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2018


Thumb xl screenshot 2018 5 9 swimming back and forth using planar flagellar propulsion at low reynolds numbers   khalil   2018   adv ...
Swimming Back and Forth Using Planar Flagellar Propulsion at Low Reynolds Numbers

Khalil, I. S. M., Tabak, A. F., Hamed, Y., Mitwally, M. E., Tawakol, M., Klingner, A., Sitti, M.

Advanced Science, 5(2):1700461, 2018 (article)

Abstract
Abstract Peritrichously flagellated Escherichia coli swim back and forth by wrapping their flagella together in a helical bundle. However, other monotrichous bacteria cannot swim back and forth with a single flagellum and planar wave propagation. Quantifying this observation, a magnetically driven soft two‐tailed microrobot capable of reversing its swimming direction without making a U‐turn trajectory or actively modifying the direction of wave propagation is designed and developed. The microrobot contains magnetic microparticles within the polymer matrix of its head and consists of two collinear, unequal, and opposite ultrathin tails. It is driven and steered using a uniform magnetic field along the direction of motion with a sinusoidally varying orthogonal component. Distinct reversal frequencies that enable selective and independent excitation of the first or the second tail of the microrobot based on their tail length ratio are found. While the first tail provides a propulsive force below one of the reversal frequencies, the second is almost passive, and the net propulsive force achieves flagellated motion along one direction. On the other hand, the second tail achieves flagellated propulsion along the opposite direction above the reversal frequency.

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link (url) DOI [BibTex]

2018


link (url) DOI [BibTex]


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Reducing 3D Vibrations to 1D in Real Time

Park, G., Kuchenbecker, K. J.

Hands-on demonstration (4 pages) presented at AsiaHaptics, Incheon, South Korea, November 2018 (misc)

Abstract
For simple and realistic vibrotactile feedback, 3D accelerations from real contact interactions are usually rendered using a single-axis vibration actuator; this dimensional reduction can be performed in many ways. This demonstration implements a real-time conversion system that simultaneously measures 3D accelerations and renders corresponding 1D vibrations using a two-pen interface. In the demonstration, a user freely interacts with various objects using an In-Pen that contains a 3-axis accelerometer. The captured accelerations are converted to a single-axis signal, and an Out-Pen renders the reduced signal for the user to feel. We prepared seven conversion methods from the simple use of a single-axis signal to applying principal component analysis (PCA) so that users can compare the performance of each conversion method in this demonstration.

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Project Page [BibTex]

Project Page [BibTex]


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A Large-Scale Fabric-Based Tactile Sensor Using Electrical Resistance Tomography

Lee, H., Park, K., Kim, J., Kuchenbecker, K. J.

Hands-on demonstration (3 pages) presented at AsiaHaptics, Incheon, South Korea, November 2018 (misc)

Abstract
Large-scale tactile sensing is important for household robots and human-robot interaction because contacts can occur all over a robot’s body surface. This paper presents a new fabric-based tactile sensor that is straightforward to manufacture and can cover a large area. The tactile sensor is made of conductive and non-conductive fabric layers, and the electrodes are stitched with conductive thread, so the resulting device is flexible and stretchable. The sensor utilizes internal array electrodes and a reconstruction method called electrical resistance tomography (ERT) to achieve a high spatial resolution with a small number of electrodes. The developed sensor shows that only 16 electrodes can accurately estimate single and multiple contacts over a square that measures 20 cm by 20 cm.

hi

Project Page [BibTex]

Project Page [BibTex]


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Universal Custom Complex Magnetic Spring Design Methodology

Woodward, M. A., Sitti, M.

IEEE Transactions on Magnetics, 54(1):1-13, October 2018 (article)

Abstract
A design methodology is presented for creating custom complex magnetic springs through the design of force-displacement curves. This methodology results in a magnet configuration, which will produce a desired force-displacement relationship. Initially, the problem is formulated and solved as a system of linear equations. Then, given the limited likelihood of a single solution being feasibly manufactured, key parameters of the solution are extracted and varied to create a family of solutions. Finally, these solutions are refined using numerical optimization. Given the properties of magnets, this methodology can create any well-defined function of force versus displacement and is model-independent. To demonstrate this flexibility, a number of example magnetic springs are designed; one of which, designed for use in a jumping-gliding robot's shape memory alloy actuated clutch, is manufactured and experimentally characterized. Due to the scaling of magnetic forces, the displacement region which these magnetic springs are most applicable is that of millimeters and below. However, this region is well situated for miniature robots and smart material actuators, where a tailored magnetic spring, designed to compliment a component, can enhance its performance while adding new functionality. The methodology is also expendable to variable interactions and multi-dimensional magnetic field design.

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DOI [BibTex]

DOI [BibTex]


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Softness, Warmth, and Responsiveness Improve Robot Hugs

Block, A. E., Kuchenbecker, K. J.

International Journal of Social Robotics, 11(1):49-64, October 2018 (article)

Abstract
Hugs are one of the first forms of contact and affection humans experience. Due to their prevalence and health benefits, roboticists are naturally interested in having robots one day hug humans as seamlessly as humans hug other humans. This project's purpose is to evaluate human responses to different robot physical characteristics and hugging behaviors. Specifically, we aim to test the hypothesis that a soft, warm, touch-sensitive PR2 humanoid robot can provide humans with satisfying hugs by matching both their hugging pressure and their hugging duration. Thirty relatively young and rather technical participants experienced and evaluated twelve hugs with the robot, divided into three randomly ordered trials that focused on physical robot characteristics (single factor, three levels) and nine randomly ordered trials with low, medium, and high hug pressure and duration (two factors, three levels each). Analysis of the results showed that people significantly prefer soft, warm hugs over hard, cold hugs. Furthermore, users prefer hugs that physically squeeze them and release immediately when they are ready for the hug to end. Taking part in the experiment also significantly increased positive user opinions of robots and robot use.

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link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Discovering and Teaching Optimal Planning Strategies

Lieder, F., Callaway, F., Krueger, P. M., Das, P., Griffiths, T. L., Gul, S.

In The 14th biannual conference of the German Society for Cognitive Science, GK, September 2018 (inproceedings)

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Project Page [BibTex]

Project Page [BibTex]


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Discovering Rational Heuristics for Risky Choice

Gul, S., Krueger, P. M., Callaway, F., Griffiths, T. L., Lieder, F.

The 14th biannual conference of the German Society for Cognitive Science, GK, The 14th biannual conference of the German Society for Cognitive Science, GK, September 2018 (conference)

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Project Page [BibTex]

Project Page [BibTex]


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Statistical Modelling of Fingertip Deformations and Contact Forces during Tactile Interaction

Gueorguiev, D., Tzionas, D., Pacchierotti, C., Black, M. J., Kuchenbecker, K. J.

