Header logo is


2017


no image
New Directions for Learning with Kernels and Gaussian Processes (Dagstuhl Seminar 16481)

Gretton, A., Hennig, P., Rasmussen, C., Schölkopf, B.

Dagstuhl Reports, 6(11):142-167, 2017 (book)

ei pn

DOI [BibTex]

2017


DOI [BibTex]


no image
Statistical Asymmetries Between Cause and Effect

Janzing, D.

In Time in Physics, pages: 129-139, Tutorials, Schools, and Workshops in the Mathematical Sciences, (Editors: Renner, Renato and Stupar, Sandra), Springer International Publishing, Cham, 2017 (inbook)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


no image
A parametric texture model based on deep convolutional features closely matches texture appearance for humans

Wallis, T. S. A., Funke, C. M., Ecker, A. S., Gatys, L. A., Wichmann, F. A., Bethge, M.

Journal of Vision, 17(12), 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Robot Learning

Peters, J., Tedrake, R., Roy, N., Morimoto, J.

In Encyclopedia of Machine Learning and Data Mining, pages: 1106-1109, 2nd, (Editors: Sammut, Claude and Webb, Geoffrey I.), Springer US, 2017 (inbook)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Development and Evaluation of a Portable BCI System for Remote Data Acquisition

Emde, T.

Graduate School of Neural Information Processing, Eberhard Karls Universität Tübingen, Germany, 2017 (mastersthesis)

ei

[BibTex]

[BibTex]


no image
Brain-Computer Interfaces for patients with Amyotrophic Lateral Sclerosis

Fomina, T.

Eberhard Karls Universität Tübingen, Germany, 2017 (phdthesis)

ei

[BibTex]

[BibTex]


no image
Model Selection for Gaussian Mixture Models

Huang, T., Peng, H., Zhang, K.

Statistica Sinica, 27(1):147-169, 2017 (article)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
An image-computable psychophysical spatial vision model

Schütt, H. H., Wichmann, F. A.

Journal of Vision, 17(12), 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Methods and measurements to compare men against machines

Wichmann, F. A., Janssen, D. H. J., Geirhos, R., Aguilar, G., Schütt, H. H., Maertens, M., Bethge, M.

Electronic Imaging, pages: 36-45(10), 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


no image
Generalized phase locking analysis of electrophysiology data

Safavi, S., Panagiotaropoulos, T., Kapoor, V., Logothetis, N. K., Besserve, M.

ESI Systems Neuroscience Conference (ESI-SyNC 2017): Principles of Structural and Functional Connectivity, 2017 (poster)

ei

[BibTex]

[BibTex]


no image
A Comparison of Autoregressive Hidden Markov Models for Multimodal Manipulations With Variable Masses

Kroemer, O., Peters, J.

IEEE Robotics and Automation Letters, 2(2):1101-1108, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


no image
Phase Estimation for Fast Action Recognition and Trajectory Generation in Human-Robot Collaboration

Maeda, G., Ewerton, M., Neumann, G., Lioutikov, R., Peters, J.

International Journal of Robotics Research, 36(13-14):1579-1594, 2017, Special Issue on the Seventeenth International Symposium on Robotics Research (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Causal models for decision making via integrative inference

Geiger, P.

University of Stuttgart, Germany, 2017 (phdthesis)

ei

[BibTex]

[BibTex]


no image
A Phase-coded Aperture Camera with Programmable Optics

Chen, J., Hirsch, M., Heintzmann, R., Eberhardt, B., Lensch, H. P. A.

Electronic Imaging, 2017(17):70-75, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


no image
On Maximum Entropy and Inference

Gresele, L., Marsili, M.

Entropy, 19(12):article no. 642, 2017 (article)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
Towards Engagement Models that Consider Individual Factors in HRI: On the Relation of Extroversion and Negative Attitude Towards Robots to Gaze and Speech During a Human-Robot Assembly Task

Ivaldi, S., Lefort, S., Peters, J., Chetouani, M., Provasi, J., Zibetti, E.

