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2018


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Temporal Difference Models: Model-Free Deep RL for Model-Based Control

Pong*, V., Gu*, S., Dalal, M., Levine, S.

6th International Conference on Learning Representations (ICLR), May 2018, *equal contribution (conference)

ei

link (url) Project Page [BibTex]

2018


link (url) Project Page [BibTex]


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Robust Dense Mapping for Large-Scale Dynamic Environments

Barsan, I. A., Liu, P., Pollefeys, M., Geiger, A.

In Proceedings of the IEEE International Conference on Robotics and Automation (ICRA) 2018, IEEE, International Conference on Robotics and Automation, May 2018 (inproceedings)

Abstract
We present a stereo-based dense mapping algorithm for large-scale dynamic urban environments. In contrast to other existing methods, we simultaneously reconstruct the static background, the moving objects, and the potentially moving but currently stationary objects separately, which is desirable for high-level mobile robotic tasks such as path planning in crowded environments. We use both instance-aware semantic segmentation and sparse scene flow to classify objects as either background, moving, or potentially moving, thereby ensuring that the system is able to model objects with the potential to transition from static to dynamic, such as parked cars. Given camera poses estimated from visual odometry, both the background and the (potentially) moving objects are reconstructed separately by fusing the depth maps computed from the stereo input. In addition to visual odometry, sparse scene flow is also used to estimate the 3D motions of the detected moving objects, in order to reconstruct them accurately. A map pruning technique is further developed to improve reconstruction accuracy and reduce memory consumption, leading to increased scalability. We evaluate our system thoroughly on the well-known KITTI dataset. Our system is capable of running on a PC at approximately 2.5Hz, with the primary bottleneck being the instance-aware semantic segmentation, which is a limitation we hope to address in future work.

avg

pdf Video Project Page Project Page [BibTex]

pdf Video Project Page Project Page [BibTex]


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Haptics and Haptic Interfaces

Kuchenbecker, K. J.

In Encyclopedia of Robotics, (Editors: Marcelo H. Ang and Oussama Khatib and Bruno Siciliano), Springer, May 2018 (incollection)

Abstract
Haptics is an interdisciplinary field that seeks to both understand and engineer touch-based interaction. Although a wide range of systems and applications are being investigated, haptics researchers often concentrate on perception and manipulation through the human hand. A haptic interface is a mechatronic system that modulates the physical interaction between a human and his or her tangible surroundings. Haptic interfaces typically involve mechanical, electrical, and computational layers that work together to sense user motions or forces, quickly process these inputs with other information, and physically respond by actuating elements of the user’s surroundings, thereby enabling him or her to act on and feel a remote and/or virtual environment.

hi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Wasserstein Auto-Encoders: Latent Dimensionality and Random Encoders

Rubenstein, P. K., Schölkopf, B., Tolstikhin, I.

Workshop at the 6th International Conference on Learning Representations (ICLR), May 2018 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Impact of Trunk Orientation for Dynamic Bipedal Locomotion

Drama, O.

Dynamic Walking Conference, May 2018 (talk)

Abstract
Impact of trunk orientation for dynamic bipedal locomotion My research revolves around investigating the functional demands of bipedal running, with focus on stabilizing trunk orientation. When we think about postural stability, there are two critical questions we need to answer: What are the necessary and sufficient conditions to achieve and maintain trunk stability? I am concentrating on how morphology affects control strategies in achieving trunk stability. In particular, I denote the trunk pitch as the predominant morphology parameter and explore the requirements it imposes on a chosen control strategy. To analyze this, I use a spring loaded inverted pendulum model extended with a rigid trunk, which is actuated by a hip motor. The challenge for the controller design here is to have a single hip actuator to achieve two coupled tasks of moving the legs to generate motion and stabilizing the trunk. I enforce orthograde and pronograde postures and aim to identify the effect of these trunk orientations on the hip torque and ground reaction profiles for different control strategies.

dlg

Impact of trunk orientation for dynamic bipedal locomotion [DW 2018] link (url) Project Page [BibTex]


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Leave no Trace: Learning to Reset for Safe and Autonomous Reinforcement Learning

Eysenbach, B., Gu, S., Ibarz, J., Levine, S.

6th International Conference on Learning Representations (ICLR), May 2018 (conference)

ei

Videos link (url) Project Page [BibTex]

Videos link (url) Project Page [BibTex]


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Online Learning of a Memory for Learning Rates

(nominated for best paper award)

Meier, F., Kappler, D., Schaal, S.

