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2016


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Bioengineered and biohybrid bacteria-based systems for drug delivery

Hosseinidoust, Z., Mostaghaci, B., Yasa, O., Park, B., Singh, A. V., Sitti, M.

Advanced Drug Delivery Reviews, 106, pages: 27-44, Elsevier, November 2016 (article)

Abstract
The use of bacterial cells as agents of medical therapy has a long history. Research that was ignited over a century ago with the accidental infection of cancer patients has matured into a platform technology that offers the promise of opening up new potential frontiers in medical treatment. Bacterial cells exhibit unique characteristics that make them well-suited as smart drug delivery agents. Our ability to genetically manipulate the molecular machinery of these cells enables the customization of their therapeutic action as well as its precise tuning and spatio-temporal control, allowing for the design of unique, complex therapeutic functions, unmatched by current drug delivery systems. Early results have been promising, but there are still many important challenges that must be addressed. We present a review of promises and challenges of employing bioengineered bacteria in drug delivery systems and introduce the biohybrid design concept as a new additional paradigm in bacteria-based drug delivery.

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DOI Project Page [BibTex]

2016


DOI Project Page [BibTex]


Thumb xl 07759726
Steering control of a water-running robot using an active tail

Kim, H., Jeong, K., Sitti, M., Seo, T.

In Intelligent Robots and Systems (IROS), 2016 IEEE/RSJ International Conference on, pages: 4945-4950, October 2016 (inproceedings)

Abstract
Many highly dynamic novel mobile robots have been developed being inspired by animals. In this study, we are inspired by a basilisk lizard's ability to run and steer on water surface for a hexapedal robot. The robot has an active tail with a circular plate, which the robot rotates to steer on water. We dynamically modeled the platform and conducted simulations and experiments on steering locomotion with a bang-bang controller. The robot can steer on water by rotating the tail, and the controlled steering locomotion is stable. The dynamic modelling approximates the robot's steering locomotion and the trends of the simulations and experiments are similar, although there are errors between the desired and actual angles. The robot's maneuverability on water can be improved through further research.

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DOI [BibTex]

DOI [BibTex]


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A 5-D localization method for a magnetically manipulated untethered robot using a 2-D array of Hall-effect sensors

Son, D., Yim, S., Sitti, M.

IEEE/ASME Transactions on Mechatronics, 21(2):708-716, IEEE, October 2016 (article)

Abstract
This paper introduces a new five-dimensional localization method for an untethered meso-scale magnetic robot, which is manipulated by a computer-controlled electromagnetic system. The developed magnetic localization setup is a two-dimensional array of mono-axial Hall-effect sensors, which measure the perpendicular magnetic fields at their given positions. We introduce two steps for localizing a magnetic robot more accurately. First, the dipole modeled magnetic field of the electromagnet is subtracted from the measured data in order to determine the robot's magnetic field. Secondly, the subtracted magnetic field is twice differentiated in the perpendicular direction of the array, so that the effect of the electromagnetic field in the localization process is minimized. Five variables regarding the position and orientation of the robot are determined by minimizing the error between the measured magnetic field and the modeled magnetic field in an optimization method. The resulting position error is 2.1±0.8 mm and angular error is 6.7±4.3° within the applicable range (5 cm) of magnetic field sensors at 200 Hz. The proposed localization method would be used for the position feedback control of untethered magnetic devices or robots for medical applications in the future.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


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High-Performance Multiresponsive Paper Actuators

Amjadi, M., Sitti, M.

ACS Nano, 10(11):10202-10210, American Chemical Society, October 2016 (article)

Abstract
There is an increasing demand for soft actuators because of their importance in soft robotics, artificial muscles, biomimetic devices, and beyond. However, the development of soft actuators capable of low-voltage operation, powerful actuation, and programmable shape-changing is still challenging. In this work, we propose programmable bilayer actuators that operate based on the large hygroscopic contraction of the copy paper and simultaneously large thermal expansion of the polypropylene film upon increasing the temperature. The electrothermally activated bending actuators can function with low voltages (≤ 8 V), low input electric power per area (P ≤ 0.14 W cm–2), and low temperature changes (≤ 35 °C). They exhibit reversible shape-changing behavior with curvature radii up to 1.07 cm–1 and bending angle of 360°, accompanied by powerful actuation. Besides the electrical activation, they can be powered by humidity or light irradiation. We finally demonstrate the use of our paper actuators as a soft gripper robot and a lightweight paper wing for aerial robotics.

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DOI Project Page Project Page [BibTex]

DOI Project Page Project Page [BibTex]


Thumb xl publications toc
Programmable assembly of heterogeneous microparts by an untethered mobile capillary microgripper

Giltinan, J., Diller, E., Sitti, M.

Lab on a Chip, 16(22):4445-4457, Royal Society of Chemistry, October 2016 (article)

Abstract
At the sub-millimeter scale, capillary forces enable robust and reversible adhesion between biological organisms and varied substrates. Current human-engineered mobile untethered micromanipulation systems rely on forces which scale poorly or utilize gripper-part designs that promote manipulation. Capillary forces, alternatively, are dependent upon the surface chemistry (which is scale independent) and contact perimeter, which conforms to the part surface. We report a mobile capillary microgripper that is able to pick and place parts of various materials and geometries, and is thus ideal for microassembly tasks that cannot be accomplished by large tethered manipulators. We achieve the programmable assembly of sub-millimeter parts in an enclosed three-dimensional aqueous environment by creating a capillary bridge between the targeted part and a synthetic, untethered, mobile body. The parts include both hydrophilic and hydrophobic components: hydrogel, kapton, human hair, and biological tissue. The 200 μm untethered system can be controlled with five-degrees-of-freedom and advances progress towards autonomous desktop manufacturing for tissue engineering, complex micromachines, microfluidic devices, and meta-materials.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


Thumb xl 5fc6a94719a2ed61820a6fd031f53c39682a1f157b1c10c35d5d4c88d087d90e
Composition-dependent underwater adhesion of catechol-bearing hydrogels

Wu, H., Sariola, V., Zhao, J., Ding, H., Sitti, M., Bettinger, C. J.

Polymer International, 65(11):1355-1359, John Wiley & Sons, Ltd, September 2016 (article)

Abstract
Interfacial adhesion-mediated transfer printing processes can integrate functional electronic microstructures with polymeric substrates that are bendable and stretchable. Transfer printing has also been extended to catechol-bearing adhesive hydrogels. This study presents indentation adhesion tests between catechol-bearing hydrogel substrates with catechol concentrations varying from 0 to 10% (mol/mol) and thin-film materials commonly used in microelectronic fabrication including polymers, noble metals and oxides. The results indicate that the interfacial adhesion of catechol-bearing hydrogels is positively correlated with the concentration of catechol-bearing monomers as well as the retraction velocity during transfer printing. This study can inform transfer printing processes for microfabricated structures to compliant hydrated substrates such as hygroscopic monomers, mesoporous polymer networks and hydrogels. © 2016 Society of Chemical Industry

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DOI [BibTex]

DOI [BibTex]


Thumb xl singh et al 2016 advanced healthcare materials
Bacteria-Driven Particles: Patterned and Specific Attachment of Bacteria on Biohybrid Bacteria-Driven Microswimmers (Adv. Healthcare Mater. 18/2016)

Singh, A. V., Sitti, M.