International Journal of Social Robotics, 9(1):63-86, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


no image
Non-parametric Policy Search with Limited Information Loss

van Hoof, H., Neumann, G., Peters, J.

Journal of Machine Learning Research , 18(73):1-46, 2017 (article)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


no image
Stability of Controllers for Gaussian Process Dynamics

Vinogradska, J., Bischoff, B., Nguyen-Tuong, D., Peters, J.

Journal of Machine Learning Research, 18(100):1-37, 2017 (article)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


no image
Learning Optimal Configurations for Modeling Frowning by Transcranial Electrical Stimulation

Sücker, K.

Graduate School of Neural Information Processing, Eberhard Karls Universität Tübingen, Germany, 2017 (mastersthesis)

ei

[BibTex]

[BibTex]


no image
SUV-quantification of physiological lung tissue in an integrated PET/MR-system: Impact of lung density and bone tissue

Seith, F., Schmidt, H., Gatidis, S., Bezrukov, I., Schraml, C., Pfannenberg, C., la Fougère, C., Nikolaou, K., Schwenzer, N.

PLOS ONE, 12(5):1-13, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]

2010


no image
Computationally efficient algorithms for statistical image processing: Implementation in R

Langovoy, M., Wittich, O.

(2010-053), EURANDOM, Technische Universiteit Eindhoven, December 2010 (techreport)

Abstract
In the series of our earlier papers on the subject, we proposed a novel statistical hy- pothesis testing method for detection of objects in noisy images. The method uses results from percolation theory and random graph theory. We developed algorithms that allowed to detect objects of unknown shapes in the presence of nonparametric noise of unknown level and of un- known distribution. No boundary shape constraints were imposed on the objects, only a weak bulk condition for the object's interior was required. Our algorithms have linear complexity and exponential accuracy. In the present paper, we describe an implementation of our nonparametric hypothesis testing method. We provide a program that can be used for statistical experiments in image processing. This program is written in the statistical programming language R.

ei

PDF [BibTex]

2010


PDF [BibTex]


no image
Learning Table Tennis with a Mixture of Motor Primitives

Mülling, K., Kober, J., Peters, J.

In Proceedings of the 10th IEEE-RAS International Conference on Humanoid Robots (Humanoids 2010), pages: 411-416, IEEE, Piscataway, NJ, USA, 10th IEEE-RAS International Conference on Humanoid Robots (Humanoids), December 2010 (inproceedings)

Abstract
Table tennis is a sufficiently complex motor task for studying complete skill learning systems. It consists of several elementary motions and requires fast movements, accurate control, and online adaptation. To represent the elementary movements needed for robot table tennis, we rely on dynamic systems motor primitives (DMP). While such DMPs have been successfully used for learning a variety of simple motor tasks, they only represent single elementary actions. In order to select and generalize among different striking movements, we present a new approach, called Mixture of Motor Primitives that uses a gating network to activate appropriate motor primitives. The resulting policy enables us to select among the appropriate motor primitives as well as to generalize between them. In order to obtain a fully learned robot table tennis setup, we also address the problem of predicting the necessary context information, i.e., the hitting point in time and space where we want to hit the ball. We show that the resulting setup was capable of playing rudimentary table tennis using an anthropomorphic robot arm.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
Similarities in resting state and feature-driven activity: Non-parametric evaluation of human fMRI

Shelton, J., Blaschko, M., Gretton, A., Müller, J., Fischer, E., Bartels, A.

NIPS Workshop on Learning and Planning from Batch Time Series Data, December 2010 (poster)

ei

PDF Web [BibTex]

PDF Web [BibTex]


no image
Fast Convergent Algorithms for Expectation Propagation Approximate Bayesian Inference

Seeger, M., Nickisch, H.

Max Planck Institute for Biological Cybernetics, December 2010 (techreport)

Abstract
We propose a novel algorithm to solve the expectation propagation relaxation of Bayesian inference for continuous-variable graphical models. In contrast to most previous algorithms, our method is provably convergent. By marrying convergent EP ideas from (Opper&Winther 05) with covariance decoupling techniques (Wipf&Nagarajan 08, Nickisch&Seeger 09), it runs at least an order of magnitude faster than the most commonly used EP solver.

ei

Web [BibTex]

Web [BibTex]


no image
Learning an interactive segmentation system

Nickisch, H., Rother, C., Kohli, P., Rhemann, C.