Extended abstract presented at the Hand, Brain and Technology conference (HBT), Ascona, Switzerland, August 2018 (misc)

Abstract
Little is known about the shape and properties of the human finger during haptic interaction, even though these are essential parameters for controlling wearable finger devices and deliver realistic tactile feedback. This study explores a framework for four-dimensional scanning (3D over time) and modelling of finger-surface interactions, aiming to capture the motion and deformations of the entire finger with high resolution while simultaneously recording the interfacial forces at the contact. Preliminary results show that when the fingertip is actively pressing a rigid surface, it undergoes lateral expansion and proximal/distal bending, deformations that cannot be captured by imaging of the contact area alone. Therefore, we are currently capturing a dataset that will enable us to create a statistical model of the finger’s deformations and predict the contact forces induced by tactile interaction with objects. This technique could improve current methods for tactile rendering in wearable haptic devices, which rely on general physical modelling of the skin’s compliance, by developing an accurate model of the variations in finger properties across the human population. The availability of such a model will also enable a more realistic simulation of virtual finger behaviour in virtual reality (VR) environments, as well as the ability to accurately model a specific user’s finger from lower resolution data. It may also be relevant for inferring the physical properties of the underlying tissue from observing the surface mesh deformations, as previously shown for body tissues.

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Project Page [BibTex]

Project Page [BibTex]


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Instrumentation, Data, and Algorithms for Visually Understanding Haptic Surface Properties

Burka, A. L.

University of Pennsylvania, Philadelphia, USA, August 2018, Department of Electrical and Systems Engineering (phdthesis)

Abstract
Autonomous robots need to efficiently walk over varied surfaces and grasp diverse objects. We hypothesize that the association between how such surfaces look and how they physically feel during contact can be learned from a database of matched haptic and visual data recorded from various end-effectors' interactions with hundreds of real-world surfaces. Testing this hypothesis required the creation of a new multimodal sensing apparatus, the collection of a large multimodal dataset, and development of a machine-learning pipeline. This thesis begins by describing the design and construction of the Portable Robotic Optical/Tactile ObservatioN PACKage (PROTONPACK, or Proton for short), an untethered handheld sensing device that emulates the capabilities of the human senses of vision and touch. Its sensory modalities include RGBD vision, egomotion, contact force, and contact vibration. Three interchangeable end-effectors (a steel tooling ball, an OptoForce three-axis force sensor, and a SynTouch BioTac artificial fingertip) allow for different material properties at the contact point and provide additional tactile data. We then detail the calibration process for the motion and force sensing systems, as well as several proof-of-concept surface discrimination experiments that demonstrate the reliability of the device and the utility of the data it collects. This thesis then presents a large-scale dataset of multimodal surface interaction recordings, including 357 unique surfaces such as furniture, fabrics, outdoor fixtures, and items from several private and public material sample collections. Each surface was touched with one, two, or three end-effectors, comprising approximately one minute per end-effector of tapping and dragging at various forces and speeds. We hope that the larger community of robotics researchers will find broad applications for the published dataset. Lastly, we demonstrate an algorithm that learns to estimate haptic surface properties given visual input. Surfaces were rated on hardness, roughness, stickiness, and temperature by the human experimenter and by a pool of purely visual observers. Then we trained an algorithm to perform the same task as well as infer quantitative properties calculated from the haptic data. Overall, the task of predicting haptic properties from vision alone proved difficult for both humans and computers, but a hybrid algorithm using a deep neural network and a support vector machine achieved a correlation between expected and actual regression output between approximately ρ = 0.3 and ρ = 0.5 on previously unseen surfaces.

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Project Page [BibTex]

Project Page [BibTex]


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Programmable collective behavior in dynamically self-assembled mobile microrobotic swarms

B Yigit, , Y Alapan, , Sitti, M.

Advanced Science, July 2018 (article)

Abstract
Collective control of mobile microrobotic swarms is indispensable for their potential high-impact applications in targeted drug delivery, medical diagnostics, parallel micromanipulation, and environmental sensing and remediation. Lack of on-board computational and sensing capabilities in current microrobotic systems necessitates use of physical interactions among individual microrobots for local physical communication and cooperation. Here, we show that mobile microrobotic swarms with well-defined collective behavior can be designed by engineering magnetic interactions among individual units. Microrobots, consisting of a linear chain of self-assembled magnetic microparticles, locomote on surfaces in response to a precessing magnetic field. Control over the direction of precessing magnetic field allows engineering attractive and repulsive interactions among microrobots and, thus, collective order with well-defined spatial organization and parallel operation over macroscale distances (~ 1 cm). These microrobotic swarms can be guided through confined spaces, while preserving microrobot morphology and function. These swarms can further achieve directional transport of large cargoes on surfaces and small cargoes in bulk fluids. Described design approach, exploiting physical interactions among individual robots, enables facile and rapid formation of self-organized and reconfigurable microrobotic swarms with programmable collective order.

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link (url) [BibTex]


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3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Hakan Ceylan, , I. Ceren Yasa, , Oncay Yasa, , Ahmet Fatih Tabak, , Joshua Giltinan, , Sitti, M.

bioRxiv, pages: 379024, July 2018 (article)

Abstract
Miniaturization of interventional medical devices can leverage minimally invasive technologies by enabling operational resolution at cellular length scales with high precision and repeatability. Untethered micron-scale mobile robots can realize this by navigating and performing in hard-to-reach, confined and delicate inner body sites. However, such a complex task requires an integrated design and engineering strategy, where powering, control, environmental sensing, medical functionality and biodegradability need to be considered altogether. The present study reports a hydrogel-based, biodegradable microrobotic swimmer, which is responsive to the changes in its microenvironment for theranostic cargo delivery and release tasks. We design a double-helical magnetic microswimmer of 20 micrometers length, which is 3D-printed with complex geometrical and compositional features. At normal physiological concentrations, matrix metalloproteinase-2 (MMP-2) enzyme can entirely degrade the microswimmer body in 118 h to solubilized non-toxic products. The microswimmer can respond to the pathological concentrations of MMP-2 by swelling and thereby accelerating the release kinetics of the drug payload. Anti-ErbB 2 antibody-tagged magnetic nanoparticles released from the degraded microswimmers serve for targeted labeling of SKBR3 breast cancer cells to realize the potential of medical imaging of local tissue sites following the therapeutic intervention. These results represent a leap forward toward clinical medical microrobots that are capable of sensing, responding to the local pathological information, and performing specific therapeutic and diagnostic tasks as orderly executed operations using their smart composite material architectures.

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DOI Project Page [BibTex]


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Robust Visual Augmented Reality in Robot-Assisted Surgery

Forte, M. P.

