Header logo is


2015


Thumb xl toc image
Enzymatically active biomimetic micropropellers for the penetration of mucin gels

Walker (Schamel), D., Käsdorf, B. T., Jeong, H. H., Lieleg, O., Fischer, P.

Science Advances, 1(11):e1500501, December 2015 (article)

Abstract
In the body, mucus provides an important defense mechanism by limiting the penetration of pathogens. It is therefore also a major obstacle for the efficient delivery of particle-based drug carriers. The acidic stomach lining in particular is difficult to overcome because mucin glycoproteins form viscoelastic gels under acidic conditions. The bacterium Helicobacter pylori has developed a strategy to overcome the mucus barrier by producing the enzyme urease, which locally raises the pH and consequently liquefies the mucus. This allows the bacteria to swim through mucus and to reach the epithelial surface. We present an artificial system of reactive magnetic micropropellers that mimic this strategy to move through gastric mucin gels by making use of surface-immobilized urease. The results demonstrate the validity of this biomimetic approach to penetrate biological gels, and show that externally propelled microstructures can actively and reversibly manipulate the physical state of their surroundings, suggesting that such particles could potentially penetrate native mucus.

pf

link (url) DOI [BibTex]

2015


link (url) DOI [BibTex]


no image
Distributed Event-based State Estimation

Trimpe, S.

Max Planck Institute for Intelligent Systems, November 2015 (techreport)

Abstract
An event-based state estimation approach for reducing communication in a networked control system is proposed. Multiple distributed sensor-actuator-agents observe a dynamic process and sporadically exchange their measurements and inputs over a bus network. Based on these data, each agent estimates the full state of the dynamic system, which may exhibit arbitrary inter-agent couplings. Local event-based protocols ensure that data is transmitted only when necessary to meet a desired estimation accuracy. This event-based scheme is shown to mimic a centralized Luenberger observer design up to guaranteed bounds, and stability is proven in the sense of bounded estimation errors for bounded disturbances. The stability result extends to the distributed control system that results when the local state estimates are used for distributed feedback control. Simulation results highlight the benefit of the event-based approach over classical periodic ones in reducing communication requirements.

am ics

arXiv [BibTex]

arXiv [BibTex]


Thumb xl posterior
Automatic LQR Tuning Based on Gaussian Process Optimization: Early Experimental Results

Marco, A., Hennig, P., Bohg, J., Schaal, S., Trimpe, S.

Machine Learning in Planning and Control of Robot Motion Workshop at the IEEE/RSJ International Conference on Intelligent Robots and Systems (iROS), pages: , , Machine Learning in Planning and Control of Robot Motion Workshop, October 2015 (conference)

Abstract
This paper proposes an automatic controller tuning framework based on linear optimal control combined with Bayesian optimization. With this framework, an initial set of controller gains is automatically improved according to a pre-defined performance objective evaluated from experimental data. The underlying Bayesian optimization algorithm is Entropy Search, which represents the latent objective as a Gaussian process and constructs an explicit belief over the location of the objective minimum. This is used to maximize the information gain from each experimental evaluation. Thus, this framework shall yield improved controllers with fewer evaluations compared to alternative approaches. A seven-degree-of-freedom robot arm balancing an inverted pole is used as the experimental demonstrator. Preliminary results of a low-dimensional tuning problem highlight the method’s potential for automatic controller tuning on robotic platforms.

am ei ics pn

PDF DOI Project Page [BibTex]

PDF DOI Project Page [BibTex]


Thumb xl mt cover
Gaussian Process Optimization for Self-Tuning Control

Marco, A.

Polytechnic University of Catalonia (BarcelonaTech), October 2015 (mastersthesis)

am ics

PDF Project Page [BibTex]

PDF Project Page [BibTex]


Thumb xl toc image
The EChemPen: A Guiding Hand To Learn Electrochemical Surface Modifications

Valetaud, M., Loget, G., Roche, J., Hueken, N., Fattah, Z., Badets, V., Fontaine, O., Zigah, D.

