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Three‐dimensional patterning in biomedicine: Importance and applications in neuropharmacology

2017

Article

pi


Abstract Nature manufactures biological systems in three dimensions with precisely controlled spatiotemporal profiles on hierarchical length and time scales. In this article, we review 3D patterning of biological systems on synthetic platforms for neuropharmacological applications. We briefly describe 3D versus 2D chemical and topographical patterning methods and their limitations. Subsequently, an overview of introducing a third dimension in neuropharmacological research with delineation of chemical and topographical roles is presented. Finally, toward the end of this article, an explanation of how 3D patterning has played a pivotal role in relevant fields of neuropharmacology to understand neurophysiology during development, normal health, and disease conditions is described. The future prospects of organs‐on‐a‐‐like devices to mimic patterned blood–brain barrier in the context of neurotherapeutic discovery and development for the prioritization of lead candidates, membrane potential, and toxicity testing are also described. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1369–1382, 2018.

Author(s): Ajay, Vikram Singh and Tanmay, Gharat and Madu, Batuwangala and Byung‐Wook, Park and Thomas, Endlein and Metin, Sitti
Journal: Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume: 106
Number (issue): 3
Pages: 1369-1382
Year: 2017
Month: June
Day: 05

Department(s): Physical Intelligence
Bibtex Type: Article (article)

DOI: 10.1002/jbm.b.33922
Eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.33922
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33922

BibTex

@article{doi:10.1002/jbm.b.33922,
  title = {Three‐dimensional patterning in biomedicine: Importance and applications in neuropharmacology},
  author = {Ajay, Vikram Singh and Tanmay, Gharat and Madu, Batuwangala and Byung‐Wook, Park and Thomas, Endlein and Metin, Sitti},
  journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
  volume = {106},
  number = {3},
  pages = {1369-1382},
  month = jun,
  year = {2017},
  eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.33922},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33922},
  month_numeric = {6}
}