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Targeting of cell mockups using sperm-shaped microrobots in vitro

2016

Conference Paper

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Sperm-shaped microrobots are controlled under the influence of weak oscillating magnetic fields (milliTesla range) to selectively target cell mockups (i.e., gas bubbles with average diameter of 200 μm). The sperm-shaped microrobots are fabricated by electrospinning using a solution of polystyrene, dimethylformamide, and iron oxide nanoparticles. These nanoparticles are concentrated within the head of the microrobot, and hence enable directional control along external magnetic fields. The magnetic dipole moment of the microrobot is characterized (using the flip-time technique) to be 1.4×10-11 A.m2, at magnetic field of 28 mT. In addition, the morphology of the microrobot is characterized using Scanning Electron Microscopy images. The characterized parameters and morphology are used in the simulation of the locomotion mechanism of the microrobot to prove that its motion depends on breaking the time-reversal symmetry, rather than pulling with the magnetic field gradient. We experimentally demonstrate that the microrobot can controllably follow S-shaped, U-shaped, and square paths, and selectively target the cell mockups using image guidance and under the influence of the oscillating magnetic fields.

Author(s): Khalil, Islam SM and Tabak, Ahmet Fatih and Hosney, Abdelrahman and Klingner, Anke and Shalaby, Marwan and Abdel-Kader, Reham M and Serry, Mohamed and Sitti, Metin
Book Title: Biomedical Robotics and Biomechatronics (BioRob), 2016 6th IEEE International Conference on
Pages: 495--501
Year: 2016
Month: July
Day: 28

Department(s): Physical Intelligence
Bibtex Type: Conference Paper (inproceedings)

DOI: 10.1109/BIOROB.2016.7523675

ISBN: 978-1-5090-3287-7
Organization: IEEE

BibTex

@inproceedings{khalil2016targeting,
  title = {Targeting of cell mockups using sperm-shaped microrobots in vitro},
  author = {Khalil, Islam SM and Tabak, Ahmet Fatih and Hosney, Abdelrahman and Klingner, Anke and Shalaby, Marwan and Abdel-Kader, Reham M and Serry, Mohamed and Sitti, Metin},
  booktitle = {Biomedical Robotics and Biomechatronics (BioRob), 2016 6th IEEE International Conference on},
  pages = {495--501},
  organization = {IEEE},
  month = jul,
  year = {2016},
  month_numeric = {7}
}