Header logo is


2017


Six Degree-of-Freedom Localization of Endoscopic Capsule Robots using Recurrent Neural Networks embedded into a Convolutional Neural Network
Six Degree-of-Freedom Localization of Endoscopic Capsule Robots using Recurrent Neural Networks embedded into a Convolutional Neural Network

Turan, M., Abdullah, A., Jamiruddin, R., Araujo, H., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.06196, May 2017 (article)

Abstract
Since its development, ingestible wireless endoscopy is considered to be a painless diagnostic method to detect a number of diseases inside GI tract. Medical related engineering companies have made significant improvements in this technology in last decade; however, some major limitations still residue. Localization of the next generation steerable endoscopic capsule robot in six degreeof-freedom (DoF) and active motion control are some of these limitations. The significance of localization capability concerns with the doctors correct diagnosis of the disease area. This paper presents a very robust 6-DoF localization method based on supervised training of an architecture consisting of recurrent networks (RNN) embedded into a convolutional neural network (CNN) to make use of both just-in-moment information obtained by CNN and correlative information across frames obtained by RNN. To our knowledge, our idea of embedding RNNs into a CNN architecture is for the first time proposed in literature. The experimental results show that the proposed RNN-in-CNN architecture performs very well for endoscopic capsule robot localization in cases vignetting, reflection distortions, noise, sudden camera movements and lack of distinguishable features.

pi

DOI Project Page [BibTex]


Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces
Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces

Song, S., Drotlef, D., Majidi, C., Sitti, M.

Proceedings of the National Academy of Sciences, 114(22):E4344–E4353, National Acad Sciences, May 2017 (article)

Abstract
For adhering to three-dimensional (3D) surfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surface conformability and high adhesion strength. This limitation arises from the need for a soft, mechanically compliant interface, which enables conformability to nonflat and irregularly shaped surfaces but significantly reduces the interfacial fracture strength. In this work, we overcome this trade-off with an adhesion-based soft-gripping system that exhibits enhanced fracture strength without sacrificing conformability to nonplanar 3D surfaces. Composed of a gecko-inspired elastomeric microfibrillar adhesive membrane supported by a pressure-controlled deformable gripper body, the proposed soft-gripping system controls the bonding strength by changing its internal pressure and exploiting the mechanics of interfacial equal load sharing. The soft adhesion system can use up to ∼26% of the maximum adhesion of the fibrillar membrane, which is 14× higher than the adhering membrane without load sharing. Our proposed load-sharing method suggests a paradigm for soft adhesion-based gripping and transfer-printing systems that achieves area scaling similar to that of a natural gecko footpad.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


A Non-Rigid Map Fusion-Based RGB-Depth SLAM Method for Endoscopic Capsule Robots
A Non-Rigid Map Fusion-Based RGB-Depth SLAM Method for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Araujo, H., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.05444, May 2017 (article)

Abstract
In the gastrointestinal (GI) tract endoscopy field, ingestible wireless capsule endoscopy is considered as a minimally invasive novel diagnostic technology to inspect the entire GI tract and to diagnose various diseases and pathologies. Since the development of this technology, medical device companies and many groups have made significant progress to turn such passive capsule endoscopes into robotic active capsule endoscopes to achieve almost all functions of current active flexible endoscopes. However, the use of robotic capsule endoscopy still has some challenges. One such challenge is the precise localization of such active devices in 3D world, which is essential for a precise three-dimensional (3D) mapping of the inner organ. A reliable 3D map of the explored inner organ could assist the doctors to make more intuitive and correct diagnosis. In this paper, we propose to our knowledge for the first time in literature a visual simultaneous localization and mapping (SLAM) method specifically developed for endoscopic capsule robots. The proposed RGB-Depth SLAM method is capable of capturing comprehensive dense globally consistent surfel-based maps of the inner organs explored by an endoscopic capsule robot in real time. This is achieved by using dense frame-to-model camera tracking and windowed surfelbased fusion coupled with frequent model refinement through non-rigid surface deformations.

pi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties
Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties

Singh, A. V., Baylan, S., Park, B., Richter, G., Sitti, M.