J. of Chem. Ed., 92(10):1700-1704, September 2015 (article)

Abstract
The Electrochemical Pen (EChemPen) was developed as an attractive tool for learning electrochemistry. The fabrication, principle, and operation of the EChemPen are simple and can be easily performed by students in practical classes. It is based on a regular fountain pen principle, where the electrolytic solution is dispensed at a tip to locally modify a conductive surface by triggering a localized electrochemical reaction. Three simple model reactions were chosen to demonstrate the versatility of the EChemPen for teaching various electrochemical processes. We describe first the reversible writing/erasing of metal letters, then the electrodeposition of a black conducting polymer "ink", and finally the colorful writings that can be generated by titanium anodization and that can be controlled by the applied potential. These entertaining and didactic experiments are adapted for teaching undergraduate students that start to study electrochemistry by means of surface modification reactions.

pf

DOI [BibTex]

DOI [BibTex]


no image
Adaptive and Learning Concepts in Hydraulic Force Control

Doerr, A.

University of Stuttgart, September 2015 (mastersthesis)

am ics

[BibTex]

[BibTex]


Thumb xl toc image
3D-printed Soft Microrobot for Swimming in Biological Fluids

Qiu, T., Palagi, S., Fischer, P.

In Conf. Proc. IEEE Eng. Med. Biol. Soc., pages: 4922-4925, August 2015 (inproceedings)

Abstract
Microscopic artificial swimmers hold the potential to enable novel non-invasive medical procedures. In order to ease their translation towards real biomedical applications, simpler designs as well as cheaper yet more reliable materials and fabrication processes should be adopted, provided that the functionality of the microrobots can be kept. A simple single-hinge design could already enable microswimming in non-Newtonian fluids, which most bodily fluids are. Here, we address the fabrication of such single-hinge microrobots with a 3D-printed soft material. Firstly, a finite element model is developed to investigate the deformability of the 3D-printed microstructure under typical values of the actuating magnetic fields. Then the microstructures are fabricated by direct 3D-printing of a soft material and their swimming performances are evaluated. The speeds achieved with the 3D-printed microrobots are comparable to those obtained in previous work with complex fabrication procedures, thus showing great promise for 3D-printed microrobots to be operated in biological fluids.

pf

link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl screen shot 2015 08 22 at 21.47.37
Direct Loss Minimization Inverse Optimal Control

Doerr, A., Ratliff, N., Bohg, J., Toussaint, M., Schaal, S.

In Proceedings of Robotics: Science and Systems, Rome, Italy, Robotics: Science and Systems XI, July 2015 (inproceedings)

Abstract
Inverse Optimal Control (IOC) has strongly impacted the systems engineering process, enabling automated planner tuning through straightforward and intuitive demonstration. The most successful and established applications, though, have been in lower dimensional problems such as navigation planning where exact optimal planning or control is feasible. In higher dimensional systems, such as humanoid robots, research has made substantial progress toward generalizing the ideas to model free or locally optimal settings, but these systems are complicated to the point where demonstration itself can be difficult. Typically, real-world applications are restricted to at best noisy or even partial or incomplete demonstrations that prove cumbersome in existing frameworks. This work derives a very flexible method of IOC based on a form of Structured Prediction known as Direct Loss Minimization. The resulting algorithm is essentially Policy Search on a reward function that rewards similarity to demonstrated behavior (using Covariance Matrix Adaptation (CMA) in our experiments). Our framework blurs the distinction between IOC, other forms of Imitation Learning, and Reinforcement Learning, enabling us to derive simple, versatile, and practical algorithms that blend imitation and reinforcement signals into a unified framework. Our experiments analyze various aspects of its performance and demonstrate its efficacy on conveying preferences for motion shaping and combined reach and grasp quality optimization.

am ics

PDF Video Project Page [BibTex]

PDF Video Project Page [BibTex]


no image
LMI-Based Synthesis for Distributed Event-Based State Estimation

Muehlebach, M., Trimpe, S.

In Proceedings of the American Control Conference, July 2015 (inproceedings)

Abstract
This paper presents an LMI-based synthesis procedure for distributed event-based state estimation. Multiple agents observe and control a dynamic process by sporadically exchanging data over a broadcast network according to an event-based protocol. In previous work [1], the synthesis of event-based state estimators is based on a centralized design. In that case three different types of communication are required: event-based communication of measurements, periodic reset of all estimates to their joint average, and communication of inputs. The proposed synthesis problem eliminates the communication of inputs as well as the periodic resets (under favorable circumstances) by accounting explicitly for the distributed structure of the control system.

am ics

PDF DOI Project Page [BibTex]

PDF DOI Project Page [BibTex]


no image
Guaranteed H2 Performance in Distributed Event-Based State Estimation

Muehlebach, M., Trimpe, S.