Advanced Healthcare Materials, 5(18):2306-2306, September 2016 (article)

Abstract
On page 2325, Ajay Vikram Singh and Metin Sitti propose a facile surface patterning technique and a specific, strong biotin–streptavidin bonding of bacteria on patterned surfaces to fabricate Janus particles that are propelled by the attached bacteria. Such bacteria-driven Janus microswimmers could be used for future medicine in targeted drug delivery and environmental remediation.

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DOI Project Page [BibTex]


Thumb xl publications toc
The effect of temperature and humidity on adhesion of a gecko-inspired adhesive: implications for the natural system

Stark, A. Y., Klittich, M. R., Sitti, M., Niewiarowski, P. H., Dhinojwala, A.

Scientific Reports, 6, pages: 30936, Nature Publishing Group, August 2016 (article)

Abstract
The adhesive system of geckos has inspired hundreds of synthetic adhesives. While this system has been used relentlessly as a source of inspiration, less work has been done in reverse, where synthetics are used to test questions and hypotheses about the natural system. Here we take such an approach. We tested shear adhesion of a mushroom-tipped synthetic gecko adhesive under conditions that produced perplexing results in the natural adhesive system. Synthetic samples were tested at two temperatures (12 °C and 32 °C) and four different humidity levels (30%, 55%, 70%, and 80% RH). Surprisingly, adhesive performance of the synthetic samples matched that of living geckos, suggesting that uncontrolled parameters in the natural system, such as surface chemistry and material changes, may not be as influential in whole-animal performance as previously thought. There was one difference, however, when comparing natural and synthetic adhesive performance. At 12 °C and 80% RH, adhesion of the synthetic structures was lower than expected based on the natural system’s performance. Our approach highlights a unique opportunity for both biologists and material scientists, where new questions and hypotheses can be fueled by joint comparisons of the natural and synthetic systems, ultimately improving knowledge of both.

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DOI [BibTex]

DOI [BibTex]


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Targeting of cell mockups using sperm-shaped microrobots in vitro

Khalil, I. S., Tabak, A. F., Hosney, A., Klingner, A., Shalaby, M., Abdel-Kader, R. M., Serry, M., Sitti, M.

In Biomedical Robotics and Biomechatronics (BioRob), 2016 6th IEEE International Conference on, pages: 495-501, July 2016 (inproceedings)

Abstract
Sperm-shaped microrobots are controlled under the influence of weak oscillating magnetic fields (milliTesla range) to selectively target cell mockups (i.e., gas bubbles with average diameter of 200 μm). The sperm-shaped microrobots are fabricated by electrospinning using a solution of polystyrene, dimethylformamide, and iron oxide nanoparticles. These nanoparticles are concentrated within the head of the microrobot, and hence enable directional control along external magnetic fields. The magnetic dipole moment of the microrobot is characterized (using the flip-time technique) to be 1.4×10-11 A.m2, at magnetic field of 28 mT. In addition, the morphology of the microrobot is characterized using Scanning Electron Microscopy images. The characterized parameters and morphology are used in the simulation of the locomotion mechanism of the microrobot to prove that its motion depends on breaking the time-reversal symmetry, rather than pulling with the magnetic field gradient. We experimentally demonstrate that the microrobot can controllably follow S-shaped, U-shaped, and square paths, and selectively target the cell mockups using image guidance and under the influence of the oscillating magnetic fields.

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DOI [BibTex]

DOI [BibTex]


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Analysis of the magnetic torque on a tilted permanent magnet for drug delivery in capsule robots

Munoz, F., Alici, G., Zhou, H., Li, W., Sitti, M.

In Advanced Intelligent Mechatronics (AIM), 2016 IEEE International Conference on, pages: 1386-1391, July 2016 (inproceedings)

Abstract
In this paper, we present the analysis of the torque transmitted to a tilted permanent magnet that is to be embedded in a capsule robot to achieve targeted drug delivery. This analysis is carried out by using an analytical model and experimental results for a small cubic permanent magnet that is driven by an external magnetic system made of an array of arc-shaped permanent magnets (ASMs). Our experimental results, which are in agreement with the analytical results, show that the cubic permanent magnet can safely be actuated for inclinations lower than 75° without having to make positional adjustments in the external magnetic system. We have found that with further inclinations, the cubic permanent magnet to be embedded in a drug delivery mechanism may stall. When it stalls, the external magnetic system's position and orientation would have to be adjusted to actuate the cubic permanent magnet and the drug release mechanism. This analysis of the transmitted torque is helpful for the development of real-time control strategies for magnetically articulated devices.

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DOI [BibTex]

DOI [BibTex]


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Magnetic propulsion of robotic sperms at low-Reynolds number

Khalil, I. S., Fatih Tabak, A., Klingner, A., Sitti, M.

Applied Physics Letters, 109(3):033701, AIP Publishing, July 2016 (article)

Abstract
We investigate the microswimming behaviour of robotic sperms in viscous fluids. These robotic sperms are fabricated from polystyrene dissolved in dimethyl formamide and iron-oxide nanoparticles. This composition allows the nanoparticles to be concentrated within the bead of the robotic sperm and provide magnetic dipole, whereas the flexibility of the ultra-thin tail enables flagellated locomotion using magnetic fields in millitesla range. We show that these robotic sperms have similar morphology and swimming behaviour to those of sperm cells. Moreover, we show experimentally that our robotic sperms swim controllably at an average speed of approximately one body length per second (around 125 μm s−1), and they are relatively faster than the microswimmers that depend on planar wave propulsion in low-Reynolds number fluids.

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DOI [BibTex]

DOI [BibTex]


Thumb xl 0278364915583539
Six-degree-of-freedom magnetic actuation for wireless microrobotics

Diller, E., Giltinan, J., Lum, G. Z., Ye, Z., Sitti, M.