PloS One, 12(4):e0175428, Public Library of Science, April 2017 (article)

Abstract
The considerable morbidity associated with hospitalized patients and clinics in developed countries due to biofilm formation on biomedical implants and surgical instruments is a heavy economic burden. An alternative to chemically treated surfaces for bactericidal activity started emerging from micro/nanoscale topographical cues in the last decade. Here, we demonstrate a putative antibacterial surface using copper nanowhiskers deposited by molecular beam epitaxy. Furthermore, the control of biological response is based on hydrophobic pinning of water droplets in the Wenzel regime, causing mechanical injury and cell death. Scanning electron microscopy images revealed the details of the surface morphology and non-contact mode laser scanning of the surface revealed the microtopography-associated quantitative parameters. Introducing the bacterial culture over nanowhiskers produces mechanical injury to cells, leading to a reduction in cell density over time due to local pinning of culture medium to whisker surfaces. Extended culture to 72 hours to observe biofilm formation revealed biofilm inhibition with scattered microcolonies and significantly reduced biovolume on nanowhiskers. Therefore, surfaces patterned with copper nanowhiskers can serve as potential antibiofilm surfaces. The topography-based antibacterial surfaces introduce a novel prospect in developing mechanoresponsive nanobiomaterials to reduce the risk of medical device biofilm-associated infections, contrary to chemical leaching of copper as a traditional bactericidal agent.

pi

link (url) [BibTex]

link (url) [BibTex]


Biohybrid microtube swimmers driven by single captured bacteria
Biohybrid microtube swimmers driven by single captured bacteria

Stanton, M. M., Park, B., Miguel-López, A., Ma, X., Sitti, M., Sánchez, S.

Small, 13(19), March 2017 (article)

Abstract
Bacteria biohybrids employ the motility and power of swimming bacteria to carry and maneuver microscale particles. They have the potential to perform microdrug and cargo delivery in vivo, but have been limited by poor design, reduced swimming capabilities, and impeded functionality. To address these challenge, motile Escherichia coli are captured inside electropolymerized microtubes, exhibiting the first report of a bacteria microswimmer that does not utilize a spherical particle chassis. Single bacterium becomes partially trapped within the tube and becomes a bioengine to push the microtube though biological media. Microtubes are modified with “smart” material properties for motion control, including a bacteria-attractant polydopamine inner layer, addition of magnetic components for external guidance, and a biochemical kill trigger to cease bacterium swimming on demand. Swimming dynamics of the bacteria biohybrid are quantified by comparing “length of protrusion” of bacteria from the microtubes with respect to changes in angular autocorrelation and swimmer mean squared displacement. The multifunctional microtubular swimmers present a new generation of biocompatible micromotors toward future microbiorobots and minimally invasive medical applications.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Sticky Solution Provides Grip for the First Robotic Pollinator

Amador, G. J., Hu, D. L.

Chem, 2(2):162 - 164, Febuary 2017 (article)

Abstract
Bees, move over. A lily has been pollinated by a remote-controlled flying robot. The robot is hairy, just like a real bee, and sticks to pollen by virtue of an ionic liquid gel, whose fabrication is discussed by Svetlana Chechetka et al. in this issue of Chem.

pi

link (url) DOI [BibTex]


The use of clamping grips and friction pads by tree frogs for climbing curved surfaces
The use of clamping grips and friction pads by tree frogs for climbing curved surfaces

Endlein, T., Ji, A., Yuan, S., Hill, I., Wang, H., Barnes, W. J. P., Dai, Z., Sitti, M.

In Proc. R. Soc. B, 284(1849):20162867, Febuary 2017 (inproceedings)

Abstract
Most studies on the adhesive mechanisms of climbing animals have addressed attachment against flat surfaces, yet many animals can climb highly curved surfaces, like twigs and small branches. Here we investigated whether tree frogs use a clamping grip by recording the ground reaction forces on a cylindrical object with either a smooth or anti-adhesive, rough surface. Furthermore, we measured the contact area of fore and hindlimbs against differently sized transparent cylinders and the forces of individual pads and subarticular tubercles in restrained animals. Our study revealed that frogs use friction and normal forces of roughly a similar magnitude for holding on to cylindrical objects. When challenged with climbing a non-adhesive surface, the compressive forces between opposite legs nearly doubled, indicating a stronger clamping grip. In contrast to climbing flat surfaces, frogs increased the contact area on all limbs by engaging not just adhesive pads but also subarticular tubercles on curved surfaces. Our force measurements showed that tubercles can withstand larger shear stresses than pads. SEM images of tubercles revealed a similar structure to that of toe pads including the presence of nanopillars, though channels surrounding epithelial cells were less pronounced. The tubercles' smaller size, proximal location on the toes and shallow cells make them probably less prone to buckling and thus ideal for gripping curved surfaces.

pi

DOI [BibTex]

DOI [BibTex]


Rubbing Against Blood Clots Using Helical Robots: Modeling and In Vitro Experimental Validation
Rubbing Against Blood Clots Using Helical Robots: Modeling and In Vitro Experimental Validation

Khalil, I. S., Tabak, A. F., Sadek, K., Mahdy, D., Hamdi, N., Sitti, M.

