 2015, US Patent App. 14/625,162 (patent)

Abstract

Dry adhesives and methods for forming dry adhesives. A method of forming a dry adhesive structure on a substrate, comprises: forming a template backing layer of energy sensitive material on the substrate; forming a template layer of energy sensitive material on the template backing layer; exposing the template layer to a predetermined pattern of energy; removing a portion of the template layer related to the predetermined pattern of energy, and leaving a template structure formed from energy sensitive material and connected to the substrate via the template backing layer.

pi Sitti, M., Murphy, M., Aksak, B. Dry adhesives and methods for making dry adhesives March 2015, US Patent App. 14/625,162 (patent)

Biomedical applications of untethered mobile milli/microrobots

Sitti, M., Ceylan, H., Hu, W., Giltinan, J., Turan, M., Yim, S., Diller, E.

Proceedings of the IEEE, 103(2):205-224, IEEE, March 2015 (article)

Abstract

Untethered robots miniaturized to the length scale of millimeter and below attract growing attention for the prospect of transforming many aspects of health care and bioengineering. As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations. This unprecedented direct access would enable an extensive range of minimally invasive medical operations. Here, we provide a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots. We put a special emphasis on the potential impacts of biomedical microrobots in the near future. Finally, we discuss the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.

pi Sitti, M., Ceylan, H., Hu, W., Giltinan, J., Turan, M., Yim, S., Diller, E. Biomedical applications of untethered mobile milli/microrobots Proceedings of the IEEE, 103(2):205-224, IEEE, March 2015 (article)

Collective 3D Migration of Embryonic Epithelial Mesenchymal Composite Tissues are Regulated by Surface Topology

Song, J., Shawky, J., Kim, Y. T., Hazar, M., Sitti, M., LeDuc, P. R., Davidson, L. A.

Biophysical Journal, 108(2):455a, Elsevier, January 2015 (article)

Abstract

Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topology. Most studies on surface topology and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multicellular tissues to topological cues. Here, we examine the behaviors of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis to complex topological cues. We control topology using fabricated micropost arrays (MPAs) with different diameters (e.g., different spacing gaps) and investigate the collective 3D migration of these multicellular systems in these MPAs. Our topographical controlled approach for cellular application enables us to achieve a high degree of control over micropost positioning and geometry via simple, accurate, and repeatable microfabrication processes. We find that the topology regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing within MPAs we discover a role for topology in disrupting collective enhancement of cell migration. We find 3D topological cues can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

pi Song, J., Shawky, J., Kim, Y. T., Hazar, M., Sitti, M., LeDuc, P. R., Davidson, L. A. Collective 3D Migration of Embryonic Epithelial Mesenchymal Composite Tissues are Regulated by Surface Topology Biophysical Journal, 108(2):455a, Elsevier, January 2015 (article)

Three-dimensional heterogeneous assembly of coded microgels using an untethered mobile microgripper

Chung, S. E., Dong, X., Sitti, M.

Lab on a Chip, 15(7):1667-1676, Royal Society of Chemistry, January 2015 (article)

Abstract

Three-dimensional (3D) heterogeneous assembly of coded microgels in enclosed aquatic environments is demonstrated using a remotely actuated and controlled magnetic microgripper by a customized electromagnetic coil system. The microgripper uses different ‘stick–slip’ and ‘rolling’ locomotion in 2D and also levitation in 3D by magnetic gradient-based pulling force. This enables the microrobot to precisely manipulate each microgel by controlling its position and orientation in all x–y–z directions. Our microrobotic assembly method broke the barrier of limitation on the number of assembled microgel layers, because it enabled precise 3D levitation of the microgripper. We used the gripper to assemble microgels that had been coded with different colours and shapes onto prefabricated polymeric microposts. This eliminates the need for extra secondary cross-linking to fix the final construct. We demonstrated assembly of microgels on a single micropost up to ten layers. By increasing the number and changing the distribution of the posts, complex heterogeneous microsystems were possible to construct in 3D.