Publications | Max Planck Institute for Intelligent Systems

We measure the performance of five subjects in a slant-discrimination task for differently textured planes. As textures we used uniform lattices, randomly displaced lattices, circles (polka dots), Voronoi tessellations, plaids, 1/f noise, coherent noise and a leopard skin-like texture. Our results show: (1) Improving performance with larger slants for all textures. (2) Thus, following from (1), cases of non-symmetrical performance around a particular orientation. (3) For orientations sufficiently slanted, the different textures do not elicit major differences in performance, (4) while for orientations closer to the vertical plane there are marked differences between them. (5) These differences allow a rank-order of textures to be formed according to their helpfulness that is, how easy the discrimination task is when a particular texture is mapped on the plane. Polka dots tend to allow the best slant discrimination performance, noise patterns the worst. Two additional experiments were conducted to test the generality of the obtained rank-order. First, the tilt of the planes was rotated to break the axis of gravity present in the original discrimination experiment. Second, the task was changed to a slant report task via probe adjustment. The results of both control experiments confirmed the texture-based rank-order previously obtained. We comment on the importance of these results for depth perception research in general, and in particular the implications our results have for studies of cue combination (sensor fusion) using texture as one of the cues involved.

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ei Rosas, P., Wichmann, F., Wagemans, J. Some observations on the effects of slant and texture type on slant-from-texture Vision Research, 44(13):1511-1535, 2004 (article)

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A kernel view of the dimensionality reduction of manifolds

Ham, J., Lee, D., Mika, S., Schölkopf, B.

In Proceedings of the Twenty-First International Conference on Machine Learning, pages: 369-376, (Editors: CE Brodley), ACM, New York, NY, USA, ICML, 2004, also appeared as MPI-TR 110 (inproceedings)

Abstract

We interpret several well-known algorithms for dimensionality reduction of manifolds as kernel methods. Isomap, graph Laplacian eigenmap, and locally linear embedding (LLE) all utilize local neighborhood information to construct a global embedding of the manifold. We show how all three algorithms can be described as kernel PCA on specially constructed Gram matrices, and illustrate the similarities and differences between the algorithms with representative examples.

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ei Ham, J., Lee, D., Mika, S., Schölkopf, B. A kernel view of the dimensionality reduction of manifolds In Proceedings of the Twenty-First International Conference on Machine Learning, pages: 369-376, (Editors: CE Brodley), ACM, New York, NY, USA, ICML, 2004, also appeared as MPI-TR 110 (inproceedings)

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Protein Functional Class Prediction with a Combined Graph

Shin, H., Tsuda, K., Schölkopf, B.

In Proceedings of the Korean Data Mining Conference, pages: 200-219, Proceedings of the Korean Data Mining Conference, 2004 (inproceedings)

Abstract

In bioinformatics, there exist multiple descriptions of graphs for the same set of genes or proteins. For instance, in yeast systems, graph edges can represent different relationships such as protein-protein interactions, genetic interactions, or co-participation in a protein complex, etc. Relying on similarities between nodes, each graph can be used independently for prediction of protein function. However, since different graphs contain partly independent and partly complementary information about the problem at hand, one can enhance the total information extracted by combining all graphs. In this paper, we propose a method for integrating multiple graphs within a framework of semi-supervised learning. The method alternates between minimizing the objective function with respect to network output and with respect to combining weights. We apply the method to the task of protein functional class prediction in yeast. The proposed method performs significantly better than the same algorithm trained on any single graph.

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ei Shin, H., Tsuda, K., Schölkopf, B. Protein Functional Class Prediction with a Combined Graph In Proceedings of the Korean Data Mining Conference, pages: 200-219, Proceedings of the Korean Data Mining Conference, 2004 (inproceedings)

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Learning from Labeled and Unlabeled Data Using Random Walks

Zhou, D., Schölkopf, B.

In Pattern Recognition, Proceedings of the 26th DAGM Symposium, pages: 237-244, (Editors: Rasmussen, C.E., H.H. Bülthoff, M.A. Giese and B. Schölkopf), Pattern Recognition, Proceedings of the 26th DAGM Symposium, 2004 (inproceedings)

Abstract

We consider the general problem of learning from labeled and unlabeled data. Given a set of points, some of them are labeled, and the remaining points are unlabeled. The goal is to predict the labels of the unlabeled points. Any supervised learning algorithm can be applied to this problem, for instance, Support Vector Machines (SVMs). The problem of our interest is if we can implement a classifier which uses the unlabeled data information in some way and has higher accuracy than the classifiers which use the labeled data only. Recently we proposed a simple algorithm, which can substantially benefit from large amounts of unlabeled data and demonstrates clear superiority to supervised learning methods. In this paper we further investigate the algorithm using random walks and spectral graph theory, which shed light on the key steps in this algorithm.