IEEE Robotics and Automation Letters, 2(2):927-934, IEEE, January 2017 (article)

Abstract
The risk of side effects from thrombolytic agents can be minimized by using smaller doses, assisted by mechanical rubbing against blood clots using helical robots. Quantifying this observation, we study the influence of rubbing against clots on their removal rate in vitro. First, we present a hydrodynamic model of the helical robot based on the resistive-force theory to investigate the rubbing behavior of the clots using robot driven by two rotating dipole fields. Second, we experimentally evaluate the influence of the rubbing on the removal rate of the blood clots. Not only do we find that the removal rate of mechanical rubbing (-0.56 ± 0.27 mm3 /min) is approximately three times greater than the dissolution rate of chemical lysis using streptokinase (-0.17 ± 0.032 mm3/min), but we also show that this removal rate can be controlled via the rubbing speed of the robot.

pi

DOI [BibTex]

DOI [BibTex]


no image
Nanoscale topographical control of capillary assembly of nanoparticles

Flauraud, V., Mastrangeli, M., Bernasconi, G., Butet, J., Alexander, D., Shahrabi, E., Martin, O., Brugger, J.

Scientific Reports, Nature Nanotechnology, 12, pages: 73-80, January 2017 (article)

Abstract
Predetermined and selective placement of nanoparticles onto large-area substrates with nanometre-scale precision is essential to harness the unique properties of nanoparticle assemblies, in particular for functional optical and electro-optical nanodevices. Unfortunately, such high spatial organization is currently beyond the reach of top-down nanofabrication techniques alone. Here, we demonstrate that topographic features comprising lithographed funnelled traps and auxiliary sidewalls on a solid substrate can deterministically direct the capillary assembly of Au nanorods to attain simultaneous control of position, orientation and interparticle distance at the nanometre level. We report up to 100% assembly yield over centimetre-scale substrates. We achieve this by optimizing the three sequential stages of capillary nanoparticle assembly: insertion of nanorods into the traps, resilience against the receding suspension front and drying of the residual solvent. Finally, using electron energy-loss spectroscopy we characterize the spectral response and near-field properties of spatially programmable Au nanorod dimers, highlighting the opportunities for precise tunability of the plasmonic modes in larger assemblies.

pi

DOI [BibTex]

DOI [BibTex]


no image
Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality

Raymond, M. J., Ray, P., Kaur, G., Fredericks, M., Singh, A. V., Wan, L. Q.

Cellular and Molecular Bioengineering, 10(1):63-74, 2017 (article)

Abstract
Intrinsic cell chirality has been implicated in the left--right (LR) asymmetry of embryonic development. Impaired cell chirality could lead to severe birth defects in laterality. Previously, we detected cell chirality with an in vitro micropatterning system. Here, we demonstrate for the first time that chirality can be quantified as the coordination of multiaxial polarization of individual cells and nuclei. Using an object labeling, connected component based method, we characterized cell chirality based on cell and nuclear shape polarization and nuclear positioning of each cell in multicellular patterns of epithelial cells. We found that the cells adopted a LR bias the boundaries by positioning the sharp end towards the leading edge and leaving the nucleus at the rear. This behavior is consistent with the directional migration observed previously on the boundary of micropatterns. Although the nucleus is chirally aligned, it is not strongly biased towards or away from the boundary. As the result of the rear positioning of nuclei, the nuclear positioning has an opposite chirality to that of cell alignment. Overall, our results have revealed deep insights of chiral morphogenesis as the coordination of multiaxial polarization at the cellular and subcellular levels.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


no image
Gene delivery particle engineering strategies for shape-dependent targeting of cells and tissues.

Kozielski, K., Sitti, M.

Current Gene Therapy, 17, 2017 (article)

Abstract
Background: Successful gene delivery requires overcoming both systemic and intracellular obstacles before the nucleic acid cargo can successfully reach its tissue and subcellular target location. Materials & Methods: Non-viral mechanisms to enable targeting while avoiding off-target delivery have arisen via biological, chemical, and physical engineering strategies. Discussion: Herein we will discuss the physical parameters in particle design that promote tissue- and cell-targeted delivery of genetic cargo. We will discuss systemic concerns, such as circulation, tissue localization, and clearance, as well as cell-scale obstacles, such as cellular uptake and nucleic acid packaging. Conclusion: In particular, we will focus on engineering particle shape and size in order to enhance delivery and promote precise targeting. We will also address methods to program or change particle shape in situ using environmentally triggered cues.

pi

DOI [BibTex]


Multi-fractal characterization of bacterial swimming dynamics: a case study on real and simulated Serratia marcescens
Multi-fractal characterization of bacterial swimming dynamics: a case study on real and simulated Serratia marcescens

Koorehdavoudi, H., Bogdan, P., Wei, G., Marculescu, R., Zhuang, J., Carlsen, R. W., Sitti, M.

Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences, 473(2203), The Royal Society, 2017 (article)

Abstract
To add to the current state of knowledge about bacterial swimming dynamics, in this paper, we study the fractal swimming dynamics of populations of Serratia marcescens bacteria both in vitro and in silico, while accounting for realistic conditions like volume exclusion, chemical interactions, obstacles and distribution of chemoattractant in the environment. While previous research has shown that bacterial motion is non-ergodic, we demonstrate that, besides the non-ergodicity, the bacterial swimming dynamics is multi-fractal in nature. Finally, we demonstrate that the multi-fractal characteristic of bacterial dynamics is strongly affected by bacterial density and chemoattractant concentration.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


Microemulsion-Based Soft Bacteria-Driven Microswimmers for Active Cargo Delivery
Microemulsion-Based Soft Bacteria-Driven Microswimmers for Active Cargo Delivery

Singh, A. V., Hosseinidoust, Z., Park, B., Yasa, O., Sitti, M.

ACS Nano, 0(0):null, 2017, PMID: 28858477 (article)

Abstract
Biohybrid cell-driven microsystems offer unparalleled possibilities for realization of soft microrobots at the micron scale. Here, we introduce a bacteria-driven microswimmer that combines the active locomotion and sensing capabilities of bacteria with the desirable encapsulation and viscoelastic properties of a soft double-micelle microemulsion for active transport and delivery of cargo (e.g., imaging agents, genes, and drugs) to living cells. Quasi-monodisperse double emulsions were synthesized with an aqueous core that encapsulated the fluorescence imaging agents, as a proof-of-concept cargo in this study, and an outer oil shell that was functionalized with streptavidin for specific and stable attachment of biotin-conjugated Escherichia coli. Motile bacteria effectively propelled the soft microswimmers across a Transwell membrane, actively delivering imaging agents (i.e., dyes) encapsulated inside of the micelles to a monolayer of cultured MCF7 breast cancer and J744A.1 macrophage cells, which enabled real-time, live-cell imaging of cell organelles, namely mitochondria, endoplasmic reticulum, and Golgi body. This in vitro model demonstrates the proof-of-concept feasibility of the proposed soft microswimmers and offers promise for potential biomedical applications in active and/or targeted transport and delivery of imaging agents, drugs, stem cells, siRNA, and therapeutic genes to live tissue in in vitro disease models (e.g., organ-on-a-chip devices) and stagnant or low-flow-velocity fluidic regions of the human body.

pi

link (url) DOI Project Page [BibTex]


no image
Mode Evolution in Strongly Coupled Plasmonic Dolmens Fabricated by Templated Assembly

Flauraud, V., Bernasconi, G. D., Butet, J., Mastrangeli, M., Alexander, D. T. L., Martin, O. J. F., Brugger, J.

ACS Photonics, 4(7):1661-1668, 2017 (article)

Abstract
Plasmonic antennas have enabled a wealth of applications that exploit tailored near-fields and radiative properties, further endowed by the bespoke interactions of multiple resonant building blocks. Specifically, when the interparticle distances are reduced to a few nanometers, coupling may be greatly enhanced leading to ultimate near-field intensities and confinement along with a large energy splitting of resonant modes. While this concept is well-known, the fabrication and characterization of suitable multimers with controlled geometries and few-nanometer gaps remains highly challenging. In this article, we present the topographically templated assembly of single-crystal colloidal gold nanorods into trimers, with a dolmen geometry. This fabrication method enables the precise positioning of high-quality nanorods, with gaps as small as 1.5 nm, which permits a gradual and controlled symmetry breaking by tuning the arrangement of these strongly coupled nanostructures. To characterize the fabricated structures, we perform electron energy loss spectroscopy (EELS) near-field hyperspectral imaging and geometrically accurate EELS, plane wave, and eigenmode full-wave computations to reveal the principles governing the electromagnetic response of such nanostructures that have been extensively studied under plane wave excitation for their Fano resonant properties. These experiments track the evolution of the multipolar interactions with high accuracy as the antenna geometry varies. Our results provide new insights in strongly coupled single-crystal building blocks and open news opportunities for the design and fabrication of plasmonic systems.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery
Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery

Amjadia, M., Mostaghacia, B., Sittia, M.