In Proceeding of the First International Conference on Event-based Control, Communication, and Signal Processing, June 2015 (inproceedings)

am ics

PDF DOI Project Page [BibTex]

PDF DOI Project Page [BibTex]


no image
On the Choice of the Event Trigger in Event-based Estimation

Trimpe, S., Campi, M.

In Proceeding of the First International Conference on Event-based Control, Communication, and Signal Processing, June 2015 (inproceedings)

am ics

PDF DOI Project Page [BibTex]

PDF DOI Project Page [BibTex]


Thumb xl toc image
Optimal Length of Low Reynolds Number Nanopropellers

Walker (Schamel), D., Kuebler, M., Morozov, K. I., Fischer, P., Leshansky, A. M.

Nano Letters, 15(7):4412-4416, June 2015 (article)

Abstract
Locomotion in fluids at the nanoscale is dominated by viscous drag. One efficient propulsion scheme is to use a weak rotating magnetic field that drives a chiral object. Froth bacterial flagella to artificial drills, the corkscrew is a universally useful chiral shape for propulsion in viscous environments. Externally powered magnetic micro- and nanomotors have been recently developed that allow for precise fuel-free propulsion in complex media. Here, we combine analytical and numerical theory with experiments on nanostructured screw-propellers to show that the optimal length is surprisingly short only about one helical turn, which is shorter than most of the structures in use to date. The results have important implications for the design of artificial actuated nano- and micropropellers and can dramatically reduce fabrication times, while ensuring optimal performance.

pf

DOI [BibTex]

DOI [BibTex]


Thumb xl toc image
A theoretical study of potentially observable chirality-sensitive NMR effects in molecules

Garbacz, P., Cukras, J., Jaszunski, M.

Phys. Chem. Chem. Phys., 17(35):22642-22651, May 2015 (article)

Abstract
Two recently predicted nuclear magnetic resonance effects, the chirality-induced rotating electric polarization and the oscillating magnetization, are examined for several experimentally available chiral molecules. We discuss in detail the requirements for experimental detection of chirality-sensitive NMR effects of the studied molecules. These requirements are related to two parameters: the shielding polarizability and the antisymmetric part of the nuclear magnetic shielding tensor. The dominant second contribution has been computed for small molecules at the coupled cluster and density functional theory levels. It was found that DFT calculations using the KT2 functional and the aug-cc-pCVTZ basis set adequately reproduce the CCSD(T) values obtained with the same basis set. The largest values of parameters, thus most promising from the experimental point of view, were obtained for the fluorine nuclei in 1,3-difluorocyclopropene and 1,3-diphenyl-2-fluoro-3-trifluoromethylcyclopropene.

pf

DOI [BibTex]

DOI [BibTex]


no image
Event-based Estimation and Control for Remote Robot Operation with Reduced Communication

Trimpe, S., Buchli, J.

In Proceedings of the IEEE International Conference on Robotics and Automation, May 2015 (inproceedings)

Abstract
An event-based communication framework for remote operation of a robot via a bandwidth-limited network is proposed. The robot sends state and environment estimation data to the operator, and the operator transmits updated control commands or policies to the robot. Event-based communication protocols are designed to ensure that data is transmitted only when required: the robot sends new estimation data only if this yields a significant information gain at the operator, and the operator transmits an updated control policy only if this comes with a significant improvement in control performance. The developed framework is modular and can be used with any standard estimation and control algorithms. Simulation results of a robotic arm highlight its potential for an efficient use of limited communication resources, for example, in disaster response scenarios such as the DARPA Robotics Challenge.

am ics

PDF DOI Project Page [BibTex]

PDF DOI Project Page [BibTex]


no image
Lernende Roboter

Trimpe, S.

In Jahrbuch der Max-Planck-Gesellschaft, Max Planck Society, May 2015, (popular science article in German) (inbook)

am ics

link (url) [BibTex]

link (url) [BibTex]


Thumb xl af4e540bee9e66bef88de83541787fe62fb3803ca149aa6a76018772ebe5b95f
Dynamic Inclusion Complexes of Metal Nanoparticles Inside Nanocups

Alarcon-Correa, M., Lee, T. C., Fischer, P.