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ei Zhou, D., Schölkopf, B. Learning from Labeled and Unlabeled Data Using Random Walks In Pattern Recognition, Proceedings of the 26th DAGM Symposium, pages: 237-244, (Editors: Rasmussen, C.E., H.H. Bülthoff, M.A. Giese and B. Schölkopf), Pattern Recognition, Proceedings of the 26th DAGM Symposium, 2004 (inproceedings)

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Learning from Labeled and Unlabeled Data Using Random Walks

Zhou, D., Schölkopf, B.

Max Planck Institute for Biological Cybernetics, 2004 (techreport)

Abstract

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ei Zhou, D., Schölkopf, B. Learning from Labeled and Unlabeled Data Using Random Walks Max Planck Institute for Biological Cybernetics, 2004 (techreport)

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Masking by plaid patterns revisited

Wichmann, F.

Experimentelle Psychologie. Beitr{\"a}ge zur 46. Tagung experimentell arbeitender Psychologen, 46, pages: 285, 2004 (poster)

[BibTex]

ei Wichmann, F. Masking by plaid patterns revisited Experimentelle Psychologie. Beitr{\"a}ge zur 46. Tagung experimentell arbeitender Psychologen, 46, pages: 285, 2004 (poster)

[BibTex]

Minimizing the Cross Validation Error to Mix Kernel Matrices of Heterogeneous Biological Data

Tsuda, K., Uda, S., Kin, T., Asai, K.

Neural Processing Letters, 19, pages: 63-72, 2004 (article)

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ei Tsuda, K., Uda, S., Kin, T., Asai, K. Minimizing the Cross Validation Error to Mix Kernel Matrices of Heterogeneous Biological Data Neural Processing Letters, 19, pages: 63-72, 2004 (article)

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A Tutorial on Support Vector Regression

Smola, A., Schölkopf, B.

Statistics and Computing, 14(3):199-222, 2004 (article)

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ei Smola, A., Schölkopf, B. A Tutorial on Support Vector Regression Statistics and Computing, 14(3):199-222, 2004 (article)

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Multivariate Regression via Stiefel Manifold Constraints

BakIr, G., Gretton, A., Franz, M., Schölkopf, B.

In Lecture Notes in Computer Science, Vol. 3175, pages: 262-269, (Editors: CE Rasmussen and HH Bülthoff and B Schölkopf and MA Giese), Springer, Berlin, Germany, Pattern Recognition, Proceedings of the 26th DAGM Symposium, 2004 (inproceedings)

Abstract

We introduce a learning technique for regression between high-dimensional spaces. Standard methods typically reduce this task to many one-dimensional problems, with each output dimension considered independently. By contrast, in our approach the feature construction and the regression estimation are performed jointly, directly minimizing a loss function that we specify, subject to a rank constraint. A major advantage of this approach is that the loss is no longer chosen according to the algorithmic requirements, but can be tailored to the characteristics of the task at hand; the features will then be optimal with respect to this objective, and dependence between the outputs can be exploited.

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ei BakIr, G., Gretton, A., Franz, M., Schölkopf, B. Multivariate Regression via Stiefel Manifold Constraints In Lecture Notes in Computer Science, Vol. 3175, pages: 262-269, (Editors: CE Rasmussen and HH Bülthoff and B Schölkopf and MA Giese), Springer, Berlin, Germany, Pattern Recognition, Proceedings of the 26th DAGM Symposium, 2004 (inproceedings)

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Implicit estimation of Wiener series

Franz, M., Schölkopf, B.

In Machine Learning for Signal Processing XIV, Proc. 2004 IEEE Signal Processing Society Workshop, pages: 735-744, (Editors: A Barros and J Principe and J Larsen and T Adali and S Douglas), IEEE, New York, Machine Learning for Signal Processing XIV, Proc. IEEE Signal Processing Society Workshop, 2004 (inproceedings)

Abstract

The Wiener series is one of the standard methods to systematically characterize the nonlinearity of a system. The classical estimation method of the expansion coefficients via cross-correlation suffers from severe problems that prevent its application to high-dimensional and strongly nonlinear systems. We propose an implicit estimation method based on regression in a reproducing kernel Hilbert space that alleviates these problems. Experiments show performance advantages in terms of convergence, interpretability, and system sizes that can be handled.

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ei Franz, M., Schölkopf, B. Implicit estimation of Wiener series In Machine Learning for Signal Processing XIV, Proc. 2004 IEEE Signal Processing Society Workshop, pages: 735-744, (Editors: A Barros and J Principe and J Larsen and T Adali and S Douglas), IEEE, New York, Machine Learning for Signal Processing XIV, Proc. IEEE Signal Processing Society Workshop, 2004 (inproceedings)

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Hilbertian Metrics on Probability Measures and their Application in SVM’s

Hein, H., Lal, T., Bousquet, O.

