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2015


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Controlled surface topography regulates collective 3D migration by epithelial–mesenchymal composite embryonic tissues

Song, J., Shawky, J. H., Kim, Y., Hazar, M., LeDuc, P. R., Sitti, M., Davidson, L. A.

Biomaterials, 58, pages: 1-9, Elsevier, April 2015 (article)

Abstract
Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topography. Most studies on surface topography and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multi-cellular tissues to topographical cues. Here, we examine the response to complex topographical cues of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis. We control topography using fabricated micropost arrays (MPAs) and investigate the collective 3D migration of these multi-cellular systems in these MPAs. We find that the topography regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing of the MPAs we uncover how 3D topographical cues disrupt collective cell migration. We find surface topography can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

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DOI [BibTex]

2015


DOI [BibTex]


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Transfer Printing of Metallic Microstructures on Adhesion-Promoting Hydrogel Substrates

Wu, H., Sariola, V., Zhu, C., Zhao, J., Sitti, M., Bettinger, C. J.

Advanced Materials, 27(22):3398-3404, April 2015 (article)

Abstract
Fabrication schemes that integrate inorganic microstructures with hydrogel substrates are essential for advancing flexible electronics. A transfer printing process that is made possible through the design and synthesis of adhesion-promoting hydrogels as target substrates is reported. This fabrication technique may advance ultracompliant electronics by melding microfabricated structures with swollen hydrogel substrates.

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DOI [BibTex]

DOI [BibTex]


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Dry adhesives and methods for making dry adhesives

Sitti, M., Murphy, M., Aksak, B.

March 2015, US Patent App. 14/625,162 (patent)

Abstract
Dry adhesives and methods for forming dry adhesives. A method of forming a dry adhesive structure on a substrate, comprises: forming a template backing layer of energy sensitive material on the substrate; forming a template layer of energy sensitive material on the template backing layer; exposing the template layer to a predetermined pattern of energy; removing a portion of the template layer related to the predetermined pattern of energy, and leaving a template structure formed from energy sensitive material and connected to the substrate via the template backing layer.

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[BibTex]

[BibTex]


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Biomedical applications of untethered mobile milli/microrobots

Sitti, M., Ceylan, H., Hu, W., Giltinan, J., Turan, M., Yim, S., Diller, E.

Proceedings of the IEEE, 103(2):205-224, IEEE, March 2015 (article)

Abstract
Untethered robots miniaturized to the length scale of millimeter and below attract growing attention for the prospect of transforming many aspects of health care and bioengineering. As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations. This unprecedented direct access would enable an extensive range of minimally invasive medical operations. Here, we provide a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots. We put a special emphasis on the potential impacts of biomedical microrobots in the near future. Finally, we discuss the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.

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DOI [BibTex]

DOI [BibTex]


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Collective 3D Migration of Embryonic Epithelial Mesenchymal Composite Tissues are Regulated by Surface Topology

Song, J., Shawky, J., Kim, Y. T., Hazar, M., Sitti, M., LeDuc, P. R., Davidson, L. A.

Biophysical Journal, 108(2):455a, Elsevier, January 2015 (article)

Abstract
Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topology. Most studies on surface topology and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multicellular tissues to topological cues. Here, we examine the behaviors of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis to complex topological cues. We control topology using fabricated micropost arrays (MPAs) with different diameters (e.g., different spacing gaps) and investigate the collective 3D migration of these multicellular systems in these MPAs. Our topographical controlled approach for cellular application enables us to achieve a high degree of control over micropost positioning and geometry via simple, accurate, and repeatable microfabrication processes. We find that the topology regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing within MPAs we discover a role for topology in disrupting collective enhancement of cell migration. We find 3D topological cues can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

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DOI [BibTex]

DOI [BibTex]


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Three-dimensional heterogeneous assembly of coded microgels using an untethered mobile microgripper

Chung, S. E., Dong, X., Sitti, M.