In Proceedings of the IEEE International Conference on Robotics and Automation (ICRA) 2018, IEEE, International Conference on Robotics and Automation, May 2018, accepted (inproceedings)

Abstract
The promise of learning to learn for robotics rests on the hope that by extracting some information about the learning process itself we can speed up subsequent similar learning tasks. Here, we introduce a computationally efficient online meta-learning algorithm that builds and optimizes a memory model of the optimal learning rate landscape from previously observed gradient behaviors. While performing task specific optimization, this memory of learning rates predicts how to scale currently observed gradients. After applying the gradient scaling our meta-learner updates its internal memory based on the observed effect its prediction had. Our meta-learner can be combined with any gradient-based optimizer, learns on the fly and can be transferred to new optimization tasks. In our evaluations we show that our meta-learning algorithm speeds up learning of MNIST classification and a variety of learning control tasks, either in batch or online learning settings.

am

pdf video code [BibTex]

pdf video code [BibTex]


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Learning 3D Shape Completion under Weak Supervision

Stutz, D., Geiger, A.

Arxiv, May 2018 (article)

Abstract
We address the problem of 3D shape completion from sparse and noisy point clouds, a fundamental problem in computer vision and robotics. Recent approaches are either data-driven or learning-based: Data-driven approaches rely on a shape model whose parameters are optimized to fit the observations; Learning-based approaches, in contrast, avoid the expensive optimization step by learning to directly predict complete shapes from incomplete observations in a fully-supervised setting. However, full supervision is often not available in practice. In this work, we propose a weakly-supervised learning-based approach to 3D shape completion which neither requires slow optimization nor direct supervision. While we also learn a shape prior on synthetic data, we amortize, i.e., learn, maximum likelihood fitting using deep neural networks resulting in efficient shape completion without sacrificing accuracy. On synthetic benchmarks based on ShapeNet and ModelNet as well as on real robotics data from KITTI and Kinect, we demonstrate that the proposed amortized maximum likelihood approach is able to compete with fully supervised baselines and outperforms data-driven approaches, while requiring less supervision and being significantly faster.

avg

PDF Project Page Project Page [BibTex]


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Tempered Adversarial Networks

Sajjadi, M. S. M., Parascandolo, G., Mehrjou, A., Schölkopf, B.

Workshop at the 6th International Conference on Learning Representations (ICLR), May 2018 (conference)

ei

arXiv [BibTex]

arXiv [BibTex]


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Learning Coupled Forward-Inverse Models with Combined Prediction Errors

Koert, D., Maeda, G., Neumann, G., Peters, J.

IEEE International Conference on Robotics and Automation, (ICRA), pages: 2433-2439, IEEE, May 2018 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Learning Disentangled Representations with Wasserstein Auto-Encoders

Rubenstein, P. K., Schölkopf, B., Tolstikhin, I.

Workshop at the 6th International Conference on Learning Representations (ICLR), May 2018 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Shaping in Practice: Training Wheels to Learn Fast Hopping Directly in Hardware

Heim, S., Ruppert, F., Sarvestani, A., Sproewitz, A.

In Proceedings of the IEEE International Conference on Robotics and Automation (ICRA) 2018, pages: 5076-5081, IEEE, International Conference on Robotics and Automation, May 2018 (inproceedings)

Abstract
Learning instead of designing robot controllers can greatly reduce engineering effort required, while also emphasizing robustness. Despite considerable progress in simulation, applying learning directly in hardware is still challenging, in part due to the necessity to explore potentially unstable parameters. We explore the of concept shaping the reward landscape with training wheels; temporary modifications of the physical hardware that facilitate learning. We demonstrate the concept with a robot leg mounted on a boom learning to hop fast. This proof of concept embodies typical challenges such as instability and contact, while being simple enough to empirically map out and visualize the reward landscape. Based on our results we propose three criteria for designing effective training wheels for learning in robotics.

dlg

Video Youtube link (url) Project Page [BibTex]

Video Youtube link (url) Project Page [BibTex]


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Automatic Estimation of Modulation Transfer Functions

Bauer, M., Volchkov, V., Hirsch, M., Schölkopf, B.

IEEE International Conference on Computational Photography (ICCP), May 2018 (conference)

ei sf

DOI [BibTex]

DOI [BibTex]


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Learning Sensor Feedback Models from Demonstrations via Phase-Modulated Neural Networks

Sutanto, G., Su, Z., Schaal, S., Meier, F.

In Proceedings of the IEEE International Conference on Robotics and Automation (ICRA) 2018, IEEE, International Conference on Robotics and Automation, May 2018 (inproceedings)

am

pdf video [BibTex]

pdf video [BibTex]


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Nonlinear decoding of a complex movie from the mammalian retina

Botella-Soler, V., Deny, S., Martius, G., Marre, O., Tkačik, G.

