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2015


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Biomedical applications of untethered mobile milli/microrobots

Sitti, M., Ceylan, H., Hu, W., Giltinan, J., Turan, M., Yim, S., Diller, E.

Proceedings of the IEEE, 103(2):205-224, IEEE, March 2015 (article)

Abstract
Untethered robots miniaturized to the length scale of millimeter and below attract growing attention for the prospect of transforming many aspects of health care and bioengineering. As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations. This unprecedented direct access would enable an extensive range of minimally invasive medical operations. Here, we provide a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots. We put a special emphasis on the potential impacts of biomedical microrobots in the near future. Finally, we discuss the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.

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DOI [BibTex]

2015


DOI [BibTex]


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Collective 3D Migration of Embryonic Epithelial Mesenchymal Composite Tissues are Regulated by Surface Topology

Song, J., Shawky, J., Kim, Y. T., Hazar, M., Sitti, M., LeDuc, P. R., Davidson, L. A.

Biophysical Journal, 108(2):455a, Elsevier, January 2015 (article)

Abstract
Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topology. Most studies on surface topology and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multicellular tissues to topological cues. Here, we examine the behaviors of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis to complex topological cues. We control topology using fabricated micropost arrays (MPAs) with different diameters (e.g., different spacing gaps) and investigate the collective 3D migration of these multicellular systems in these MPAs. Our topographical controlled approach for cellular application enables us to achieve a high degree of control over micropost positioning and geometry via simple, accurate, and repeatable microfabrication processes. We find that the topology regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing within MPAs we discover a role for topology in disrupting collective enhancement of cell migration. We find 3D topological cues can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

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DOI [BibTex]

DOI [BibTex]


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Three-dimensional heterogeneous assembly of coded microgels using an untethered mobile microgripper

Chung, S. E., Dong, X., Sitti, M.

Lab on a Chip, 15(7):1667-1676, Royal Society of Chemistry, January 2015 (article)

Abstract
Three-dimensional (3D) heterogeneous assembly of coded microgels in enclosed aquatic environments is demonstrated using a remotely actuated and controlled magnetic microgripper by a customized electromagnetic coil system. The microgripper uses different ‘stick–slip’ and ‘rolling’ locomotion in 2D and also levitation in 3D by magnetic gradient-based pulling force. This enables the microrobot to precisely manipulate each microgel by controlling its position and orientation in all x–y–z directions. Our microrobotic assembly method broke the barrier of limitation on the number of assembled microgel layers, because it enabled precise 3D levitation of the microgripper. We used the gripper to assemble microgels that had been coded with different colours and shapes onto prefabricated polymeric microposts. This eliminates the need for extra secondary cross-linking to fix the final construct. We demonstrated assembly of microgels on a single micropost up to ten layers. By increasing the number and changing the distribution of the posts, complex heterogeneous microsystems were possible to construct in 3D.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Integrating mechanism synthesis and topological optimization technique for stiffness-oriented design of a three degrees-of-freedom flexure-based parallel mechanism

Lum, G. Z., Teo, T. J., Yang, G., Yeo, S. H., Sitti, M.

Precision Engineering, 39, pages: 125-133, Elsevier, January 2015 (article)

Abstract
This paper introduces a new design approach to synthesize multiple degrees-of-freedom (DOF) flexure-based parallel mechanism (FPM). Termed as an integrated design approach, it is a systematic design methodology, which integrates both classical mechanism synthesis and modern topology optimization technique, to deliver an optimized multi-DOF FPM. This design approach is separated into two levels. At sub-chain level, a novel topology optimization technique, which uses the classical linkage mechanisms as DNA seeds, is used to synthesize the compliant joints or limbs. At configuration level, the optimal compliant joints are used to form the parallel limbs of the multi-DOF FPM and another stage of optimization was conducted to determine the optimal space distribution between these compliant joints so as to generate a multi-DOF FPM with optimized stiffness characteristic. In this paper, the design of a 3-DOF planar motion FPM was used to demonstrate the effectiveness and accuracy of this proposed design approach.

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DOI [BibTex]


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Actively controlled fibrillar friction surfaces

Marvi, H, Han, Y, Sitti, M

Applied Physics Letters, 106(5):051602, AIP Publishing, January 2015 (article)

Abstract
In this letter, we propose a technique by which we can actively adjust frictional properties of elastic fibrillar structures in different directions. Using a mesh attached to a two degree-of-freedom linear stage, we controlled the active length and the tilt angle of fibers, independently. Thus, we were able to achieve desired levels of friction forces in different directions and significantly improve passive friction anisotropies observed in the same fiber arrays. The proposed technique would allow us to readily control the friction anisotropy and the friction magnitude of fibrillar structures in any planar direction.