In Proceedings of the Seventh Indian Conference on Computer Vision, Graphics and Image Processing (ICVGIP 2010), pages: 274-281, (Editors: Chellapa, R. , P. Anandan, A. N. Rajagopalan, P. J. Narayanan, P. Torr), ACM Press, Nw York, NY, USA, Seventh Indian Conference on Computer Vision, Graphics and Image Processing (ICVGIP), December 2010 (inproceedings)

Abstract
Many successful applications of computer vision to image or video manipulation are interactive by nature. However, parameters of such systems are often trained neglecting the user. Traditionally, interactive systems have been treated in the same manner as their fully automatic counterparts. Their performance is evaluated by computing the accuracy of their solutions under some fixed set of user interactions. This paper proposes a new evaluation and learning method which brings the user in the loop. It is based on the use of an active robot user -- a simulated model of a human user. We show how this approach can be used to evaluate and learn parameters of state-of-the-art interactive segmentation systems. We also show how simulated user models can be integrated into the popular max-margin method for parameter learning and propose an algorithm to solve the resulting optimisation problem.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


no image
Using an Infinite Von Mises-Fisher Mixture Model to Cluster Treatment Beam Directions in External Radiation Therapy

Bangert, M., Hennig, P., Oelfke, U.

In pages: 746-751 , (Editors: Draghici, S. , T.M. Khoshgoftaar, V. Palade, W. Pedrycz, M.A. Wani, X. Zhu), IEEE, Piscataway, NJ, USA, Ninth International Conference on Machine Learning and Applications (ICMLA), December 2010 (inproceedings)

Abstract
We present a method for fully automated selection of treatment beam ensembles for external radiation therapy. We reformulate the beam angle selection problem as a clustering problem of locally ideal beam orientations distributed on the unit sphere. For this purpose we construct an infinite mixture of von Mises-Fisher distributions, which is suited in general for density estimation from data on the D-dimensional sphere. Using a nonparametric Dirichlet process prior, our model infers probability distributions over both the number of clusters and their parameter values. We describe an efficient Markov chain Monte Carlo inference algorithm for posterior inference from experimental data in this model. The performance of the suggested beam angle selection framework is illustrated for one intra-cranial, pancreas, and prostate case each. The infinite von Mises-Fisher mixture model (iMFMM) creates between 18 and 32 clusters, depending on the patient anatomy. This suggests to use the iMFMM directly for beam ensemble selection in robotic radio surgery, or to generate low-dimensional input for both subsequent optimization of trajectories for arc therapy and beam ensemble selection for conventional radiation therapy.

ei pn

Web DOI [BibTex]

Web DOI [BibTex]


no image
Markerless tracking of Dynamic 3D Scans of Faces

Walder, C., Breidt, M., Bülthoff, H., Schölkopf, B., Curio, C.

In Dynamic Faces: Insights from Experiments and Computation, pages: 255-276, (Editors: Curio, C., Bülthoff, H. H. and Giese, M. A.), MIT Press, Cambridge, MA, USA, December 2010 (inbook)

ei

Web [BibTex]

Web [BibTex]


no image
Causal relationships between frequency bands of extracellular signals in visual cortex revealed by an information theoretic analysis

Besserve, M., Schölkopf, B., Logothetis, N., Panzeri, S.

Journal of Computational Neuroscience, 29(3):547-566, December 2010 (article)

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


no image
Tackling Box-Constrained Optimization via a New Projected Quasi-Newton Approach

Kim, D., Sra, S., Dhillon, I.