PLOS Computational Biology, 14(5):1-27, Public Library of Science, May 2018 (article)

Abstract
Author summary Neurons in the retina transform patterns of incoming light into sequences of neural spikes. We recorded from ∼100 neurons in the rat retina while it was stimulated with a complex movie. Using machine learning regression methods, we fit decoders to reconstruct the movie shown from the retinal output. We demonstrated that retinal code can only be read out with a low error if decoders make use of correlations between successive spikes emitted by individual neurons. These correlations can be used to ignore spontaneous spiking that would, otherwise, cause even the best linear decoders to “hallucinate” nonexistent stimuli. This work represents the first high resolution single-trial full movie reconstruction and suggests a new paradigm for separating spontaneous from stimulus-driven neural activity.

al

DOI [BibTex]

DOI [BibTex]


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Causal Discovery Using Proxy Variables

Rojas-Carulla, M., Baroni, M., Lopez-Paz, D.

Workshop at 6th International Conference on Learning Representations (ICLR), May 2018 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Sample and Feedback Efficient Hierarchical Reinforcement Learning from Human Preferences

Pinsler, R., Akrour, R., Osa, T., Peters, J., Neumann, G.

IEEE International Conference on Robotics and Automation, (ICRA), pages: 596-601, IEEE, May 2018 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Graphene-silver hybrid devices for sensitive photodetection in the ultraviolet

Paria, D., Jeong, H. H., Vadakkumbatt, V., Deshpande, P., Fischer, P., Ghosh, A., Ghosh, A.

Nanoscale, 10, pages: 7685-7693, April 2018 (article)

Abstract
The weak light-matter interaction in graphene can be enhanced with a number of strategies, among which sensitization with plasmonic nanostructures is particularly attractive. This has resulted in the development of graphene-plasmonic hybrid systems with strongly enhanced photodetection efficiencies in the visible and the IR, but none in the UV. Here, we describe a silver nanoparticle-graphene stacked optoelectronic device that shows strong enhancement of its photoresponse across the entire UV spectrum. The device fabrication strategy is scalable and modular. Self-assembly techniques are combined with physical shadow growth techniques to fabricate a regular large-area array of 50 nm silver nanoparticles onto which CVD graphene is transferred. The presence of the silver nanoparticles resulted in a plasmonically enhanced photoresponse as high as 3.2 A W-1 in the wavelength range from 330 nm to 450 nm. At lower wavelengths, close to the Van Hove singularity of the density of states in graphene, we measured an even higher responsivity of 14.5 A W-1 at 280 nm, which corresponds to a more than 10 000-fold enhancement over the photoresponse of native graphene.

pf

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Nanoparticles on the move for medicine

Fischer, P.

Physics World Focus on Nanotechnology, pages: 26028, (Editors: Margaret Harris), IOP Publishing Ltd and individual contributors, April 2018 (article)

Abstract
Peer Fischer outlines the prospects for creating “nanoswimmers” that can be steered through the body to deliver drugs directly to their targets Molecules don’t move very fast on their own. If they had to rely solely on diffusion – a slow and inefficient process linked to the Brownian motion of small particles and molecules in solution – then a protein mole­cule, for instance, would take around three weeks to travel a single centimetre down a nerve fibre. This is why active transport mechanisms exist in cells and in the human body: without them, all the processes of life would happen at a pace that would make snails look speedy.

pf

link (url) [BibTex]

link (url) [BibTex]


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Group invariance principles for causal generative models

Besserve, M., Shajarisales, N., Schölkopf, B., Janzing, D.

Proceedings of the 21st International Conference on Artificial Intelligence and Statistics (AISTATS), 84, pages: 557-565, Proceedings of Machine Learning Research, (Editors: Amos Storkey and Fernando Perez-Cruz), PMLR, April 2018 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Poster Abstract: Toward Fast Closed-loop Control over Multi-hop Low-power Wireless Networks

Mager, F., Baumann, D., Trimpe, S., Zimmerling, M.

Proceedings of the 17th ACM/IEEE Conference on Information Processing in Sensor Networks (IPSN), pages: 158-159, Porto, Portugal, April 2018 (poster)

ics

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Boosting Variational Inference: an Optimization Perspective

Locatello, F., Khanna, R., Ghosh, J., Rätsch, G.

Proceedings of the 21st International Conference on Artificial Intelligence and Statistics (AISTATS), 84, pages: 464-472, Proceedings of Machine Learning Research, (Editors: Amos Storkey and Fernando Perez-Cruz), PMLR, April 2018 (conference)

ei

link (url) Project Page Project Page [BibTex]

link (url) Project Page Project Page [BibTex]


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Mixture of Attractors: A Novel Movement Primitive Representation for Learning Motor Skills From Demonstrations

Manschitz, S., Gienger, M., Kober, J., Peters, J.

IEEE Robotics and Automation Letters, 3(2):926-933, April 2018 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Soft erythrocyte-based bacterial microswimmers for cargo delivery

Alapan, Y., Yasa, O., Schauer, O., Giltinan, J., Tabak, A. F., Sourjik, V., Sitti, M.