In Pattern Recognition, Proceedings of th 26th DAGM Symposium, 3175, pages: 270-277, Lecture Notes in Computer Science, (Editors: Rasmussen, C. E., H. H. Bülthoff, M. Giese and B. Schölkopf), Pattern Recognition, Proceedings of th 26th DAGM Symposium, 2004 (inproceedings)

Abstract

The goal of this article is to investigate the field of Hilbertian metrics on probability measures. Since they are very versatile and can therefore be applied in various problems they are of great interest in kernel methods. Quit recently Tops{o}e and Fuglede introduced a family of Hilbertian metrics on probability measures. We give basic properties of the Hilbertian metrics of this family and other used metrics in the literature. Then we propose an extension of the considered metrics which incorporates structural information of the probability space into the Hilbertian metric. Finally we compare all proposed metrics in an image and text classification problem using histogram data.

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ei Hein, H., Lal, T., Bousquet, O. Hilbertian Metrics on Probability Measures and their Application in SVM’s In Pattern Recognition, Proceedings of th 26th DAGM Symposium, 3175, pages: 270-277, Lecture Notes in Computer Science, (Editors: Rasmussen, C. E., H. H. Bülthoff, M. Giese and B. Schölkopf), Pattern Recognition, Proceedings of th 26th DAGM Symposium, 2004 (inproceedings)

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Gasussian process model based predictive control

Kocijan, J., Murray-Smith, R., Rasmussen, CE., Girard, A.

In Proceedings of the ACC 2004, pages: 2214-2219, Proceedings of the ACC, 2004 (inproceedings)

Abstract

Gaussian process models provide a probabilistic non-parametric modelling approach for black-box identi cation of non-linear dynamic systems. The Gaussian processes can highlight areas of the input space where prediction quality is poor, due to the lack of data or its complexity, by indicating the higher variance around the predicted mean. Gaussian process models contain noticeably less coef cients to be optimised. This paper illustrates possible application of Gaussian process models within model-based predictive control. The extra information provided within Gaussian process model is used in predictive control, where optimisation of control signal takes the variance information into account. The predictive control principle is demonstrated on control of pH process benchmark.

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ei Kocijan, J., Murray-Smith, R., Rasmussen, CE., Girard, A. Gasussian process model based predictive control In Proceedings of the ACC 2004, pages: 2214-2219, Proceedings of the ACC, 2004 (inproceedings)

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A New Variational Framework for Rigid-Body Alignment

Kato, T., Tsuda, K., Tomii, K., Asai, K.

In Joint IAPR International Workshops on Syntactical and Structural Pattern Recognition (SSPR 2004) and Statistical Pattern Recognition (SPR 2004), pages: 171-179, (Editors: Fred, A.,T. Caelli, R.P.W. Duin, A. Campilho and D. de Ridder), Joint IAPR International Workshops on Syntactical and Structural Pattern Recognition (SSPR) and Statistical Pattern Recognition (SPR), 2004 (inproceedings)

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ei Kato, T., Tsuda, K., Tomii, K., Asai, K. A New Variational Framework for Rigid-Body Alignment In Joint IAPR International Workshops on Syntactical and Structural Pattern Recognition (SSPR 2004) and Statistical Pattern Recognition (SPR 2004), pages: 171-179, (Editors: Fred, A.,T. Caelli, R.P.W. Duin, A. Campilho and D. de Ridder), Joint IAPR International Workshops on Syntactical and Structural Pattern Recognition (SSPR) and Statistical Pattern Recognition (SPR), 2004 (inproceedings)

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Protein Classification via Kernel Matrix Completion

Kin, T., Kato, T., Tsuda, K.

In pages: 261-274, (Editors: Schoelkopf, B., K. Tsuda and J.P. Vert), MIT Press, Cambridge, MA; USA, 2004 (inbook)

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ei Kin, T., Kato, T., Tsuda, K. Protein Classification via Kernel Matrix Completion In pages: 261-274, (Editors: Schoelkopf, B., K. Tsuda and J.P. Vert), MIT Press, Cambridge, MA; USA, 2004 (inbook)

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Behaviour and Convergence of the Constrained Covariance

Gretton, A., Smola, A., Bousquet, O., Herbrich, R., Schölkopf, B., Logothetis, N.

(130), MPI for Biological Cybernetics, 2004 (techreport)

Abstract

We discuss reproducing kernel Hilbert space (RKHS)-based measures of statistical dependence, with emphasis on constrained covariance (COCO), a novel criterion to test dependence of random variables. We show that COCO is a test for independence if and only if the associated RKHSs are universal. That said, no independence test exists that can distinguish dependent and independent random variables in all circumstances. Dependent random variables can result in a COCO which is arbitrarily close to zero when the source densities are highly non-smooth, which can make dependence hard to detect empirically. All current kernel-based independence tests share this behaviour. Finally, we demonstrate exponential convergence between the population and empirical COCO, which implies that COCO does not suffer from slow learning rates when used as a dependence test.

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ei Gretton, A., Smola, A., Bousquet, O., Herbrich, R., Schölkopf, B., Logothetis, N. Behaviour and Convergence of the Constrained Covariance (130), MPI for Biological Cybernetics, 2004 (techreport)

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Early visual processing—data, theory, models

Wichmann, F.