The International Journal of Robotics Research, 35(1-3):114-128, SAGE Publications Sage UK: London, England, June 2016 (article)

Abstract
Existing remotely actuated magnetic microrobots exhibit a maximum of only five-degree-of-freedom (DOF) actuation, as creation of a driving torque about the microrobot magnetization axis is not achievable. This lack of full orientation control limits the effectiveness of existing microrobots for precision tasks of object manipulation and orientation for advanced medical, biological and micromanufacturing applications. This paper presents a magnetic actuation method that allows remotely powered microrobots to achieve full six-DOF actuation by considering the case of a non-uniform magnetization profile within the microrobot body. This non-uniform magnetization allows for additional rigid-body torques to be induced from magnetic forces via a moment arm. A general analytical model presents the working principle for continuous and discrete magnetization profiles, which is applied to permanent or non-permanent (soft) magnet bodies. Several discrete-magnetization designs are also presented which possess reduced coupling between magnetic forces and induced rigid-body torques. Design guidelines are introduced which can be followed to ensure that a magnetic microrobot design is capable of six-DOF actuation. A simple permanent-magnet prototype is fabricated and used to quantitatively demonstrate the accuracy of the analytical model in a constrained-DOF environment and qualitatively for free motion in a viscous liquid three-dimensional environment. Results show that desired forces and torques can be created with high precision and limited parasitic actuation, allowing for full six-DOF actuation using limited feedback control

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DOI [BibTex]

DOI [BibTex]


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Patches, Planes and Probabilities: A Non-local Prior for Volumetric 3D Reconstruction

Ulusoy, A. O., Black, M. J., Geiger, A.

In IEEE Conf. on Computer Vision and Pattern Recognition (CVPR), IEEE International Conference on Computer Vision and Pattern Recognition (CVPR), June 2016 (inproceedings)

Abstract
In this paper, we propose a non-local structured prior for volumetric multi-view 3D reconstruction. Towards this goal, we present a novel Markov random field model based on ray potentials in which assumptions about large 3D surface patches such as planarity or Manhattan world constraints can be efficiently encoded as probabilistic priors. We further derive an inference algorithm that reasons jointly about voxels, pixels and image segments, and estimates marginal distributions of appearance, occupancy, depth, normals and planarity. Key to tractable inference is a novel hybrid representation that spans both voxel and pixel space and that integrates non-local information from 2D image segmentations in a principled way. We compare our non-local prior to commonly employed local smoothness assumptions and a variety of state-of-the-art volumetric reconstruction baselines on challenging outdoor scenes with textureless and reflective surfaces. Our experiments indicate that regularizing over larger distances has the potential to resolve ambiguities where local regularizers fail.

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YouTube pdf poster suppmat Project Page [BibTex]

YouTube pdf poster suppmat Project Page [BibTex]


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Semantic Instance Annotation of Street Scenes by 3D to 2D Label Transfer

Xie, J., Kiefel, M., Sun, M., Geiger, A.

In IEEE Conf. on Computer Vision and Pattern Recognition (CVPR), IEEE International Conference on Computer Vision and Pattern Recognition (CVPR), June 2016 (inproceedings)

Abstract
Semantic annotations are vital for training models for object recognition, semantic segmentation or scene understanding. Unfortunately, pixelwise annotation of images at very large scale is labor-intensive and only little labeled data is available, particularly at instance level and for street scenes. In this paper, we propose to tackle this problem by lifting the semantic instance labeling task from 2D into 3D. Given reconstructions from stereo or laser data, we annotate static 3D scene elements with rough bounding primitives and develop a probabilistic model which transfers this information into the image domain. We leverage our method to obtain 2D labels for a novel suburban video dataset which we have collected, resulting in 400k semantic and instance image annotations. A comparison of our method to state-of-the-art label transfer baselines reveals that 3D information enables more efficient annotation while at the same time resulting in improved accuracy and time-coherent labels.

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pdf suppmat Project Page Project Page [BibTex]

pdf suppmat Project Page Project Page [BibTex]


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System and method to magnetically actuate a capsule endoscopic robot for diagnosis and treatment

Sitti, M., Yim, S.

May 2016, US Patent 9,445,711 (patent)

Abstract
Present invention describes a swallowable device with a soft, compliant exterior, whose shape can be changed through the use of magnetic fields, and which can be locomoted in a rolling motion through magnetic control from the exterior of the patient. The present invention could be used for a variety of medical applications inside the GI tract including but not limited to drug delivery, biopsy, heat cauterization, pH sensing, biochemical sensing, micro-surgery, and active imaging.

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link (url) [BibTex]


Thumb xl ye et al 2016 advanced materials
Gallium Adhesion: Phase Change of Gallium Enables Highly Reversible and Switchable Adhesion (Adv. Mater. 25/2016)

Ye, Z., Lum, G. Z., Song, S., Rich, S., Sitti, M.

Advanced Materials, 28(25):5087-5087, May 2016 (article)

Abstract
Gallium exhibits highly reversible and switchable adhesion when it undergoes a solid–liquid phase transition. The robustness of gallium is notable as it exhibits strong performance on a wide range of smooth and rough surfaces, under both dry and wet conditions. Gallium may therefore find numerous applications in transfer printing, robotics, electronic packaging, and biomedicine.

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DOI [BibTex]


Thumb xl singh et al 2016 advanced healthcare materials
Patterned and Specific Attachment of Bacteria on Biohybrid Bacteria-Driven Microswimmers

Singh, A. V., Sitti, M.

Advanced Healthcare Materials, 5(18):2325-2331, May 2016 (article)

Abstract
A surface patterning technique and a specific and strong biotin–streptavidin bonding of bacteria on patterned surfaces are proposed to fabricate Janus particles that are propelled by the attached bacteria. Bacteria-driven Janus microswimmers with diameters larger than 3 μm show enhanced mean propulsion speed. Such microswimmers could be used for future applications such as targeted drug delivery and environmental remediation.

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DOI [BibTex]


Thumb xl pnas 2016 lum 1608193113 2
Shape-programmable magnetic soft matter

Lum, G. Z., Ye, Z., Dong, X., Marvi, H., Erin, O., Hu, W., Sitti, M.

Proceedings of the National Academy of Sciences, 113(41):E6007–E6015, National Acad Sciences, May 2016 (article)

Abstract
Shape-programmable matter is a class of active materials whose geometry can be controlled to potentially achieve mechanical functionalities beyond those of traditional machines. Among these materials, magnetically actuated matter is particularly promising for achieving complex time-varying shapes at small scale (overall dimensions smaller than 1 cm). However, previous work can only program these materials for limited applications, as they rely solely on human intuition to approximate the required magnetization profile and actuating magnetic fields for their materials. Here, we propose a universal programming methodology that can automatically generate the required magnetization profile and actuating fields for soft matter to achieve new time-varying shapes. The universality of the proposed method can therefore inspire a vast number of miniature soft devices that are critical in robotics, smart engineering surfaces and materials, and biomedical devices. Our proposed method includes theoretical formulations, computational strategies, and fabrication procedures for programming magnetic soft matter. The presented theory and computational method are universal for programming 2D or 3D time-varying shapes, whereas the fabrication technique is generic only for creating planar beams. Based on the proposed programming method, we created a jellyfish-like robot, a spermatozoid-like undulating swimmer, and an artificial cilium that could mimic the complex beating patterns of its biological counterpart.

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DOI [BibTex]

DOI [BibTex]


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Sperm-shaped magnetic microrobots: Fabrication using electrospinning, modeling, and characterization

Khalil, I. S., Tabak, A. F., Hosney, A., Mohamed, A., Klingner, A., Ghoneima, M., Sitti, M.