Science Robotics, 3(17):eaar4423, Science Robotics, April 2018 (article)

Abstract
Bacteria-propelled biohybrid microswimmers have recently shown to be able to actively transport and deliver cargos encapsulated into their synthetic constructs to specific regions locally. However, usage of synthetic materials as cargo carriers can result in inferior performance in load-carrying efficiency, biocompatibility, and biodegradability, impeding clinical translation of biohybrid microswimmers. Here, we report construction and external guidance of bacteria-driven microswimmers using red blood cells (RBCs; erythrocytes) as autologous cargo carriers for active and guided drug delivery. Multifunctional biohybrid microswimmers were fabricated by attachment of RBCs [loaded with anticancer doxorubicin drug molecules and superparamagnetic iron oxide nanoparticles (SPIONs)] to bioengineered motile bacteria, Escherichia coli MG1655, via biotin-avidin-biotin binding complex. Autonomous and on-board propulsion of biohybrid microswimmers was provided by bacteria, and their external magnetic guidance was enabled by SPIONs loaded into the RBCs. Furthermore, bacteria-driven RBC microswimmers displayed preserved deformability and attachment stability even after squeezing in microchannels smaller than their sizes, as in the case of bare RBCs. In addition, an on-demand light-activated hyperthermia termination switch was engineered for RBC microswimmers to control bacteria population after operations. RBCs, as biological and autologous cargo carriers in the biohybrid microswimmers, offer notable advantages in stability, deformability, biocompatibility, and biodegradability over synthetic cargo-carrier materials. The biohybrid microswimmer design presented here transforms RBCs from passive cargo carriers into active and guidable cargo carriers toward targeted drug and other cargo delivery applications in medicine.

pi

link (url) DOI Project Page Project Page [BibTex]

link (url) DOI Project Page Project Page [BibTex]


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Evaluating Low-Power Wireless Cyber-Physical Systems

Baumann, D., Mager, F., Singh, H., Zimmerling, M., Trimpe, S.

In Proceedings of the IEEE Workshop on Benchmarking Cyber-Physical Networks and Systems (CPSBench), pages: 13-18, IEEE Workshop on Benchmarking Cyber-Physical Networks and Systems (CPSBench), April 2018 (inproceedings)

ics

arXiv PDF DOI Project Page [BibTex]

arXiv PDF DOI Project Page [BibTex]


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Automatically Rating Trainee Skill at a Pediatric Laparoscopic Suturing Task

Oquendo, Y. A., Riddle, E. W., Hiller, D., Blinman, T. A., Kuchenbecker, K. J.

Surgical Endoscopy, 32(4):1840-1857, April 2018 (article)

hi

DOI [BibTex]

DOI [BibTex]


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Miniature soft robots – road to the clinic

Sitti, M.

Nature Reviews Materials, April 2018 (article)

Abstract
Soft small robots offer the opportunity to non-invasively access human tissue to perform medical operations and deliver drugs; however, challenges in materials design, biocompatibility and function control remain to be overcome for soft robots to reach the clinic.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Model-based Optical Flow: Layers, Learning, and Geometry

Wulff, J.

Tuebingen University, April 2018 (phdthesis)

Abstract
The estimation of motion in video sequences establishes temporal correspondences between pixels and surfaces and allows reasoning about a scene using multiple frames. Despite being a focus of research for over three decades, computing motion, or optical flow, remains challenging due to a number of difficulties, including the treatment of motion discontinuities and occluded regions, and the integration of information from more than two frames. One reason for these issues is that most optical flow algorithms only reason about the motion of pixels on the image plane, while not taking the image formation pipeline or the 3D structure of the world into account. One approach to address this uses layered models, which represent the occlusion structure of a scene and provide an approximation to the geometry. The goal of this dissertation is to show ways to inject additional knowledge about the scene into layered methods, making them more robust, faster, and more accurate. First, this thesis demonstrates the modeling power of layers using the example of motion blur in videos, which is caused by fast motion relative to the exposure time of the camera. Layers segment the scene into regions that move coherently while preserving their occlusion relationships. The motion of each layer therefore directly determines its motion blur. At the same time, the layered model captures complex blur overlap effects at motion discontinuities. Using layers, we can thus formulate a generative model for blurred video sequences, and use this model to simultaneously deblur a video and compute accurate optical flow for highly dynamic scenes containing motion blur. Next, we consider the representation of the motion within layers. Since, in a layered model, important motion discontinuities are captured by the segmentation into layers, the flow within each layer varies smoothly and can be approximated using a low dimensional subspace. We show how this subspace can be learned from training data using principal component analysis (PCA), and that flow estimation using this subspace is computationally efficient. The combination of the layered model and the low-dimensional subspace gives the best of both worlds, sharp motion discontinuities from the layers and computational efficiency from the subspace. Lastly, we show how layered methods can be dramatically improved using simple semantics. Instead of treating all layers equally, a semantic segmentation divides the scene into its static parts and moving objects. Static parts of the scene constitute a large majority of what is shown in typical video sequences; yet, in such regions optical flow is fully constrained by the depth structure of the scene and the camera motion. After segmenting out moving objects, we consider only static regions, and explicitly reason about the structure of the scene and the camera motion, yielding much better optical flow estimates. Furthermore, computing the structure of the scene allows to better combine information from multiple frames, resulting in high accuracies even in occluded regions. For moving regions, we compute the flow using a generic optical flow method, and combine it with the flow computed for the static regions to obtain a full optical flow field. By combining layered models of the scene with reasoning about the dynamic behavior of the real, three-dimensional world, the methods presented herein push the envelope of optical flow computation in terms of robustness, speed, and accuracy, giving state-of-the-art results on benchmarks and pointing to important future research directions for the estimation of motion in natural scenes.