Experimentelle Psychologie. Beitr{\"a}ge zur 46. Tagung experimentell arbeitender Psychologen, 46, pages: 24, 2004 (poster)

[BibTex]

ei Wichmann, F. Early visual processing—data, theory, models Experimentelle Psychologie. Beitr{\"a}ge zur 46. Tagung experimentell arbeitender Psychologen, 46, pages: 24, 2004 (poster)

[BibTex]

Statistical Learning with Similarity and Dissimilarity Functions

von Luxburg, U.

pages: 1-166, Technische Universität Berlin, Germany, Technische Universität Berlin, Germany, 2004 (phdthesis)

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ei von Luxburg, U. Statistical Learning with Similarity and Dissimilarity Functions pages: 1-166, Technische Universität Berlin, Germany, Technische Universität Berlin, Germany, 2004 (phdthesis)

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Statistische Lerntheorie und Empirische Inferenz

Schölkopf, B.

Jahrbuch der Max-Planck-Gesellschaft, 2004, pages: 377-382, 2004 (misc)

Abstract

Statistical learning theory studies the process of inferring regularities from empirical data. The fundamental problem is what is called generalization: how it is possible to infer a law which will be valid for an infinite number of future observations, given only a finite amount of data? This problem hinges upon fundamental issues of statistics and science in general, such as the problems of complexity of explanations, a priori knowledge, and representation of data.

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ei Schölkopf, B. Statistische Lerntheorie und Empirische Inferenz Jahrbuch der Max-Planck-Gesellschaft, 2004, pages: 377-382, 2004 (misc)

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Bayesian analysis of the Scatterometer Wind Retrieval Inverse Problem: Some New Approaches

Cornford, D., Csato, L., Evans, D., Opper, M.

Journal of the Royal Statistical Society B, 66, pages: 1-17, 3, 2004 (article)

Abstract

The retrieval of wind vectors from satellite scatterometer observations is a non-linear inverse problem.A common approach to solving inverse problems is to adopt a Bayesian framework and to infer the posterior distribution of the parameters of interest given the observations by using a likelihood model relating the observations to the parameters, and a prior distribution over the parameters.We show how Gaussian process priors can be used efficiently with a variety of likelihood models, using local forward (observation) models and direct inverse models for the scatterometer.We present an enhanced Markov chain Monte Carlo method to sample from the resulting multimodal posterior distribution.We go on to show how the computational complexity of the inference can be controlled by using a sparse, sequential Bayes algorithm for estimation with Gaussian processes.This helps to overcome the most serious barrier to the use of probabilistic, Gaussian process methods in remote sensing inverse problems, which is the prohibitively large size of the data sets.We contrast the sampling results with the approximations that are found by using the sparse, sequential Bayes algorithm.

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ei Cornford, D., Csato, L., Evans, D., Opper, M. Bayesian analysis of the Scatterometer Wind Retrieval Inverse Problem: Some New Approaches Journal of the Royal Statistical Society B, 66, pages: 1-17, 3, 2004 (article)

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Feature Selection for Support Vector Machines Using Genetic Algorithms

Fröhlich, H., Chapelle, O., Schölkopf, B.

International Journal on Artificial Intelligence Tools (Special Issue on Selected Papers from the 15th IEEE International Conference on Tools with Artificial Intelligence 2003), 13(4):791-800, 2004 (article)

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ei Fröhlich, H., Chapelle, O., Schölkopf, B. Feature Selection for Support Vector Machines Using Genetic Algorithms International Journal on Artificial Intelligence Tools (Special Issue on Selected Papers from the 15th IEEE International Conference on Tools with Artificial Intelligence 2003), 13(4):791-800, 2004 (article)

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Semi-supervised kernel regression using whitened function classes

Franz, M., Kwon, Y., Rasmussen, C., Schölkopf, B.

In Pattern Recognition, Proceedings of the 26th DAGM Symposium, Lecture Notes in Computer Science, Vol. 3175, LNCS 3175, pages: 18-26, (Editors: CE Rasmussen and HH Bülthoff and MA Giese and B Schölkopf), Springer, Berlin, Gerrmany, 26th DAGM Symposium, 2004 (inproceedings)

Abstract

The use of non-orthonormal basis functions in ridge regression leads to an often undesired non-isotropic prior in function space. In this study, we investigate an alternative regularization technique that results in an implicit whitening of the basis functions by penalizing directions in function space with a large prior variance. The regularization term is computed from unlabelled input data that characterizes the input distribution. Tests on two datasets using polynomial basis functions showed an improved average performance compared to standard ridge regression.

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ei Franz, M., Kwon, Y., Rasmussen, C., Schölkopf, B. Semi-supervised kernel regression using whitened function classes In Pattern Recognition, Proceedings of the 26th DAGM Symposium, Lecture Notes in Computer Science, Vol. 3175, LNCS 3175, pages: 18-26, (Editors: CE Rasmussen and HH Bülthoff and MA Giese and B Schölkopf), Springer, Berlin, Gerrmany, 26th DAGM Symposium, 2004 (inproceedings)

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Maximal Margin Classification for Metric Spaces

Hein, M., Bousquet, O.