Politecnico di Milano, Milan, Italy, July 2018, Department of Electronic, Information, and Biomedical Engineering (mastersthesis)

Abstract
The broader research objective of this line of research is to test the hypothesis that real-time stereo video analysis and augmented reality can increase safety and task efficiency in robot-assisted surgery. This master’s thesis aims to solve the first step needed to achieve this goal: the creation of a robust system that delivers the envisioned feedback to a surgeon while he or she controls a surgical robot that is identical to those used on human patients. Several approaches for applying augmented reality to da Vinci Surgical Systems have been proposed, but none of them entirely rely on a clinical robot; specifically, they require additional sensors, depend on access to the da Vinci API, are designed for a very specific task, or were tested on systems that are starkly different from those in clinical use. There has also been prior work that presents the real-world camera view and the computer graphics on separate screens, or not in real time. In other scenarios, the digital information is overlaid manually by the surgeons themselves or by computer scientists, rather than being generated automatically in response to the surgeon’s actions. We attempted to overcome the aforementioned constraints by acquiring input signals from the da Vinci stereo endoscope and providing augmented reality to the console in real time (less than 150 ms delay, including the 62 ms of inherent latency of the da Vinci). The potential benefits of the resulting system are broad because it was built to be general, rather than customized for any specific task. The entire platform is compatible with any generation of the da Vinci System and does not require a dVRK (da Vinci Research Kit) or access to the API. Thus, it can be applied to existing da Vinci Systems in operating rooms around the world.

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Project Page [BibTex]

Project Page [BibTex]


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Task-Driven PCA-Based Design Optimization of Wearable Cutaneous Devices

Pacchierotti, C., Young, E. M., Kuchenbecker, K. J.

IEEE Robotics and Automation Letters, 3(3):2214-2221, July 2018, Presented at ICRA 2018 (article)

Abstract
Small size and low weight are critical requirements for wearable and portable haptic interfaces, making it essential to work toward the optimization of their sensing and actuation systems. This paper presents a new approach for task-driven design optimization of fingertip cutaneous haptic devices. Given one (or more) target tactile interactions to render and a cutaneous device to optimize, we evaluate the minimum number and best configuration of the device’s actuators to minimize the estimated haptic rendering error. First, we calculate the motion needed for the original cutaneous device to render the considered target interaction. Then, we run a principal component analysis (PCA) to search for possible couplings between the original motor inputs, looking also for the best way to reconfigure them. If some couplings exist, we can re-design our cutaneous device with fewer motors, optimally configured to render the target tactile sensation. The proposed approach is quite general and can be applied to different tactile sensors and cutaneous devices. We validated it using a BioTac tactile sensor and custom plate-based 3-DoF and 6-DoF fingertip cutaneous devices, considering six representative target tactile interactions. The algorithm was able to find couplings between each device’s motor inputs, proving it to be a viable approach to optimize the design of wearable and portable cutaneous devices. Finally, we present two examples of optimized designs for our 3-DoF fingertip cutaneous device.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Teaching a Robot Bimanual Hand-Clapping Games via Wrist-Worn IMUs

Fitter, N. T., Kuchenbecker, K. J.

Frontiers in Robotics and Artificial Intelligence, 5(85), July 2018 (article)

Abstract
Colleagues often shake hands in greeting, friends connect through high fives, and children around the world rejoice in hand-clapping games. As robots become more common in everyday human life, they will have the opportunity to join in these social-physical interactions, but few current robots are intended to touch people in friendly ways. This article describes how we enabled a Baxter Research Robot to both teach and learn bimanual hand-clapping games with a human partner. Our system monitors the user's motions via a pair of inertial measurement units (IMUs) worn on the wrists. We recorded a labeled library of 10 common hand-clapping movements from 10 participants; this dataset was used to train an SVM classifier to automatically identify hand-clapping motions from previously unseen participants with a test-set classification accuracy of 97.0%. Baxter uses these sensors and this classifier to quickly identify the motions of its human gameplay partner, so that it can join in hand-clapping games. This system was evaluated by N = 24 naïve users in an experiment that involved learning sequences of eight motions from Baxter, teaching Baxter eight-motion game patterns, and completing a free interaction period. The motion classification accuracy in this less structured setting was 85.9%, primarily due to unexpected variations in motion timing. The quantitative task performance results and qualitative participant survey responses showed that learning games from Baxter was significantly easier than teaching games to Baxter, and that the teaching role caused users to consider more teamwork aspects of the gameplay. Over the course of the experiment, people felt more understood by Baxter and became more willing to follow the example of the robot. Users felt uniformly safe interacting with Baxter, and they expressed positive opinions of Baxter and reported fun interacting with the robot. Taken together, the results indicate that this robot achieved credible social-physical interaction with humans and that its ability to both lead and follow systematically changed the human partner's experience.

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DOI [BibTex]

DOI [BibTex]


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Innate turning preference of leaf-cutting ants in the absence of external orientation cues

Endlein, T., Sitti, M.

Journal of Experimental Biology, The Company of Biologists Ltd, June 2018 (article)

Abstract
Many ants use a combination of cues for orientation but how do ants find their way when all external cues are suppressed? Do they walk in a random way or are their movements spatially oriented? Here we show for the first time that leaf-cutting ants (Acromyrmex lundii) have an innate preference of turning counter-clockwise (left) when external cues are precluded. We demonstrated this by allowing individual ants to run freely on the water surface of a newly-developed treadmill. The surface tension supported medium-sized workers but effectively prevented ants from reaching the wall of the vessel, important to avoid wall-following behaviour (thigmotaxis). Most ants ran for minutes on the spot but also slowly turned counter-clockwise in the absence of visual cues. Reconstructing the effectively walked path revealed a looping pattern which could be interpreted as a search strategy. A similar turning bias was shown for groups of ants in a symmetrical Y-maze where twice as many ants chose the left branch in the absence of optical cues. Wall-following behaviour was tested by inserting a coiled tube before the Y-fork. When ants traversed a left-coiled tube, more ants chose the left box and vice versa. Adding visual cues in form of vertical black strips either outside the treadmill or on one branch of the Y-maze led to oriented walks towards the strips. It is suggested that both, the turning bias and the wall-following are employed as search strategies for an unknown environment which can be overridden by visual cues.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Motility and chemotaxis of bacteria-driven microswimmers fabricated using antigen 43-mediated biotin display

Schauer, O., Mostaghaci, B., Colin, R., Hürtgen, D., Kraus, D., Sitti, M., Sourjik, V.

