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Clustering Protein Sequence and Structure Space with Infinite Gaussian Mixture Models

2004

Conference Paper

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We describe a novel approach to the problem of automatically clustering protein sequences and discovering protein families, subfamilies etc., based on the thoery of infinite Gaussian mixture models. This method allows the data itself to dictate how many mixture components are required to model it, and provides a measure of the probability that two proteins belong to the same cluster. We illustrate our methods with application to three data sets: globin sequences, globin sequences with known tree-dimensional structures and G-pretein coupled receptor sequences. The consistency of the clusters indicate that that our methods is producing biologically meaningful results, which provide a very good indication of the underlying families and subfamilies. With the inclusion of secondary structure and residue solvent accessibility information, we obtain a classification of sequences of known structure which reflects and extends their SCOP classifications. A supplementary web site containing larger versions of the figures is available at http://public.kgi.edu/~wild/PSB04

Author(s): Dubey, A. and Hwang, S. and Rangel, C. and Rasmussen, CE. and Ghahramani, Z. and Wild, DL.
Journal: Pacific Symposium on Biocomputing 2004; Vol. 9
Pages: 399-410
Year: 2004
Day: 0
Publisher: World Scientific Publishing

Department(s): Empirical Inference
Bibtex Type: Conference Paper (inproceedings)

Event Name: Pacific Symposium on Biocomputing 2004
Event Place: The Big Island of Hawaii

Address: Singapore
Digital: 0
Organization: Max-Planck-Gesellschaft
School: Biologische Kybernetik

Links: PDF

BibTex

@inproceedings{2373,
  title = {Clustering Protein Sequence and Structure Space with Infinite Gaussian Mixture Models},
  author = {Dubey, A. and Hwang, S. and Rangel, C. and Rasmussen, CE. and Ghahramani, Z. and Wild, DL.},
  journal = {Pacific Symposium on Biocomputing 2004; Vol. 9},
  pages = {399-410},
  publisher = {World Scientific Publishing},
  organization = {Max-Planck-Gesellschaft},
  school = {Biologische Kybernetik},
  address = {Singapore},
  year = {2004}
}