In Learning Theory and Kernel Machines, pages: 72-86, (Editors: Schölkopf, B. and Warmuth, M. K.), Springer, Heidelberg, Germany, 16. Annual Conference on Computational Learning Theory / COLT Kernel, 2004 (inproceedings)

Abstract

In this article we construct a maximal margin classification algorithm for arbitrary metric spaces. At first we show that the Support Vector Machine (SVM) is a maximal margin algorithm for the class of metric spaces where the negative squared distance is conditionally positive definite (CPD). This means that the metric space can be isometrically embedded into a Hilbert space, where one performs linear maximal margin separation. We will show that the solution only depends on the metric, but not on the kernel. Following the framework we develop for the SVM, we construct an algorithm for maximal margin classification in arbitrary metric spaces. The main difference compared with SVM is that we no longer embed isometrically into a Hilbert space, but a Banach space. We further give an estimate of the capacity of the function class involved in this algorithm via Rademacher averages. We recover an algorithm of Graepel et al. [6].

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ei Hein, M., Bousquet, O. Maximal Margin Classification for Metric Spaces In Learning Theory and Kernel Machines, pages: 72-86, (Editors: Schölkopf, B. and Warmuth, M. K.), Springer, Heidelberg, Germany, 16. Annual Conference on Computational Learning Theory / COLT Kernel, 2004 (inproceedings)

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On the Convergence of Spectral Clustering on Random Samples: The Normalized Case

von Luxburg, U., Bousquet, O., Belkin, M.

In Proceedings of the 17th Annual Conference on Learning Theory, pages: 457-471, Proceedings of the 17th Annual Conference on Learning Theory, 2004 (inproceedings)

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ei von Luxburg, U., Bousquet, O., Belkin, M. On the Convergence of Spectral Clustering on Random Samples: The Normalized Case In Proceedings of the 17th Annual Conference on Learning Theory, pages: 457-471, Proceedings of the 17th Annual Conference on Learning Theory, 2004 (inproceedings)

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Introduction to Statistical Learning Theory

Bousquet, O., Boucheron, S., Lugosi, G.

In Lecture Notes in Artificial Intelligence 3176, pages: 169-207, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, Germany, 2004 (inbook)

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ei Bousquet, O., Boucheron, S., Lugosi, G. Introduction to Statistical Learning Theory In Lecture Notes in Artificial Intelligence 3176, pages: 169-207, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, Germany, 2004 (inbook)

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A Primer on Kernel Methods

Vert, J., Tsuda, K., Schölkopf, B.

In Kernel Methods in Computational Biology, pages: 35-70, (Editors: B Schölkopf and K Tsuda and JP Vert), MIT Press, Cambridge, MA, USA, 2004 (inbook)

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ei Vert, J., Tsuda, K., Schölkopf, B. A Primer on Kernel Methods In Kernel Methods in Computational Biology, pages: 35-70, (Editors: B Schölkopf and K Tsuda and JP Vert), MIT Press, Cambridge, MA, USA, 2004 (inbook)

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Confidence Sets for Ratios: A Purely Geometric Approach To Fieller’s Theorem

von Luxburg, U., Franz, V.

(133), Max Planck Institute for Biological Cybernetics, 2004 (techreport)

Abstract

We present a simple, geometric method to construct Fieller's exact confidence sets for ratios of jointly normally distributed random variables. Contrary to previous geometric approaches in the literature, our method is valid in the general case where both sample mean and covariance are unknown. Moreover, not only the construction but also its proof are purely geometric and elementary, thus giving intuition into the nature of the confidence sets.

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ei von Luxburg, U., Franz, V. Confidence Sets for Ratios: A Purely Geometric Approach To Fieller’s Theorem (133), Max Planck Institute for Biological Cybernetics, 2004 (techreport)

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Transductive Inference with Graphs

Zhou, D., Schölkopf, B.

Max Planck Institute for Biological Cybernetics, 2004, See the improved version Regularization on Discrete Spaces. (techreport)

Abstract

We propose a general regularization framework for transductive inference. The given data are thought of as a graph, where the edges encode the pairwise relationships among data. We develop discrete analysis and geometry on graphs, and then naturally adapt the classical regularization in the continuous case to the graph situation. A new and effective algorithm is derived from this general framework, as well as an approach we developed before.

[BibTex]

ei Zhou, D., Schölkopf, B. Transductive Inference with Graphs Max Planck Institute for Biological Cybernetics, 2004, See the improved version Regularization on Discrete Spaces. (techreport)

[BibTex]

Classification and Feature Extraction in Man and Machine

Graf, AAB.

Biologische Kybernetik, University of Tübingen, Germany, 2004, online publication (phdthesis)

[BibTex]

ei Graf, AAB. Classification and Feature Extraction in Man and Machine Biologische Kybernetik, University of Tübingen, Germany, 2004, online publication (phdthesis)

[BibTex]

Phenotypic Characterization of Human Chondrocyte Cell Line C-20/A4: A Comparison between Monolayer and Alginate Suspension Culture

Finger, F., Schorle, C., Söder, S., Zien, A., Goldring, M., Aigner, T.