Scientific Reports, 8(1):9801, Nature Publishing Group, June 2018 (article)

Abstract
Bacteria-driven biohybrid microswimmers (bacteriabots) combine synthetic cargo with motile living bacteria that enable propulsion and steering. Although fabrication and potential use of such bacteriabots have attracted much attention, existing methods of fabrication require an extensive sample preparation that can drastically decrease the viability and motility of bacteria. Moreover, chemotactic behavior of bacteriabots in a liquid medium with chemical gradients has remained largely unclear. To overcome these shortcomings, we designed Escherichia coli to autonomously display biotin on its cell surface via the engineered autotransporter antigen 43 and thus to bind streptavidin-coated cargo. We show that the cargo attachment to these bacteria is greatly enhanced by motility and occurs predominantly at the cell poles, which is greatly beneficial for the fabrication of motile bacteriabots. We further performed a systemic study to understand and optimize the ability of these bacteriabots to follow chemical gradients. We demonstrate that the chemotaxis of bacteriabots is primarily limited by the cargo-dependent reduction of swimming speed and show that the fabrication of bacteriabots using elongated E. coli cells can be used to overcome this limitation.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Multifunctional ferrofluid-infused surfaces with reconfigurable multiscale topography

Wang, W., Timonen, J. V. I., Carlson, A., Drotlef, D., Zhang, C. T., Kolle, S., Grinthal, A., Wong, T., Hatton, B., Kang, S. H., Kennedy, S., Chi, J., Blough, R. T., Sitti, M., Mahadevan, L., Aizenberg, J.

Nature, June 2018 (article)

Abstract
Developing adaptive materials with geometries that change in response to external stimuli provides fundamental insights into the links between the physical forces involved and the resultant morphologies and creates a foundation for technologically relevant dynamic systems1,2. In particular, reconfigurable surface topography as a means to control interfacial properties 3 has recently been explored using responsive gels 4 , shape-memory polymers 5 , liquid crystals6-8 and hybrid composites9-14, including magnetically active slippery surfaces12-14. However, these designs exhibit a limited range of topographical changes and thus a restricted scope of function. Here we introduce a hierarchical magneto-responsive composite surface, made by infiltrating a ferrofluid into a microstructured matrix (termed ferrofluid-containing liquid-infused porous surfaces, or FLIPS). We demonstrate various topographical reconfigurations at multiple length scales and a broad range of associated emergent behaviours. An applied magnetic-field gradient induces the movement of magnetic nanoparticles suspended in the ferrofluid, which leads to microscale flow of the ferrofluid first above and then within the microstructured surface. This redistribution changes the initially smooth surface of the ferrofluid (which is immobilized by the porous matrix through capillary forces) into various multiscale hierarchical topographies shaped by the size, arrangement and orientation of the confining microstructures in the magnetic field. We analyse the spatial and temporal dynamics of these reconfigurations theoretically and experimentally as a function of the balance between capillary and magnetic pressures15-19 and of the geometric anisotropy of the FLIPS system. Several interesting functions at three different length scales are demonstrated: self-assembly of colloidal particles at the micrometre scale; regulated flow of liquid droplets at the millimetre scale; and switchable adhesion and friction, liquid pumping and removal of biofilms at the centimetre scale. We envision that FLIPS could be used as part of integrated control systems for the manipulation and transport of matter, thermal management, microfluidics and fouling-release materials.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Reducing 3D Vibrations to 1D in Real Time

Park, G., Kuchenbecker, K. J.

Hands-on demonstration presented at EuroHaptics, Pisa, Italy, June 2018 (misc)

Abstract
In this demonstration, you will hold two pen-shaped modules: an in-pen and an out-pen. The in-pen is instrumented with a high-bandwidth three-axis accelerometer, and the out-pen contains a one-axis voice coil actuator. Use the in-pen to interact with different surfaces; the measured 3D accelerations are continually converted into 1D vibrations and rendered with the out-pen for you to feel. You can test conversion methods that range from simply selecting a single axis to applying a discrete Fourier transform or principal component analysis for realistic and brisk real-time conversion.

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Project Page [BibTex]

Project Page [BibTex]


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Haptipedia: Exploring Haptic Device Design Through Interactive Visualizations

Seifi, H., Fazlollahi, F., Park, G., Kuchenbecker, K. J., MacLean, K. E.

Hands-on demonstration presented at EuroHaptics, Pisa, Italy, June 2018 (misc)

Abstract
How many haptic devices have been proposed in the last 30 years? How can we leverage this rich source of design knowledge to inspire future innovations? Our goal is to make historical haptic invention accessible through interactive visualization of a comprehensive library – a Haptipedia – of devices that have been annotated with designer-relevant metadata. In this demonstration, participants can explore Haptipedia’s growing library of grounded force feedback devices through several prototype visualizations, interact with 3D simulations of the device mechanisms and movements, and tell us about the attributes and devices that could make Haptipedia a useful resource for the haptic design community.

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Project Page [BibTex]

Project Page [BibTex]


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Delivering 6-DOF Fingertip Tactile Cues

Young, E., Kuchenbecker, K. J.

Work-in-progress paper (5 pages) presented at EuroHaptics, Pisa, Italy, June 2018 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


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Designing a Haptic Empathetic Robot Animal for Children with Autism

Burns, R., Kuchenbecker, K. J.

Workshop paper (4 pages) presented at the Robotics: Science and Systems Workshop on Robot-Mediated Autism Intervention: Hardware, Software and Curriculum, Pittsburgh, USA, June 2018 (misc)

Abstract
Children with autism often endure sensory overload, may be nonverbal, and have difficulty understanding and relaying emotions. These experiences result in heightened stress during social interaction. Animal-assisted intervention has been found to improve the behavior of children with autism during social interaction, but live animal companions are not always feasible. We are thus in the process of designing a robotic animal to mimic some successful characteristics of animal-assisted intervention while trying to improve on others. The over-arching hypothesis of this research is that an appropriately designed robot animal can reduce stress in children with autism and empower them to engage in social interaction.

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link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Soft Multi-Axis Boundary-Electrode Tactile Sensors for Whole-Body Robotic Skin

Lee, H., Kim, J., Kuchenbecker, K. J.

Workshop paper (2 pages) presented at the RSS Pioneers Workshop, Pittsburgh, USA, June 2018 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


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Self-Sensing Paper Actuators Based on Graphite–Carbon Nanotube Hybrid Films

Amjadi, M., Sitti, M.

Advanced Science, pages: 1800239, May 2018 (article)

Abstract
Abstract Soft actuators have demonstrated potential in a range of applications, including soft robotics, artificial muscles, and biomimetic devices. However, the majority of current soft actuators suffer from the lack of real-time sensory feedback, prohibiting their effective sensing and multitask function. Here, a promising strategy is reported to design bilayer electrothermal actuators capable of simultaneous actuation and sensation (i.e., self-sensing actuators), merely through two input electric terminals. Decoupled electrothermal stimulation and strain sensation is achieved by the optimal combination of graphite microparticles and carbon nanotubes (CNTs) in the form of hybrid films. By finely tuning the charge transport properties of hybrid films, the signal-to-noise ratio (SNR) of self-sensing actuators is remarkably enhanced to over 66. As a result, self-sensing actuators can actively track their displacement and distinguish the touch of soft and hard objects.