Current Gene Therapy, 17, 2017 (article)

Abstract
There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement. We show that approaches such as ultrasound waves, laser, and microneedle patches have successfully been employed to physically disrupt the stratum corneum structure for enhanced transdermal delivery. Rather than physical approaches, several non-physical route have also been utilized for efficient transdermal delivery across the skin barrier. Finally, we discuss some clinical applications of transdermal delivery systems for gene and drug delivery. This paper shows that transdermal delivery devices can potentially function for diverse healthcare and medical applications while further investigations are still necessary for more efficient skin penetration of gene and drugs.

pi

DOI [BibTex]


A fully dense and globally consistent 3D map reconstruction approach for GI tract to enhance therapeutic relevance of the endoscopic capsule robot
A fully dense and globally consistent 3D map reconstruction approach for GI tract to enhance therapeutic relevance of the endoscopic capsule robot

Turan, M., Pilavci, Y. Y., Jamiruddin, R., Araujo, H., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.06524, 2017 (article)

Abstract
In the gastrointestinal (GI) tract endoscopy field, ingestible wireless capsule endoscopy is emerging as a novel, minimally invasive diagnostic technology for inspection of the GI tract and diagnosis of a wide range of diseases and pathologies. Since the development of this technology, medical device companies and many research groups have made substantial progress in converting passive capsule endoscopes to robotic active capsule endoscopes with most of the functionality of current active flexible endoscopes. However, robotic capsule endoscopy still has some challenges. In particular, the use of such devices to generate a precise three-dimensional (3D) mapping of the entire inner organ remains an unsolved problem. Such global 3D maps of inner organs would help doctors to detect the location and size of diseased areas more accurately and intuitively, thus permitting more reliable diagnoses. To our knowledge, this paper presents the first complete pipeline for a complete 3D visual map reconstruction of the stomach. The proposed pipeline is modular and includes a preprocessing module, an image registration module, and a final shape-from-shading-based 3D reconstruction module; the 3D map is primarily generated by a combination of image stitching and shape-from-shading techniques, and is updated in a frame-by-frame iterative fashion via capsule motion inside the stomach. A comprehensive quantitative analysis of the proposed 3D reconstruction method is performed using an esophagus gastro duodenoscopy simulator, three different endoscopic cameras, and a 3D optical scanner.

pi

link (url) Project Page [BibTex]


Mobile Microrobotics
Mobile Microrobotics

Sitti, M.

Mobile Microrobotics, The MIT Press, Cambridge, MA, 2017 (book)

Abstract
Progress in micro- and nano-scale science and technology has created a demand for new microsystems for high-impact applications in healthcare, biotechnology, manufacturing, and mobile sensor networks. The new robotics field of microrobotics has emerged to extend our interactions and explorations to sub-millimeter scales. This is the first textbook on micron-scale mobile robotics, introducing the fundamentals of design, analysis, fabrication, and control, and drawing on case studies of existing approaches. The book covers the scaling laws that can be used to determine the dominant forces and effects at the micron scale; models forces acting on microrobots, including surface forces, friction, and viscous drag; and describes such possible microfabrication techniques as photo-lithography, bulk micromachining, and deep reactive ion etching. It presents on-board and remote sensing methods, noting that remote sensors are currently more feasible; studies possible on-board microactuators; discusses self-propulsion methods that use self-generated local gradients and fields or biological cells in liquid environments; and describes remote microrobot actuation methods for use in limited spaces such as inside the human body. It covers possible on-board powering methods, indispensable in future medical and other applications; locomotion methods for robots on surfaces, in liquids, in air, and on fluid-air interfaces; and the challenges of microrobot localization and control, in particular multi-robot control methods for magnetic microrobots. Finally, the book addresses current and future applications, including noninvasive medical diagnosis and treatment, environmental remediation, and scientific tools.

pi

Mobile Microrobotics By Metin Sitti - Chapter 1 (PDF) link (url) [BibTex]

Mobile Microrobotics By Metin Sitti - Chapter 1 (PDF) link (url) [BibTex]


Planning spin-walking locomotion for automatic grasping of microobjects by an untethered magnetic microgripper
Planning spin-walking locomotion for automatic grasping of microobjects by an untethered magnetic microgripper

Dong, X., Sitti, M.

In 2017 IEEE International Conference on Robotics and Automation (ICRA), pages: 6612-6618, 2017 (inproceedings)