In Robotics and Automation (ICRA), 2016 IEEE International Conference on, pages: 1939-1944, May 2016 (inproceedings)

Abstract
We use electrospinning to fabricate sperm-shaped magnetic microrobots with a range of diameters from 50 μm to 500 μm. The variables of the electrospinning operation (voltage, concentration of the solution, dynamic viscosity, and distance between the syringe needle and collector) to achieve beading effect are determined. This beading effect allows us to fabricate microrobots with similar morphology to that of sperm cells. The bead and the ultra-fine fiber resemble the morphology of the head and tail of the sperm cell, respectively. We incorporate iron oxide nanoparticles to the head of the sperm-shaped microrobot to provide a magnetic dipole moment. This dipole enables directional control under the influence of external magnetic fields. We also apply weak (less than 2 mT) oscillating magnetic fields to exert a magnetic torque on the magnetic head, and generate planar flagellar waves and flagellated swim. The average speed of the sperm-shaped microrobot is calculated to be 0.5 body lengths per second and 1 body lengths per second at frequencies of 5 Hz and 10 Hz, respectively. We also develop a model of the microrobot using elastohydrodynamics approach and Timoshenko-Rayleigh beam theory, and find good agreement with the experimental results.

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DOI [BibTex]

DOI [BibTex]


Thumb xl inflateble robots
Inflated soft actuators with reversible stable deformations

Hines, L., Petersen, K., Sitti, M.

Advanced Materials, 28(19):3690-3696, March 2016 (article)

Abstract
Most soft robotic systems are currently dependent on bulky compressors or pumps. A soft actuation method is presented combining hyperelastic membranes and dielectric elastomer actuators to switch between stable deformations of sealed chambers. This method is capable of large repeatable deformations, and has a number of stable states proportional to the number of actuatable membranes in the chamber.

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DOI Project Page [BibTex]


Thumb xl publications toc
Chemotaxis of bio-hybrid multiple bacteria-driven microswimmers

Zhuang, J., Sitti, M.

Scientific reports, 6, pages: 32135, Nature Publishing Group, March 2016 (article)

Abstract
In this study, in a bio-hybrid microswimmer system driven by multiple Serratia marcescens bacteria, we quantify the chemotactic drift of a large number of microswimmers towards L-serine and elucidate the associated collective chemotaxis behavior by statistical analysis of over a thousand swimming trajectories of the microswimmers. The results show that the microswimmers have a strong heading preference for moving up the L-serine gradient, while their speed does not change considerably when moving up and down the gradient; therefore, the heading bias constitutes the major factor that produces the chemotactic drift. The heading direction of a microswimmer is found to be significantly more persistent when it moves up the L-serine gradient than when it travels down the gradient; this effect causes the apparent heading preference of the microswimmers and is the crucial reason that enables the seemingly cooperative chemotaxis of multiple bacteria on a microswimmer. In addition, we find that their chemotactic drift velocity increases superquadratically with their mean swimming speed, suggesting that chemotaxis of bio-hybrid microsystems can be enhanced by designing and building faster microswimmers. Such bio-hybrid microswimmers with chemotactic steering capability may find future applications in targeted drug delivery, bioengineering, and lab-on-a-chip devices.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


Thumb xl publications toc
Targeted drug delivery and imaging using mobile milli/microrobots: A promising future towards theranostic pharmaceutical design

Vikram Singh, A., Sitti, M.

Current Pharmaceutical Design, 22(11):1418-1428, Bentham Science Publishers, March 2016 (article)

Abstract
Miniature untethered medical robots have been receiving growing attention due to technological advances in microactuation, microsensors, and microfabrication and have significant potential to reduce the invasiveness and improve the accessibility of medical devices into unprecedented small spaces inside the human body. In this review, we discuss therapeutic and diagnostic applications of untethered medical microrobots. Wirelessly controlled milli/microrobots with integrated sensors are revolutionizing micromanipulation based medical interventions and are enabling doctors to perform minimally invasive procedures not possible before. 3D fabrication technologies enabling milli/microrobot fabrication at the single cell scale are empowering high-resolution visual imaging and in vivo manipulation capabilities. Swallowable millirobots and injectabale ocular microrobots allow the gastric ulcer imaging, and performance of vitreoretinal microsurgery at previously inaccessible ocular sites. Many invasive excision and incision based diagnostic biopsy, prostrate, and nephrolgical procedures can be performed minimally or almost noninvasively due to recent advancements in microrobotic technology. Advances in biohybrid microrobot systems are pushing microrobotic systems even smaller, using biological cells as on-board microactuators and microsensors using the chemical energy. Such microrobotic systems could be used for local targeted delivery of imaging contrast agents, drugs, genes, and mRNA, minimally invasive surgery, and cell micromanipulation in the near future.

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link (url) [BibTex]


Thumb xl publications toc
Parallel microcracks-based ultrasensitive and highly stretchable strain sensors

Amjadi, M., Turan, M., Clementson, C. P., Sitti, M.

ACS Applied Materials \& Interfaces, 8(8):5618-5626, American Chemical Society, Febuary 2016 (article)

Abstract
There is an increasing demand for flexible, skin-attachable, and wearable strain sensors due to their various potential applications. However, achieving strain sensors with both high sensitivity and high stretchability is still a grand challenge. Here, we propose highly sensitive and stretchable strain sensors based on the reversible microcrack formation in composite thin films. Controllable parallel microcracks are generated in graphite thin films coated on elastomer films. Sensors made of graphite thin films with short microcracks possess high gauge factors (maximum value of 522.6) and stretchability (ε ≥ 50%), whereas sensors with long microcracks show ultrahigh sensitivity (maximum value of 11 344) with limited stretchability (ε ≤ 50%). We demonstrate the high performance strain sensing of our sensors in both small and large strain sensing applications such as human physiological activity recognition, human body large motion capturing, vibration detection, pressure sensing, and soft robotics.

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DOI [BibTex]

DOI [BibTex]


Thumb xl amjadi et al 2016 advanced functional materials
Stretchable, Skin-Mountable, and Wearable Strain Sensors and Their Potential Applications: A Review

Amjadi, M., Kyung, K., Park, I., Sitti, M.

Advanced Functional Materials, 26, pages: 1678-1698, Febuary 2016 (article)

Abstract
There is a growing demand for flexible and soft electronic devices. In particular, stretchable, skin-mountable, and wearable strain sensors are needed for several potential applications including personalized health-monitoring, human motion detection, human-machine interfaces, soft robotics, and so forth. This Feature Article presents recent advancements in the development of flexible and stretchable strain sensors. The article shows that highly stretchable strain sensors are successfully being developed by new mechanisms such as disconnection between overlapped nanomaterials, crack propagation in thin films, and tunneling effect, different from traditional strain sensing mechanisms. Strain sensing performances of recently reported strain sensors are comprehensively studied and discussed, showing that appropriate choice of composite structures as well as suitable interaction between functional nanomaterials and polymers are essential for the high performance strain sensing. Next, simulation results of piezoresistivity of stretchable strain sensors by computational models are reported. Finally, potential applications of flexible strain sensors are described. This survey reveals that flexible, skin-mountable, and wearable strain sensors have potential in diverse applications while several grand challenges have to be still overcome.