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link (url) DOI Project Page [BibTex]


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Haptics and Haptic Interfaces

Kuchenbecker, K. J.

In Encyclopedia of Robotics, (Editors: Marcelo H. Ang and Oussama Khatib and Bruno Siciliano), Springer, May 2018 (incollection)

Abstract
Haptics is an interdisciplinary field that seeks to both understand and engineer touch-based interaction. Although a wide range of systems and applications are being investigated, haptics researchers often concentrate on perception and manipulation through the human hand. A haptic interface is a mechatronic system that modulates the physical interaction between a human and his or her tangible surroundings. Haptic interfaces typically involve mechanical, electrical, and computational layers that work together to sense user motions or forces, quickly process these inputs with other information, and physically respond by actuating elements of the user’s surroundings, thereby enabling him or her to act on and feel a remote and/or virtual environment.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Soft erythrocyte-based bacterial microswimmers for cargo delivery

Alapan, Y., Yasa, O., Schauer, O., Giltinan, J., Tabak, A. F., Sourjik, V., Sitti, M.

Science Robotics, 3(17):eaar4423, Science Robotics, April 2018 (article)

Abstract
Bacteria-propelled biohybrid microswimmers have recently shown to be able to actively transport and deliver cargos encapsulated into their synthetic constructs to specific regions locally. However, usage of synthetic materials as cargo carriers can result in inferior performance in load-carrying efficiency, biocompatibility, and biodegradability, impeding clinical translation of biohybrid microswimmers. Here, we report construction and external guidance of bacteria-driven microswimmers using red blood cells (RBCs; erythrocytes) as autologous cargo carriers for active and guided drug delivery. Multifunctional biohybrid microswimmers were fabricated by attachment of RBCs [loaded with anticancer doxorubicin drug molecules and superparamagnetic iron oxide nanoparticles (SPIONs)] to bioengineered motile bacteria, Escherichia coli MG1655, via biotin-avidin-biotin binding complex. Autonomous and on-board propulsion of biohybrid microswimmers was provided by bacteria, and their external magnetic guidance was enabled by SPIONs loaded into the RBCs. Furthermore, bacteria-driven RBC microswimmers displayed preserved deformability and attachment stability even after squeezing in microchannels smaller than their sizes, as in the case of bare RBCs. In addition, an on-demand light-activated hyperthermia termination switch was engineered for RBC microswimmers to control bacteria population after operations. RBCs, as biological and autologous cargo carriers in the biohybrid microswimmers, offer notable advantages in stability, deformability, biocompatibility, and biodegradability over synthetic cargo-carrier materials. The biohybrid microswimmer design presented here transforms RBCs from passive cargo carriers into active and guidable cargo carriers toward targeted drug and other cargo delivery applications in medicine.

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link (url) DOI Project Page Project Page [BibTex]

link (url) DOI Project Page Project Page [BibTex]


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Automatically Rating Trainee Skill at a Pediatric Laparoscopic Suturing Task

Oquendo, Y. A., Riddle, E. W., Hiller, D., Blinman, T. A., Kuchenbecker, K. J.

Surgical Endoscopy, 32(4):1840-1857, April 2018 (article)

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DOI [BibTex]

DOI [BibTex]


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Miniature soft robots – road to the clinic

Sitti, M.

Nature Reviews Materials, April 2018 (article)

Abstract
Soft small robots offer the opportunity to non-invasively access human tissue to perform medical operations and deliver drugs; however, challenges in materials design, biocompatibility and function control remain to be overcome for soft robots to reach the clinic.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Wrinkling Instability and Adhesion of a Highly Bendable Gallium Oxide Nanofilm Encapsulating a Liquid-Gallium Droplet

Yunusa, M., Amador, G. J., Drotlef, D., Sitti, M.

Nano Letters, 18(4):2498-2504, March 2018 (article)

Abstract
The wrinkling and interfacial adhesion mechanics of a gallium-oxide nanofilm encapsulating a liquid-gallium droplet are presented. The native oxide nanofilm provides mechanical stability by preventing the flow of the liquid metal. We show how a crumpled oxide skin a few nanometers thick behaves akin to a highly bendable elastic nanofilm under ambient conditions. Upon compression, a wrinkling instability emerges at the contact interface to relieve the applied stress. As the load is further increased, radial wrinkles evolve, and, eventually, the oxide nanofilm ruptures. The observed wrinkling closely resembles the instability experienced by nanofilms under axisymmetric loading, thus providing further insights into the behaviors of elastic nanofilms. Moreover, the mechanical attributes of the oxide skin enable high surface conformation by exhibiting liquid-like behavior. We measured an adhesion energy of 0.238 ± 0.008 J m–2 between a liquid-gallium droplet and smooth flat glass, which is close to the measurements of thin-sheet nanomaterials such as graphene on silicon dioxide.

pi

link (url) DOI [BibTex]


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Magnetic-Visual Sensor Fusion-based Dense 3D Reconstruction and Localization for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Ornek, E. P., Araujo, H., Yanik, M. F., Sitti, M.

ArXiv e-prints, March 2018 (article)

Abstract
Reliable and real-time 3D reconstruction and localization functionality is a crucial prerequisite for the navigation of actively controlled capsule endoscopic robots as an emerging, minimally invasive diagnostic and therapeutic technology for use in the gastrointestinal (GI) tract. In this study, we propose a fully dense, non-rigidly deformable, strictly real-time, intraoperative map fusion approach for actively controlled endoscopic capsule robot applications which combines magnetic and vision-based localization, with non-rigid deformations based frame-to-model map fusion. The performance of the proposed method is demonstrated using four different ex-vivo porcine stomach models. Across different trajectories of varying speed and complexity, and four different endoscopic cameras, the root mean square surface reconstruction errors 1.58 to 2.17 cm.

pi

link (url) [BibTex]

link (url) [BibTex]


Thumb xl screenshot 2018 5 9 1803 01047 pdf
Unsupervised Odometry and Depth Learning for Endoscopic Capsule Robots

Turan, M., Ornek, E. P., Ibrahimli, N., Giracoglu, C., Almalioglu, Y., Yanik, M. F., Sitti, M.