Angew. Chem. Int. Ed., 54(23):6730-6734, May 2015, Featured cover article. (article)

Abstract
Host-guest inclusion complexes are abundant in molecular systems and of fundamental importance in living organisms. Realizing a colloidal analogue of a molecular dynamic inclusion complex is challenging because inorganic nanoparticles (NPs) with a well-defined cavity and portal are difficult to synthesize in high yield and with good structural fidelity. Herein, a generic strategy towards the fabrication of dynamic 1: 1 inclusion complexes of metal nanoparticles inside oxide nanocups with high yield (> 70%) and regiospecificity (> 90%) by means of a reactive double Janus nanoparticle intermediate is reported. Experimental evidence confirms that the inclusion complexes are formed by a kinetically controlled mechanism involving a delicate interplay between bipolar galvanic corrosion and alloying-dealloying oxidation. Release of the NP guest from the nanocups can be efficiently triggered by an external stimulus. Featured cover article.

pf

DOI [BibTex]

DOI [BibTex]


Thumb xl toc image
Surface roughness-induced speed increase for active Janus micromotors

Choudhury, U., Soler, L., Gibbs, J. G., Sanchez, S., Fischer, P.

Chem. Comm., 51(41):8660-8663, April 2015 (article)

Abstract
We demonstrate a simple physical fabrication method to control surface roughness of Janus micromotors and fabricate self-propelled active Janus microparticles with rough catalytic platinum surfaces that show a four-fold increase in their propulsion speed compared to conventional Janus particles coated with a smooth Pt layer.

pf

DOI [BibTex]

DOI [BibTex]


Thumb xl toc image
Active colloidal microdrills

Gibbs, J. G., Fischer, P.

Chem. Comm., 51(20):4192-4195, Febuary 2015 (article)

Abstract
We demonstrate a chemically driven, autonomous catalytic microdrill. An asymmetric distribution of catalyst causes the helical swimmer to twist while it undergoes directed propulsion. A driving torque and hydrodynamic coupling between translation and rotation at low Reynolds number leads to drill-like swimming behaviour.

pf

DOI [BibTex]

DOI [BibTex]


no image
Policy Search for Imitation Learning

Doerr, A.

University of Stuttgart, January 2015 (thesis)

am ics

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


Thumb xl advs201570022 gra 0001 m
Selectable Nanopattern Arrays for Nanolithographic Imprint and Etch-Mask Applications

Jeong, H. H., Mark, A. G., Lee, T., Son, K., Chen, W., Alarcon-Correa, M., Kim, I., Schütz, G., Fischer, P.

Adv. Science, 2(7):1500016, 2015, Featured cover article. (article)

Abstract
A parallel nanolithographic patterning method is presented that can be used to obtain arrays of multifunctional nanoparticles. These patterns can simply be converted into a variety of secondary nanopatterns that are useful for nanolithographic imprint, plasmonic, and etch-mask applications.

pf

link (url) DOI [BibTex]

link (url) DOI [BibTex]


no image
A New Perspective and Extension of the Gaussian Filter

Wüthrich, M., Trimpe, S., Kappler, D., Schaal, S.

In Robotics: Science and Systems, 2015 (inproceedings)

Abstract
The Gaussian Filter (GF) is one of the most widely used filtering algorithms; instances are the Extended Kalman Filter, the Unscented Kalman Filter and the Divided Difference Filter. GFs represent the belief of the current state by a Gaussian with the mean being an affine function of the measurement. We show that this representation can be too restrictive to accurately capture the dependencies in systems with nonlinear observation models, and we investigate how the GF can be generalized to alleviate this problem. To this end we view the GF from a variational-inference perspective, and analyze how restrictions on the form of the belief can be relaxed while maintaining simplicity and efficiency. This analysis provides a basis for generalizations of the GF. We propose one such generalization which coincides with a GF using a virtual measurement, obtained by applying a nonlinear function to the actual measurement. Numerical experiments show that the proposed Feature Gaussian Filter (FGF) can have a substantial performance advantage over the standard GF for systems with nonlinear observation models.

am ics

Web PDF Project Page [BibTex]

2013


Thumb xl toc image
Hybrid nanocolloids with programmed three-dimensional shape and material composition

Mark, A. G., Gibbs, J. G., Lee, T., Fischer, P.