ps

Official link DOI Project Page [BibTex]


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Probabilistic movement primitives under unknown system dynamics

Paraschos, A., Rueckert, E., Peters, J., Neumann, G.

Advanced Robotics, 32(6):297-310, April 2018 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Cause-Effect Inference by Comparing Regression Errors

Blöbaum, P., Janzing, D., Washio, T., Shimizu, S., Schölkopf, B.

Proceedings of the 21st International Conference on Artificial Intelligence and Statistics (AISTATS) , 84, pages: 900-909, Proceedings of Machine Learning Research, (Editors: Amos Storkey and Fernando Perez-Cruz), PMLR, April 2018 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Wrinkling Instability and Adhesion of a Highly Bendable Gallium Oxide Nanofilm Encapsulating a Liquid-Gallium Droplet

Yunusa, M., Amador, G. J., Drotlef, D., Sitti, M.

Nano Letters, 18(4):2498-2504, March 2018 (article)

Abstract
The wrinkling and interfacial adhesion mechanics of a gallium-oxide nanofilm encapsulating a liquid-gallium droplet are presented. The native oxide nanofilm provides mechanical stability by preventing the flow of the liquid metal. We show how a crumpled oxide skin a few nanometers thick behaves akin to a highly bendable elastic nanofilm under ambient conditions. Upon compression, a wrinkling instability emerges at the contact interface to relieve the applied stress. As the load is further increased, radial wrinkles evolve, and, eventually, the oxide nanofilm ruptures. The observed wrinkling closely resembles the instability experienced by nanofilms under axisymmetric loading, thus providing further insights into the behaviors of elastic nanofilms. Moreover, the mechanical attributes of the oxide skin enable high surface conformation by exhibiting liquid-like behavior. We measured an adhesion energy of 0.238 ± 0.008 J m–2 between a liquid-gallium droplet and smooth flat glass, which is close to the measurements of thin-sheet nanomaterials such as graphene on silicon dioxide.

pi

link (url) DOI [BibTex]


Thumb xl screenshot 2018 5 9 1803 01048 pdf
Magnetic-Visual Sensor Fusion-based Dense 3D Reconstruction and Localization for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Ornek, E. P., Araujo, H., Yanik, M. F., Sitti, M.

ArXiv e-prints, March 2018 (article)

Abstract
Reliable and real-time 3D reconstruction and localization functionality is a crucial prerequisite for the navigation of actively controlled capsule endoscopic robots as an emerging, minimally invasive diagnostic and therapeutic technology for use in the gastrointestinal (GI) tract. In this study, we propose a fully dense, non-rigidly deformable, strictly real-time, intraoperative map fusion approach for actively controlled endoscopic capsule robot applications which combines magnetic and vision-based localization, with non-rigid deformations based frame-to-model map fusion. The performance of the proposed method is demonstrated using four different ex-vivo porcine stomach models. Across different trajectories of varying speed and complexity, and four different endoscopic cameras, the root mean square surface reconstruction errors 1.58 to 2.17 cm.

pi

link (url) [BibTex]

link (url) [BibTex]


Thumb xl screenshot 2018 5 9 1803 01047 pdf
Unsupervised Odometry and Depth Learning for Endoscopic Capsule Robots

Turan, M., Ornek, E. P., Ibrahimli, N., Giracoglu, C., Almalioglu, Y., Yanik, M. F., Sitti, M.

ArXiv e-prints, March 2018 (article)

Abstract
In the last decade, many medical companies and research groups have tried to convert passive capsule endoscopes as an emerging and minimally invasive diagnostic technology into actively steerable endoscopic capsule robots which will provide more intuitive disease detection, targeted drug delivery and biopsy-like operations in the gastrointestinal(GI) tract. In this study, we introduce a fully unsupervised, real-time odometry and depth learner for monocular endoscopic capsule robots. We establish the supervision by warping view sequences and assigning the re-projection minimization to the loss function, which we adopt in multi-view pose estimation and single-view depth estimation network. Detailed quantitative and qualitative analyses of the proposed framework performed on non-rigidly deformable ex-vivo porcine stomach datasets proves the effectiveness of the method in terms of motion estimation and depth recovery.

pi

link (url) [BibTex]

link (url) [BibTex]


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Self‐Folded Hydrogel Tubes for Implantable Muscular Tissue Scaffolds

Vannozzi, L., Yasa, I. C., Ceylan, H., Menciassi, A., Ricotti, L., Sitti, M.