Lab on a Chip, 15(7):1667-1676, Royal Society of Chemistry, January 2015 (article)

Abstract
Three-dimensional (3D) heterogeneous assembly of coded microgels in enclosed aquatic environments is demonstrated using a remotely actuated and controlled magnetic microgripper by a customized electromagnetic coil system. The microgripper uses different ‘stick–slip’ and ‘rolling’ locomotion in 2D and also levitation in 3D by magnetic gradient-based pulling force. This enables the microrobot to precisely manipulate each microgel by controlling its position and orientation in all x–y–z directions. Our microrobotic assembly method broke the barrier of limitation on the number of assembled microgel layers, because it enabled precise 3D levitation of the microgripper. We used the gripper to assemble microgels that had been coded with different colours and shapes onto prefabricated polymeric microposts. This eliminates the need for extra secondary cross-linking to fix the final construct. We demonstrated assembly of microgels on a single micropost up to ten layers. By increasing the number and changing the distribution of the posts, complex heterogeneous microsystems were possible to construct in 3D.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Integrating mechanism synthesis and topological optimization technique for stiffness-oriented design of a three degrees-of-freedom flexure-based parallel mechanism

Lum, G. Z., Teo, T. J., Yang, G., Yeo, S. H., Sitti, M.

Precision Engineering, 39, pages: 125-133, Elsevier, January 2015 (article)

Abstract
This paper introduces a new design approach to synthesize multiple degrees-of-freedom (DOF) flexure-based parallel mechanism (FPM). Termed as an integrated design approach, it is a systematic design methodology, which integrates both classical mechanism synthesis and modern topology optimization technique, to deliver an optimized multi-DOF FPM. This design approach is separated into two levels. At sub-chain level, a novel topology optimization technique, which uses the classical linkage mechanisms as DNA seeds, is used to synthesize the compliant joints or limbs. At configuration level, the optimal compliant joints are used to form the parallel limbs of the multi-DOF FPM and another stage of optimization was conducted to determine the optimal space distribution between these compliant joints so as to generate a multi-DOF FPM with optimized stiffness characteristic. In this paper, the design of a 3-DOF planar motion FPM was used to demonstrate the effectiveness and accuracy of this proposed design approach.

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DOI [BibTex]


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Actively controlled fibrillar friction surfaces

Marvi, H, Han, Y, Sitti, M

Applied Physics Letters, 106(5):051602, AIP Publishing, January 2015 (article)

Abstract
In this letter, we propose a technique by which we can actively adjust frictional properties of elastic fibrillar structures in different directions. Using a mesh attached to a two degree-of-freedom linear stage, we controlled the active length and the tilt angle of fibers, independently. Thus, we were able to achieve desired levels of friction forces in different directions and significantly improve passive friction anisotropies observed in the same fiber arrays. The proposed technique would allow us to readily control the friction anisotropy and the friction magnitude of fibrillar structures in any planar direction.

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DOI [BibTex]

DOI [BibTex]


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Exciting Engineered Passive Dynamics in a Bipedal Robot

Renjewski, D., Spröwitz, A., Peekema, A., Jones, M., Hurst, J.

{IEEE Transactions on Robotics and Automation}, 31(5):1244-1251, IEEE, New York, NY, 2015 (article)

Abstract
A common approach in designing legged robots is to build fully actuated machines and control the machine dynamics entirely in soft- ware, carefully avoiding impacts and expending a lot of energy. However, these machines are outperformed by their human and animal counterparts. Animals achieve their impressive agility, efficiency, and robustness through a close integration of passive dynamics, implemented through mechanical components, and neural control. Robots can benefit from this same integrated approach, but a strong theoretical framework is required to design the passive dynamics of a machine and exploit them for control. For this framework, we use a bipedal spring–mass model, which has been shown to approximate the dynamics of human locomotion. This paper reports the first implementation of spring–mass walking on a bipedal robot. We present the use of template dynamics as a control objective exploiting the engineered passive spring–mass dynamics of the ATRIAS robot. The results highlight the benefits of combining passive dynamics with dynamics-based control and open up a library of spring–mass model-based control strategies for dynamic gait control of robots.

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link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]

2013


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Dry adhesives and methods for making dry adhesives

Sitti, M., Kim, S.

sep 2013, US Patent App. 14/016,651 (misc)

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[BibTex]

2013


[BibTex]


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Dry adhesives and methods for making dry adhesives

Sitti, M., Kim, S.

sep 2013, US Patent App. 14/016,683 (misc)

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[BibTex]

[BibTex]


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Dry adhesives and methods for making dry adhesives

Sitti, M., Kim, S.

sep 2013, US Patent 8,524,092 (misc)

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[BibTex]

[BibTex]


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Dry adhesives and methods of making dry adhesives

Sitti, M., Murphy, M., Aksak, B.