Cells Tissues Organs, 178(2):65-77, 2004 (article)

Abstract

DNA microarray analysis was used to investigate the molecular phenotype of one of the first human chondrocyte cell lines, C-20/A4, derived from juvenile costal chondrocytes by immortalization with origin-defective simian virus 40 large T antigen. Clontech Human Cancer Arrays 1.2 and quantitative PCR were used to examine gene expression profiles of C-20/A4 cells cultured in the presence of serum in monolayer and alginate beads. In monolayer cultures, genes involved in cell proliferation were strongly upregulated compared to those expressed by human adult articular chondrocytes in primary culture. Of the cell cycle-regulated genes, only two, the CDK regulatory subunit and histone H4, were downregulated after culture in alginate beads, consistent with the ability of these cells to proliferate in suspension culture. In contrast, the expression of several genes that are involved in pericellular matrix formation, including MMP-14, COL6A1, fibronectin, biglycan and decorin, was upregulated when the C-20/A4 cells were transferred to suspension culture in alginate. Also, nexin-1, vimentin, and IGFBP-3, which are known to be expressed by primary chondrocytes, were differentially expressed in our study. Consistent with the proliferative phenotype of this cell line, few genes involved in matrix synthesis and turnover were highly expressed in the presence of serum. These results indicate that immortalized chondrocyte cell lines, rather than substituting for primary chondrocytes, may serve as models for extending findings on chondrocyte function not achievable by the use of primary chondrocytes.

[BibTex]

ei Finger, F., Schorle, C., Söder, S., Zien, A., Goldring, M., Aigner, T. Phenotypic Characterization of Human Chondrocyte Cell Line C-20/A4: A Comparison between Monolayer and Alginate Suspension Culture Cells Tissues Organs, 178(2):65-77, 2004 (article)

[BibTex]

Kernel Methods and their Potential Use in Signal Processing

Perez-Cruz, F., Bousquet, O.

IEEE Signal Processing Magazine, (Special issue on Signal Processing for Mining), 2004 (article) Accepted

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ei Perez-Cruz, F., Bousquet, O. Kernel Methods and their Potential Use in Signal Processing IEEE Signal Processing Magazine, (Special issue on Signal Processing for Mining), 2004 (article) Accepted

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Concentration Inequalities

Boucheron, S., Lugosi, G., Bousquet, O.

In Lecture Notes in Artificial Intelligence 3176, pages: 208-240, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, Germany, 2004 (inbook)

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ei Boucheron, S., Lugosi, G., Bousquet, O. Concentration Inequalities In Lecture Notes in Artificial Intelligence 3176, pages: 208-240, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, Germany, 2004 (inbook)

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Kernels for graphs

Kashima, H., Tsuda, K., Inokuchi, A.

In pages: 155-170, (Editors: Schoelkopf, B., K. Tsuda and J.P. Vert), MIT Press, Cambridge, MA; USA, 2004 (inbook)

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ei Kashima, H., Tsuda, K., Inokuchi, A. Kernels for graphs In pages: 155-170, (Editors: Schoelkopf, B., K. Tsuda and J.P. Vert), MIT Press, Cambridge, MA; USA, 2004 (inbook)

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A primer on molecular biology

Zien, A.

In pages: 3-34, (Editors: Schoelkopf, B., K. Tsuda and J. P. Vert), MIT Press, Cambridge, MA, USA, 2004 (inbook)

Abstract

Modern molecular biology provides a rich source of challenging machine learning problems. This tutorial chapter aims to provide the necessary biological background knowledge required to communicate with biologists and to understand and properly formalize a number of most interesting problems in this application domain. The largest part of the chapter (its first section) is devoted to the cell as the basic unit of life. Four aspects of cells are reviewed in sequence: (1) the molecules that cells make use of (above all, proteins, RNA, and DNA); (2) the spatial organization of cells (``compartmentalization''); (3) the way cells produce proteins (``protein expression''); and (4) cellular communication and evolution (of cells and organisms). In the second section, an overview is provided of the most frequent measurement technologies, data types, and data sources. Finally, important open problems in the analysis of these data (bioinformatics challenges) are briefly outlined.

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ei Zien, A. A primer on molecular biology In pages: 3-34, (Editors: Schoelkopf, B., K. Tsuda and J. P. Vert), MIT Press, Cambridge, MA, USA, 2004 (inbook)

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Implicit Wiener series for capturing higher-order interactions in images

Franz, M., Schölkopf, B.