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DOI [BibTex]

DOI [BibTex]


Thumb xl toc image patent
Remotely addressable magnetic composite micro-actuators

Sitti, M., Diller, E., Miyashita, S.

Febuary 2016, US Patent App. 15/018,008 (patent)

Abstract
The present invention describes methods to fabricate actuators that can be remotely controlled in an addressable manner, and methods to provide remote control such micro-actuators. The actuators are composites of two permanent magnet materials, one of which is has high coercivity, and the other of which switches magnetization direction by applied fields. By switching the second material's magnetization direction, the two magnets either work together or cancel each other, resulting in distinct “on” and “off” behavior of the devices. The device can be switched “on” or “off” remotely using a field pulse of short duration.

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[BibTex]

[BibTex]


Thumb xl toc image patent
Remotely addressable magnetic composite micro-actuators

Sitti, M., Diller, E., Miyashita, S.

Febuary 2016, US Patent 9,281,112 (patent)

Abstract
The present invention describes methods to fabricate actuators that can be remotely controlled in an addressable manner, and methods to provide remote control such micro-actuators. The actuators are composites of two permanent magnet materials, one of which is has high coercivity, and the other of which switches magnetization direction by applied fields. By switching the second material's magnetization direction, the two magnets either work together or cancel each other, resulting in distinct “on” and “off” behavior of the devices. The device can be switched “on” or “off” remotely using a field pulse of short duration.

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link (url) [BibTex]

link (url) [BibTex]


Thumb xl b 07384529
Size optimization of a magnetic system for drug delivery with capsule robots

Munoz, F., Alici, G., Li, W., Sitti, M.

IEEE Transactions on Magnetics, 52(5):1-11, IEEE, January 2016 (article)

Abstract
In this paper, we present a methodology for the size optimization of an external magnetic system made of arc-shaped permanent magnets (ASMs). This magnetic system is able to remotely actuate a drug-release module embedded in a prototype of a capsule robot. The optimization of the magnetic system is carried out by using an accurate analytical model that is valid for any arbitrary dimensions of the ASMs. By using this analytical model, we perform parametric studies and conduct a statistical analysis [analysis of variance (ANOVA)] to investigate efficient ways to distribute the volume of the ASMs so that the dimensions and volume of the magnetic system are minimized while optimal flux densities and magnetic torques are obtained to actuate the drug delivery system (DDS). The ANOVA results, at 5% significance level, indicate that changes in the angular width followed by changes in the length of the ASMs have the highest impact on the magnetic linkage. Furthermore, our experimental results, which are in agreement with the analytical results, show that the size optimization of the magnetic system is effective for the actuation of the DDS in capsule robots.

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DOI [BibTex]

DOI [BibTex]


Thumb xl teaser
Deep Discrete Flow

Güney, F., Geiger, A.

Asian Conference on Computer Vision (ACCV), 2016 (conference) Accepted

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pdf suppmat Project Page [BibTex]

pdf suppmat Project Page [BibTex]


Thumb xl img02
Probabilistic Duality for Parallel Gibbs Sampling without Graph Coloring

Mescheder, L., Nowozin, S., Geiger, A.

Arxiv, 2016 (article)

Abstract
We present a new notion of probabilistic duality for random variables involving mixture distributions. Using this notion, we show how to implement a highly-parallelizable Gibbs sampler for weakly coupled discrete pairwise graphical models with strictly positive factors that requires almost no preprocessing and is easy to implement. Moreover, we show how our method can be combined with blocking to improve mixing. Even though our method leads to inferior mixing times compared to a sequential Gibbs sampler, we argue that our method is still very useful for large dynamic networks, where factors are added and removed on a continuous basis, as it is hard to maintain a graph coloring in this setup. Similarly, our method is useful for parallelizing Gibbs sampling in graphical models that do not allow for graph colorings with a small number of colors such as densely connected graphs.

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pdf [BibTex]


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Map-Based Probabilistic Visual Self-Localization

Brubaker, M. A., Geiger, A., Urtasun, R.

IEEE Trans. on Pattern Analysis and Machine Intelligence (PAMI), 2016 (article)

Abstract
Accurate and efficient self-localization is a critical problem for autonomous systems. This paper describes an affordable solution to vehicle self-localization which uses odometry computed from two video cameras and road maps as the sole inputs. The core of the method is a probabilistic model for which an efficient approximate inference algorithm is derived. The inference algorithm is able to utilize distributed computation in order to meet the real-time requirements of autonomous systems in some instances. Because of the probabilistic nature of the model the method is capable of coping with various sources of uncertainty including noise in the visual odometry and inherent ambiguities in the map (e.g., in a Manhattan world). By exploiting freely available, community developed maps and visual odometry measurements, the proposed method is able to localize a vehicle to 4m on average after 52 seconds of driving on maps which contain more than 2,150km of drivable roads.

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pdf Project Page [BibTex]

pdf Project Page [BibTex]


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A Convex Model of Momentum Dynamics for Multi-Contact Motion Generation

Ponton, B., Herzog, A., Schaal, S., Righetti, L.

In 2016 IEEE-RAS 16th International Conference on Humanoid Robots Humanoids, pages: 842-849, IEEE, Cancun, Mexico, 2016 (inproceedings)

Abstract
Linear models for control and motion generation of humanoid robots have received significant attention in the past years, not only due to their well known theoretical guarantees, but also because of practical computational advantages. However, to tackle more challenging tasks and scenarios such as locomotion on uneven terrain, a more expressive model is required. In this paper, we are interested in contact interaction-centered motion optimization based on the momentum dynamics model. This model is non-linear and non-convex; however, we find a relaxation of the problem that allows us to formulate it as a single convex quadratically-constrained quadratic program (QCQP) that can be very efficiently optimized and is useful for multi-contact planning. This convex model is then coupled to the optimization of end-effector contact locations using a mixed integer program, which can also be efficiently solved. This becomes relevant e.g. to recover from external pushes, where a predefined stepping plan is likely to fail and an online adaptation of the contact location is needed. The performance of our algorithm is demonstrated in several multi-contact scenarios for a humanoid robot.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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On the Effects of Measurement Uncertainty in Optimal Control of Contact Interactions

Ponton, B., Schaal, S., Righetti, L.