Macromolecular Bioscience, (0), March 2018 (article)

Abstract
Abstract Programming materials with tunable physical and chemical interactions among its components pave the way of generating 3D functional active microsystems with various potential applications in tissue engineering, drug delivery, and soft robotics. Here, the development of a recapitulated fascicle‐like implantable muscle construct by programmed self‐folding of poly(ethylene glycol) diacrylate hydrogels is reported. The system comprises two stacked layers, each with differential swelling degrees, stiffnesses, and thicknesses in 2D, which folds into a 3D tube together. Inside the tubes, muscle cell adhesion and their spatial alignment are controlled. Both skeletal and cardiac muscle cells also exhibit high viability, and cardiac myocytes preserve their contractile function over the course of 7 d. Integration of biological cells with smart, shape‐changing materials could give rise to the development of new cellular constructs for hierarchical tissue assembly, drug testing platforms, and biohybrid actuators that can perform sophisticated tasks.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

Sheykhansari, S., Kozielski, K., Bill, J., Sitti, M., Gemmati, D., Zamboni, P., Singh, A. V.

Cell Death \& Disease, 9(3):348, March 2018 (article)

Abstract
The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases' lesions. On the other hand, the role of other metals like cadmium participating indirectly in the redox cascade of neurobiological mechanism is less studied. In the second part of this review, we focus on this less conspicuous correlation between cadmium as an inactive-redox metal and multiple sclerosis and amyotrophic lateral sclerosis, providing novel treatment modalities and approaches as future prospects.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Cancer cells biomineralize ionic gold into nanoparticles-microplates via secreting defense proteins with specific gold-binding peptides

Singh, A. V., Jahnke, T., Kishore, V., Park, B., Batuwangala, M., Bill, J., Sitti, M.

Acta Biomaterialia, March 2018 (article)

Abstract
Cancer cells have the capacity to synthesize nanoparticles (NPs). The detailed mechanism of this process is not very well documented. We report the mechanism of biomineralization of aqueous gold chloride into NPs and microplates in the breast-cancer cell line MCF7. Spherical gold NPs are synthesized in these cells in the presence of serum in the culture media by the reduction of HAuCl4. In the absence of serum, the cells exhibit gold microplate formation through seed-mediate growth albeit slower reduction. The structural characteristics of the two types of NPs under different media conditions were confirmed using scanning electron microscopy (SEM); crystallinity and metallic properties were assessed with transmission electron microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). Gold-reducing proteins, related to cell stress initiate the biomineralization of HAuCl4 in cells (under serum free conditions) as confirmed by infrared (IR) spectroscopy. MCF7 cells undergo irreversible replicative senescence when exposed to a high concentration of ionic gold and conversely remain in a dormant reversible quiescent state when exposed to a low gold concentration. The latter cellular state was achievable in the presence of the rho/ROCK inhibitor Y-27632. Proteomic analysis revealed consistent expression of specific proteins under serum and serum-free conditions. A high-throughput proteomic approach to screen gold-reducing proteins and peptide sequences was utilized and validated by quartz crystal microbalance with dissipation (QCM-D). Statement of significance Cancer cells are known to synthesize gold nanoparticles and microstructures, which are promising for bioimaging and other therapeutic applications. However, the detailed mechanism of such biomineralization process is not well understood yet. Herein, we demonstrate that cancer cells exposed to gold ions (grown in serum/serum-free conditions) secrete shock and stress-related proteins with specific gold-binding/reducing polypeptides. Cells undergo reversible senescence and can recover normal physiology when treated with the senescence inhibitor depending on culture condition. The use of mammalian cells as microincubators for synthesis of such particles could have potential influence on their uptake and biocompatibility. This study has important implications for in-situ reduction of ionic gold to anisotropic micro-nanostructures that could be used in-vivo clinical applications and tumor photothermal therapy.

pi

link (url) DOI [BibTex]


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Arm-Worn Tactile Displays

Kuchenbecker, K. J.