Abstract
Most demonstrated mobile microrobot tasks so far have been achieved via pick-and-placing and dynamic trapping with teleoperation or simple path following algorithms. In our previous work, an untethered magnetic microgripper has been developed which has advanced functions, such as gripping objects. Both teleoperated manipulation in 2D and 3D have been demonstrated. However, it is challenging to control the magnetic microgripper to carry out manipulation tasks, because the grasping of objects so far in the literature relies heavily on teleoperation, which takes several minutes with even a skilled human expert. Here, we propose a new spin-walking locomotion and an automated 2D grasping motion planner for the microgripper, which enables time-efficient automatic grasping of microobjects that has not been achieved yet for untethered microrobots. In its locomotion, the microgripper repeatedly rotates about two principal axes to regulate its pose and move precisely on a surface. The motion planner could plan different motion primitives for grasping and compensate the uncertainties in the motion by learning the uncertainties and planning accordingly. We experimentally demonstrated that, using the proposed method, the microgripper could align to the target pose with error less than 0.1 body length and grip the objects within 40 seconds. Our method could significantly improve the time efficiency of micro-scale manipulation and have potential applications in microassembly and biomedical engineering.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Functionalised metal-organic frameworks: a novel approach to stabilising single metal atoms

Szilágyi, P. Á., Rogers, D. M., Zaiser, I., Callini, E., Turner, S., Borgschulte, A., Züttel, A., Geerlings, H., Hirscher, M., Dam, B.

{Journal of Materials Chemistry A}, 5(30):15559-15566, Royal Society of Chemistry, Cambridge, UK, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Exploiting diffusion barrier and chemical affinity of metal-organic frameworks for efficient hydrogen isotope separation

Kim, J. Y., Balderas-Xicohténcatl, R., Zhang, L., Kang, S. G., Hirscher, M., Oh, H., Moon, H. R.

{Journal of the American Chemical Society}, 139(42):15135-15141, American Chemical Society, Washington, DC, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Facile fabrication of mesoporous silica micro-jets with multi-functionalities

Vilela, D., Hortelao, A. C., Balderas-Xicohténcatl, R., Hirscher, M., Hahn, K., Ma, X., Sánchez, S.

{Nanoscale}, 9(37):13990-13997, Royal Society of Chemistry, Cambridge, UK, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


Mobile microrobots for bioengineering applications
Mobile microrobots for bioengineering applications

Ceylan, H., Giltinan, J., Kozielski, K., Sitti, M.

Lab on a Chip, 17(10):1705-1724, Royal Society of Chemistry, 2017 (article)

Abstract
Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic devices with live cells. They are aimed to operate robustly and safely in complex physiological environments where they will have a transforming impact in bioengineering and healthcare. Research along this line has already demonstrated significant progress, increasing attention, and high promise over the past several years. The first-generation microrobots, which could deliver therapeutics and other cargo to targeted specific body sites, have just been started to be tested inside small animals toward clinical use. Here, we review frontline advances in design, fabrication, and testing of untethered mobile microrobots for bioengineering applications. We convey the most impactful and recent strategies in actuation, mobility, sensing, and other functional capabilities of mobile microrobots, and discuss their potential advantages and drawbacks to operate inside complex, enclosed and physiologically relevant environments. We lastly draw an outlook to provide directions in the veins of more sophisticated designs and applications, considering biodegradability, immunogenicity, mobility, sensing, and possible medical interventions in complex microenvironments.

pi

DOI [BibTex]

DOI [BibTex]


Methods, apparatuses, and systems for micromanipulation with adhesive fibrillar structures
Methods, apparatuses, and systems for micromanipulation with adhesive fibrillar structures

Sitti, M., Mengüç, Y.

US Patent 9,731,422, 2017 (patent)

Abstract
The present invention are methods for fabrication of micro- and/or nano-scale adhesive fibers and their use for movement and manipulation of objects. Further disclosed is a method of manipulating a part by providing a manipulation device with a plurality of fibers, where each fiber has a tip with a flat surface that is parallel to a backing layer, contacting the flat surfaces on an object, moving the object to a new location, then disengaging the tips from the object.

pi

link (url) [BibTex]


no image
Surface tension-driven self-alignment

Mastrangeli, M., Zhou, Q., Sariola, V., Lambert, P.

Soft Matter, 13, pages: 304-327, The Royal Society of Chemistry, 2017 (article)

Abstract
Surface tension-driven self-alignment is a passive and highly-accurate positioning mechanism that can significantly simplify and enhance the construction of advanced microsystems. After years of research{,} demonstrations and developments{,} the surface engineering and manufacturing technology enabling capillary self-alignment has achieved a degree of maturity conducive to a successful transfer to industrial practice. In view of this transition{,} a broad and accessible review of the physics{,} material science and applications of capillary self-alignment is presented. Statics and dynamics of the self-aligning action of deformed liquid bridges are explained through simple models and experiments{,} and all fundamental aspects of surface patterning and conditioning{,} of choice{,} deposition and confinement of liquids{,} and of component feeding and interconnection to substrates are illustrated through relevant applications in micro- and nanotechnology. A final outline addresses remaining challenges and additional extensions envisioned to further spread the use and fully exploit the potential of the technique.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


no image
Selective hydrogen isotope separation via breathing transition in MIL-53(Al)

Kim, J. Y., Zhang, L., Balderas-Xicohténcatl, R., Park, J., Hirscher, M., Moon, H. R., Oh, H.

