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Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells

2018

Article

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Devising strategies for the controlled injection of functional nanoparticles and reagents into living cells paves the way for novel applications in nanosurgery, sensing, and drug delivery. Here, we demonstrate the light-controlled guiding and injection of plasmonic Janus nanopens into living cells. The pens are made of a gold nanoparticle attached to a dielectric alumina shaft. Balancing optical and thermophoretic forces in an optical tweezer allows single Janus nanopens to be trapped and positioned on the surface of living cells. While the optical injection process involves strong heating of the plasmonic side, the temperature of the alumina stays significantly lower, thus allowing the functionalization with fluorescently labeled, single-stranded DNA and, hence, the spatially controlled injection of genetic material with an untethered nanocarrier.

Author(s): Maier, Christoph M. and Huergo, Maria Ana and Milosevic, Sara and Pernpeintner, Carla and Li, Miao and Singh, Dhruv P. and Walker, Debora and Fischer, Peer and Feldmann, Jochen and Lohmüller, Theobald
Journal: Nano Letters
Year: 2018
Month: November
Day: 23

Department(s): Micro, Nano, and Molecular Systems
Bibtex Type: Article (article)

DOI: 10.1021/acs.nanolett.8b03885
Eprint: https://doi.org/10.1021/acs.nanolett.8b03885
State: Accepted
URL: https://doi.org/10.1021/acs.nanolett.8b03885

BibTex

@article{2018maier,
  title = {Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells},
  author = {Maier, Christoph M. and Huergo, Maria Ana and Milosevic, Sara and Pernpeintner, Carla and Li, Miao and Singh, Dhruv P. and Walker, Debora and Fischer, Peer and Feldmann, Jochen and Lohm{\"u}ller, Theobald},
  journal = {Nano Letters},
  month = nov,
  year = {2018},
  eprint = {  https://doi.org/10.1021/acs.nanolett.8b03885 },
  url = {  https://doi.org/10.1021/acs.nanolett.8b03885 },
  month_numeric = {11}
}