Cross-Cutting Challenge Interactive Discussion presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Fingertips and hands captivate the attention of most haptic interface designers, but humans can feel touch stimuli across the entire body surface. Trying to create devices that both can be worn and can deliver good haptic sensations raises challenges that rarely arise in other contexts. Most notably, tactile cues such as vibration, tapping, and squeezing are far simpler to implement in wearable systems than kinesthetic haptic feedback. This interactive discussion will present a variety of relevant projects to which I have contributed, attempting to pull out common themes and ideas for the future.

hi

[BibTex]

[BibTex]


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Haptipedia: An Expert-Sourced Interactive Device Visualization for Haptic Designers

Seifi, H., MacLean, K. E., Kuchenbecker, K. J., Park, G.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Much of three decades of haptic device invention is effectively lost to today’s designers: dispersion across time, region, and discipline imposes an incalculable drag on innovation in this field. Our goal is to make historical haptic invention accessible through interactive navigation of a comprehensive library – a Haptipedia – of devices that have been annotated with designer-relevant metadata. To build this open resource, we will systematically mine the literature and engage the haptics community for expert annotation. In a multi-year broad-based initiative, we will empirically derive salient attributes of haptic devices, design an interactive visualization tool where device creators and repurposers can efficiently explore and search Haptipedia, and establish methods and tools to manually and algorithmically collect data from the haptics literature and our community of experts. This paper outlines progress in compiling an initial corpus of grounded force-feedback devices and their attributes, and it presents a concept sketch of the interface we envision.

hi

Project Page [BibTex]

Project Page [BibTex]


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Will People Like Your Image? Learning the Aesthetic Space

Schwarz, K., Wieschollek, P., Lensch, H. P. A.

2018 IEEE Winter Conference on Applications of Computer Vision (WACV), pages: 2048-2057, March 2018 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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An Algorithmic Perspective on Imitation Learning

Osa, T., Pajarinen, J., Neumann, G., Bagnell, J., Abbeel, P., Peters, J.

Foundations and Trends in Robotics, 7(1-2):1-179, March 2018 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Assessing body image in anorexia nervosa using biometric self-avatars in virtual reality: Attitudinal components rather than visual body size estimation are distorted

Mölbert, S. C., Thaler, A., Mohler, B. J., Streuber, S., Romero, J., Black, M. J., Zipfel, S., Karnath, H., Giel, K. E.

Psychological Medicine, 48(4):642-653, March 2018 (article)

Abstract
Background: Body image disturbance (BID) is a core symptom of anorexia nervosa (AN), but as yet distinctive features of BID are unknown. The present study aimed at disentangling perceptual and attitudinal components of BID in AN. Methods: We investigated n=24 women with AN and n=24 controls. Based on a 3D body scan, we created realistic virtual 3D bodies (avatars) for each participant that were varied through a range of ±20% of the participants' weights. Avatars were presented in a virtual reality mirror scenario. Using different psychophysical tasks, participants identified and adjusted their actual and their desired body weight. To test for general perceptual biases in estimating body weight, a second experiment investigated perception of weight and shape matched avatars with another identity. Results: Women with AN and controls underestimated their weight, with a trend that women with AN underestimated more. The average desired body of controls had normal weight while the average desired weight of women with AN corresponded to extreme AN (DSM-5). Correlation analyses revealed that desired body weight, but not accuracy of weight estimation, was associated with eating disorder symptoms. In the second experiment, both groups estimated accurately while the most attractive body was similar to Experiment 1. Conclusions: Our results contradict the widespread assumption that patients with AN overestimate their body weight due to visual distortions. Rather, they illustrate that BID might be driven by distorted attitudes with regard to the desired body. Clinical interventions should aim at helping patients with AN to change their desired weight.

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doi pdf DOI Project Page [BibTex]


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Exercising with Baxter: Design and Evaluation of Assistive Social-Physical Human-Robot Interaction

Fitter, N. T., Mohan, M., Kuchenbecker, K. J., Johnson, M. J.

Workshop paper (6 pages) presented at the HRI Workshop on Personal Robots for Exercising and Coaching, Chicago, USA, March 2018 (misc)

Abstract
The worldwide population of older adults is steadily increasing and will soon exceed the capacity of assisted living facilities. Accordingly, we aim to understand whether appropriately designed robots could help older adults stay active and engaged while living at home. We developed eight human-robot exercise games for the Baxter Research Robot with the guidance of experts in game design, therapy, and rehabilitation. After extensive iteration, these games were employed in a user study that tested their viability with 20 younger and 20 older adult users. All participants were willing to enter Baxter’s workspace and physically interact with the robot. User trust and confidence in Baxter increased significantly between pre- and post-experiment assessments, and one individual from the target user population supplied us with abundant positive feedback about her experience. The preliminary results presented in this paper indicate potential for the use of two-armed human-scale robots for social-physical exercise interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Using Probabilistic Movement Primitives in Robotics

Paraschos, A., Daniel, C., Peters, J., Neumann, G.

Autonomous Robots, 42(3):529-551, March 2018 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Representation of sensory uncertainty in macaque visual cortex

Goris, R., Henaff, O., Meding, K.

Computational and Systems Neuroscience (COSYNE) 2018, March 2018 (poster)

ei

[BibTex]

[BibTex]


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Emotionally Supporting Humans Through Robot Hugs

Block, A. E., Kuchenbecker, K. J.

