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2018


Nanoscale robotic agents in biological fluids and tissues
Nanoscale robotic agents in biological fluids and tissues

Palagi, S., Walker, D. Q. T., Fischer, P.

In The Encyclopedia of Medical Robotics, 2, pages: 19-42, 2, (Editors: Desai, J. P. and Ferreira, A.), World Scientific, October 2018 (inbook)

Abstract
Nanorobots are untethered structures of sub-micron size that can be controlled in a non-trivial way. Such nanoscale robotic agents are envisioned to revolutionize medicine by enabling minimally invasive diagnostic and therapeutic procedures. To be useful, nanorobots must be operated in complex biological fluids and tissues, which are often difficult to penetrate. In this chapter, we first discuss potential medical applications of motile nanorobots. We briefly present the challenges related to swimming at such small scales and we survey the rheological properties of some biological fluids and tissues. We then review recent experimental results in the development of nanorobots and in particular their design, fabrication, actuation, and propulsion in complex biological fluids and tissues. Recent work shows that their nanoscale dimension is a clear asset for operation in biological tissues, since many biological tissues consist of networks of macromolecules that prevent the passage of larger micron-scale structures, but contain dynamic pores through which nanorobots can move.

pf

link (url) DOI [BibTex]

2018


link (url) DOI [BibTex]


Colloidal Chemical Nanomotors
Colloidal Chemical Nanomotors

Alarcon-Correa, M.

Colloidal Chemical Nanomotors, pages: 150, Cuvillier Verlag, MPI-IS , June 2018 (phdthesis)

Abstract
Synthetic sophisticated nanostructures represent a fundamental building block for the development of nanotechnology. The fabrication of nanoparticles complex in structure and material composition is key to build nanomachines that can operate as man-made nanoscale motors, which autonomously convert external energy into motion. To achieve this, asymmetric nanoparticles were fabricated combining a physical vapor deposition technique known as NanoGLAD and wet chemical synthesis. This thesis primarily concerns three complex colloidal systems that have been developed: i)Hollow nanocup inclusion complexes that have a single Au nanoparticle in their pocket. The Au particle can be released with an external trigger. ii)The smallest self-propelling nanocolloids that have been made to date, which give rise to a local concentration gradient that causes enhanced diffusion of the particles. iii)Enzyme-powered pumps that have been assembled using bacteriophages as biological nanoscaffolds. This construct also can be used for enzyme recovery after heterogeneous catalysis.

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[BibTex]

[BibTex]

1999


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Nonparametric regression for learning nonlinear transformations

Schaal, S.

In Prerational Intelligence in Strategies, High-Level Processes and Collective Behavior, 2, pages: 595-621, (Editors: Ritter, H.;Cruse, H.;Dean, J.), Kluwer Academic Publishers, 1999, clmc (inbook)

Abstract
Information processing in animals and artificial movement systems consists of a series of transformations that map sensory signals to intermediate representations, and finally to motor commands. Given the physical and neuroanatomical differences between individuals and the need for plasticity during development, it is highly likely that such transformations are learned rather than pre-programmed by evolution. Such self-organizing processes, capable of discovering nonlinear dependencies between different groups of signals, are one essential part of prerational intelligence. While neural network algorithms seem to be the natural choice when searching for solutions for learning transformations, this paper will take a more careful look at which types of neural networks are actually suited for the requirements of an autonomous learning system. The approach that we will pursue is guided by recent developments in learning theory that have linked neural network learning to well established statistical theories. In particular, this new statistical understanding has given rise to the development of neural network systems that are directly based on statistical methods. One family of such methods stems from nonparametric regression. This paper will compare nonparametric learning with the more widely used parametric counterparts in a non technical fashion, and investigate how these two families differ in their properties and their applicabilities. We will argue that nonparametric neural networks offer a set of characteristics that make them a very promising candidate for on-line learning in autonomous system.

am

link (url) [BibTex]

1999


link (url) [BibTex]

1996


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From isolation to cooperation: An alternative of a system of experts

Schaal, S., Atkeson, C. G.

In Advances in Neural Information Processing Systems 8, pages: 605-611, (Editors: Touretzky, D. S.;Mozer, M. C.;Hasselmo, M. E.), MIT Press, Cambridge, MA, 1996, clmc (inbook)

Abstract
We introduce a constructive, incremental learning system for regression problems that models data by means of locally linear experts. In contrast to other approaches, the experts are trained independently and do not compete for data during learning. Only when a prediction for a query is required do the experts cooperate by blending their individual predictions. Each expert is trained by minimizing a penalized local cross validation error using second order methods. In this way, an expert is able to adjust the size and shape of the receptive field in which its predictions are valid, and also to adjust its bias on the importance of individual input dimensions. The size and shape adjustment corresponds to finding a local distance metric, while the bias adjustment accomplishes local dimensionality reduction. We derive asymptotic results for our method. In a variety of simulations we demonstrate the properties of the algorithm with respect to interference, learning speed, prediction accuracy, feature detection, and task oriented incremental learning. 

am

link (url) [BibTex]

1996


link (url) [BibTex]