SIAM Journal on Scientific Computing, 32(6):3548-3563 , December 2010 (article)

Abstract
Numerous scientific applications across a variety of fields depend on box-constrained convex optimization. Box-constrained problems therefore continue to attract research interest. We address box-constrained (strictly convex) problems by deriving two new quasi-Newton algorithms. Our algorithms are positioned between the projected-gradient [J. B. Rosen, J. SIAM, 8 (1960), pp. 181–217] and projected-Newton [D. P. Bertsekas, SIAM J. Control Optim., 20 (1982), pp. 221–246] methods. We also prove their convergence under a simple Armijo step-size rule. We provide experimental results for two particular box-constrained problems: nonnegative least squares (NNLS), and nonnegative Kullback–Leibler (NNKL) minimization. For both NNLS and NNKL our algorithms perform competitively as compared to well-established methods on medium-sized problems; for larger problems our approach frequently outperforms the competition.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
Algorithmen zum Automatischen Erlernen von Motorfähigkeiten

Peters, J., Kober, J., Schaal, S.

at - Automatisierungstechnik, 58(12):688-694, December 2010 (article)

Abstract
Robot learning methods which allow autonomous robots to adapt to novel situations have been a long standing vision of robotics, artificial intelligence, and cognitive sciences. However, to date, learning techniques have yet to fulfill this promise as only few methods manage to scale into the high-dimensional domains of manipulator robotics, or even the new upcoming trend of humanoid robotics. If possible, scaling was usually only achieved in precisely pre-structured domains. In this paper, we investigate the ingredients for a general approach policy learning with the goal of an application to motor skill refinement in order to get one step closer towards human-like performance. For doing so, we study two major components for such an approach, i. e., firstly, we study policy learning algorithms which can be applied in the general setting of motor skill learning, and, secondly, we study a theoretically well-founded general approach to representing the required control structures for task representation and execution.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
Online algorithms for submodular minimization with combinatorial constraints

Jegelka, S., Bilmes, J.

In pages: 1-6, NIPS Workshop on Discrete Optimization in Machine Learning: Structures, Algorithms and Applications (DISCML), December 2010 (inproceedings)

Abstract
Building on recent results for submodular minimization with combinatorial constraints, and on online submodular minimization, we address online approximation algorithms for submodular minimization with combinatorial constraints. We discuss two types of algorithms and outline approximation algorithms that integrate into those.

ei

PDF Web [BibTex]

PDF Web [BibTex]


no image
PAC-Bayesian Analysis of Co-clustering and Beyond

Seldin, Y., Tishby, N.

Journal of Machine Learning Research, 11, pages: 3595-3646, December 2010 (article)

ei

PDF PDF [BibTex]

PDF PDF [BibTex]


no image
Multi-agent random walks for local clustering

Alamgir, M., von Luxburg, U.

In Proceedings of the IEEE International Conference on Data Mining (ICDM 2010), pages: 18-27, (Editors: Webb, G. I., B. Liu, C. Zhang, D. Gunopulos, X. Wu), IEEE, Piscataway, NJ, USA, IEEE International Conference on Data Mining (ICDM), December 2010 (inproceedings)

Abstract
We consider the problem of local graph clustering where the aim is to discover the local cluster corresponding to a point of interest. The most popular algorithms to solve this problem start a random walk at the point of interest and let it run until some stopping criterion is met. The vertices visited are then considered the local cluster. We suggest a more powerful alternative, the multi-agent random walk. It consists of several “agents” connected by a fixed rope of length l. All agents move independently like a standard random walk on the graph, but they are constrained to have distance at most l from each other. The main insight is that for several agents it is harder to simultaneously travel over the bottleneck of a graph than for just one agent. Hence, the multi-agent random walk has less tendency to mistakenly merge two different clusters than the original random walk. In our paper we analyze the multi-agent random walk theoretically and compare it experimentally to the major local graph clustering algorithms from the literature. We find that our multi-agent random walk consistently outperforms these algorithms.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


no image
Policy Gradient Methods

Peters, J., Bagnell, J.

In Encyclopedia of Machine Learning, pages: 774-776, (Editors: Sammut, C. and Webb, G. I.), Springer, Berlin, Germany, December 2010 (inbook)

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


no image
Augmentation of fMRI Data Analysis using Resting State Activity and Semi-supervised Canonical Correlation Analysis

Shelton, JA., Blaschko, MB., Bartels, A.