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DOI [BibTex]

DOI [BibTex]


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Kinematic and gait similarities between crawling human infants and other quadruped mammals

Righetti, L., Nylen, A., Rosander, K., Ijspeert, A.

Frontiers in Neurology, 6(17), February 2015 (article)

Abstract
Crawling on hands and knees is an early pattern of human infant locomotion, which offers an interesting way of studying quadrupedalism in one of its simplest form. We investigate how crawling human infants compare to other quadruped mammals, especially primates. We present quantitative data on both the gait and kinematics of seven 10-month-old crawling infants. Body movements were measured with an optoelectronic system giving precise data on 3-dimensional limb movements. Crawling on hands and knees is very similar to the locomotion of non-human primates in terms of the quite protracted arm at touch-down, the coordination between the spine movements in the lateral plane and the limbs, the relatively extended limbs during locomotion and the strong correlation between stance duration and speed of locomotion. However, there are important differences compared to primates, such as the choice of a lateral-sequence walking gait, which is similar to most non-primate mammals and the relatively stiff elbows during stance as opposed to the quite compliant gaits of primates. These finding raise the question of the role of both the mechanical structure of the body and neural control on the determination of these characteristics.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Trajectory generation for multi-contact momentum control

Herzog, A., Rotella, N., Schaal, S., Righetti, L.

In 2015 IEEE-RAS 15th International Conference on Humanoid Robots (Humanoids), pages: 874-880, IEEE, Seoul, South Korea, 2015 (inproceedings)

Abstract
Simplified models of the dynamics such as the linear inverted pendulum model (LIPM) have proven to perform well for biped walking on flat ground. However, for more complex tasks the assumptions of these models can become limiting. For example, the LIPM does not allow for the control of contact forces independently, is limited to co-planar contacts and assumes that the angular momentum is zero. In this paper, we propose to use the full momentum equations of a humanoid robot in a trajectory optimization framework to plan its center of mass, linear and angular momentum trajectories. The model also allows for planning desired contact forces for each end-effector in arbitrary contact locations. We extend our previous results on linear quadratic regulator (LQR) design for momentum control by computing the (linearized) optimal momentum feedback law in a receding horizon fashion. The resulting desired momentum and the associated feedback law are then used in a hierarchical whole body control approach. Simulation experiments show that the approach is computationally fast and is able to generate plans for locomotion on complex terrains while demonstrating good tracking performance for the full humanoid control.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Humanoid Momentum Estimation Using Sensed Contact Wrenches

Rotella, N., Herzog, A., Schaal, S., Righetti, L.

In 2015 IEEE-RAS 15th International Conference on Humanoid Robots (Humanoids), pages: 556-563, IEEE, Seoul, South Korea, 2015 (inproceedings)

Abstract
This work presents approaches for the estimation of quantities important for the control of the momentum of a humanoid robot. In contrast to previous approaches which use simplified models such as the Linear Inverted Pendulum Model, we present estimators based on the momentum dynamics of the robot. By using this simple yet dynamically-consistent model, we avoid the issues of using simplified models for estimation. We develop an estimator for the center of mass and full momentum which can be reformulated to estimate center of mass offsets as well as external wrenches applied to the robot. The observability of these estimators is investigated and their performance is evaluated in comparison to previous approaches.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]

2007


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Space exploration-towards bio-inspired climbing robots

Menon, C., Murphy, M., Sitti, M., Lan, N.

INTECH Open Access Publisher, 2007 (misc)

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2007


[BibTex]


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Bacterial flagella-based propulsion and on/off motion control of microscale objects

Behkam, B., Sitti, M.

Applied Physics Letters, 90(2):023902, AIP, 2007 (article)

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[BibTex]

[BibTex]


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A strategy for vision-based controlled pushing of microparticles

Lynch, N. A., Onal, C., Schuster, E., Sitti, M.

In Robotics and Automation, 2007 IEEE International Conference on, pages: 1413-1418, 2007 (inproceedings)

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[BibTex]

[BibTex]


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Friction of partially embedded vertically aligned carbon nanofibers inside elastomers

Aksak, B., Sitti, M., Cassell, A., Li, J., Meyyappan, M., Callen, P.

Applied Physics Letters, 91(6):061906, AIP, 2007 (article)

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[BibTex]

[BibTex]


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Enhanced friction of elastomer microfiber adhesives with spatulate tips

Kim, S., Aksak, B., Sitti, M.