March 2013, US Patent App. 13/845,702 (misc)

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[BibTex]

[BibTex]


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Angular Motion Control Using a Closed-Loop CPG for a Water-Running Robot

Thatte, N., Khoramshahi, M., Ijspeert, A., Sitti, M.

In Dynamic Walking 2013, (EPFL-CONF-199763), 2013 (inproceedings)

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[BibTex]

[BibTex]


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Two-dimensional magnetic micro-module reconfigurations based on inter-modular interactions

Miyashita, S., Diller, E., Sitti, M.

The International Journal of Robotics Research, 32(5):591-613, SAGE Publications Sage UK: London, England, 2013 (article)

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[BibTex]

[BibTex]


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Contact compliance effects in the frictional response of bioinspired fibrillar adhesives

Piccardo, M., Chateauminois, A., Fretigny, C., Pugno, N. M., Sitti, M.

Journal of The Royal Society Interface, 10(83):20130182, The Royal Society, 2013 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Co-chairs

VINCENT, Julian, ZHU, Di, DAI, Zhendong, CHEN, Da, JIANG, Lei, KANG, Le, REN, Luquan, XUE, Qunji, Zhao, Chunsheng, BARNES, Jon, others

2013 (article)

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[BibTex]

[BibTex]


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Topological Control of Cell Sheet Migration by the 3D Microenvironment

Song, J., Kim, Y. T., Hazar, M., LeDuc, P. R., Davidson, L. A., Sitti, M.

Biophysical Journal, 104(2):147a, Elsevier, 2013 (article)

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[BibTex]

[BibTex]


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Independent control of multiple magnetic microrobots in three dimensions

Diller, E., Giltinan, J., Sitti, M.

The International Journal of Robotics Research, 32(5):614-631, SAGE Publications Sage UK: London, England, 2013 (article)

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[BibTex]

[BibTex]


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A hybrid topological and structural optimization method to design a 3-DOF planar motion compliant mechanism

Lum, G. Z., Teo, T. J., Yang, G., Yeo, S. H., Sitti, M.

In Advanced Intelligent Mechatronics (AIM), 2013 IEEE/ASME International Conference on, pages: 247-254, 2013 (inproceedings)

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[BibTex]

[BibTex]


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Modular micro-robotic assembly through magnetic actuation and thermal bonding

Diller, E., Zhang, N., Sitti, M.

Journal of Micro-Bio Robotics, 8(3-4):121-131, Springer Berlin Heidelberg, 2013 (article)

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[BibTex]

[BibTex]


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Light-induced microbubble poration of localized cells

Fan, Qihui, Hu, Wenqi, Ohta, Aaron T

In Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, pages: 4482-4485, 2013 (inproceedings)

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[BibTex]

[BibTex]


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A simulation and design tool for a passive rotation flapping wing mechanism

Arabagi, V., Hines, L., Sitti, M.

IEEE/ASME Transactions on Mechatronics, 18(2):787-798, 2013 (article)

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Project Page [BibTex]

Project Page [BibTex]


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GECKO-INSPIRED POLYMER ADHESIVES

Menguc, Yigit, Metin, Metin

Polymer Adhesion, Friction, and Lubrication, pages: 351, Wiley, 2013 (article)

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[BibTex]

[BibTex]


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Near and far-wall effects on the three-dimensional motion of bacteria-driven microbeads

Edwards, M. R., Wright Carlsen, R., Sitti, M.

Applied Physics Letters, 102(14):143701, AIP, 2013 (article)

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Project Page [BibTex]

Project Page [BibTex]


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SoftCubes: towards a soft modular matter

Yim, S., Sitti, M.

In Robotics and Automation (ICRA), 2013 IEEE International Conference on, pages: 530-536, 2013 (inproceedings)

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Project Page [BibTex]

Project Page [BibTex]


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Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function

Yim, S., Goyal, K., Sitti, M.