NIPS Women in Machine Learning Workshop (WiML), December 2010 (poster)

Abstract
Resting state activity is brain activation that arises in the absence of any task, and is usually measured in awake subjects during prolonged fMRI scanning sessions where the only instruction given is to close the eyes and do nothing. It has been recognized in recent years that resting state activity is implicated in a wide variety of brain function. While certain networks of brain areas have different levels of activation at rest and during a task, there is nevertheless significant similarity between activations in the two cases. This suggests that recordings of resting state activity can be used as a source of unlabeled data to augment kernel canonical correlation analysis (KCCA) in a semisupervised setting. We evaluate this setting empirically yielding three main results: (i) KCCA tends to be improved by the use of Laplacian regularization even when no additional unlabeled data are available, (ii) resting state data seem to have a similar marginal distribution to that recorded during the execution of a visual processing task implying largely similar types of activation, and (iii) this source of information can be broadly exploited to improve the robustness of empirical inference in fMRI studies, an inherently data poor domain.

ei

PDF Web [BibTex]

PDF Web [BibTex]


no image
Effects of Packet Losses to Stability in Bilateral Teleoperation Systems

Hong, A., Cho, JH., Lee, DY.

In pages: 1043-1044, Korean Society of Mechanical Engineers, Seoul, South Korea, KSME Fall Annual Meeting, November 2010 (inproceedings)

ei

[BibTex]

[BibTex]


no image
Gaussian Processes for Machine Learning (GPML) Toolbox

Rasmussen, C., Nickisch, H.

Journal of Machine Learning Research, 11, pages: 3011-3015, November 2010 (article)

Abstract
The GPML toolbox provides a wide range of functionality for Gaussian process (GP) inference and prediction. GPs are specified by mean and covariance functions; we offer a library of simple mean and covariance functions and mechanisms to compose more complex ones. Several likelihood functions are supported including Gaussian and heavy-tailed for regression as well as others suitable for classification. Finally, a range of inference methods is provided, including exact and variational inference, Expectation Propagation, and Laplace's method dealing with non-Gaussian likelihoods and FITC for dealing with large regression tasks.

ei

Web [BibTex]

Web [BibTex]


no image
Combining Real-Time Brain-Computer Interfacing and Robot Control for Stroke Rehabilitation

Gomez Rodriguez, M., Peters, J., Hill, J., Gharabaghi, A., Schölkopf, B., Grosse-Wentrup, M.

In Proceedings of SIMPAR 2010 Workshops, pages: 59-63, Brain-Computer Interface Workshop at SIMPAR: 2nd International Conference on Simulation, Modeling, and Programming for Autonomous Robots, November 2010 (inproceedings)

Abstract
Brain-Computer Interfaces based on electrocorticography (ECoG) or electroencephalography (EEG), in combination with robot-assisted active physical therapy, may support traditional rehabilitation procedures for patients with severe motor impairment due to cerebrovascular brain damage caused by stroke. In this short report, we briefly review the state-of-the art in this exciting new field, give an overview of the work carried out at the Max Planck Institute for Biological Cybernetics and the University of T{\"u}bingen, and discuss challenges that need to be addressed in order to move from basic research to clinical studies.

ei

PDF Web [BibTex]

PDF Web [BibTex]


no image
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution

Armache, J-P., Jarasch, A., Anger, AM., Villa, E., Becker, T., Bhushan, S., Jossinet, F., Habeck, M., Dindar, G., Franckenberg, S., Marquez, V., Mielke, T., Thomm, M., Berninghausen, O., Beatrix, B., Söding, J., Westhof, E., Wilson, DN., Beckmann, R.

Proceedings of the National Academy of Sciences of the United States of America, 107(46):19748-19753, November 2010 (article)

Abstract
Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES–ES and r-protein–ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
Policy gradient methods

Peters, J.