Applied Physics Letters, 91(22):221913, AIP, 2007 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Hand placement during quadruped locomotion in a humanoid robot: A dynamical system approach

Degallier, S., Righetti, L., Ijspeert, A.

In 2007 IEEE/RSJ International Conference on Intelligent Robots and Systems, pages: 2047-2052, IEEE, San Diego, USA, 2007 (inproceedings)

Abstract
Locomotion on an irregular surface is a challenging task in robotics. Among different problems to solve to obtain robust locomotion, visually guided locomotion and accurate foot placement are of crucial importance. Robust controllers able to adapt to sensory-motor feedbacks, in particular to properly place feet on specific locations, are thus needed. Dynamical systems are well suited for this task as any online modification of the parameters leads to a smooth adaptation of the trajectories, allowing a safe integration of sensory-motor feedback. In this contribution, as a first step in the direction of locomotion on irregular surfaces, we present a controller that allows hand placement during crawling in a simulated humanoid robot. The goal of the controller is to superimpose rhythmic movements for crawling with discrete (i.e. short-term) modulations of the hand placements to reach specific marks on the ground.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Microscale and nanoscale robotics systems [grand challenges of robotics]

Sitti, M.

IEEE Robotics \& Automation Magazine, 14(1):53-60, IEEE, 2007 (article)

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[BibTex]

[BibTex]


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A new biomimetic adhesive for therapeutic capsule endoscope applications in the gastrointestinal tract

Glass, P., Sitti, M., Appasamy, R.

Gastrointestinal Endoscopy, 65(5):AB91, Mosby, 2007 (article)

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[BibTex]

[BibTex]


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Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe

Onal, C. D., Sitti, M.

IEEE Transactions on control systems technology, 15(5):842-852, IEEE, 2007 (article)

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[BibTex]

[BibTex]


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Lower body realization of the baby humanoid - ‘iCub’

Tsagarakis, N., Becchi, F., Righetti, L., Ijspeert, A., Caldwell, D.

In 2007 IEEE/RSJ International Conference on Intelligent Robots and Systems, pages: 3616-3622, IEEE, San Diego, USA, 2007 (inproceedings)

Abstract
Nowadays, the understanding of the human cognition and it application to robotic systems forms a great challenge of research. The iCub is a robotic platform that was developed within the RobotCub European project to provide the cognition research community with an open baby- humanoid platform for understanding and development of cognitive systems. In this paper we present the design requirements and mechanical realization of the lower body developed for the "iCub". In particular the leg and the waist mechanisms adopted for lower body to match the size and physical abilities of a 2 frac12 year old human baby are introduced.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Bacteria integrated swimming microrobots

Behkam, B., Sitti, M.

In 50 years of artificial intelligence, pages: 154-163, Springer Berlin Heidelberg, 2007 (incollection)

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[BibTex]

[BibTex]


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Adhesion of biologically inspired vertical and angled polymer microfiber arrays

Aksak, B., Murphy, M. P., Sitti, M.

Langmuir, 23(6):3322-3332, ACS Publications, 2007 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Waalbot: An agile small-scale wall-climbing robot utilizing dry elastomer adhesives

Murphy, M. P., Sitti, M.

IEEE/ASME transactions on Mechatronics, 12(3):330-338, IEEE, 2007 (article)

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[BibTex]

[BibTex]


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Autonomous 2D microparticle manipulation based on visual feedback

Onal, C. D., Sitti, M.

In Advanced intelligent mechatronics, 2007 IEEE/ASME international conference on, pages: 1-6, 2007 (inproceedings)

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[BibTex]

[BibTex]


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iCub - The Design and Realization of an Open Humanoid Platform for Cognitive and Neuroscience Research

Tsagarakis, N., Metta, G., Sandini, G., Vernon, D., Beira, R., Becchi, F., Righetti, L., Santos-Victor, J., Ijspeert, A., Carrozza, M., Caldwell, D.

Advanced Robotics, 21(10):1151-1175, 2007 (article)

Abstract
The development of robotic cognition and the advancement of understanding of human cognition form two of the current greatest challenges in robotics and neuroscience, respectively. The RobotCub project aims to develop an embodied robotic child (iCub) with the physical (height 90 cm and mass less than 23 kg) and ultimately cognitive abilities of a 2.5-year-old human child. The iCub will be a freely available open system which can be used by scientists in all cognate disciplines from developmental psychology to epigenetic robotics to enhance understanding of cognitive systems through the study of cognitive development. The iCub will be open both in software, but more importantly in all aspects of the hardware and mechanical design. In this paper the design of the mechanisms and structures forming the basic 'body' of the iCub are described. The papers considers kinematic structures dynamic design criteria, actuator specification and selection, and detailed mechanical and electronic design. The paper concludes with tests of the performance of sample joints, and comparison of these results with the design requirements and simulation projects.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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STRIDE: A highly maneuverable and non-tethered water strider robot

Song, Y. S., Sitti, M.