{Journal of the American Chemical Society}, 139(49):17743-17746, American Chemical Society, Washington, DC, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Efficient synthesis for large-scale production and characterization for hydrogen storage of ligand exchanged MOF-74/174/184-M (M\textequalsMg2+, Ni2+)

Oh, H., Maurer, S., Balderas-Xicohténcatl, R., Arnold, L., Magdysyuk, O. V., Schütz, G., Müller, U., Hirscher, M.

{International Journal of Hydrogen Energy}, 42(2):1027-1035, Elsevier, Amsterdam, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


A Deep Learning Based 6 Degree-of-Freedom Localization Method for Endoscopic Capsule Robots
A Deep Learning Based 6 Degree-of-Freedom Localization Method for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.05435, 2017 (article)

Abstract
We present a robust deep learning based 6 degrees-of-freedom (DoF) localization system for endoscopic capsule robots. Our system mainly focuses on localization of endoscopic capsule robots inside the GI tract using only visual information captured by a mono camera integrated to the robot. The proposed system is a 23-layer deep convolutional neural network (CNN) that is capable to estimate the pose of the robot in real time using a standard CPU. The dataset for the evaluation of the system was recorded inside a surgical human stomach model with realistic surface texture, softness, and surface liquid properties so that the pre-trained CNN architecture can be transferred confidently into a real endoscopic scenario. An average error of 7.1% and 3.4% for translation and rotation has been obtained, respectively. The results accomplished from the experiments demonstrate that a CNN pre-trained with raw 2D endoscopic images performs accurately inside the GI tract and is robust to various challenges posed by reflection distortions, lens imperfections, vignetting, noise, motion blur, low resolution, and lack of unique landmarks to track.

pi

link (url) Project Page [BibTex]


{Deep EndoVO: A Recurrent Convolutional Neural Network (RCNN) based Visual Odometry Approach for Endoscopic Capsule Robots}
Deep EndoVO: A Recurrent Convolutional Neural Network (RCNN) based Visual Odometry Approach for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Araujo, H., Konukoglu, E., Sitti, M.

ArXiv e-prints, 2017 (article)

Abstract
Ingestible wireless capsule endoscopy is an emerging minimally invasive diagnostic technology for inspection of the GI tract and diagnosis of a wide range of diseases and pathologies. Medical device companies and many research groups have recently made substantial progresses in converting passive capsule endoscopes to active capsule robots, enabling more accurate, precise, and intuitive detection of the location and size of the diseased areas. Since a reliable real time pose estimation functionality is crucial for actively controlled endoscopic capsule robots, in this study, we propose a monocular visual odometry (VO) method for endoscopic capsule robot operations. Our method lies on the application of the deep Recurrent Convolutional Neural Networks (RCNNs) for the visual odometry task, where Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs) are used for the feature extraction and inference of dynamics across the frames, respectively. Detailed analyses and evaluations made on a real pig stomach dataset proves that our system achieves high translational and rotational accuracies for different types of endoscopic capsule robot trajectories.

pi

link (url) Project Page [BibTex]


no image
Understanding FORC using synthetic micro-structured systems with variable coupling- and coercivefield distributions

Groß, Felix

Universität Stuttgart, Stuttgart, 2017 (mastersthesis)

mms

[BibTex]


no image
Corrosion-protected hybrid nanoparticles

Jeong, H., Alarcón-Correa, M., Mark, A. G., Son, K., Lee, T., Fischer, P.

{Advanced Science}, 4(12), Wiley-VCH, Weinheim, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Investigation of the Dzyaloshinskii-Moriya interaction and room temperature skyrmions in W/CoFeB/MgO thin films and microwires

Jaiswal, S., Litzius, K., Lemesh, I., Büttner, F., Finizio, S., Raabe, J., Weigand, M., Lee, K., Langer, J., Ocker, B., Jakob, G., Beach, G. S. D., Kläui, M.

{Applied Physics Letters}, 111(2), American Institute of Physics, Melville, NY, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Ultrafast demagnetization after femtosecond laser pulses: Transfer of angular momentum from the electronic system to magnetoelastic spin-phonon modes

Fähnle, M., Tsatsoulis, T., Illg, C., Haag, M., Müller, B. Y., Zhang, L.

{Journal of Superconductivity and Novel Magnetism}, 30(5):1381-1387, Springer Science + Business Media B.V., New York, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Magnetic behavior of single chain magnets in metal organic frameworks CPO-27-Co

Son, K., Goering, E., Hirscher, M., Oh, H.