Sensory coding and the natural environment, (Editors: Olshausen, B.A. and M. Lewicki), 2004 (poster)

Abstract

The information about the objects in an image is almost exclusively described by the higher-order interactions of its pixels. The Wiener series is one of the standard methods to systematically characterize these interactions. However, the classical estimation method of the Wiener expansion coefficients via cross-correlation suffers from severe problems that prevent its application to high-dimensional and strongly nonlinear signals such as images. We propose an estimation method based on regression in a reproducing kernel Hilbert space that overcomes these problems using polynomial kernels as known from Support Vector Machines and other kernel-based methods. Numerical experiments show performance advantages in terms of convergence, interpretability and system sizes that can be handled. By the time of the conference, we will be able to present first results on the higher-order structure of natural images.

[BibTex]

ei Franz, M., Schölkopf, B. Implicit Wiener series for capturing higher-order interactions in images Sensory coding and the natural environment, (Editors: Olshausen, B.A. and M. Lewicki), 2004 (poster)

[BibTex]

Classification and Memory Behaviour of Man Revisited by Machine

Graf, A., Wichmann, F., Bülthoff, H., Schölkopf, B.

CSHL Meeting on Computational & Systems Neuroscience (COSYNE), 2004 (poster)

[BibTex]

ei Graf, A., Wichmann, F., Bülthoff, H., Schölkopf, B. Classification and Memory Behaviour of Man Revisited by Machine CSHL Meeting on Computational & Systems Neuroscience (COSYNE), 2004 (poster)

[BibTex]

Advanced Statistical Learning Theory

Bousquet, O.

Machine Learning Summer School, 2004 (talk)

PDF [BibTex]

ei Bousquet, O. Advanced Statistical Learning Theory Machine Learning Summer School, 2004 (talk)

PDF [BibTex]

E. Coli Inspired Propulsion for Swimming Microrobots

Behkam, Bahareh, Sitti, Metin

pages: 1037–1041, 2004 (article)

Abstract

Medical applications are among the most fascinating areas of microrobotics. For long, scientists have dreamed of miniature smart devices that can travel inside the human body and carry out a host of complex operations such as minimally invasive surgery (MIS), highly localized drug delivery, and screening for diseases that are in their very early stages. Still a distant dream, significant progress in micro and nanotechnology brings us closer to materializing it. For such a miniature device to be injected into the body, it has to be 800 μm or smaller in diameter. Miniature, safe and energy efficient propulsion systems hold the key to maturing this technology but they pose significant challenges. Scaling the macroscale natation mechanisms to micro/nano length scales is unfeasible. It has been estimated that a vibrating-fin driven swimming robot shorter than 6 mm can not overcome the viscous drag forces in water. In this paper, the authors propose a new type of propulsion inspired by the motility mechanism of bacteria with peritrichous flagellation, such as Escherichia coli, Salmonella typhimurium and Serratia marcescens. The perfomance of the propulsive mechanism is estimated by modeling the dynamics of the motion. The motion of the moving organelle is simulated and key parameters such as velocity, distribution of force and power requirments for different configurations of the tail are determined theoretically. In order to validate the theoretical result, a scaled up model of the swimming robot is fabricated and characterized in silicone oil using the Buckingham PI theorem for scaling. The results are compared with the theoretically computed values. These robots are intended to swim in stagnation/low velocity biofluid and reach currently inaccessible areas of the human body for disease inspection and possibly treatment. Potential target regions to use these robots include eyeball cavity, cerebrospinal fluid and the urinary system.

link (url) DOI [BibTex]

pi Behkam, Bahareh, Sitti, Metin E. Coli Inspired Propulsion for Swimming Microrobots pages: 1037–1041, 2004 (article)

link (url) DOI [BibTex]

E. coli inspired propulsion for swimming microrobots

Behkam, B., Sitti, M.

In ASME 2004 International Mechanical Engineering Congress and Exposition, pages: 1037-1041, 2004 (inproceedings)

Project Page [BibTex]

pi Behkam, B., Sitti, M. E. coli inspired propulsion for swimming microrobots In ASME 2004 International Mechanical Engineering Congress and Exposition, pages: 1037-1041, 2004 (inproceedings)

Project Page [BibTex]

Dynamic modes of nanoparticle motion during nanoprobe-based manipulation

Tafazzoli, A., Sitti, M.

In Nanotechnology, 2004. 4th IEEE Conference on, pages: 35-37, 2004 (inproceedings)

[BibTex]

pi Tafazzoli, A., Sitti, M. Dynamic modes of nanoparticle motion during nanoprobe-based manipulation In Nanotechnology, 2004. 4th IEEE Conference on, pages: 35-37, 2004 (inproceedings)

[BibTex]

Modeling and design of biomimetic adhesives inspired by gecko foot-hairs

Shah, G. J., Sitti, M.

In Robotics and Biomimetics, 2004. ROBIO 2004. IEEE International Conference on, pages: 873-878, 2004 (inproceedings)

Project Page [BibTex]

pi Shah, G. J., Sitti, M. Modeling and design of biomimetic adhesives inspired by gecko foot-hairs In Robotics and Biomimetics, 2004. ROBIO 2004. IEEE International Conference on, pages: 873-878, 2004 (inproceedings)

Project Page [BibTex]

Discovering optimal imitation strategies

Billard, A., Epars, Y., Calinon, S., Cheng, G., Schaal, S.