In Robotics and Automation, 2007 IEEE International Conference on, pages: 980-984, 2007 (inproceedings)

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[BibTex]

[BibTex]


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Subfeature patterning of organic and inorganic materials using robotic assembly

Tafazzoli, A., Cheng, C., Pawashe, C., Sabo, E. K., Trofin, L., Sitti, M., LeDuc, P. R.

Journal of materials research, 22(06):1601-1608, Cambridge University Press, 2007 (article)

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[BibTex]

[BibTex]


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Dry spinning polymeric nano/microfiber arrays using glass micropipettes with controlled porosities and fiber diameters

Nain, A. S., Gupta, A., Amon, C., Sitti, M.

In Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on, pages: 728-732, 2007 (inproceedings)

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[BibTex]

[BibTex]


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Effect of backing layer thickness on adhesion of single-level elastomer fiber arrays

Kim, S., Sitti, M., Hui, C., Long, R., Jagota, A.

Applied Physics Letters, 91(16):161905, AIP, 2007 (article)

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[BibTex]

[BibTex]


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Adhesion and anisotropic friction enhancements of angled heterogeneous micro-fiber arrays with spherical and spatula tips

Murphy, M. P., Aksak, B., Sitti, M.

Journal of Adhesion Science and Technology, 21(12-13):1281-1296, Taylor & Francis Group, 2007 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Microrobotically fabricated biological scaffolds for tissue engineering

Nain, A. S., Chung, F., Rule, M., Jadlowiec, J. A., Campbell, P. G., Amon, C., Sitti, M.

In Robotics and Automation, 2007 IEEE International Conference on, pages: 1918-1923, 2007 (inproceedings)

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[BibTex]

[BibTex]


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Surface-tension-driven biologically inspired water strider robots: Theory and experiments

Song, Y. S., Sitti, M.

IEEE Transactions on robotics, 23(3):578-589, IEEE, 2007 (article)

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[BibTex]

[BibTex]


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Bacterial flagella assisted propulsion of patterned latex particles: Effect of particle size

Behkam, B., Sitti, M.

In Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on, pages: 723-727, 2007 (inproceedings)

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Project Page [BibTex]

Project Page [BibTex]


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A scaled bilateral control system for experimental 1-D teleoperated nanomanipulation applications

Onal, C. D., Pawashe, C., Sitti, M.

In Intelligent Robots and Systems, 2007. IROS 2007. IEEE/RSJ International Conference on, pages: 483-488, 2007 (inproceedings)

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[BibTex]

[BibTex]


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In vivo diabetic wound healing with nanofibrous scaffolds modified with gentamicin and recombinant human epidermal growth factor

Dwivedi, C., Pandey, I., Pandey, H., Patil, S., Mishra, S. B., Pandey, A. C., Zamboni, P., Ramteke, P. W., Singh, A. V.

Journal of Biomedical Materials Research Part A, 106(3):641-651, March (article)

Abstract
Abstract Diabetic wounds are susceptible to microbial infection. The treatment of these wounds requires a higher payload of growth factors. With this in mind, the strategy for this study was to utilize a novel payload comprising of Eudragit RL/RS 100 nanofibers carrying the bacterial inhibitor gentamicin sulfate (GS) in concert with recombinant human epidermal growth factor (rhEGF); an accelerator of wound healing. GS containing Eudragit was electrospun to yield nanofiber scaffolds, which were further modified by covalent immobilization of rhEGF to their surface. This novel fabricated nanoscaffold was characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction. The thermal behavior of the nanoscaffold was determined using thermogravimetric analysis and differential scanning calorimetry. In the in vitro antibacterial assays, the nanoscaffolds exhibited comparable antibacterial activity to pure gentemicin powder. In vivo work using female C57/BL6 mice, the nanoscaffolds induced faster wound healing activity in dorsal wounds compared to the control. The paradigm in this study presents a robust in vivo model to enhance the applicability of drug delivery systems in wound healing applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 641–651, 2018.

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link (url) DOI [BibTex]


link (url) DOI [BibTex]


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Robotics Research

Tong, Chi Hay, Furgale, Paul, Barfoot, Timothy D, Guizilini, Vitor, Ramos, Fabio, Chen, Yushan, T\uumová, Jana, Ulusoy, Alphan, Belta, Calin, Tenorth, Moritz, others

(article)

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[BibTex]

[BibTex]