Scholarpedia, 5(11):3698, November 2010 (article)

Abstract
Policy gradient methods are a type of reinforcement learning techniques that rely upon optimizing parametrized policies with respect to the expected return (long-term cumulative reward) by gradient descent. They do not suffer from many of the problems that have been marring traditional reinforcement learning approaches such as the lack of guarantees of a value function, the intractability problem resulting from uncertain state information and the complexity arising from continuous states & actions.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
High frequency phase-spike synchronization of extracellular signals modulates causal interactions in monkey primary visual cortex

Besserve, M., Murayama, Y., Schölkopf, B., Logothetis, N., Panzeri, S.

40(616.2), 40th Annual Meeting of the Society for Neuroscience (Neuroscience), November 2010 (poster)

Abstract
Functional correlates of Rhythms in the gamma band (30-100Hz) are observed in the mammalian brain with a large variety of functional correlates. Nevertheless, their functional role is still debated. One way to disentangle this issue is to go beyond usual correlation analysis and apply causality measures that quantify the directed interactions between the gamma rhythms and other aspects of neural activity. These measures can be further compared with other aspects of neurophysicological signals to find markers of neural interactions. In a recent study, we analyzed extracellular recordings in the primary visual cortex of 4 anesthetized macaques during the presentation of movie stimuli using a causality measure named Transfer Entropy. We found causal interactions between high frequency gamma rhythms (60-100Hz) recorded in different electrodes, involving in particular their phase, and between the gamma phase and spiking activity quantified by the instantaneous envelope of the MUA band (1-3kHz). Here, we further investigate in the same dataset the meaning of these phase-MUA and phase-phase causal interactions by studying the distribution of phases at multiple recording sites at lags around the occurrence of spiking events. First, we found a sharpening of the gamma phase distribution in one electrode when spikes are occurring in other recording site. This phenomena appeared as a form of phase-spike synchronization and was quantified by an information theoretic measure. We found this measure correlates significantly with phase-MUA causal interactions. Additionally, we quantified in a similar way the interplay between spiking and the phase difference between two recording sites (reflecting the well-know concept of phase synchronization). We found that, depending on the couple of recording site, spiking can correlate either with a phase synchronization or with a desynchronization with respect to the baseline. This effect correlates very well with the phase-phase causality measure. These results provide evidence for high frequency phase-spike synchronization to reflect communication between distant neural populations in V1. Conversely, both phase synchronization or desynchronization may favor neural communication between recording sites. This new result, which contrasts with current hypothesis on the role of phase synchronization, could be interpreted as the presence of inhibitory interactions that are suppressed by desynchronization. Finally, our findings give new insights into the role of gamma rhythms in regulating local computation in the visual cortex.

ei

Web [BibTex]

Web [BibTex]


no image
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome

Armache, J-P., Jarasch, A., Anger, AM., Villa, E., Becker, T., Bhushan, S., Jossinet, F., Habeck, M., Dindar, G., Franckenberg, S., Marquez, V., Mielke, T., Thomm, M., Berninghausen, O., Beatrix, B., Söding, J., Westhof, E., Wilson, DN., Beckmann, R.

Proceedings of the National Academy of Sciences of the United States of America, 107(46):19754-19759, November 2010 (article)

Abstract
Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectron microscopy reconstructions of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution, together with a 6.1-Å map of a translating Saccharomyces cerevisiae 80S ribosome, we have localized and modeled 74/80 (92.5%) of the ribosomal proteins, encompassing 12 archaeal/eukaryote-specific small subunit proteins as well as the complete complement of the ribosomal proteins of the eukaryotic large subunit. Near-complete atomic models of the 80S ribosome provide insights into the structure, function, and evolution of the eukaryotic translational apparatus.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
Attenuation Correction for Whole Body PET/MR: Quantitative Evaluation and Lung Attenuation Estimation with Consistency Information

Bezrukov, I., Hofmann, M., Aschoff, P., Beyer, T., Mantlik, F., Pichler, B., Schölkopf, B.

2010(M13-122), 2010 Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), November 2010 (poster)

ei

[BibTex]

[BibTex]


no image
PET/MRI: Observation of Non-Isotropic Positron Distribution in High Magnetic Fields and Its Diagnostic Impact

Kolb, A., Hofmann, M., Sauter, A., Liu, C., Schölkopf, B., Pichler, B.