Robotics and Autonomous Systems, 47(2-3):68-77, 2004, clmc (article)

Abstract

This paper develops a general policy for learning relevant features of an imitation task. We restrict our study to imitation of manipulative tasks or of gestures. The imitation process is modeled as a hierarchical optimization system, which minimizes the discrepancy between two multi-dimensional datasets. To classify across manipulation strategies, we apply a probabilistic analysis to data in Cartesian and joint spaces. We determine a general metric that optimizes the policy of task reproduction, following strategy determination. The model successfully discovers strategies in six different imitative tasks and controls task reproduction by a full body humanoid robot.

[BibTex]

am Billard, A., Epars, Y., Calinon, S., Cheng, G., Schaal, S. Discovering optimal imitation strategies Robotics and Autonomous Systems, 47(2-3):68-77, 2004, clmc (article)

[BibTex]

Learning Composite Adaptive Control for a Class of Nonlinear Systems

Nakanishi, J., Farrell, J. A., Schaal, S.

In IEEE International Conference on Robotics and Automation, pages: 2647-2652, New Orleans, LA, USA, April 2004, 2004, clmc (inproceedings)

link (url) [BibTex]

am Nakanishi, J., Farrell, J. A., Schaal, S. Learning Composite Adaptive Control for a Class of Nonlinear Systems In IEEE International Conference on Robotics and Automation, pages: 2647-2652, New Orleans, LA, USA, April 2004, 2004, clmc (inproceedings)

link (url) [BibTex]

Rhythmic movement is not discrete

Schaal, S., Sternad, D., Osu, R., Kawato, M.

Nature Neuroscience, 7(10):1137-1144, 2004, clmc (article)

Abstract

Rhythmic movements, like walking, chewing, or scratching, are phylogenetically old mo-tor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, like reaching, grasping, or kicking, are behaviors that have reached sophistication primarily in younger species, particularly in primates. Neurophysiological and computational research on arm motor control has focused almost exclusively on dis-crete movements, essentially assuming similar neural circuitry for rhythmic tasks. In con-trast, many behavioral studies focused on rhythmic models, subsuming discrete move-ment as a special case. Here, using a human functional neuroimaging experiment, we show that in addition to areas activated in rhythmic movement, discrete movement in-volves several higher cortical planning areas, despite both movement conditions were confined to the same single wrist joint. These results provide the first neuroscientific evi-dence that rhythmic arm movement cannot be part of a more general discrete movement system, and may require separate neurophysiological and theoretical treatment.

link (url) [BibTex]

am Schaal, S., Sternad, D., Osu, R., Kawato, M. Rhythmic movement is not discrete Nature Neuroscience, 7(10):1137-1144, 2004, clmc (article)

link (url) [BibTex]

Investigation of oxide layers in tunnel junctions

Amaladass, E. P.

University of Stuttgart, Stuttgart, 2004 (mastersthesis)

mms

[BibTex]

mms Amaladass, E. P. Investigation of oxide layers in tunnel junctions University of Stuttgart, Stuttgart, 2004 (mastersthesis)

[BibTex]

Uncompensated spins in a micro-patterned CoFeB / MnIr exchange bias system

Eimüller, T., Kato, T., Mizuno, T., Tsunashima, S., Quitmann, C., Ramsvik, T., Iwata, S., Schütz, G.

{Applied Physics Letters}, 85(12):2310-2312, 2004 (article)

mms

[BibTex]

mms Eimüller, T., Kato, T., Mizuno, T., Tsunashima, S., Quitmann, C., Ramsvik, T., Iwata, S., Schütz, G. Uncompensated spins in a micro-patterned CoFeB / MnIr exchange bias system {Applied Physics Letters}, 85(12):2310-2312, 2004 (article)

[BibTex]

Comparative study of magnetization reversal in isolated and strayfield coupled microcontacts

Meier, G., Eiselt, R., Bolte, M., Barthelmess, M., Eimüller, T., Fischer, P.

{Applied Physics Letters}, 85(7):1193-1195, 2004 (article)

mms

[BibTex]

mms Meier, G., Eiselt, R., Bolte, M., Barthelmess, M., Eimüller, T., Fischer, P. Comparative study of magnetization reversal in isolated and strayfield coupled microcontacts {Applied Physics Letters}, 85(7):1193-1195, 2004 (article)

[BibTex]

Grain boundary faceting close to the \Sigma3 coincidence misorientation in copper

Straumal, B., Polyakov, S., Bischoff, E., Mittemeijer, E.

{Zeitschrift f\"ur Metallkunde}, 95, pages: 939-944, 2004 (article)

mms

[BibTex]

mms Straumal, B., Polyakov, S., Bischoff, E., Mittemeijer, E. Grain boundary faceting close to the \Sigma3 coincidence misorientation in copper {Zeitschrift f\"ur Metallkunde}, 95, pages: 939-944, 2004 (article)

[BibTex]