NATURE MATERIALS, 12(9):802-807, 2013, Max Planck Press Release. (article)

Abstract
Tuning the optical(1,2), electromagnetic(3,4) and mechanical properties of a material requires simultaneous control over its composition and shape(5). This is particularly challenging for complex structures at the nanoscale because surface-energy minimization generally causes small structures to be highly symmetric(5). Here we combine low-temperature shadow deposition with nanoscale patterning to realize nanocolloids with anisotropic three-dimensional shapes, feature sizes down to 20 nm and a wide choice of materials. We demonstrate the versatility of the fabrication scheme by growing three-dimensional hybrid nanostructures that contain several functional materials with the lowest possible symmetry, and by fabricating hundreds of billions of plasmonic nanohelices, which we use as chiral metafluids with record circular dichroism and tunable chiroptical properties.

Max Planck Press Release.

pf

Video - Fabrication of Designer Nanostructures DOI [BibTex]


Thumb xl fig1
Chiral Colloidal Molecules And Observation of The Propeller Effect

Schamel, D., Pfeifer, M., Gibbs, J. G., Miksch, B., Mark, A. G., Fischer, P.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(33):12353-12359, 2013 (article)

Abstract
Chiral molecules play an important role in biological and chemical processes, but physical effects due to their symmetry-breaking are generally weak. Several physical chiral separation schemes which could potentially be useful, including the propeller effect, have therefore not yet been demonstrated at the molecular scale. However, it has been proposed that complex nonspherical colloidal particles could act as ``colloidal molecules{''} in mesoscopic model systems to permit the visualization of molecular phenomena that are otherwise difficult to observe. Unfortunately, it is difficult to synthesize such colloids because surface minimization generally favors the growth of symmetric particles. Here we demonstrate the production of large numbers of complex colloids with glancing angle physical vapor deposition. We use chiral colloids to demonstrate the Baranova and Zel'dovich (Baranova, N. B.; Zel'dovich, B. Y. Chem. Phys. Lett. 1978, 57, 435) propeller effect: the separation of a racemic mixture by application of a rotating field that couples to the dipole moment of the enantiomers and screw propels them in opposite directions. The handedness of the colloidal suspensions is monitored with circular differential light scattering. An exact solution for the colloid's propulsion is derived, and comparisons between the colloidal system and the corresponding effect at the molecular scale are made.

pf

Video - Nanospropellers DOI [BibTex]

Video - Nanospropellers DOI [BibTex]


Thumb xl toc image
Indirect absorption spectroscopy using quantum cascade lasers: mid-infrared refractometry and photothermal spectroscopy

Pfeifer, M., Ruf, A., Fischer, P.

OPTICS EXPRESS, 21(22):25643-25654, 2013 (article)

Abstract
We record vibrational spectra with two indirect schemes that depend on the real part of the index of refraction: mid-infrared refractometry and photothermal spectroscopy. In the former, a quantum cascade laser (QCL) spot is imaged to determine the angles of total internal reflection, which yields the absorption line via a beam profile analysis. In the photothermal measurements, a tunable QCL excites vibrational resonances of a molecular monolayer, which heats the surrounding medium and changes its refractive index. This is observed with a probe laser in the visible. Sub-monolayer sensitivities are demonstrated. (C) 2013 Optical Society of America

pf

DOI [BibTex]


Thumb xl applied physics cover vol 103 number 21
Plasmonic nanohelix metamaterials with tailorable giant circular dichroism

Gibbs, J. G., Mark, A. G., Eslami, S., Fischer, P.

APPLIED PHYSICS LETTERS, 103(21), 2013, Featured cover article. (article)

Abstract
Plasmonic nanohelix arrays are shown to interact with electromagnetic fields in ways not typically seen with ordinary matter. Chiral metamaterials (CMMs) with feature sizes small with respect to the wavelength of visible light are a promising route to experimentally achieve such phenomena as negative refraction without the need for simultaneously negative e and mu. Here we not only show that giant circular dichroism in the visible is achievable with hexagonally arranged plasmonic nanohelix arrays, but that we can precisely tune the optical activity via morphology and lattice spacing. The discrete dipole approximation is implemented to support experimental data. (C) 2013 AIP Publishing LLC.

Featured cover article.

pf

DOI [BibTex]

DOI [BibTex]