2010 Nuclear Science Symposium and Medical Imaging Conference, 2010(M18-119):1, November 2010 (poster)

ei

Web [BibTex]

Web [BibTex]


no image
Comparative Quantitative Evaluation of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Kolb, A., Beyer, T., Reimold, M., Pichler, B., Schölkopf, B.

2010(M08-4), 2010 Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), November 2010 (talk)

Abstract
Combined PET/MR provides at the same time molecular and functional imaging as well as excellent soft tissue contrast. It does not allow one to directly measure the attenuation properties of scanned tissues, despite the fact that accurate attenuation maps are necessary for quantitative PET imaging. Several methods have therefore been proposed for MR-based attenuation correction (MR-AC). So far, they have only been evaluated on data acquired from separate MR and PET scanners. We evaluated several MR-AC methods on data from 10 patients acquired on a combined BrainPET/MR scanner. This allowed the consideration of specific PET/MR issues, such as the RF coil that attenuates and scatters 511 keV gammas. We evaluated simple MR thresholding methods as well as atlas and machine learning-based MR-AC. CT-based AC served as gold standard reference. To comprehensively evaluate the MR-AC accuracy, we used RoIs from 2 anatomic brain atlases with different levels of detail. Visual inspection of the PET images indicated that even the basic FLASH threshold MR-AC may be sufficient for several applications. Using a UTE sequence for bone prediction in MR-based thresholding occasionally led to false prediction of bone tissue inside the brain, causing a significant overestimation of PET activity. Although it yielded a lower mean underestimation of activity, it exhibited the highest variance of all methods. The atlas averaging approach had a smaller mean error, but showed high maximum overestimation on the RoIs of the more detailed atlas. The Nave Bayes and Atlas-Patch MR-AC yielded the smallest variance, and the Atlas-Patch also showed the smallest mean error. In conclusion, Atlas-based AC using only MR information on the BrainPET/MR yields a high level of accuracy that is sufficient for clinical quantitative imaging requirements. The Atlas-Patch approach was superior to alternative atlas-based methods, yielding a quantification error below 10% for all RoIs except very small ones.

ei

[BibTex]

[BibTex]


no image
Spatio-Spectral Remote Sensing Image Classification With Graph Kernels

Camps-Valls, G., Shervashidze, N., Borgwardt, K.

IEEE Geoscience and Remote Sensing Letters, 7(4):741-745, October 2010 (article)

Abstract
This letter presents a graph kernel for spatio-spectral remote sensing image classification with support vector machines (SVMs). The method considers higher order relations in the neighborhood (beyond pairwise spatial relations) to iteratively compute a kernel matrix for SVM learning. The proposed kernel is easy to compute and constitutes a powerful alternative to existing approaches. The capabilities of the method are illustrated in several multi- and hyperspectral remote sensing images acquired over both urban and agricultural areas.

ei

Web DOI [BibTex]

Web DOI [BibTex]


no image
Causal Inference Using the Algorithmic Markov Condition

Janzing, D., Schölkopf, B.

IEEE Transactions on Information Theory, 56(10):5168-5194, October 2010 (article)

Abstract
Inferring the causal structure that links $n$ observables is usually based upon detecting statistical dependences and choosing simple graphs that make the joint measure Markovian. Here we argue why causal inference is also possible when the sample size is one. We develop a theory how to generate causal graphs explaining similarities between single objects. To this end, we replace the notion of conditional stochastic independence in the causal Markov condition with the vanishing of conditional algorithmic mutual information and describe the corresponding causal inference rules. We explain why a consistent reformulation of causal inference in terms of algorithmic complexity implies a new inference principle that takes into account also the complexity of conditional probability densities, making it possible to select among Markov equivalent causal graphs. This insight provides a theoretical foundation of a heuristic principle proposed in earlier work. We also sketch some ideas on how to replace Kolmogorov complexity with decidable complexity criteria. This can be seen as an algorithmic analog of replacing the empirically undecidable question of statistical independence with practical independence tests that are based on implicit or explicit assumptions on the underlying distribution.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]