Workshop paper (2 pages) presented at the HRI Pioneers Workshop, Chicago, USA, March 2018 (misc)

Abstract
Hugs are one of the first forms of contact and affection humans experience. Due to their prevalence and health benefits, we want to enable robots to safely hug humans. This research strives to create and study a high fidelity robotic system that provides emotional support to people through hugs. This paper outlines our previous work evaluating human responses to a prototype’s physical and behavioral characteristics, and then it lays out our ongoing and future work.

hi

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Towards a Statistical Model of Fingertip Contact Deformations from 4D Data

Gueorguiev, D., Tzionas, D., Pacchierotti, C., Black, M. J., Kuchenbecker, K. J.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Little is known about the shape and properties of the human finger during haptic interaction even though this knowledge is essential to control wearable finger devices and deliver realistic tactile feedback. This study explores a framework for four-dimensional scanning and modeling of finger-surface interactions, aiming to capture the motion and deformations of the entire finger with high resolution. The results show that when the fingertip is actively pressing a rigid surface, it undergoes lateral expansion of about 0.2 cm and proximal/distal bending of about 30◦, deformations that cannot be captured by imaging of the contact area alone. This project constitutes a first step towards an accurate statistical model of the finger’s behavior during haptic interaction.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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A kernel-based approach to learning contact distributions for robot manipulation tasks

Kroemer, O., Leischnig, S., Luettgen, S., Peters, J.

Autonomous Robots, 42(3):581-600, March 2018 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Can Humans Infer Haptic Surface Properties from Images?

Burka, A., Kuchenbecker, K. J.

Work-in-progress paper (3 pages) presented at the IEEE Haptics Symposium, San Francisco, USA, March 2018 (misc)

Abstract
Human children typically experience their surroundings both visually and haptically, providing ample opportunities to learn rich cross-sensory associations. To thrive in human environments and interact with the real world, robots also need to build models of these cross-sensory associations; current advances in machine learning should make it possible to infer models from large amounts of data. We previously built a visuo-haptic sensing device, the Proton Pack, and are using it to collect a large database of matched multimodal data from tool-surface interactions. As a benchmark to compare with machine learning performance, we conducted a human subject study (n = 84) on estimating haptic surface properties (here: hardness, roughness, friction, and warmness) from images. Using a 100-surface subset of our database, we showed images to study participants and collected 5635 ratings of the four haptic properties, which we compared with ratings made by the Proton Pack operator and with physical data recorded using motion, force, and vibration sensors. Preliminary results indicate weak correlation between participant and operator ratings, but potential for matching up certain human ratings (particularly hardness and roughness) with features from the literature.

hi

Project Page [BibTex]

Project Page [BibTex]


Thumb xl singh et al 2018 advanced functional materials
Photogravitactic Microswimmers

Singh, D. P., Uspal, W. E., Popescu, M. N., Wilson, L. G., Fischer, P.

Adv. Func. Mat., 28, pages: 1706660, Febuary 2018 (article)

Abstract
Abstract Phototactic microorganisms are commonly observed to respond to natural sunlight by swimming upward against gravity. This study demonstrates that synthetic photochemically active microswimmers can also swim against gravity. The particles initially sediment and, when illuminated at low light intensities exhibit wall‐bound states of motion near the bottom surface. Upon increasing the intensity of light, the artificial swimmers lift off from the wall and swim against gravity and away from the light source. This motion in the bulk has been further confirmed using holographic microscopy. A theoretical model is presented within the framework of self‐diffusiophoresis, which allows to unequivocally identify the photochemical activity and the phototactic response as key mechanisms in the observed phenomenology. Since the lift‐off threshold intensity depends on the particle size, it can be exploited to selectively address particles with the same density from a polydisperse mixture of active particles and move them in or out of the boundary region. This study provides a simple design strategy to fabricate artificial microswimmers whose two‐ or three‐dimensional swimming behavior can be controlled with light.

pf

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Chiral Plasmonic Hydrogen Sensors

Matuschek, M., Singh, D. P., Hyeon-Ho, J., Nesterov, M., Weiss, T., Fischer, P., Neubrech, F., Na Liu, L.

Small, 14(7):1702990, Febuary 2018 (article)

Abstract
In this article, a chiral plasmonic hydrogen‐sensing platform using palladium‐based nanohelices is demonstrated. Such 3D chiral nanostructures fabricated by nanoglancing angle deposition exhibit strong circular dichroism both experimentally and theoretically. The chiroptical properties of the palladium nanohelices are altered upon hydrogen uptake and sensitively depend on the hydrogen concentration. Such properties are well suited for remote and spark‐free hydrogen sensing in the flammable range. Hysteresis is reduced, when an increasing amount of gold is utilized in the palladium‐gold hybrid helices. As a result, the linearity of the circular dichroism in response to hydrogen is significantly improved. The chiral plasmonic sensor scheme is of potential interest for hydrogen‐sensing applications, where good linearity and high sensitivity are required.

pf

link (url) DOI [BibTex]

link (url) DOI [BibTex]