In The 12th International Workshop on the Algorithmic Foundations of Robotics WAFR, Berkeley, USA, 2016 (inproceedings)

Abstract
Stochastic Optimal Control (SOC) typically considers noise only in the process model, i.e. unknown disturbances. However, in many robotic applications involving interaction with the environment, such as locomotion and manipulation, uncertainty also comes from lack of precise knowledge of the world, which is not an actual disturbance. We analyze the effects of also considering noise in the measurement model, by devel- oping a SOC algorithm based on risk-sensitive control, that includes the dynamics of an observer in such a way that the control law explicitly de- pends on the current measurement uncertainty. In simulation results on a simple 2D manipulator, we have observed that measurement uncertainty leads to low impedance behaviors, a result in contrast with the effects of process noise that creates stiff behaviors. This suggests that taking into account measurement uncertainty could be a potentially very interesting way to approach problems involving uncertain contact interactions.

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link (url) [BibTex]

link (url) [BibTex]


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Momentum Control with Hierarchical Inverse Dynamics on a Torque-Controlled Humanoid

Herzog, A., Rotella, N., Mason, S., Grimminger, F., Schaal, S., Righetti, L.

Autonomous Robots, 40(3):473-491, 2016 (article)

Abstract
Hierarchical inverse dynamics based on cascades of quadratic programs have been proposed for the control of legged robots. They have important benefits but to the best of our knowledge have never been implemented on a torque controlled humanoid where model inaccuracies, sensor noise and real-time computation requirements can be problematic. Using a reformulation of existing algorithms, we propose a simplification of the problem that allows to achieve real-time control. Momentum-based control is integrated in the task hierarchy and a LQR design approach is used to compute the desired associated closed-loop behavior and improve performance. Extensive experiments on various balancing and tracking tasks show very robust performance in the face of unknown disturbances, even when the humanoid is standing on one foot. Our results demonstrate that hierarchical inverse dynamics together with momentum control can be efficiently used for feedback control under real robot conditions.

am mg

link (url) DOI [BibTex]


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Inertial Sensor-Based Humanoid Joint State Estimation

Rotella, N., Mason, S., Schaal, S., Righetti, L.

In 2016 IEEE International Conference on Robotics and Automation (ICRA), pages: 1825-1831, IEEE, Stockholm, Sweden, 2016 (inproceedings)

Abstract
This work presents methods for the determination of a humanoid robot's joint velocities and accelerations directly from link-mounted Inertial Measurement Units (IMUs) each containing a three-axis gyroscope and a three-axis accelerometer. No information about the global pose of the floating base or its links is required and precise knowledge of the link IMU poses is not necessary due to presented calibration routines. Additionally, a filter is introduced to fuse gyroscope angular velocities with joint position measurements and compensate the computed joint velocities for time-varying gyroscope biases. The resulting joint velocities are subject to less noise and delay than filtered velocities computed from numerical differentiation of joint potentiometer signals, leading to superior performance in joint feedback control as demonstrated in experiments performed on a SARCOS hydraulic humanoid.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Stepping Stabilization Using a Combination of DCM Tracking and Step Adjustment

Khadiv, M., Kleff, S., Herzog, A., Moosavian, S. A. A., Schaal, S., Righetti, L.

In 2016 4th International Conference on Robotics and Mechatronics (ICROM), pages: 130-135, IEEE, Teheran, Iran, 2016 (inproceedings)

Abstract
In this paper, a method for stabilizing biped robots stepping by a combination of Divergent Component of Motion (DCM) tracking and step adjustment is proposed. In this method, the DCM trajectory is generated, consistent with the predefined footprints. Furthermore, a swing foot trajectory modification strategy is proposed to adapt the landing point, using DCM measurement. In order to apply the generated trajectories to the full robot, a Hierarchical Inverse Dynamics (HID) is employed. The HID enables us to use different combinations of the DCM tracking and step adjustment for stabilizing different biped robots. Simulation experiments on two scenarios for two different simulated robots, one with active ankles and the other with passive ankles, are carried out. Simulation results demonstrate the effectiveness of the proposed method for robots with both active and passive ankles.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Structured contact force optimization for kino-dynamic motion generation

Herzog, A., Schaal, S., Righetti, L.

In 2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), pages: 2703-2710, IEEE, Daejeon, South Korea, 2016 (inproceedings)

Abstract
Optimal control approaches in combination with trajectory optimization have recently proven to be a promising control strategy for legged robots. Computationally efficient and robust algorithms were derived using simplified models of the contact interaction between robot and environment such as the linear inverted pendulum model (LIPM). However, as humanoid robots enter more complex environments, less restrictive models become increasingly important. As we leave the regime of linear models, we need to build dedicated solvers that can compute interaction forces together with consistent kinematic plans for the whole-body. In this paper, we address the problem of planning robot motion and interaction forces for legged robots given predefined contact surfaces. The motion generation process is decomposed into two alternating parts computing force and motion plans in coherence. We focus on the properties of the momentum computation leading to sparse optimal control formulations to be exploited by a dedicated solver. In our experiments, we demonstrate that our motion generation algorithm computes consistent contact forces and joint trajectories for our humanoid robot. We also demonstrate the favorable time complexity due to our formulation and composition of the momentum equations.

am mg

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Balancing and Walking Using Full Dynamics LQR Control With Contact Constraints

Mason, S., Rotella, N., Schaal, S., Righetti, L.

In 2016 IEEE-RAS 16th International Conference on Humanoid Robots (Humanoids), pages: 63-68, IEEE, Cancun, Mexico, 2016 (inproceedings)

Abstract
Torque control algorithms which consider robot dynamics and contact constraints are important for creating dynamic behaviors for humanoids. As computational power increases, algorithms tend to also increase in complexity. However, it is not clear how much complexity is really required to create controllers which exhibit good performance. In this paper, we study the capabilities of a simple approach based on contact consistent LQR controllers designed around key poses to control various tasks on a humanoid robot. We present extensive experimental results on a hydraulic, torque controlled humanoid performing balancing and stepping tasks. This feedback control approach captures the necessary synergies between the DoFs of the robot to guarantee good control performance. We show that for the considered tasks, it is only necessary to re-linearize the dynamics of the robot at different contact configurations and that increasing the number of LQR controllers along desired trajectories does not improve performance. Our result suggest that very simple controllers can yield good performance competitive with current state of the art, but more complex, optimization-based whole-body controllers. A video of the experiments can be found at https://youtu.be/5T08CNKV1hw.

am mg

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Step Timing Adjustement: a Step toward Generating Robust Gaits

Khadiv, M., Herzog, A., Moosavian, S. A. A., Righetti, L.