ArXiv e-prints, March 2018 (article)

Abstract
In the last decade, many medical companies and research groups have tried to convert passive capsule endoscopes as an emerging and minimally invasive diagnostic technology into actively steerable endoscopic capsule robots which will provide more intuitive disease detection, targeted drug delivery and biopsy-like operations in the gastrointestinal(GI) tract. In this study, we introduce a fully unsupervised, real-time odometry and depth learner for monocular endoscopic capsule robots. We establish the supervision by warping view sequences and assigning the re-projection minimization to the loss function, which we adopt in multi-view pose estimation and single-view depth estimation network. Detailed quantitative and qualitative analyses of the proposed framework performed on non-rigidly deformable ex-vivo porcine stomach datasets proves the effectiveness of the method in terms of motion estimation and depth recovery.

pi

link (url) [BibTex]

link (url) [BibTex]


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Self‐Folded Hydrogel Tubes for Implantable Muscular Tissue Scaffolds

Vannozzi, L., Yasa, I. C., Ceylan, H., Menciassi, A., Ricotti, L., Sitti, M.

Macromolecular Bioscience, (0), March 2018 (article)

Abstract
Abstract Programming materials with tunable physical and chemical interactions among its components pave the way of generating 3D functional active microsystems with various potential applications in tissue engineering, drug delivery, and soft robotics. Here, the development of a recapitulated fascicle‐like implantable muscle construct by programmed self‐folding of poly(ethylene glycol) diacrylate hydrogels is reported. The system comprises two stacked layers, each with differential swelling degrees, stiffnesses, and thicknesses in 2D, which folds into a 3D tube together. Inside the tubes, muscle cell adhesion and their spatial alignment are controlled. Both skeletal and cardiac muscle cells also exhibit high viability, and cardiac myocytes preserve their contractile function over the course of 7 d. Integration of biological cells with smart, shape‐changing materials could give rise to the development of new cellular constructs for hierarchical tissue assembly, drug testing platforms, and biohybrid actuators that can perform sophisticated tasks.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

Sheykhansari, S., Kozielski, K., Bill, J., Sitti, M., Gemmati, D., Zamboni, P., Singh, A. V.

Cell Death \& Disease, 9(3):348, March 2018 (article)

Abstract
The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases' lesions. On the other hand, the role of other metals like cadmium participating indirectly in the redox cascade of neurobiological mechanism is less studied. In the second part of this review, we focus on this less conspicuous correlation between cadmium as an inactive-redox metal and multiple sclerosis and amyotrophic lateral sclerosis, providing novel treatment modalities and approaches as future prospects.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Cancer cells biomineralize ionic gold into nanoparticles-microplates via secreting defense proteins with specific gold-binding peptides

Singh, A. V., Jahnke, T., Kishore, V., Park, B., Batuwangala, M., Bill, J., Sitti, M.

Acta Biomaterialia, March 2018 (article)

Abstract
Cancer cells have the capacity to synthesize nanoparticles (NPs). The detailed mechanism of this process is not very well documented. We report the mechanism of biomineralization of aqueous gold chloride into NPs and microplates in the breast-cancer cell line MCF7. Spherical gold NPs are synthesized in these cells in the presence of serum in the culture media by the reduction of HAuCl4. In the absence of serum, the cells exhibit gold microplate formation through seed-mediate growth albeit slower reduction. The structural characteristics of the two types of NPs under different media conditions were confirmed using scanning electron microscopy (SEM); crystallinity and metallic properties were assessed with transmission electron microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). Gold-reducing proteins, related to cell stress initiate the biomineralization of HAuCl4 in cells (under serum free conditions) as confirmed by infrared (IR) spectroscopy. MCF7 cells undergo irreversible replicative senescence when exposed to a high concentration of ionic gold and conversely remain in a dormant reversible quiescent state when exposed to a low gold concentration. The latter cellular state was achievable in the presence of the rho/ROCK inhibitor Y-27632. Proteomic analysis revealed consistent expression of specific proteins under serum and serum-free conditions. A high-throughput proteomic approach to screen gold-reducing proteins and peptide sequences was utilized and validated by quartz crystal microbalance with dissipation (QCM-D). Statement of significance Cancer cells are known to synthesize gold nanoparticles and microstructures, which are promising for bioimaging and other therapeutic applications. However, the detailed mechanism of such biomineralization process is not well understood yet. Herein, we demonstrate that cancer cells exposed to gold ions (grown in serum/serum-free conditions) secrete shock and stress-related proteins with specific gold-binding/reducing polypeptides. Cells undergo reversible senescence and can recover normal physiology when treated with the senescence inhibitor depending on culture condition. The use of mammalian cells as microincubators for synthesis of such particles could have potential influence on their uptake and biocompatibility. This study has important implications for in-situ reduction of ionic gold to anisotropic micro-nanostructures that could be used in-vivo clinical applications and tumor photothermal therapy.

pi

link (url) DOI [BibTex]


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Arm-Worn Tactile Displays

Kuchenbecker, K. J.

Cross-Cutting Challenge Interactive Discussion presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Fingertips and hands captivate the attention of most haptic interface designers, but humans can feel touch stimuli across the entire body surface. Trying to create devices that both can be worn and can deliver good haptic sensations raises challenges that rarely arise in other contexts. Most notably, tactile cues such as vibration, tapping, and squeezing are far simpler to implement in wearable systems than kinesthetic haptic feedback. This interactive discussion will present a variety of relevant projects to which I have contributed, attempting to pull out common themes and ideas for the future.

hi

[BibTex]

[BibTex]


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Haptipedia: An Expert-Sourced Interactive Device Visualization for Haptic Designers

Seifi, H., MacLean, K. E., Kuchenbecker, K. J., Park, G.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Much of three decades of haptic device invention is effectively lost to today’s designers: dispersion across time, region, and discipline imposes an incalculable drag on innovation in this field. Our goal is to make historical haptic invention accessible through interactive navigation of a comprehensive library – a Haptipedia – of devices that have been annotated with designer-relevant metadata. To build this open resource, we will systematically mine the literature and engage the haptics community for expert annotation. In a multi-year broad-based initiative, we will empirically derive salient attributes of haptic devices, design an interactive visualization tool where device creators and repurposers can efficiently explore and search Haptipedia, and establish methods and tools to manually and algorithmically collect data from the haptics literature and our community of experts. This paper outlines progress in compiling an initial corpus of grounded force-feedback devices and their attributes, and it presents a concept sketch of the interface we envision.

hi

Project Page [BibTex]

Project Page [BibTex]


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Exercising with Baxter: Design and Evaluation of Assistive Social-Physical Human-Robot Interaction

Fitter, N. T., Mohan, M., Kuchenbecker, K. J., Johnson, M. J.