IEEE/ASME Trans. on Mechatronics, 18(4):1413-1418, IEEE, 2013 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Tank-like module-based climbing robot using passive compliant joints

Seo, T., Sitti, M.

IEEE/ASME Transactions on Mechatronics, 18(1):397-408, 2013 (article)

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[BibTex]

[BibTex]


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Flapping wings via direct-driving by DC motors

Azhar, M., Campolo, D., Lau, G., Hines, L., Sitti, M.

In Robotics and Automation (ICRA), 2013 IEEE International Conference on, pages: 1397-1402, 2013 (inproceedings)

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[BibTex]

[BibTex]


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Three dimensional independent control of multiple magnetic microrobots

Diller, E., Giltinan, J., Jena, P., Sitti, M.

In Robotics and Automation (ICRA), 2013 IEEE International Conference on, pages: 2576-2581, 2013 (inproceedings)

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[BibTex]

[BibTex]


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Enhanced fabrication and characterization of gecko-inspired mushroom-tipped microfiber adhesives

Song, J., Mengüç, Y., Sitti, M.

Journal of Adhesion Science and Technology, 27(17):1921-1932, Routledge, 2013 (article)

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Project Page [BibTex]

Project Page [BibTex]


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A Perching Mechanism for Flying Robots Using a Fibre-Based Adhesive

Daler, L., Klaptocz, A., Briod, A., Sitti, M., Floreano, D.

In Robotics and Automation (ICRA), 2013 IEEE International Conference on, 2013 (inproceedings)

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[BibTex]

[BibTex]


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Micro-scale mobile robotics

Diller, E., Sitti, M.

Foundations and Trends in Robotics, 2(3):143-259, Now Publishers Incorporated, 2013 (article)

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[BibTex]

[BibTex]


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Survey and Introduction to the Focused Section on Bio-Inspired Mechatronics

Sitti, M., Menciassi, A., Ijspeert, A., Low, K. H., Kim, S.

Mechatronics, IEEE/ASME Transactions on, 18(2):409-418, DOI: 10.1109/TMECH.2012. 2233492, 2013 (article)

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[BibTex]

[BibTex]


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Bonding methods for modular micro-robotic assemblies

Diller, E., Zhang, N., Sitti, M.

In Robotics and Automation (ICRA), 2013 IEEE International Conference on, pages: 2588-2593, 2013 (inproceedings)

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[BibTex]

[BibTex]


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In vivo diabetic wound healing with nanofibrous scaffolds modified with gentamicin and recombinant human epidermal growth factor

Dwivedi, C., Pandey, I., Pandey, H., Patil, S., Mishra, S. B., Pandey, A. C., Zamboni, P., Ramteke, P. W., Singh, A. V.

Journal of Biomedical Materials Research Part A, 106(3):641-651, March (article)

Abstract
Abstract Diabetic wounds are susceptible to microbial infection. The treatment of these wounds requires a higher payload of growth factors. With this in mind, the strategy for this study was to utilize a novel payload comprising of Eudragit RL/RS 100 nanofibers carrying the bacterial inhibitor gentamicin sulfate (GS) in concert with recombinant human epidermal growth factor (rhEGF); an accelerator of wound healing. GS containing Eudragit was electrospun to yield nanofiber scaffolds, which were further modified by covalent immobilization of rhEGF to their surface. This novel fabricated nanoscaffold was characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction. The thermal behavior of the nanoscaffold was determined using thermogravimetric analysis and differential scanning calorimetry. In the in vitro antibacterial assays, the nanoscaffolds exhibited comparable antibacterial activity to pure gentemicin powder. In vivo work using female C57/BL6 mice, the nanoscaffolds induced faster wound healing activity in dorsal wounds compared to the control. The paradigm in this study presents a robust in vivo model to enhance the applicability of drug delivery systems in wound healing applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 641–651, 2018.

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link (url) DOI [BibTex]


link (url) DOI [BibTex]


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Robotics Research

Tong, Chi Hay, Furgale, Paul, Barfoot, Timothy D, Guizilini, Vitor, Ramos, Fabio, Chen, Yushan, T\uumová, Jana, Ulusoy, Alphan, Belta, Calin, Tenorth, Moritz, others

(article)

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[BibTex]

[BibTex]