{Journal of Nanoscience and Nanotechnology}, 17(10):7541-7546, American Scientific Publishers, Stevenson Ranch, Calif., 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Switching by domain-wall automotion in asymmetric ferromagnetic rings

Mawass, M., Richter, K., Bisig, A., Reeve, R. M., Krüger, B., Weigand, M., Stoll, H., Krone, A., Kronast, F., Schütz, G., Kläui, M.

{Physical Review Applied}, 7(4), American Physical Society, College Park, Md. [u.a.], 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
A neutral atom moving in an external magnetic field does not feel a Lorentz force

Fähnle, M.

{American Journal of Modern Physics}, 6(6):153-155, Science Publishing Group, New York, NY, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Adsorption von Wasserstoffmolekülen in nanoporösen Gerüststrukturen

Kotzur, Nadine

Universität Stuttgart, Stuttgart, 2017 (mastersthesis)

mms

[BibTex]

[BibTex]


no image
Temperature-dependent first-order reversal curve measurements on unusually hard magnetic low-temperature phase of MnBi

Muralidhar, S., Gräfe, J., Chen, Y., Etter, M., Gregori, G., Ener, S., Sawatzki, S., Hono, K., Gutfleisch, O., Kronmüller, H., Schütz, G., Goering, E. J.

{Physical Review B}, 95(2), American Physical Society, Woodbury, NY, 2017 (article)

mms

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Smooth and rapid microwave synthesis of MIL-53(Fe) including superparamagnetic \textlessgamma\textgreater-Fe2O3 nanoparticles

Wengert, S., Albrecht, J., Ruoß, S., Stahl, C., Schütz, G., Schäfer, R.

{Journal of Magnetism and Magnetic Materials}, 444, pages: 168-172, NH, Elsevier, Amsterdam, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Characterization and differentiation of rock varnish types from different environments by microanalytical techniques

Macholdt, D. S., Jochum, K. P., Pöhlker, C., Arangio, A., Förster, J., Stoll, B., Weis, U., Weber, B., Müller, M., Kappl, M., Shiraiwa, M., Kilcoyne, A. L. D., Weigand, M., Scholz, D., Haug, G. H., Al-Amri, A., Andreae, M. O.

{Chemical Geology}, 459, pages: 91-118, Elsevier, Amsterdam, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Skyrmion Hall effect revealed by direct time-resolved X-ray microscopy

Litzius, K., Lemesh, I., Krüger, B., Bassirian, P., Caretta, L., Richter, K., Büttner, F., Sato, K., Tretiakov, O. A., Förster, J., Reeve, R. M., Weigand, M., Bykova, I., Stoll, H., Schütz, G., Beach, G. S. D., Kläui, M.

{Nature Physics}, 13(2):170-175, Nature Pub. Group, London, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Comment on magnonic black holes

Fähnle, M., Schütz, G.

{Journal of Magnetism and Magnetic Materials}, 444, pages: 146-146, NH, Elsevier, Amsterdam, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Cr-Substitution in Ba2In2O5 \mbox⋅ (H2O)x (x \textequals 0.16, 0.74)

Yoon, S., Son, K., Hagemann, H., Widenmeyer, M., Weidenkaff, A.

{Solid State Sciences}, 73, pages: 1-6, Elsevier Masson SAS, Paris, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Comment on half-integer quantum numbers for the total angular momentum of photons in light beams with finite lateral extensions

Fähnle, M.

{American Journal of Modern Physics}, 6(5):88-90, Science Publishing Group, New York, NY, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Advanced magneto-optical Kerr effect measurements of superconductors at low temperatures

Stahl, C., Gräfe, J., Ruoß, S., Zahn, P., Bayer, J., Simmendinger, J., Schütz, G., Albrecht, J.

{AIP Advances}, 7(10), 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Unifying ultrafast demagnetization and intrinsic Gilbert damping in Co/Ni bilayers with electronic relaxation near the Fermi surface

Zhang, W., He, W., Zhang, X.-Q., Cheng, Z.-H., Teng, J., Fähnle, M.

{Physical Review B}, 96(22), American Physical Society, Woodbury, NY, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]


no image
Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy

Yamamoto, K., Klossek, A., Flesch, R., Rancan, F., Weigand, M., Bykova, I., Bechtel, M., Ahlberg, S., Vogt, A., Blume-Peytavi, U., Schrade, P., Bachmann, S., Hedtrich, S., Schäfer-Korting, M., Rühl, E.

{European Journal of Pharmaceutics and Biopharmaceutics}, 118, pages: 30-37, Elsevier, Amsterdam, 2017 (article)

mms

DOI [BibTex]

DOI [BibTex]