Workshop paper (6 pages) presented at the HRI Workshop on Personal Robots for Exercising and Coaching, Chicago, USA, March 2018 (misc)

Abstract
The worldwide population of older adults is steadily increasing and will soon exceed the capacity of assisted living facilities. Accordingly, we aim to understand whether appropriately designed robots could help older adults stay active and engaged while living at home. We developed eight human-robot exercise games for the Baxter Research Robot with the guidance of experts in game design, therapy, and rehabilitation. After extensive iteration, these games were employed in a user study that tested their viability with 20 younger and 20 older adult users. All participants were willing to enter Baxter’s workspace and physically interact with the robot. User trust and confidence in Baxter increased significantly between pre- and post-experiment assessments, and one individual from the target user population supplied us with abundant positive feedback about her experience. The preliminary results presented in this paper indicate potential for the use of two-armed human-scale robots for social-physical exercise interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Emotionally Supporting Humans Through Robot Hugs

Block, A. E., Kuchenbecker, K. J.

Workshop paper (2 pages) presented at the HRI Pioneers Workshop, Chicago, USA, March 2018 (misc)

Abstract
Hugs are one of the first forms of contact and affection humans experience. Due to their prevalence and health benefits, we want to enable robots to safely hug humans. This research strives to create and study a high fidelity robotic system that provides emotional support to people through hugs. This paper outlines our previous work evaluating human responses to a prototype’s physical and behavioral characteristics, and then it lays out our ongoing and future work.

hi

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Towards a Statistical Model of Fingertip Contact Deformations from 4D Data

Gueorguiev, D., Tzionas, D., Pacchierotti, C., Black, M. J., Kuchenbecker, K. J.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Little is known about the shape and properties of the human finger during haptic interaction even though this knowledge is essential to control wearable finger devices and deliver realistic tactile feedback. This study explores a framework for four-dimensional scanning and modeling of finger-surface interactions, aiming to capture the motion and deformations of the entire finger with high resolution. The results show that when the fingertip is actively pressing a rigid surface, it undergoes lateral expansion of about 0.2 cm and proximal/distal bending of about 30◦, deformations that cannot be captured by imaging of the contact area alone. This project constitutes a first step towards an accurate statistical model of the finger’s behavior during haptic interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Can Humans Infer Haptic Surface Properties from Images?

Burka, A., Kuchenbecker, K. J.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Human children typically experience their surroundings both visually and haptically, providing ample opportunities to learn rich cross-sensory associations. To thrive in human environments and interact with the real world, robots also need to build models of these cross-sensory associations; current advances in machine learning should make it possible to infer models from large amounts of data. We previously built a visuo-haptic sensing device, the Proton Pack, and are using it to collect a large database of matched multimodal data from tool-surface interactions. As a benchmark to compare with machine learning performance, we conducted a human subject study (n = 84) on estimating haptic surface properties (here: hardness, roughness, friction, and warmness) from images. Using a 100-surface subset of our database, we showed images to study participants and collected 5635 ratings of the four haptic properties, which we compared with ratings made by the Proton Pack operator and with physical data recorded using motion, force, and vibration sensors. Preliminary results indicate weak correlation between participant and operator ratings, but potential for matching up certain human ratings (particularly hardness and roughness) with features from the literature.

hi

Project Page [BibTex]

Project Page [BibTex]


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Thermocapillary-driven fluid flow within microchannels

Amador, G. J., Tabak, A. F., Ren, Z., Alapan, Y., Yasa, O., Sitti, M.

ArXiv e-prints, Febuary 2018 (article)

Abstract
Surface tension gradients induce Marangoni flow, which may be exploited for fluid transport. At the micrometer scale, these surface-driven flows can be more significant than those driven by pressure. By introducing fluid-fluid interfaces on the walls of microfluidic channels, we use surface tension gradients to drive bulk fluid flows. The gradients are specifically induced through thermal energy, exploiting the temperature dependence of a fluid-fluid interface to generate thermocapillary flow. In this report, we provide the design concept for a biocompatible, thermocapillary microchannel capable of being powered by solar irradiation. Using temperature gradients on the order of degrees Celsius per centimeter, we achieve fluid velocities on the order of millimeters per second. Following experimental observations, fluid dynamic models, and numerical simulation, we find that the fluid velocity is linearly proportional to the provided temperature gradient, enabling full control of the fluid flow within the microchannels.

pi

link (url) Project Page [BibTex]


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Sparse-then-dense alignment-based 3D map reconstruction method for endoscopic capsule robots

Turan, M., Pilavci, Y. Y., Ganiyusufoglu, I., Araujo, H., Konukoglu, E., Sitti, M.

Machine Vision and Applications, 29(2):345-359, Febuary 2018 (article)

Abstract
Despite significant progress achieved in the last decade to convert passive capsule endoscopes to actively controllable robots, robotic capsule endoscopy still has some challenges. In particular, a fully dense three-dimensional (3D) map reconstruction of the explored organ remains an unsolved problem. Such a dense map would help doctors detect the locations and sizes of the diseased areas more reliably, resulting in more accurate diagnoses. In this study, we propose a comprehensive medical 3D reconstruction method for endoscopic capsule robots, which is built in a modular fashion including preprocessing, keyframe selection, sparse-then-dense alignment-based pose estimation, bundle fusion, and shading-based 3D reconstruction. A detailed quantitative analysis is performed using a non-rigid esophagus gastroduodenoscopy simulator, four different endoscopic cameras, a magnetically activated soft capsule robot, a sub-millimeter precise optical motion tracker, and a fine-scale 3D optical scanner, whereas qualitative ex-vivo experiments are performed on a porcine pig stomach. To the best of our knowledge, this study is the first complete endoscopic 3D map reconstruction approach containing all of the necessary functionalities for a therapeutically relevant 3D map reconstruction.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Independent Actuation of Two-Tailed Microrobots

Khalil, I. S. M., Tabak, A. F., Hamed, Y., Tawakol, M., Klingner, A., Gohary, N. E., Mizaikoff, B., Sitti, M.

IEEE Robotics and Automation Letters, 3(3):1703-1710, Febuary 2018 (article)

Abstract
A soft two-tailed microrobot in low Reynolds number fluids does not achieve forward locomotion by identical tails regardless to its wiggling frequency. If the tails are nonidentical, zero forward locomotion is also observed at specific oscillation frequencies (which we refer to as the reversal frequencies), as the propulsive forces imparted to the fluid by each tail are almost equal in magnitude and opposite in direction. We find distinct reversal frequencies for the two-tailed microrobots based on their tail length ratio. At these frequencies, the microrobot achieves negligible net displacement under the influence of a periodic magnetic field. This observation allows us to fabricate groups of microrobots with tail length ratio of 1.24 ± 0.11, 1.48 ± 0.08, and 1.71 ± 0.09. We demonstrate selective actuation of microrobots based on prior characterization of their reversal frequencies. We also implement simultaneous flagellar propulsion of two microrobots and show that they can be controlled to swim along the same direction and opposite to each other using common periodic magnetic fields. In addition, independent motion control of two microrobots is achieved toward two different reference positions with average steady-state error of 110.1 ± 91.8 μm and 146.9 ± 105.9 μm.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Recent Advances in Wearable Transdermal Delivery Systems

Amjadi, M., Sheykhansari, S., Nelson, B. J., Sitti, M.