In 2016 IEEE-RAS 16th International Conference on Humanoid Robots (Humanoids), pages: 35-42, IEEE, Cancun, Mexico, 2016 (inproceedings)

Abstract
Step adjustment for humanoid robots has been shown to improve robustness in gaits. However, step duration adaptation is often neglected in control strategies. In this paper, we propose an approach that combines both step location and timing adjustment for generating robust gaits. In this approach, step location and step timing are decided, based on feedback from the current state of the robot. The proposed approach is comprised of two stages. In the first stage, the nominal step location and step duration for the next step or a previewed number of steps are specified. In this stage which is done at the start of each step, the main goal is to specify the best step length and step duration for a desired walking speed. The second stage deals with finding the best landing point and landing time of the swing foot at each control cycle. In this stage, stability of the gaits is preserved by specifying a desired offset between the swing foot landing point and the Divergent Component of Motion (DCM) at the end of current step. After specifying the landing point of the swing foot at a desired time, the swing foot trajectory is regenerated at each control cycle to realize desired landing properties. Simulation on different scenarios shows the robustness of the generated gaits from our proposed approach compared to the case where no timing adjustment is employed.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]

2015


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Exploiting Object Similarity in 3D Reconstruction

Zhou, C., Güney, F., Wang, Y., Geiger, A.

In International Conference on Computer Vision (ICCV), December 2015 (inproceedings)

Abstract
Despite recent progress, reconstructing outdoor scenes in 3D from movable platforms remains a highly difficult endeavor. Challenges include low frame rates, occlusions, large distortions and difficult lighting conditions. In this paper, we leverage the fact that the larger the reconstructed area, the more likely objects of similar type and shape will occur in the scene. This is particularly true for outdoor scenes where buildings and vehicles often suffer from missing texture or reflections, but share similarity in 3D shape. We take advantage of this shape similarity by locating objects using detectors and jointly reconstructing them while learning a volumetric model of their shape. This allows us to reduce noise while completing missing surfaces as objects of similar shape benefit from all observations for the respective category. We evaluate our approach with respect to LIDAR ground truth on a novel challenging suburban dataset and show its advantages over the state-of-the-art.

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pdf suppmat [BibTex]

2015


pdf suppmat [BibTex]


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FollowMe: Efficient Online Min-Cost Flow Tracking with Bounded Memory and Computation

Lenz, P., Geiger, A., Urtasun, R.

In International Conference on Computer Vision (ICCV), International Conference on Computer Vision (ICCV), December 2015 (inproceedings)

Abstract
One of the most popular approaches to multi-target tracking is tracking-by-detection. Current min-cost flow algorithms which solve the data association problem optimally have three main drawbacks: they are computationally expensive, they assume that the whole video is given as a batch, and they scale badly in memory and computation with the length of the video sequence. In this paper, we address each of these issues, resulting in a computationally and memory-bounded solution. First, we introduce a dynamic version of the successive shortest-path algorithm which solves the data association problem optimally while reusing computation, resulting in faster inference than standard solvers. Second, we address the optimal solution to the data association problem when dealing with an incoming stream of data (i.e., online setting). Finally, we present our main contribution which is an approximate online solution with bounded memory and computation which is capable of handling videos of arbitrary length while performing tracking in real time. We demonstrate the effectiveness of our algorithms on the KITTI and PETS2009 benchmarks and show state-of-the-art performance, while being significantly faster than existing solvers.

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pdf suppmat video project [BibTex]

pdf suppmat video project [BibTex]


Thumb xl screen shot 2015 09 09 at 12.09.20
Untethered Magnetic Micromanipulation

Diller, E., Sitti, M.

In Micro-and Nanomanipulation Tools, 13, 10, Wiley-VCH Verlag GmbH & Co. KGaA, November 2015 (inbook)

Abstract
This chapter discusses the methods and state of the art in microscale manipulation in remote environments using untethered microrobotic devices. It focuses on manipulation at the size scale of tens to hundreds of microns, where small size leads to a dominance of microscale physical effects and challenges in fabrication and actuation. To motivate the challenges of operating at this size scale, the chapter includes coverage of the physical forces relevant to microrobot motion and manipulation below the millimeter-size scale. It then introduces the actuation methods commonly used in untethered manipulation schemes, with particular focus on magnetic actuation due to its wide use in the field. The chapter divides these manipulation techniques into two types: contact manipulation, which relies on direct pushing or grasping of objects for motion, and noncontact manipulation, which relies indirectly on induced fluid flow from the microrobot motion to move objects without any direct contact.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Towards Probabilistic Volumetric Reconstruction using Ray Potentials

(Best Paper Award)

Ulusoy, A. O., Geiger, A., Black, M. J.

In 3D Vision (3DV), 2015 3rd International Conference on, pages: 10-18, Lyon, October 2015 (inproceedings)

Abstract
This paper presents a novel probabilistic foundation for volumetric 3-d reconstruction. We formulate the problem as inference in a Markov random field, which accurately captures the dependencies between the occupancy and appearance of each voxel, given all input images. Our main contribution is an approximate highly parallelized discrete-continuous inference algorithm to compute the marginal distributions of each voxel's occupancy and appearance. In contrast to the MAP solution, marginals encode the underlying uncertainty and ambiguity in the reconstruction. Moreover, the proposed algorithm allows for a Bayes optimal prediction with respect to a natural reconstruction loss. We compare our method to two state-of-the-art volumetric reconstruction algorithms on three challenging aerial datasets with LIDAR ground truth. Our experiments demonstrate that the proposed algorithm compares favorably in terms of reconstruction accuracy and the ability to expose reconstruction uncertainty.

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code YouTube pdf suppmat DOI Project Page [BibTex]

code YouTube pdf suppmat DOI Project Page [BibTex]


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Compliant wing design for a flapping wing micro air vehicle

Colmenares, D., Kania, R., Zhang, W., Sitti, M.

In Intelligent Robots and Systems (IROS), 2015 IEEE/RSJ International Conference on, pages: 32-39, September 2015 (inproceedings)

Abstract
In this work, we examine several wing designs for a motor-driven, flapping-wing micro air vehicle capable of liftoff. The full system consists of two wings independently driven by geared pager motors that include a spring in parallel with the output shaft. The linear transmission allows for resonant operation, while control is achieved by direct drive of the wing angle. Wings used in previous work were chosen to be fully rigid for simplicity of modeling and fabrication. However, biological wings are highly flexible and other micro air vehicles have successfully utilized flexible wing structures for specialized tasks. The goal of our study is to determine if wing flexibility can be generally used to increase wing performance. Two approaches to lift improvement using flexible wings are explored, resonance of the wing cantilever structure and dynamic wing twisting. We design and test several wings that are compared using different figures of merit. A twisted design improved lift per power by 73.6% and maximum lift production by 53.2% compared to the original rigid design. Wing twist is then modeled in order to propose optimal wing twist profiles that can maximize either wing efficiency or lift production.

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DOI [BibTex]

DOI [BibTex]


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Methods of forming dry adhesive structures

Sitti, M., Murphy, M., Aksak, B.

September 2015, US Patent 9,120,953 (patent)

Abstract
Methods of forming dry adhesives including a method of making a dry adhesive including applying a liquid polymer to the second end of the stem, molding the liquid polymer on the stem in a mold, wherein the mold includes a recess having a cross-sectional area that is less than a cross-sectional area of the second end of the stem, curing the liquid polymer in the mold to form a tip at the second end of the stem, wherein the tip includes a second layer stem; corresponding to the recess in the mold, and removing the tip from the mold after the liquid polymer cures.