Advanced Materials, 30(7):1704530, January 2018 (article)

Abstract
Abstract Wearable transdermal delivery systems have recently received tremendous attention due to their noninvasive, convenient, and prolonged administration of pharmacological agents. Here, the material prospects, fabrication processes, and drug‐release mechanisms of these types of therapeutic delivery systems are critically reviewed. The latest progress in the development of multifunctional wearable devices capable of closed‐loop sensation and drug delivery is also discussed. This survey reveals that wearable transdermal delivery has already made an impact in diverse healthcare applications, while several grand challenges remain.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Deep EndoVO: A recurrent convolutional neural network (RCNN) based visual odometry approach for endoscopic capsule robots

Turan, M., Almalioglu, Y., Araujo, H., Konukoglu, E., Sitti, M.

Neurocomputing, 275, pages: 1861 - 1870, January 2018 (article)

Abstract
Ingestible wireless capsule endoscopy is an emerging minimally invasive diagnostic technology for inspection of the GI tract and diagnosis of a wide range of diseases and pathologies. Medical device companies and many research groups have recently made substantial progresses in converting passive capsule endoscopes to active capsule robots, enabling more accurate, precise, and intuitive detection of the location and size of the diseased areas. Since a reliable real time pose estimation functionality is crucial for actively controlled endoscopic capsule robots, in this study, we propose a monocular visual odometry (VO) method for endoscopic capsule robot operations. Our method lies on the application of the deep recurrent convolutional neural networks (RCNNs) for the visual odometry task, where convolutional neural networks (CNNs) and recurrent neural networks (RNNs) are used for the feature extraction and inference of dynamics across the frames, respectively. Detailed analyses and evaluations made on a real pig stomach dataset proves that our system achieves high translational and rotational accuracies for different types of endoscopic capsule robot trajectories.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Small-scale soft-bodied robot with multimodal locomotion

Hu, W., Lum, G. Z., Mastrangeli, M., Sitti, M.

Nature, 554, pages: 81-85, Nature, January 2018 (article)

Abstract
Untethered small-scale (from several millimetres down to a few micrometres in all dimensions) robots that can non-invasively access confined, enclosed spaces may enable applications in microfactories such as the construction of tissue scaffolds by robotic assembly1, in bioengineering such as single-cell manipulation and biosensing2, and in healthcare3,4,5,6 such as targeted drug delivery4 and minimally invasive surgery3,5. Existing small-scale robots, however, have very limited mobility because they are unable to negotiate obstacles and changes in texture or material in unstructured environments7,8,9,10,11,12,13. Of these small-scale robots, soft robots have greater potential to realize high mobility via multimodal locomotion, because such machines have higher degrees of freedom than their rigid counterparts14,15,16. Here we demonstrate magneto-elastic soft millimetre-scale robots that can swim inside and on the surface of liquids, climb liquid menisci, roll and walk on solid surfaces, jump over obstacles, and crawl within narrow tunnels. These robots can transit reversibly between different liquid and solid terrains, as well as switch between locomotive modes. They can additionally execute pick-and-place and cargo-release tasks. We also present theoretical models to explain how the robots move. Like the large-scale robots that can be used to study locomotion17, these soft small-scale robots could be used to study soft-bodied locomotion produced by small organisms.

pi

link (url) DOI Project Page [BibTex]


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Light‐Driven Janus Hollow Mesoporous TiO2–Au Microswimmers

Sridhar, V., Park, B., Sitti, M.

Advanced Functional Materials, 28(5):1704902, January 2018 (article)

Abstract
Abstract Light‐driven microswimmers have garnered attention for their potential use in various applications, such as environmental remediation, hydrogen evolution, and targeted drug delivery. Janus hollow mesoporous TiO2/Au (JHP–TiO2–Au) microswimmers with enhanced swimming speeds under low‐intensity ultraviolet (UV) light are presented. The swimmers show enhanced swimming speeds both in presence and absence of H2O2. The microswimmers move due to self‐electrophoresis when UV light is incident on them. There is a threefold increase in speed of JHP–TiO2–Au microswimmers in comparison with Janus solid TiO2/Au (JS–TiO2–Au) microswimmers. This increase in their speed is due to the increase in surface area of the porous swimmers and their hollow structure. These microswimmers are also made steerable by using a thin Co magnetic layer. They can be used in potential environmental applications for active photocatalytic degradation of methylene blue and targeted active drug delivery of an anticancer drug (doxurobicin) in vitro in H2O2 solution. Their increased speed from the presence of a hollow mesoporous structure is beneficial for future potential applications, such as hydrogen evolution, selective heterogeneous photocatalysis, and targeted cargo delivery.

pi

link (url) DOI Project Page [BibTex]


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Mechanical Rubbing of Blood Clots Using Helical Robots Under Ultrasound Guidance

Khalil, I. S. M., Mahdy, D., Sharkawy, A. E., Moustafa, R. R., Tabak, A. F., Mitwally, M. E., Hesham, S., Hamdi, N., Klingner, A., Mohamed, A., Sitti, M.

IEEE Robotics and Automation Letters, 3(2):1112-1119, January 2018 (article)

Abstract
A simple way to mitigate the potential negative sideeffects associated with chemical lysis of a blood clot is to tear its fibrin network via mechanical rubbing using a helical robot. Here, we achieve mechanical rubbing of blood clots under ultrasound guidance and using external magnetic actuation. Position of the helical robot is determined using ultrasound feedback and used to control its motion toward the clot, whereas the volume of the clots is estimated simultaneously using visual feedback. We characterize the shear modulus and ultimate shear strength of the blood clots to predict their removal rate during rubbing. Our in vitro experiments show the ability to move the helical robot controllably toward clots using ultrasound feedback with average and maximum errors of 0.84 ± 0.41 and 2.15 mm, respectively, and achieve removal rate of -0.614 ± 0.303 mm3/min at room temperature (25 °C) and -0.482 ± 0.23 mm3/min at body temperature (37 °C), under the influence of two rotating dipole fields at frequency of 35 Hz. We also validate the effectiveness of mechanical rubbing by measuring the number of red blood cells and platelets past the clot. Our measurements show that rubbing achieves cell count of (46 ± 10.9) × 104 cell/ml, whereas the count in the absence of rubbing is (2 ± 1.41) × 104 cell/ml, after 40 min.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]