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[BibTex]

[BibTex]


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Millimeter-scale magnetic swimmers using elastomeric undulations

Zhang, J., Diller, E.

In 2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), pages: 1706-1711, September 2015 (inproceedings)

Abstract
This paper presents a new soft-bodied millimeterscale swimmer actuated by rotating uniform magnetic fields. The proposed swimmer moves through internal undulatory deformations, resulting from a magnetization profile programmed into its body. To understand the motion of the swimmer, a mathematical model is developed to describe the general relationship between the deflection of a flexible strip and its magnetization profile. As a special case, the situation of the swimmer on the water surface is analyzed and predictions made by the model are experimentally verified. Experimental results show the controllability of the proposed swimmer under a computer vision-based closed-loop controller. The swimmers have nominal dimensions of 1.5×4.9×0.06 mm and a top speed of 50 mm/s (10 body lengths per second). Waypoint following and multiagent control are demonstrated for swimmers constrained at the air-water interface and underwater swimming is also shown, suggesting the promising potential of this type of swimmer in biomedical and microfluidic applications.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Experimental investigation of optimal adhesion of mushroomlike elastomer microfibrillar adhesives

Marvi, H., Song, S., Sitti, M.

Langmuir, 31(37):10119-10124, American Chemical Society, August 2015 (article)

Abstract
Optimal fiber designs for the maximal pull-off force have been indispensable for increasing the attachment performance of recently introduced gecko-inspired reversible micro/nanofibrillar adhesives. There are several theoretical studies on such optimal designs; however, due to the lack of three-dimensional (3D) fabrication techniques that can fabricate such optimal designs in 3D, there have not been many experimental investigations on this challenge. In this study, we benefitted from recent advances in two-photon lithography techniques to fabricate mushroomlike polyurethane elastomer fibers with different aspect ratios of tip to stalk diameter (β) and tip wedge angles (θ) to investigate the effect of these two parameters on the pull-off force. We found similar trends to those predicted theoretically. We found that β has an impact on the slope of the force-displacement curve while both β and θ play a role in the stress distribution and crack propagation. We found that these effects are coupled and the optimal set of parameters also depends on the fiber material. This is the first experimental verification of such optimal designs proposed for mushroomlike microfibers. This experimental approach could be used to evaluate a wide range of complex microstructured adhesive designs suggested in the literature and optimize them.

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DOI [BibTex]

DOI [BibTex]


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Micro-fiber arrays with tip coating and transfer method for preparing same

Sitti, M., Washburn, N. R., Glass, P. S., Chung, H.

July 2015, US Patent 9,079,215 (patent)

Abstract
Present invention describes a patterned and coated micro- and nano-scale fibers elastomeric material for enhanced adhesion in wet or dry environments. A multi-step fabrication process including optical lithography, micromolding, polymer synthesis, dipping, stamping, and photopolymerization is described to produce uniform arrays of micron-scale fibers with mushroom-shaped tips coated with a thin layer of an intrinsically adhesive synthetic polymer, such as lightly crosslinked p(DMA-co-MEA).

pi

[BibTex]

[BibTex]


Thumb xl publications toc
pH-taxis of biohybrid microsystems

Zhuang, J., Carlsen, R. W., Sitti, M.

Scientific reports, 5, Nature Publishing Group, June 2015 (article)

Abstract
The last decade has seen an increasing number of studies developing bacteria and other cell-integrated biohybrid microsystems. However, the highly stochastic motion of these microsystems severely limits their potential use. Here, we present a method that exploits the pH sensing of flagellated bacteria to realize robust drift control of multi-bacteria propelled microrobots. Under three specifically configured pH gradients, we demonstrate that the microrobots exhibit both unidirectional and bidirectional pH-tactic behaviors, which are also observed in free-swimming bacteria. From trajectory analysis, we find that the swimming direction and speed biases are two major factors that contribute to their tactic drift motion. The motion analysis of microrobots also sheds light on the propulsion dynamics of the flagellated bacteria as bioactuators. It is expected that similar driving mechanisms are shared among pH-taxis, chemotaxis, and thermotaxis. By identifying the mechanism that drives the tactic behavior of bacteria-propelled microsystems, this study opens up an avenue towards improving the control of biohybrid microsystems. Furthermore, assuming that it is possible to tune the preferred pH of bioactuators by genetic engineering, these biohybrid microsystems could potentially be applied to sense the pH gradient induced by cancerous cells in stagnant fluids inside human body and realize targeted drug delivery.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Displets: Resolving Stereo Ambiguities using Object Knowledge

Güney, F., Geiger, A.

In IEEE Conf. on Computer Vision and Pattern Recognition (CVPR) 2015, pages: 4165-4175, IEEE International Conference on Computer Vision and Pattern Recognition (CVPR), June 2015 (inproceedings)

Abstract
Stereo techniques have witnessed tremendous progress over the last decades, yet some aspects of the problem still remain challenging today. Striking examples are reflecting and textureless surfaces which cannot easily be recovered using traditional local regularizers. In this paper, we therefore propose to regularize over larger distances using object-category specific disparity proposals (displets) which we sample using inverse graphics techniques based on a sparse disparity estimate and a semantic segmentation of the image. The proposed displets encode the fact that objects of certain categories are not arbitrarily shaped but typically exhibit regular structures. We integrate them as non-local regularizer for the challenging object class 'car' into a superpixel based CRF framework and demonstrate its benefits on the KITTI stereo evaluation.

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pdf abstract suppmat [BibTex]

pdf abstract suppmat [BibTex]


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Object Scene Flow for Autonomous Vehicles

Menze, M., Geiger, A.

In IEEE Conf. on Computer Vision and Pattern Recognition (CVPR) 2015, pages: 3061-3070, IEEE, IEEE International Conference on Computer Vision and Pattern Recognition (CVPR), June 2015 (inproceedings)

Abstract
This paper proposes a novel model and dataset for 3D scene flow estimation with an application to autonomous driving. Taking advantage of the fact that outdoor scenes often decompose into a small number of independently moving objects, we represent each element in the scene by its rigid motion parameters and each superpixel by a 3D plane as well as an index to the corresponding object. This minimal representation increases robustness and leads to a discrete-continuous CRF where the data term decomposes into pairwise potentials between superpixels and objects. Moreover, our model intrinsically segments the scene into its constituting dynamic components. We demonstrate the performance of our model on existing benchmarks as well as a novel realistic dataset with scene flow ground truth. We obtain this dataset by annotating 400 dynamic scenes from the KITTI raw data collection using detailed 3D CAD models for all vehicles in motion. Our experiments also reveal novel challenges which can't be handled by existing methods.

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pdf abstract suppmat DOI [BibTex]

pdf abstract suppmat DOI [BibTex]